Pentavalent Rotavirus Vaccine (RotaTeq®)
Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. R...
Ausführliche Beschreibung
Autor*in: |
Plosker, Greg L. [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2010 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Drugs - Berlin [u.a.] : Springer, 1971, 70(2010), 9 vom: Juni, Seite 1165-1188 |
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Übergeordnetes Werk: |
volume:70 ; year:2010 ; number:9 ; month:06 ; pages:1165-1188 |
Links: |
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DOI / URN: |
10.2165/11205030-000000000-00000 |
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Katalog-ID: |
SPR033207313 |
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520 | |a Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. RotaTeq® is a three-dose, orally administered, live, pentavalent human-bovine reassortant rotavirus vaccine used for the active immunization of infants for prevention of rotavirus gastroenteritis. The protective efficacy of RotaTeq® has been evaluated in terms of its effects on the incidence of rotavirus gastroenteritis and on healthcare resource use. Clinical trial data from REST (a randomized, double-blind, placebo-controlled, multinational study in ≈70 000 healthy infants aged 6–12 weeks) and various subgroup analyses, including a large European cohort, have shown that RotaTeq® may be administered at the same time as various other routine vaccines, has high and sustained efficacy covering the main period of risk for rotavirus gastroenteritis, has early protective efficacy after the first and second doses, reduces rotavirus gastroenteritis-associated hospitalization and emergency department and physician visits, and is generally well tolerated. Moreover, RotaTeq® has demonstrated efficacy against the five most prevalent serotypes of rotavirus in Europe (G1–G4, G9), in terms of reductions in associated healthcare resource use. There is also evidence that the widespread use of RotaTeq® may provide herd immunity, as it appears to have indirect benefits in older, unvaccinated children. Reports on the ‘real world’ effectiveness of RotaTeq® in Europe are just emerging, but data from the US have shown a rapid and marked reduction in rotavirus burden nationwide during the ≈2-year period following the introduction of RotaTeq® and the subsequent availability of official recommendations advocating universal use of the vaccine as part of routine childhood immunization. Similar benefits have also been demonstrated in Australia after the introduction of a publicly funded rotavirus vaccination programme. Postmarketing surveillance data from the US have not identified any concerns, such as an association with intussusception or Kawasaki disease, related to the safety of RotaTeq®. In conclusion, RotaTeq® is a generally well tolerated vaccine that has efficacy against the five most prevalent serotypes of rotavirus in Europe and provides sustained efficacy over the main risk period for rotavirus gastroenteritis in infants and children, reducing hospitalizations and emergency department visits by decreasing the incidence and severity of illness. | ||
650 | 4 | |a Kawasaki Disease |7 (dpeaa)DE-He213 | |
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650 | 4 | |a Oral Poliovirus Vaccine |7 (dpeaa)DE-He213 | |
650 | 4 | |a Inactivate Poliovirus Vaccine |7 (dpeaa)DE-He213 | |
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10.2165/11205030-000000000-00000 doi (DE-627)SPR033207313 (SPR)11205030-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Plosker, Greg L. verfasserin aut Pentavalent Rotavirus Vaccine (RotaTeq®) 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. RotaTeq® is a three-dose, orally administered, live, pentavalent human-bovine reassortant rotavirus vaccine used for the active immunization of infants for prevention of rotavirus gastroenteritis. The protective efficacy of RotaTeq® has been evaluated in terms of its effects on the incidence of rotavirus gastroenteritis and on healthcare resource use. Clinical trial data from REST (a randomized, double-blind, placebo-controlled, multinational study in ≈70 000 healthy infants aged 6–12 weeks) and various subgroup analyses, including a large European cohort, have shown that RotaTeq® may be administered at the same time as various other routine vaccines, has high and sustained efficacy covering the main period of risk for rotavirus gastroenteritis, has early protective efficacy after the first and second doses, reduces rotavirus gastroenteritis-associated hospitalization and emergency department and physician visits, and is generally well tolerated. Moreover, RotaTeq® has demonstrated efficacy against the five most prevalent serotypes of rotavirus in Europe (G1–G4, G9), in terms of reductions in associated healthcare resource use. There is also evidence that the widespread use of RotaTeq® may provide herd immunity, as it appears to have indirect benefits in older, unvaccinated children. Reports on the ‘real world’ effectiveness of RotaTeq® in Europe are just emerging, but data from the US have shown a rapid and marked reduction in rotavirus burden nationwide during the ≈2-year period following the introduction of RotaTeq® and the subsequent availability of official recommendations advocating universal use of the vaccine as part of routine childhood immunization. Similar benefits have also been demonstrated in Australia after the introduction of a publicly funded rotavirus vaccination programme. Postmarketing surveillance data from the US have not identified any concerns, such as an association with intussusception or Kawasaki disease, related to the safety of RotaTeq®. In conclusion, RotaTeq® is a generally well tolerated vaccine that has efficacy against the five most prevalent serotypes of rotavirus in Europe and provides sustained efficacy over the main risk period for rotavirus gastroenteritis in infants and children, reducing hospitalizations and emergency department visits by decreasing the incidence and severity of illness. Kawasaki Disease (dpeaa)DE-He213 Intussusception (dpeaa)DE-He213 Emergency Department Visit (dpeaa)DE-He213 Oral Poliovirus Vaccine (dpeaa)DE-He213 Inactivate Poliovirus Vaccine (dpeaa)DE-He213 Enthalten in Drugs Berlin [u.a.] : Springer, 1971 70(2010), 9 vom: Juni, Seite 1165-1188 (DE-627)320609413 (DE-600)2021165-X 1179-1950 nnns volume:70 year:2010 number:9 month:06 pages:1165-1188 https://dx.doi.org/10.2165/11205030-000000000-00000 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE 44.38 ASE AR 70 2010 9 06 1165-1188 |
spelling |
10.2165/11205030-000000000-00000 doi (DE-627)SPR033207313 (SPR)11205030-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Plosker, Greg L. verfasserin aut Pentavalent Rotavirus Vaccine (RotaTeq®) 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. RotaTeq® is a three-dose, orally administered, live, pentavalent human-bovine reassortant rotavirus vaccine used for the active immunization of infants for prevention of rotavirus gastroenteritis. The protective efficacy of RotaTeq® has been evaluated in terms of its effects on the incidence of rotavirus gastroenteritis and on healthcare resource use. Clinical trial data from REST (a randomized, double-blind, placebo-controlled, multinational study in ≈70 000 healthy infants aged 6–12 weeks) and various subgroup analyses, including a large European cohort, have shown that RotaTeq® may be administered at the same time as various other routine vaccines, has high and sustained efficacy covering the main period of risk for rotavirus gastroenteritis, has early protective efficacy after the first and second doses, reduces rotavirus gastroenteritis-associated hospitalization and emergency department and physician visits, and is generally well tolerated. Moreover, RotaTeq® has demonstrated efficacy against the five most prevalent serotypes of rotavirus in Europe (G1–G4, G9), in terms of reductions in associated healthcare resource use. There is also evidence that the widespread use of RotaTeq® may provide herd immunity, as it appears to have indirect benefits in older, unvaccinated children. Reports on the ‘real world’ effectiveness of RotaTeq® in Europe are just emerging, but data from the US have shown a rapid and marked reduction in rotavirus burden nationwide during the ≈2-year period following the introduction of RotaTeq® and the subsequent availability of official recommendations advocating universal use of the vaccine as part of routine childhood immunization. Similar benefits have also been demonstrated in Australia after the introduction of a publicly funded rotavirus vaccination programme. Postmarketing surveillance data from the US have not identified any concerns, such as an association with intussusception or Kawasaki disease, related to the safety of RotaTeq®. In conclusion, RotaTeq® is a generally well tolerated vaccine that has efficacy against the five most prevalent serotypes of rotavirus in Europe and provides sustained efficacy over the main risk period for rotavirus gastroenteritis in infants and children, reducing hospitalizations and emergency department visits by decreasing the incidence and severity of illness. Kawasaki Disease (dpeaa)DE-He213 Intussusception (dpeaa)DE-He213 Emergency Department Visit (dpeaa)DE-He213 Oral Poliovirus Vaccine (dpeaa)DE-He213 Inactivate Poliovirus Vaccine (dpeaa)DE-He213 Enthalten in Drugs Berlin [u.a.] : Springer, 1971 70(2010), 9 vom: Juni, Seite 1165-1188 (DE-627)320609413 (DE-600)2021165-X 1179-1950 nnns volume:70 year:2010 number:9 month:06 pages:1165-1188 https://dx.doi.org/10.2165/11205030-000000000-00000 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE 44.38 ASE AR 70 2010 9 06 1165-1188 |
allfields_unstemmed |
10.2165/11205030-000000000-00000 doi (DE-627)SPR033207313 (SPR)11205030-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Plosker, Greg L. verfasserin aut Pentavalent Rotavirus Vaccine (RotaTeq®) 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. RotaTeq® is a three-dose, orally administered, live, pentavalent human-bovine reassortant rotavirus vaccine used for the active immunization of infants for prevention of rotavirus gastroenteritis. The protective efficacy of RotaTeq® has been evaluated in terms of its effects on the incidence of rotavirus gastroenteritis and on healthcare resource use. Clinical trial data from REST (a randomized, double-blind, placebo-controlled, multinational study in ≈70 000 healthy infants aged 6–12 weeks) and various subgroup analyses, including a large European cohort, have shown that RotaTeq® may be administered at the same time as various other routine vaccines, has high and sustained efficacy covering the main period of risk for rotavirus gastroenteritis, has early protective efficacy after the first and second doses, reduces rotavirus gastroenteritis-associated hospitalization and emergency department and physician visits, and is generally well tolerated. Moreover, RotaTeq® has demonstrated efficacy against the five most prevalent serotypes of rotavirus in Europe (G1–G4, G9), in terms of reductions in associated healthcare resource use. There is also evidence that the widespread use of RotaTeq® may provide herd immunity, as it appears to have indirect benefits in older, unvaccinated children. Reports on the ‘real world’ effectiveness of RotaTeq® in Europe are just emerging, but data from the US have shown a rapid and marked reduction in rotavirus burden nationwide during the ≈2-year period following the introduction of RotaTeq® and the subsequent availability of official recommendations advocating universal use of the vaccine as part of routine childhood immunization. Similar benefits have also been demonstrated in Australia after the introduction of a publicly funded rotavirus vaccination programme. Postmarketing surveillance data from the US have not identified any concerns, such as an association with intussusception or Kawasaki disease, related to the safety of RotaTeq®. In conclusion, RotaTeq® is a generally well tolerated vaccine that has efficacy against the five most prevalent serotypes of rotavirus in Europe and provides sustained efficacy over the main risk period for rotavirus gastroenteritis in infants and children, reducing hospitalizations and emergency department visits by decreasing the incidence and severity of illness. 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10.2165/11205030-000000000-00000 doi (DE-627)SPR033207313 (SPR)11205030-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Plosker, Greg L. verfasserin aut Pentavalent Rotavirus Vaccine (RotaTeq®) 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. RotaTeq® is a three-dose, orally administered, live, pentavalent human-bovine reassortant rotavirus vaccine used for the active immunization of infants for prevention of rotavirus gastroenteritis. The protective efficacy of RotaTeq® has been evaluated in terms of its effects on the incidence of rotavirus gastroenteritis and on healthcare resource use. Clinical trial data from REST (a randomized, double-blind, placebo-controlled, multinational study in ≈70 000 healthy infants aged 6–12 weeks) and various subgroup analyses, including a large European cohort, have shown that RotaTeq® may be administered at the same time as various other routine vaccines, has high and sustained efficacy covering the main period of risk for rotavirus gastroenteritis, has early protective efficacy after the first and second doses, reduces rotavirus gastroenteritis-associated hospitalization and emergency department and physician visits, and is generally well tolerated. Moreover, RotaTeq® has demonstrated efficacy against the five most prevalent serotypes of rotavirus in Europe (G1–G4, G9), in terms of reductions in associated healthcare resource use. There is also evidence that the widespread use of RotaTeq® may provide herd immunity, as it appears to have indirect benefits in older, unvaccinated children. Reports on the ‘real world’ effectiveness of RotaTeq® in Europe are just emerging, but data from the US have shown a rapid and marked reduction in rotavirus burden nationwide during the ≈2-year period following the introduction of RotaTeq® and the subsequent availability of official recommendations advocating universal use of the vaccine as part of routine childhood immunization. Similar benefits have also been demonstrated in Australia after the introduction of a publicly funded rotavirus vaccination programme. Postmarketing surveillance data from the US have not identified any concerns, such as an association with intussusception or Kawasaki disease, related to the safety of RotaTeq®. In conclusion, RotaTeq® is a generally well tolerated vaccine that has efficacy against the five most prevalent serotypes of rotavirus in Europe and provides sustained efficacy over the main risk period for rotavirus gastroenteritis in infants and children, reducing hospitalizations and emergency department visits by decreasing the incidence and severity of illness. 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10.2165/11205030-000000000-00000 doi (DE-627)SPR033207313 (SPR)11205030-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl 44.38 bkl Plosker, Greg L. verfasserin aut Pentavalent Rotavirus Vaccine (RotaTeq®) 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. RotaTeq® is a three-dose, orally administered, live, pentavalent human-bovine reassortant rotavirus vaccine used for the active immunization of infants for prevention of rotavirus gastroenteritis. The protective efficacy of RotaTeq® has been evaluated in terms of its effects on the incidence of rotavirus gastroenteritis and on healthcare resource use. Clinical trial data from REST (a randomized, double-blind, placebo-controlled, multinational study in ≈70 000 healthy infants aged 6–12 weeks) and various subgroup analyses, including a large European cohort, have shown that RotaTeq® may be administered at the same time as various other routine vaccines, has high and sustained efficacy covering the main period of risk for rotavirus gastroenteritis, has early protective efficacy after the first and second doses, reduces rotavirus gastroenteritis-associated hospitalization and emergency department and physician visits, and is generally well tolerated. Moreover, RotaTeq® has demonstrated efficacy against the five most prevalent serotypes of rotavirus in Europe (G1–G4, G9), in terms of reductions in associated healthcare resource use. There is also evidence that the widespread use of RotaTeq® may provide herd immunity, as it appears to have indirect benefits in older, unvaccinated children. Reports on the ‘real world’ effectiveness of RotaTeq® in Europe are just emerging, but data from the US have shown a rapid and marked reduction in rotavirus burden nationwide during the ≈2-year period following the introduction of RotaTeq® and the subsequent availability of official recommendations advocating universal use of the vaccine as part of routine childhood immunization. Similar benefits have also been demonstrated in Australia after the introduction of a publicly funded rotavirus vaccination programme. Postmarketing surveillance data from the US have not identified any concerns, such as an association with intussusception or Kawasaki disease, related to the safety of RotaTeq®. In conclusion, RotaTeq® is a generally well tolerated vaccine that has efficacy against the five most prevalent serotypes of rotavirus in Europe and provides sustained efficacy over the main risk period for rotavirus gastroenteritis in infants and children, reducing hospitalizations and emergency department visits by decreasing the incidence and severity of illness. 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Enthalten in Drugs 70(2010), 9 vom: Juni, Seite 1165-1188 volume:70 year:2010 number:9 month:06 pages:1165-1188 |
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Kawasaki Disease Intussusception Emergency Department Visit Oral Poliovirus Vaccine Inactivate Poliovirus Vaccine |
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Plosker, Greg L. @@aut@@ |
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|
author |
Plosker, Greg L. |
spellingShingle |
Plosker, Greg L. ddc 610 bkl 44.40 bkl 44.38 misc Kawasaki Disease misc Intussusception misc Emergency Department Visit misc Oral Poliovirus Vaccine misc Inactivate Poliovirus Vaccine Pentavalent Rotavirus Vaccine (RotaTeq®) |
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610 ASE 44.40 bkl 44.38 bkl Pentavalent Rotavirus Vaccine (RotaTeq®) Kawasaki Disease (dpeaa)DE-He213 Intussusception (dpeaa)DE-He213 Emergency Department Visit (dpeaa)DE-He213 Oral Poliovirus Vaccine (dpeaa)DE-He213 Inactivate Poliovirus Vaccine (dpeaa)DE-He213 |
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ddc 610 bkl 44.40 bkl 44.38 misc Kawasaki Disease misc Intussusception misc Emergency Department Visit misc Oral Poliovirus Vaccine misc Inactivate Poliovirus Vaccine |
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ddc 610 bkl 44.40 bkl 44.38 misc Kawasaki Disease misc Intussusception misc Emergency Department Visit misc Oral Poliovirus Vaccine misc Inactivate Poliovirus Vaccine |
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Pentavalent Rotavirus Vaccine (RotaTeq®) |
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pentavalent rotavirus vaccine (rotateq®) |
title_auth |
Pentavalent Rotavirus Vaccine (RotaTeq®) |
abstract |
Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. RotaTeq® is a three-dose, orally administered, live, pentavalent human-bovine reassortant rotavirus vaccine used for the active immunization of infants for prevention of rotavirus gastroenteritis. The protective efficacy of RotaTeq® has been evaluated in terms of its effects on the incidence of rotavirus gastroenteritis and on healthcare resource use. Clinical trial data from REST (a randomized, double-blind, placebo-controlled, multinational study in ≈70 000 healthy infants aged 6–12 weeks) and various subgroup analyses, including a large European cohort, have shown that RotaTeq® may be administered at the same time as various other routine vaccines, has high and sustained efficacy covering the main period of risk for rotavirus gastroenteritis, has early protective efficacy after the first and second doses, reduces rotavirus gastroenteritis-associated hospitalization and emergency department and physician visits, and is generally well tolerated. Moreover, RotaTeq® has demonstrated efficacy against the five most prevalent serotypes of rotavirus in Europe (G1–G4, G9), in terms of reductions in associated healthcare resource use. There is also evidence that the widespread use of RotaTeq® may provide herd immunity, as it appears to have indirect benefits in older, unvaccinated children. Reports on the ‘real world’ effectiveness of RotaTeq® in Europe are just emerging, but data from the US have shown a rapid and marked reduction in rotavirus burden nationwide during the ≈2-year period following the introduction of RotaTeq® and the subsequent availability of official recommendations advocating universal use of the vaccine as part of routine childhood immunization. Similar benefits have also been demonstrated in Australia after the introduction of a publicly funded rotavirus vaccination programme. Postmarketing surveillance data from the US have not identified any concerns, such as an association with intussusception or Kawasaki disease, related to the safety of RotaTeq®. In conclusion, RotaTeq® is a generally well tolerated vaccine that has efficacy against the five most prevalent serotypes of rotavirus in Europe and provides sustained efficacy over the main risk period for rotavirus gastroenteritis in infants and children, reducing hospitalizations and emergency department visits by decreasing the incidence and severity of illness. |
abstractGer |
Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. RotaTeq® is a three-dose, orally administered, live, pentavalent human-bovine reassortant rotavirus vaccine used for the active immunization of infants for prevention of rotavirus gastroenteritis. The protective efficacy of RotaTeq® has been evaluated in terms of its effects on the incidence of rotavirus gastroenteritis and on healthcare resource use. Clinical trial data from REST (a randomized, double-blind, placebo-controlled, multinational study in ≈70 000 healthy infants aged 6–12 weeks) and various subgroup analyses, including a large European cohort, have shown that RotaTeq® may be administered at the same time as various other routine vaccines, has high and sustained efficacy covering the main period of risk for rotavirus gastroenteritis, has early protective efficacy after the first and second doses, reduces rotavirus gastroenteritis-associated hospitalization and emergency department and physician visits, and is generally well tolerated. Moreover, RotaTeq® has demonstrated efficacy against the five most prevalent serotypes of rotavirus in Europe (G1–G4, G9), in terms of reductions in associated healthcare resource use. There is also evidence that the widespread use of RotaTeq® may provide herd immunity, as it appears to have indirect benefits in older, unvaccinated children. Reports on the ‘real world’ effectiveness of RotaTeq® in Europe are just emerging, but data from the US have shown a rapid and marked reduction in rotavirus burden nationwide during the ≈2-year period following the introduction of RotaTeq® and the subsequent availability of official recommendations advocating universal use of the vaccine as part of routine childhood immunization. Similar benefits have also been demonstrated in Australia after the introduction of a publicly funded rotavirus vaccination programme. Postmarketing surveillance data from the US have not identified any concerns, such as an association with intussusception or Kawasaki disease, related to the safety of RotaTeq®. In conclusion, RotaTeq® is a generally well tolerated vaccine that has efficacy against the five most prevalent serotypes of rotavirus in Europe and provides sustained efficacy over the main risk period for rotavirus gastroenteritis in infants and children, reducing hospitalizations and emergency department visits by decreasing the incidence and severity of illness. |
abstract_unstemmed |
Abstract In Europe, rotavirus gastroenteritis is associated with a significant health, economic and social burden, as it is responsible for large numbers of hospitalizations and other healthcare encounters among infants and children, as well as numerous days of work lost by parents and caregivers. RotaTeq® is a three-dose, orally administered, live, pentavalent human-bovine reassortant rotavirus vaccine used for the active immunization of infants for prevention of rotavirus gastroenteritis. The protective efficacy of RotaTeq® has been evaluated in terms of its effects on the incidence of rotavirus gastroenteritis and on healthcare resource use. Clinical trial data from REST (a randomized, double-blind, placebo-controlled, multinational study in ≈70 000 healthy infants aged 6–12 weeks) and various subgroup analyses, including a large European cohort, have shown that RotaTeq® may be administered at the same time as various other routine vaccines, has high and sustained efficacy covering the main period of risk for rotavirus gastroenteritis, has early protective efficacy after the first and second doses, reduces rotavirus gastroenteritis-associated hospitalization and emergency department and physician visits, and is generally well tolerated. Moreover, RotaTeq® has demonstrated efficacy against the five most prevalent serotypes of rotavirus in Europe (G1–G4, G9), in terms of reductions in associated healthcare resource use. There is also evidence that the widespread use of RotaTeq® may provide herd immunity, as it appears to have indirect benefits in older, unvaccinated children. Reports on the ‘real world’ effectiveness of RotaTeq® in Europe are just emerging, but data from the US have shown a rapid and marked reduction in rotavirus burden nationwide during the ≈2-year period following the introduction of RotaTeq® and the subsequent availability of official recommendations advocating universal use of the vaccine as part of routine childhood immunization. Similar benefits have also been demonstrated in Australia after the introduction of a publicly funded rotavirus vaccination programme. Postmarketing surveillance data from the US have not identified any concerns, such as an association with intussusception or Kawasaki disease, related to the safety of RotaTeq®. In conclusion, RotaTeq® is a generally well tolerated vaccine that has efficacy against the five most prevalent serotypes of rotavirus in Europe and provides sustained efficacy over the main risk period for rotavirus gastroenteritis in infants and children, reducing hospitalizations and emergency department visits by decreasing the incidence and severity of illness. |
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title_short |
Pentavalent Rotavirus Vaccine (RotaTeq®) |
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https://dx.doi.org/10.2165/11205030-000000000-00000 |
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10.2165/11205030-000000000-00000 |
up_date |
2024-07-03T17:17:11.611Z |
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|
score |
7.3981476 |