Pharmacokinetics of Indomethacin in the Elderly
Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Oberbauer, R. [verfasserIn] Krivanek, P. [verfasserIn] Turnheim, K. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1993 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical pharmacokinetics - Berlin [u.a.] : Springer, 1976, 24(1993), 5 vom: Mai, Seite 428-434 |
|---|---|
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volume:24 ; year:1993 ; number:5 ; month:05 ; pages:428-434 |
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10.2165/00003088-199324050-00007 |
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| 520 | |a Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg in younger individuals (mean 36.9 ± 3.0 years). The apparent elimination rate constant averaged 0.23 $ h^{−1} $ in the aged and 0.32 $ h^{−1} $ in the young people. Oral bioavailability was close to 1 in the young but 0.77 in the elderly. The apparent volume of distribution was similar in each group. Based on these results it is suggested that the maintenance dose of indomethacin be reduced by 25% in the elderly. | ||
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| 700 | 1 | |a Turnheim, K. |e verfasserin |4 aut | |
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10.2165/00003088-199324050-00007 doi (DE-627)SPR033040540 (SPR)00003088-199324050-00007-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Oberbauer, R. verfasserin aut Pharmacokinetics of Indomethacin in the Elderly 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg in younger individuals (mean 36.9 ± 3.0 years). The apparent elimination rate constant averaged 0.23 $ h^{−1} $ in the aged and 0.32 $ h^{−1} $ in the young people. Oral bioavailability was close to 1 in the young but 0.77 in the elderly. The apparent volume of distribution was similar in each group. Based on these results it is suggested that the maintenance dose of indomethacin be reduced by 25% in the elderly. High Performance Liquid Chromatography (dpeaa)DE-He213 Indomethacin (dpeaa)DE-He213 Ketoprofen (dpeaa)DE-He213 Plasma Protein Binding (dpeaa)DE-He213 Total Clearance (dpeaa)DE-He213 Krivanek, P. verfasserin aut Turnheim, K. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 24(1993), 5 vom: Mai, Seite 428-434 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:24 year:1993 number:5 month:05 pages:428-434 https://dx.doi.org/10.2165/00003088-199324050-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 24 1993 5 05 428-434 |
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10.2165/00003088-199324050-00007 doi (DE-627)SPR033040540 (SPR)00003088-199324050-00007-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Oberbauer, R. verfasserin aut Pharmacokinetics of Indomethacin in the Elderly 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg in younger individuals (mean 36.9 ± 3.0 years). The apparent elimination rate constant averaged 0.23 $ h^{−1} $ in the aged and 0.32 $ h^{−1} $ in the young people. Oral bioavailability was close to 1 in the young but 0.77 in the elderly. The apparent volume of distribution was similar in each group. Based on these results it is suggested that the maintenance dose of indomethacin be reduced by 25% in the elderly. High Performance Liquid Chromatography (dpeaa)DE-He213 Indomethacin (dpeaa)DE-He213 Ketoprofen (dpeaa)DE-He213 Plasma Protein Binding (dpeaa)DE-He213 Total Clearance (dpeaa)DE-He213 Krivanek, P. verfasserin aut Turnheim, K. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 24(1993), 5 vom: Mai, Seite 428-434 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:24 year:1993 number:5 month:05 pages:428-434 https://dx.doi.org/10.2165/00003088-199324050-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 24 1993 5 05 428-434 |
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10.2165/00003088-199324050-00007 doi (DE-627)SPR033040540 (SPR)00003088-199324050-00007-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Oberbauer, R. verfasserin aut Pharmacokinetics of Indomethacin in the Elderly 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg in younger individuals (mean 36.9 ± 3.0 years). The apparent elimination rate constant averaged 0.23 $ h^{−1} $ in the aged and 0.32 $ h^{−1} $ in the young people. Oral bioavailability was close to 1 in the young but 0.77 in the elderly. The apparent volume of distribution was similar in each group. Based on these results it is suggested that the maintenance dose of indomethacin be reduced by 25% in the elderly. High Performance Liquid Chromatography (dpeaa)DE-He213 Indomethacin (dpeaa)DE-He213 Ketoprofen (dpeaa)DE-He213 Plasma Protein Binding (dpeaa)DE-He213 Total Clearance (dpeaa)DE-He213 Krivanek, P. verfasserin aut Turnheim, K. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 24(1993), 5 vom: Mai, Seite 428-434 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:24 year:1993 number:5 month:05 pages:428-434 https://dx.doi.org/10.2165/00003088-199324050-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 24 1993 5 05 428-434 |
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10.2165/00003088-199324050-00007 doi (DE-627)SPR033040540 (SPR)00003088-199324050-00007-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Oberbauer, R. verfasserin aut Pharmacokinetics of Indomethacin in the Elderly 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg in younger individuals (mean 36.9 ± 3.0 years). The apparent elimination rate constant averaged 0.23 $ h^{−1} $ in the aged and 0.32 $ h^{−1} $ in the young people. Oral bioavailability was close to 1 in the young but 0.77 in the elderly. The apparent volume of distribution was similar in each group. Based on these results it is suggested that the maintenance dose of indomethacin be reduced by 25% in the elderly. High Performance Liquid Chromatography (dpeaa)DE-He213 Indomethacin (dpeaa)DE-He213 Ketoprofen (dpeaa)DE-He213 Plasma Protein Binding (dpeaa)DE-He213 Total Clearance (dpeaa)DE-He213 Krivanek, P. verfasserin aut Turnheim, K. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 24(1993), 5 vom: Mai, Seite 428-434 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:24 year:1993 number:5 month:05 pages:428-434 https://dx.doi.org/10.2165/00003088-199324050-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 24 1993 5 05 428-434 |
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10.2165/00003088-199324050-00007 doi (DE-627)SPR033040540 (SPR)00003088-199324050-00007-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Oberbauer, R. verfasserin aut Pharmacokinetics of Indomethacin in the Elderly 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg in younger individuals (mean 36.9 ± 3.0 years). The apparent elimination rate constant averaged 0.23 $ h^{−1} $ in the aged and 0.32 $ h^{−1} $ in the young people. Oral bioavailability was close to 1 in the young but 0.77 in the elderly. The apparent volume of distribution was similar in each group. Based on these results it is suggested that the maintenance dose of indomethacin be reduced by 25% in the elderly. High Performance Liquid Chromatography (dpeaa)DE-He213 Indomethacin (dpeaa)DE-He213 Ketoprofen (dpeaa)DE-He213 Plasma Protein Binding (dpeaa)DE-He213 Total Clearance (dpeaa)DE-He213 Krivanek, P. verfasserin aut Turnheim, K. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 24(1993), 5 vom: Mai, Seite 428-434 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:24 year:1993 number:5 month:05 pages:428-434 https://dx.doi.org/10.2165/00003088-199324050-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.00 ASE 44.40 ASE AR 24 1993 5 05 428-434 |
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| abstract |
Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg in younger individuals (mean 36.9 ± 3.0 years). The apparent elimination rate constant averaged 0.23 $ h^{−1} $ in the aged and 0.32 $ h^{−1} $ in the young people. Oral bioavailability was close to 1 in the young but 0.77 in the elderly. The apparent volume of distribution was similar in each group. Based on these results it is suggested that the maintenance dose of indomethacin be reduced by 25% in the elderly. |
| abstractGer |
Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg in younger individuals (mean 36.9 ± 3.0 years). The apparent elimination rate constant averaged 0.23 $ h^{−1} $ in the aged and 0.32 $ h^{−1} $ in the young people. Oral bioavailability was close to 1 in the young but 0.77 in the elderly. The apparent volume of distribution was similar in each group. Based on these results it is suggested that the maintenance dose of indomethacin be reduced by 25% in the elderly. |
| abstract_unstemmed |
Summary In a cross-sectional study the pharmacokinetics of indomethacin were studied in old and young adults without manifest organ failure. Total clearance of indomethacin after a single oral dose of 50mg was 0.8 ml/min/kg in elderly individuals (mean 79.5 ± 1.3 years) compared with 1.4 ml/min/kg in younger individuals (mean 36.9 ± 3.0 years). The apparent elimination rate constant averaged 0.23 $ h^{−1} $ in the aged and 0.32 $ h^{−1} $ in the young people. Oral bioavailability was close to 1 in the young but 0.77 in the elderly. The apparent volume of distribution was similar in each group. Based on these results it is suggested that the maintenance dose of indomethacin be reduced by 25% in the elderly. |
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| title_short |
Pharmacokinetics of Indomethacin in the Elderly |
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Krivanek, P. Turnheim, K. |
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10.2165/00003088-199324050-00007 |
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