Dopamine $ D_{4} $ Receptors
Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Shaikh, Sanober [verfasserIn] Makoff, Andrew [verfasserIn] Collier, David [verfasserIn] Kerwin, Robert [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1997 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: CNS drugs - Berlin [u.a.] : Springer, 1994, 8(1997), 1 vom: Juli, Seite 1-11 |
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| Übergeordnetes Werk: |
volume:8 ; year:1997 ; number:1 ; month:07 ; pages:1-11 |
| Links: |
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| DOI / URN: |
10.2165/00023210-199708010-00001 |
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| Katalog-ID: |
SPR033068704 |
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| 100 | 1 | |a Shaikh, Sanober |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Dopamine $ D_{4} $ Receptors |
| 264 | 1 | |c 1997 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. Furthermore, the role of $ D_{4} $ receptors as therapeutic targets will soon be determined by the use of selective ligands about to be introduced into clinical trials. | ||
| 650 | 4 | |a Dopamine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Schizophrenia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Clozapine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dopamine Receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dopamine Receptor Gene |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Makoff, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Collier, David |e verfasserin |4 aut | |
| 700 | 1 | |a Kerwin, Robert |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t CNS drugs |d Berlin [u.a.] : Springer, 1994 |g 8(1997), 1 vom: Juli, Seite 1-11 |w (DE-627)327645172 |w (DE-600)2043806-0 |x 1179-1934 |7 nnns |
| 773 | 1 | 8 | |g volume:8 |g year:1997 |g number:1 |g month:07 |g pages:1-11 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.2165/00023210-199708010-00001 |z lizenzpflichtig |3 Volltext |
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| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
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| 912 | |a GBV_ILN_4313 | ||
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| 912 | |a GBV_ILN_4324 | ||
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| 952 | |d 8 |j 1997 |e 1 |c 07 |h 1-11 | ||
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1997 |
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1997 |
| allfields |
10.2165/00023210-199708010-00001 doi (DE-627)SPR033068704 (SPR)00023210-199708010-00001-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Shaikh, Sanober verfasserin aut Dopamine $ D_{4} $ Receptors 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. Furthermore, the role of $ D_{4} $ receptors as therapeutic targets will soon be determined by the use of selective ligands about to be introduced into clinical trials. Dopamine (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Dopamine Receptor (dpeaa)DE-He213 Dopamine Receptor Gene (dpeaa)DE-He213 Makoff, Andrew verfasserin aut Collier, David verfasserin aut Kerwin, Robert verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 8(1997), 1 vom: Juli, Seite 1-11 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:8 year:1997 number:1 month:07 pages:1-11 https://dx.doi.org/10.2165/00023210-199708010-00001 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 8 1997 1 07 1-11 |
| spelling |
10.2165/00023210-199708010-00001 doi (DE-627)SPR033068704 (SPR)00023210-199708010-00001-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Shaikh, Sanober verfasserin aut Dopamine $ D_{4} $ Receptors 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. Furthermore, the role of $ D_{4} $ receptors as therapeutic targets will soon be determined by the use of selective ligands about to be introduced into clinical trials. Dopamine (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Dopamine Receptor (dpeaa)DE-He213 Dopamine Receptor Gene (dpeaa)DE-He213 Makoff, Andrew verfasserin aut Collier, David verfasserin aut Kerwin, Robert verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 8(1997), 1 vom: Juli, Seite 1-11 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:8 year:1997 number:1 month:07 pages:1-11 https://dx.doi.org/10.2165/00023210-199708010-00001 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 8 1997 1 07 1-11 |
| allfields_unstemmed |
10.2165/00023210-199708010-00001 doi (DE-627)SPR033068704 (SPR)00023210-199708010-00001-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Shaikh, Sanober verfasserin aut Dopamine $ D_{4} $ Receptors 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. Furthermore, the role of $ D_{4} $ receptors as therapeutic targets will soon be determined by the use of selective ligands about to be introduced into clinical trials. Dopamine (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Dopamine Receptor (dpeaa)DE-He213 Dopamine Receptor Gene (dpeaa)DE-He213 Makoff, Andrew verfasserin aut Collier, David verfasserin aut Kerwin, Robert verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 8(1997), 1 vom: Juli, Seite 1-11 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:8 year:1997 number:1 month:07 pages:1-11 https://dx.doi.org/10.2165/00023210-199708010-00001 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 8 1997 1 07 1-11 |
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10.2165/00023210-199708010-00001 doi (DE-627)SPR033068704 (SPR)00023210-199708010-00001-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Shaikh, Sanober verfasserin aut Dopamine $ D_{4} $ Receptors 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. Furthermore, the role of $ D_{4} $ receptors as therapeutic targets will soon be determined by the use of selective ligands about to be introduced into clinical trials. Dopamine (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Dopamine Receptor (dpeaa)DE-He213 Dopamine Receptor Gene (dpeaa)DE-He213 Makoff, Andrew verfasserin aut Collier, David verfasserin aut Kerwin, Robert verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 8(1997), 1 vom: Juli, Seite 1-11 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:8 year:1997 number:1 month:07 pages:1-11 https://dx.doi.org/10.2165/00023210-199708010-00001 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 8 1997 1 07 1-11 |
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10.2165/00023210-199708010-00001 doi (DE-627)SPR033068704 (SPR)00023210-199708010-00001-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Shaikh, Sanober verfasserin aut Dopamine $ D_{4} $ Receptors 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. Furthermore, the role of $ D_{4} $ receptors as therapeutic targets will soon be determined by the use of selective ligands about to be introduced into clinical trials. Dopamine (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Dopamine Receptor (dpeaa)DE-He213 Dopamine Receptor Gene (dpeaa)DE-He213 Makoff, Andrew verfasserin aut Collier, David verfasserin aut Kerwin, Robert verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 8(1997), 1 vom: Juli, Seite 1-11 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:8 year:1997 number:1 month:07 pages:1-11 https://dx.doi.org/10.2165/00023210-199708010-00001 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 8 1997 1 07 1-11 |
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English |
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Enthalten in CNS drugs 8(1997), 1 vom: Juli, Seite 1-11 volume:8 year:1997 number:1 month:07 pages:1-11 |
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Enthalten in CNS drugs 8(1997), 1 vom: Juli, Seite 1-11 volume:8 year:1997 number:1 month:07 pages:1-11 |
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Article |
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findex.gbv.de |
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Dopamine Schizophrenia Clozapine Dopamine Receptor Dopamine Receptor Gene |
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610 |
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false |
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CNS drugs |
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Shaikh, Sanober @@aut@@ Makoff, Andrew @@aut@@ Collier, David @@aut@@ Kerwin, Robert @@aut@@ |
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1997-07-01T00:00:00Z |
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327645172 |
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3610 |
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SPR033068704 |
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englisch |
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This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. 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|
| author |
Shaikh, Sanober |
| spellingShingle |
Shaikh, Sanober ddc 610 bkl 44.40 misc Dopamine misc Schizophrenia misc Clozapine misc Dopamine Receptor misc Dopamine Receptor Gene Dopamine $ D_{4} $ Receptors |
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1179-1934 |
| topic_title |
610 ASE 44.40 bkl Dopamine $ D_{4} $ Receptors Dopamine (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Dopamine Receptor (dpeaa)DE-He213 Dopamine Receptor Gene (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.40 misc Dopamine misc Schizophrenia misc Clozapine misc Dopamine Receptor misc Dopamine Receptor Gene |
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ddc 610 bkl 44.40 misc Dopamine misc Schizophrenia misc Clozapine misc Dopamine Receptor misc Dopamine Receptor Gene |
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ddc 610 bkl 44.40 misc Dopamine misc Schizophrenia misc Clozapine misc Dopamine Receptor misc Dopamine Receptor Gene |
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Dopamine $ D_{4} $ Receptors |
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Dopamine $ D_{4} $ Receptors |
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Shaikh, Sanober |
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Shaikh, Sanober Makoff, Andrew Collier, David Kerwin, Robert |
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dopamine $ d_{4} $ receptors |
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Dopamine $ D_{4} $ Receptors |
| abstract |
Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. Furthermore, the role of $ D_{4} $ receptors as therapeutic targets will soon be determined by the use of selective ligands about to be introduced into clinical trials. |
| abstractGer |
Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. Furthermore, the role of $ D_{4} $ receptors as therapeutic targets will soon be determined by the use of selective ligands about to be introduced into clinical trials. |
| abstract_unstemmed |
Summary In contrast to more traditional antipsychotic drugs such as haloperidol, atypical antipsychotics such as Clozapine are characterised by low levels of extra-pyramidal side effects (EPS) and improved clinical efficacy. This may result from increased binding to dopamine $ D_{4} $ and serotonin 5-$ HT_{2} $A and 5-$ HT_{2} $C receptors concomitant with decreased dopamine $ D_{2} $ receptor blockade, particularly of $ D_{2} $ sites in the striatum where EPS are thought to originate. Although there is no genetic evidence for a direct role of variation in the $ D_{4} $ receptor gene in schizophrenia, a role for variation in the 5-$ HT_{2} $A receptor gene is supported by genetic and biochemical studies. This does not preclude the $ D_{4} $ receptor as a major therapeutic target for antipsychotic drugs, especially since it is expressed predominantly in the cortex and limbic system, where the antipsychotic effects of drugs such as Clozapine are thought to be mediated. As novel serotonin-dopamine receptor antagonists with defined pharmacological profiles become available, the careful analysis of the relationship between receptor binding profiles and efficacy will determine the most important receptor targets for improved antipsychotic action without the generation of EPS. Furthermore, the role of $ D_{4} $ receptors as therapeutic targets will soon be determined by the use of selective ligands about to be introduced into clinical trials. |
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1 |
| title_short |
Dopamine $ D_{4} $ Receptors |
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https://dx.doi.org/10.2165/00023210-199708010-00001 |
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true |
| author2 |
Makoff, Andrew Collier, David Kerwin, Robert |
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Makoff, Andrew Collier, David Kerwin, Robert |
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c |
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| doi_str |
10.2165/00023210-199708010-00001 |
| up_date |
2024-07-03T16:25:36.019Z |
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1803575818732961792 |
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| score |
7.3989067 |