Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population

Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Vercaigne, Lavern M. [verfasserIn] Ariano, Robert E. [verfasserIn] Zacharias, James M. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2004

Schlagwörter:	Gentamicin Pharmacokinetic Parameter Haemodialysis Patient Dialysis Session Haemodialysis Session

Übergeordnetes Werk:	Enthalten in: Clinical pharmacokinetics - Berlin [u.a.] : Springer, 1976, 43(2004), 3 vom: März, Seite 205-210
Übergeordnetes Werk:	volume:43 ; year:2004 ; number:3 ; month:03 ; pages:205-210

Links:	Volltext

DOI / URN:	10.2165/00003088-200443030-00004

Katalog-ID:	SPR033049998

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520			\|a Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations.
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author_variant	l m v lm lmv r e a re rea j m z jm jmz
matchkey_str	article:11791926:2004----::aeinhraoieisfetmcnnheo
hierarchy_sort_str	2004
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publishDate	2004
allfields	10.2165/00003088-200443030-00004 doi (DE-627)SPR033049998 (SPR)00003088-200443030-00004-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Vercaigne, Lavern M. verfasserin aut Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations. Gentamicin (dpeaa)DE-He213 Pharmacokinetic Parameter (dpeaa)DE-He213 Haemodialysis Patient (dpeaa)DE-He213 Dialysis Session (dpeaa)DE-He213 Haemodialysis Session (dpeaa)DE-He213 Ariano, Robert E. verfasserin aut Zacharias, James M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 43(2004), 3 vom: März, Seite 205-210 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:43 year:2004 number:3 month:03 pages:205-210 https://dx.doi.org/10.2165/00003088-200443030-00004 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.40 ASE AR 43 2004 3 03 205-210
spelling	10.2165/00003088-200443030-00004 doi (DE-627)SPR033049998 (SPR)00003088-200443030-00004-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Vercaigne, Lavern M. verfasserin aut Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations. Gentamicin (dpeaa)DE-He213 Pharmacokinetic Parameter (dpeaa)DE-He213 Haemodialysis Patient (dpeaa)DE-He213 Dialysis Session (dpeaa)DE-He213 Haemodialysis Session (dpeaa)DE-He213 Ariano, Robert E. verfasserin aut Zacharias, James M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 43(2004), 3 vom: März, Seite 205-210 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:43 year:2004 number:3 month:03 pages:205-210 https://dx.doi.org/10.2165/00003088-200443030-00004 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.40 ASE AR 43 2004 3 03 205-210
allfields_unstemmed	10.2165/00003088-200443030-00004 doi (DE-627)SPR033049998 (SPR)00003088-200443030-00004-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Vercaigne, Lavern M. verfasserin aut Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations. Gentamicin (dpeaa)DE-He213 Pharmacokinetic Parameter (dpeaa)DE-He213 Haemodialysis Patient (dpeaa)DE-He213 Dialysis Session (dpeaa)DE-He213 Haemodialysis Session (dpeaa)DE-He213 Ariano, Robert E. verfasserin aut Zacharias, James M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 43(2004), 3 vom: März, Seite 205-210 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:43 year:2004 number:3 month:03 pages:205-210 https://dx.doi.org/10.2165/00003088-200443030-00004 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.40 ASE AR 43 2004 3 03 205-210
allfieldsGer	10.2165/00003088-200443030-00004 doi (DE-627)SPR033049998 (SPR)00003088-200443030-00004-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Vercaigne, Lavern M. verfasserin aut Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations. Gentamicin (dpeaa)DE-He213 Pharmacokinetic Parameter (dpeaa)DE-He213 Haemodialysis Patient (dpeaa)DE-He213 Dialysis Session (dpeaa)DE-He213 Haemodialysis Session (dpeaa)DE-He213 Ariano, Robert E. verfasserin aut Zacharias, James M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 43(2004), 3 vom: März, Seite 205-210 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:43 year:2004 number:3 month:03 pages:205-210 https://dx.doi.org/10.2165/00003088-200443030-00004 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.40 ASE AR 43 2004 3 03 205-210
allfieldsSound	10.2165/00003088-200443030-00004 doi (DE-627)SPR033049998 (SPR)00003088-200443030-00004-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl 44.40 bkl Vercaigne, Lavern M. verfasserin aut Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations. Gentamicin (dpeaa)DE-He213 Pharmacokinetic Parameter (dpeaa)DE-He213 Haemodialysis Patient (dpeaa)DE-He213 Dialysis Session (dpeaa)DE-He213 Haemodialysis Session (dpeaa)DE-He213 Ariano, Robert E. verfasserin aut Zacharias, James M. verfasserin aut Enthalten in Clinical pharmacokinetics Berlin [u.a.] : Springer, 1976 43(2004), 3 vom: März, Seite 205-210 (DE-627)327644974 (DE-600)2043781-X 1179-1926 nnns volume:43 year:2004 number:3 month:03 pages:205-210 https://dx.doi.org/10.2165/00003088-200443030-00004 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 44.40 ASE AR 43 2004 3 03 205-210
language	English
source	Enthalten in Clinical pharmacokinetics 43(2004), 3 vom: März, Seite 205-210 volume:43 year:2004 number:3 month:03 pages:205-210
sourceStr	Enthalten in Clinical pharmacokinetics 43(2004), 3 vom: März, Seite 205-210 volume:43 year:2004 number:3 month:03 pages:205-210
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Gentamicin Pharmacokinetic Parameter Haemodialysis Patient Dialysis Session Haemodialysis Session
dewey-raw	610
isfreeaccess_bool	false
container_title	Clinical pharmacokinetics
authorswithroles_txt_mv	Vercaigne, Lavern M. @@aut@@ Ariano, Robert E. @@aut@@ Zacharias, James M. @@aut@@
publishDateDaySort_date	2004-03-01T00:00:00Z
hierarchy_top_id	327644974
dewey-sort	3610
id	SPR033049998
language_de	englisch
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Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. 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author	Vercaigne, Lavern M.
spellingShingle	Vercaigne, Lavern M. ddc 610 bkl 44.00 bkl 44.40 misc Gentamicin misc Pharmacokinetic Parameter misc Haemodialysis Patient misc Dialysis Session misc Haemodialysis Session Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population
authorStr	Vercaigne, Lavern M.
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topic_title	610 ASE 44.00 bkl 44.40 bkl Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population Gentamicin (dpeaa)DE-He213 Pharmacokinetic Parameter (dpeaa)DE-He213 Haemodialysis Patient (dpeaa)DE-He213 Dialysis Session (dpeaa)DE-He213 Haemodialysis Session (dpeaa)DE-He213
topic	ddc 610 bkl 44.00 bkl 44.40 misc Gentamicin misc Pharmacokinetic Parameter misc Haemodialysis Patient misc Dialysis Session misc Haemodialysis Session
topic_unstemmed	ddc 610 bkl 44.00 bkl 44.40 misc Gentamicin misc Pharmacokinetic Parameter misc Haemodialysis Patient misc Dialysis Session misc Haemodialysis Session
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title	Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population
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title_full	Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population
author_sort	Vercaigne, Lavern M.
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author_browse	Vercaigne, Lavern M. Ariano, Robert E. Zacharias, James M.
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title_sort	bayesian pharmacokinetics of gentamicin in a haemodialysis population
title_auth	Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population
abstract	Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations.
abstractGer	Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations.
abstract_unstemmed	Abstract Background: Aminoglycosides are commonly used in the haemodialysis population. Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. Volume of distribution (Vd), interdialytic elimination rate constant ($ k_{inter} $), interdialytic elimination half-life (t½β, inter) and interdialytic clearance ($ CL_{inter} $) were determined from a single predialysis plasma concentration. Elimination rate constant (kdinal), elimination half-life (t½β, dial) and clearance ($ CL_{dial} $) during 3.5–4 hours of dialysis were also determined from the pre- and post-plasma concentrations. Results: Pharmacokinetic parameters (mean ± SD) were: Vd 0.288 ± 0.002 L/kg, kinter 0.015 ± 0.$ 004h^{−1} $, t½β, inter 48 ± 11h, CLinter 5.9 ± 2.4 mL/min, kdial 0.25 ±0.05 $ h^{−1} $, t½β, dial 3.0 ± 1.0h and $ CL_{dial 91 ± 24} $ mL/min. Conclusion: The rate of elimination of gentamicin was 17-fold greater (95% CI 13.7–20.7) on haemodialysis with a Fresenius F80 than off haemodialysis. All of the pharmacokinetic parameters of interest were determined using Bayesian pharmacokinetic procedures and only two plasma gentamicin concentrations.
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container_issue	3
title_short	Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population
url	https://dx.doi.org/10.2165/00003088-200443030-00004
remote_bool	true
author2	Ariano, Robert E. Zacharias, James M.
author2Str	Ariano, Robert E. Zacharias, James M.
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isOA_txt	false
hochschulschrift_bool	false
doi_str	10.2165/00003088-200443030-00004
up_date	2024-07-03T16:17:15.881Z
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Standard pharmacokinetic approaches require multiple sampling to describe the parameters of drug distribution and elimination in the intra- and interdialytic periods. Objective: To characterise the pharmacokinetics of gentamicin in a haemodialysis population by using Bayesian pharmacokinetic methods and only two plasma concentrations. Design and participants: Prospective case series of 13 adult (aged 36–70 years) haemodialysis patients (Fresenius F80 dialysers were used) receiving gentamicin. Methods: Patients with suspected or confirmed Gram-negative infections were given gentamicin. At 48 hours after receiving the dose (at the next haemodialysis session), patients provided two blood samples, one immediately before the dialysis session and another 1 hour after haemodialysis. Data on dosage, timing and plasma concentrations for all subjects were analysed with PASTRX version 10.6 and Bayesian pharmacokinetic analysis. 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Bayesian Pharmacokinetics of Gentamicin in a Haemodialysis Population

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