Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors
Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tomlinson, David R. [verfasserIn] Willars, Gary B. [verfasserIn] Robinson, Jean P. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1986 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Drugs - Berlin [u.a.] : Springer, 1971, 32(1986), Suppl 2 vom: Sept., Seite 15-18 |
|---|---|
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volume:32 ; year:1986 ; number:Suppl 2 ; month:09 ; pages:15-18 |
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| DOI / URN: |
10.2165/00003495-198600322-00005 |
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| 245 | 1 | 0 | |a Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors |
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| 520 | |a Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was ‘real’ not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. | ||
| 650 | 4 | |a Sorbitol |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sciatic Nerve |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Axonal Transport |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Aldose Reductase |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Experimental Diabetes |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Willars, Gary B. |e verfasserin |4 aut | |
| 700 | 1 | |a Robinson, Jean P. |e verfasserin |4 aut | |
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10.2165/00003495-198600322-00005 doi (DE-627)SPR033145393 (SPR)00003495-198600322-00005-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Tomlinson, David R. verfasserin aut Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors 1986 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was ‘real’ not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. Sorbitol (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Axonal Transport (dpeaa)DE-He213 Aldose Reductase (dpeaa)DE-He213 Experimental Diabetes (dpeaa)DE-He213 Willars, Gary B. verfasserin aut Robinson, Jean P. verfasserin aut Enthalten in Drugs Berlin [u.a.] : Springer, 1971 32(1986), Suppl 2 vom: Sept., Seite 15-18 (DE-627)320609413 (DE-600)2021165-X 1179-1950 nnns volume:32 year:1986 number:Suppl 2 month:09 pages:15-18 https://dx.doi.org/10.2165/00003495-198600322-00005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE 44.38 ASE AR 32 1986 Suppl 2 09 15-18 |
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10.2165/00003495-198600322-00005 doi (DE-627)SPR033145393 (SPR)00003495-198600322-00005-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Tomlinson, David R. verfasserin aut Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors 1986 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was ‘real’ not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. Sorbitol (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Axonal Transport (dpeaa)DE-He213 Aldose Reductase (dpeaa)DE-He213 Experimental Diabetes (dpeaa)DE-He213 Willars, Gary B. verfasserin aut Robinson, Jean P. verfasserin aut Enthalten in Drugs Berlin [u.a.] : Springer, 1971 32(1986), Suppl 2 vom: Sept., Seite 15-18 (DE-627)320609413 (DE-600)2021165-X 1179-1950 nnns volume:32 year:1986 number:Suppl 2 month:09 pages:15-18 https://dx.doi.org/10.2165/00003495-198600322-00005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE 44.38 ASE AR 32 1986 Suppl 2 09 15-18 |
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10.2165/00003495-198600322-00005 doi (DE-627)SPR033145393 (SPR)00003495-198600322-00005-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Tomlinson, David R. verfasserin aut Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors 1986 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was ‘real’ not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. Sorbitol (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Axonal Transport (dpeaa)DE-He213 Aldose Reductase (dpeaa)DE-He213 Experimental Diabetes (dpeaa)DE-He213 Willars, Gary B. verfasserin aut Robinson, Jean P. verfasserin aut Enthalten in Drugs Berlin [u.a.] : Springer, 1971 32(1986), Suppl 2 vom: Sept., Seite 15-18 (DE-627)320609413 (DE-600)2021165-X 1179-1950 nnns volume:32 year:1986 number:Suppl 2 month:09 pages:15-18 https://dx.doi.org/10.2165/00003495-198600322-00005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE 44.38 ASE AR 32 1986 Suppl 2 09 15-18 |
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10.2165/00003495-198600322-00005 doi (DE-627)SPR033145393 (SPR)00003495-198600322-00005-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Tomlinson, David R. verfasserin aut Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors 1986 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was ‘real’ not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. Sorbitol (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Axonal Transport (dpeaa)DE-He213 Aldose Reductase (dpeaa)DE-He213 Experimental Diabetes (dpeaa)DE-He213 Willars, Gary B. verfasserin aut Robinson, Jean P. verfasserin aut Enthalten in Drugs Berlin [u.a.] : Springer, 1971 32(1986), Suppl 2 vom: Sept., Seite 15-18 (DE-627)320609413 (DE-600)2021165-X 1179-1950 nnns volume:32 year:1986 number:Suppl 2 month:09 pages:15-18 https://dx.doi.org/10.2165/00003495-198600322-00005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE 44.38 ASE AR 32 1986 Suppl 2 09 15-18 |
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10.2165/00003495-198600322-00005 doi (DE-627)SPR033145393 (SPR)00003495-198600322-00005-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Tomlinson, David R. verfasserin aut Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors 1986 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was ‘real’ not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. Sorbitol (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Axonal Transport (dpeaa)DE-He213 Aldose Reductase (dpeaa)DE-He213 Experimental Diabetes (dpeaa)DE-He213 Willars, Gary B. verfasserin aut Robinson, Jean P. verfasserin aut Enthalten in Drugs Berlin [u.a.] : Springer, 1971 32(1986), Suppl 2 vom: Sept., Seite 15-18 (DE-627)320609413 (DE-600)2021165-X 1179-1950 nnns volume:32 year:1986 number:Suppl 2 month:09 pages:15-18 https://dx.doi.org/10.2165/00003495-198600322-00005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE 44.38 ASE AR 32 1986 Suppl 2 09 15-18 |
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Tomlinson, David R. |
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Tomlinson, David R. ddc 610 bkl 44.40 bkl 44.38 misc Sorbitol misc Sciatic Nerve misc Axonal Transport misc Aldose Reductase misc Experimental Diabetes Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors |
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prevention of defects of axonal transport in experimental diabetes by aldose reductase inhibitors |
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Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors |
| abstract |
Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was ‘real’ not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. |
| abstractGer |
Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was ‘real’ not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. |
| abstract_unstemmed |
Summary Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was ‘real’ not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. |
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| title_short |
Prevention of Defects of Axonal Transport in Experimental Diabetes by Aldose Reductase Inhibitors |
| url |
https://dx.doi.org/10.2165/00003495-198600322-00005 |
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Willars, Gary B. Robinson, Jean P. |
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| doi_str |
10.2165/00003495-198600322-00005 |
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2024-07-03T16:53:38.151Z |
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