Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia
Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy unde...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zaba, Zbigniew [verfasserIn] Bienert, Agnieszka [verfasserIn] Drobnik, Leon [verfasserIn] Dyderski, Stanislaw [verfasserIn] Kusza, Krzysztof [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: CNS drugs - Berlin [u.a.] : Springer, 1994, 21(2007), 2 vom: Feb., Seite 165-171 |
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| Übergeordnetes Werk: |
volume:21 ; year:2007 ; number:2 ; month:02 ; pages:165-171 |
| Links: |
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| DOI / URN: |
10.2165/00023210-200721020-00006 |
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| Katalog-ID: |
SPR033078211 |
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| 100 | 1 | |a Zaba, Zbigniew |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia |
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| 520 | |a Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values. | ||
| 650 | 4 | |a Remifentanil |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Alfentanil |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Spontaneous Ventilation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Total Intravenous Anaesthesia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Target Control Infusion |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Bienert, Agnieszka |e verfasserin |4 aut | |
| 700 | 1 | |a Drobnik, Leon |e verfasserin |4 aut | |
| 700 | 1 | |a Dyderski, Stanislaw |e verfasserin |4 aut | |
| 700 | 1 | |a Kusza, Krzysztof |e verfasserin |4 aut | |
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10.2165/00023210-200721020-00006 doi (DE-627)SPR033078211 (SPR)00023210-200721020-00006-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Zaba, Zbigniew verfasserin aut Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values. Remifentanil (dpeaa)DE-He213 Alfentanil (dpeaa)DE-He213 Spontaneous Ventilation (dpeaa)DE-He213 Total Intravenous Anaesthesia (dpeaa)DE-He213 Target Control Infusion (dpeaa)DE-He213 Bienert, Agnieszka verfasserin aut Drobnik, Leon verfasserin aut Dyderski, Stanislaw verfasserin aut Kusza, Krzysztof verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 21(2007), 2 vom: Feb., Seite 165-171 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:21 year:2007 number:2 month:02 pages:165-171 https://dx.doi.org/10.2165/00023210-200721020-00006 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 21 2007 2 02 165-171 |
| spelling |
10.2165/00023210-200721020-00006 doi (DE-627)SPR033078211 (SPR)00023210-200721020-00006-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Zaba, Zbigniew verfasserin aut Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values. Remifentanil (dpeaa)DE-He213 Alfentanil (dpeaa)DE-He213 Spontaneous Ventilation (dpeaa)DE-He213 Total Intravenous Anaesthesia (dpeaa)DE-He213 Target Control Infusion (dpeaa)DE-He213 Bienert, Agnieszka verfasserin aut Drobnik, Leon verfasserin aut Dyderski, Stanislaw verfasserin aut Kusza, Krzysztof verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 21(2007), 2 vom: Feb., Seite 165-171 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:21 year:2007 number:2 month:02 pages:165-171 https://dx.doi.org/10.2165/00023210-200721020-00006 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 21 2007 2 02 165-171 |
| allfields_unstemmed |
10.2165/00023210-200721020-00006 doi (DE-627)SPR033078211 (SPR)00023210-200721020-00006-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Zaba, Zbigniew verfasserin aut Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values. Remifentanil (dpeaa)DE-He213 Alfentanil (dpeaa)DE-He213 Spontaneous Ventilation (dpeaa)DE-He213 Total Intravenous Anaesthesia (dpeaa)DE-He213 Target Control Infusion (dpeaa)DE-He213 Bienert, Agnieszka verfasserin aut Drobnik, Leon verfasserin aut Dyderski, Stanislaw verfasserin aut Kusza, Krzysztof verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 21(2007), 2 vom: Feb., Seite 165-171 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:21 year:2007 number:2 month:02 pages:165-171 https://dx.doi.org/10.2165/00023210-200721020-00006 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 21 2007 2 02 165-171 |
| allfieldsGer |
10.2165/00023210-200721020-00006 doi (DE-627)SPR033078211 (SPR)00023210-200721020-00006-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Zaba, Zbigniew verfasserin aut Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values. Remifentanil (dpeaa)DE-He213 Alfentanil (dpeaa)DE-He213 Spontaneous Ventilation (dpeaa)DE-He213 Total Intravenous Anaesthesia (dpeaa)DE-He213 Target Control Infusion (dpeaa)DE-He213 Bienert, Agnieszka verfasserin aut Drobnik, Leon verfasserin aut Dyderski, Stanislaw verfasserin aut Kusza, Krzysztof verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 21(2007), 2 vom: Feb., Seite 165-171 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:21 year:2007 number:2 month:02 pages:165-171 https://dx.doi.org/10.2165/00023210-200721020-00006 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 21 2007 2 02 165-171 |
| allfieldsSound |
10.2165/00023210-200721020-00006 doi (DE-627)SPR033078211 (SPR)00023210-200721020-00006-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Zaba, Zbigniew verfasserin aut Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values. Remifentanil (dpeaa)DE-He213 Alfentanil (dpeaa)DE-He213 Spontaneous Ventilation (dpeaa)DE-He213 Total Intravenous Anaesthesia (dpeaa)DE-He213 Target Control Infusion (dpeaa)DE-He213 Bienert, Agnieszka verfasserin aut Drobnik, Leon verfasserin aut Dyderski, Stanislaw verfasserin aut Kusza, Krzysztof verfasserin aut Enthalten in CNS drugs Berlin [u.a.] : Springer, 1994 21(2007), 2 vom: Feb., Seite 165-171 (DE-627)327645172 (DE-600)2043806-0 1179-1934 nnns volume:21 year:2007 number:2 month:02 pages:165-171 https://dx.doi.org/10.2165/00023210-200721020-00006 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 21 2007 2 02 165-171 |
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English |
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Enthalten in CNS drugs 21(2007), 2 vom: Feb., Seite 165-171 volume:21 year:2007 number:2 month:02 pages:165-171 |
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Enthalten in CNS drugs 21(2007), 2 vom: Feb., Seite 165-171 volume:21 year:2007 number:2 month:02 pages:165-171 |
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findex.gbv.de |
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Remifentanil Alfentanil Spontaneous Ventilation Total Intravenous Anaesthesia Target Control Infusion |
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Zaba, Zbigniew @@aut@@ Bienert, Agnieszka @@aut@@ Drobnik, Leon @@aut@@ Dyderski, Stanislaw @@aut@@ Kusza, Krzysztof @@aut@@ |
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2007-02-01T00:00:00Z |
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Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Remifentanil</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Alfentanil</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Spontaneous Ventilation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Total Intravenous Anaesthesia</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Target Control Infusion</subfield><subfield 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Zaba, Zbigniew |
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Zaba, Zbigniew ddc 610 bkl 44.40 misc Remifentanil misc Alfentanil misc Spontaneous Ventilation misc Total Intravenous Anaesthesia misc Target Control Infusion Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia |
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610 ASE 44.40 bkl Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia Remifentanil (dpeaa)DE-He213 Alfentanil (dpeaa)DE-He213 Spontaneous Ventilation (dpeaa)DE-He213 Total Intravenous Anaesthesia (dpeaa)DE-He213 Target Control Infusion (dpeaa)DE-He213 |
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Zaba, Zbigniew Bienert, Agnieszka Drobnik, Leon Dyderski, Stanislaw Kusza, Krzysztof |
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Zaba, Zbigniew |
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10.2165/00023210-200721020-00006 |
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spectral frequency index monitoring during propofol-remifentanil and propofol-alfentanil total intravenous anaesthesia |
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Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia |
| abstract |
Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values. |
| abstractGer |
Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values. |
| abstract_unstemmed |
Abstract Background: The aim of this study was to evaluate the usefulness of spectral frequency index ($ SF_{X} $) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). Methods: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 μg/kg, followed by continuous infusion from 0.25 to 0.05 μg/kg/min) [n = 18] or alfentanil (bolus of 10 μg/kg, followed by continuous infusion from 2.0 to 0.5 μg/kg/min) [n = 15]. EEG activity was monitored to achieve the desired depth of anaesthesia, and intravenous propofol was titrated to keep the $ SF_{X} $ at 70–80%. The remifentanil and alfentanil groups were compared in relation to the plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia, Pearson correlation coefficient for the relationship between the plasma propofol concentration and SFx values, recovery parameters, and recall of events during anaesthesia. Results: The study groups were comparable with regard to demographic characteristics, type and duration of surgery, and time to resumption of spontaneous ventilation. No evidence of explicit recall was noted. The mean plasma propofol concentration required for an adequate level of hypnosis during maintenance of anaesthesia was significantly higher in the alfentanil group (3.20 μg/mL) compared with the remifentanil group (2.17 μg/L) [p < 0.05]. In both groups, the Pearson correlation coefficient test showed a linear correlation between $ SF_{X} $ values and propofol concentration in the studied propofol concentration range. The mean time to orientation for name and place was significantly shorter (p < 0.05), the mean propofol concentration at orientation for name and place and at the resumption of spontaneous ventilation timepoints was significantly lower (both p < 0.01), and the mean $ SF_{X} $ value at resumption of spontaneous ventilation timepoint was significantly higher (p < 0.01) in the remifentanil group. Conclusions: As $ SF_{X} $ is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia. The results of this clinical trial are consistent with a previous computer-simulated opioid-propofol model with regard to intraoperative and recovery variables, although the recovery occurred at different propofol concentration and $ SF_{X} $ values. |
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Spectral Frequency Index Monitoring During Propofol-Remifentanil and Propofol-Alfentanil Total Intravenous Anaesthesia |
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Bienert, Agnieszka Drobnik, Leon Dyderski, Stanislaw Kusza, Krzysztof |
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| score |
7.397299 |