Interaction of Chlorpromazine and Nortriptyline in Patients with Schizophrenia
Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil siz...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Loga, S. [verfasserIn] Curry, S. [verfasserIn] Lader, M. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1981 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical pharmacokinetics - Berlin [u.a.] : Springer, 1976, 6(1981), 6 vom: Dez., Seite 454-462 |
|---|---|
| Übergeordnetes Werk: |
volume:6 ; year:1981 ; number:6 ; month:12 ; pages:454-462 |
| Links: |
|---|
| DOI / URN: |
10.2165/00003088-198106060-00003 |
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SPR033033099 |
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| 520 | |a Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care. | ||
| 650 | 4 | |a Chlorpromazine |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a Pupil Size |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Curry, S. |e verfasserin |4 aut | |
| 700 | 1 | |a Lader, M. |e verfasserin |4 aut | |
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10.2165/00003088-198106060-00003 doi (DE-627)SPR033033099 (SPR)00003088-198106060-00003-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Loga, S. verfasserin aut Interaction of Chlorpromazine and Nortriptyline in Patients with Schizophrenia 1981 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care. Chlorpromazine (dpeaa)DE-He213 Antipyrine (dpeaa)DE-He213 Nortriptyline (dpeaa)DE-He213 Critical Difference (dpeaa)DE-He213 Pupil Size (dpeaa)DE-He213 Curry, S. verfasserin aut Lader, M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 6(1981), 6 vom: Dez., Seite 454-462 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:6 year:1981 number:6 month:12 pages:454-462 https://dx.doi.org/10.2165/00003088-198106060-00003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 6 1981 6 12 454-462 |
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10.2165/00003088-198106060-00003 doi (DE-627)SPR033033099 (SPR)00003088-198106060-00003-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Loga, S. verfasserin aut Interaction of Chlorpromazine and Nortriptyline in Patients with Schizophrenia 1981 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care. Chlorpromazine (dpeaa)DE-He213 Antipyrine (dpeaa)DE-He213 Nortriptyline (dpeaa)DE-He213 Critical Difference (dpeaa)DE-He213 Pupil Size (dpeaa)DE-He213 Curry, S. verfasserin aut Lader, M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 6(1981), 6 vom: Dez., Seite 454-462 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:6 year:1981 number:6 month:12 pages:454-462 https://dx.doi.org/10.2165/00003088-198106060-00003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 6 1981 6 12 454-462 |
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10.2165/00003088-198106060-00003 doi (DE-627)SPR033033099 (SPR)00003088-198106060-00003-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Loga, S. verfasserin aut Interaction of Chlorpromazine and Nortriptyline in Patients with Schizophrenia 1981 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care. Chlorpromazine (dpeaa)DE-He213 Antipyrine (dpeaa)DE-He213 Nortriptyline (dpeaa)DE-He213 Critical Difference (dpeaa)DE-He213 Pupil Size (dpeaa)DE-He213 Curry, S. verfasserin aut Lader, M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 6(1981), 6 vom: Dez., Seite 454-462 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:6 year:1981 number:6 month:12 pages:454-462 https://dx.doi.org/10.2165/00003088-198106060-00003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 6 1981 6 12 454-462 |
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10.2165/00003088-198106060-00003 doi (DE-627)SPR033033099 (SPR)00003088-198106060-00003-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Loga, S. verfasserin aut Interaction of Chlorpromazine and Nortriptyline in Patients with Schizophrenia 1981 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care. Chlorpromazine (dpeaa)DE-He213 Antipyrine (dpeaa)DE-He213 Nortriptyline (dpeaa)DE-He213 Critical Difference (dpeaa)DE-He213 Pupil Size (dpeaa)DE-He213 Curry, S. verfasserin aut Lader, M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 6(1981), 6 vom: Dez., Seite 454-462 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:6 year:1981 number:6 month:12 pages:454-462 https://dx.doi.org/10.2165/00003088-198106060-00003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 6 1981 6 12 454-462 |
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10.2165/00003088-198106060-00003 doi (DE-627)SPR033033099 (SPR)00003088-198106060-00003-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Loga, S. verfasserin aut Interaction of Chlorpromazine and Nortriptyline in Patients with Schizophrenia 1981 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care. Chlorpromazine (dpeaa)DE-He213 Antipyrine (dpeaa)DE-He213 Nortriptyline (dpeaa)DE-He213 Critical Difference (dpeaa)DE-He213 Pupil Size (dpeaa)DE-He213 Curry, S. verfasserin aut Lader, M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 6(1981), 6 vom: Dez., Seite 454-462 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:6 year:1981 number:6 month:12 pages:454-462 https://dx.doi.org/10.2165/00003088-198106060-00003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 6 1981 6 12 454-462 |
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interaction of chlorpromazine and nortriptyline in patients with schizophrenia |
| title_auth |
Interaction of Chlorpromazine and Nortriptyline in Patients with Schizophrenia |
| abstract |
Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care. |
| abstractGer |
Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care. |
| abstract_unstemmed |
Summary Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care. |
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| title_short |
Interaction of Chlorpromazine and Nortriptyline in Patients with Schizophrenia |
| url |
https://dx.doi.org/10.2165/00003088-198106060-00003 |
| remote_bool |
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| author2 |
Curry, S. Lader, M. |
| author2Str |
Curry, S. Lader, M. |
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| doi_str |
10.2165/00003088-198106060-00003 |
| up_date |
2024-07-03T16:11:25.938Z |
| _version_ |
1803574927361572864 |
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7.4018393 |