The Pathophysiological Role and Therapeutic Implications of Platelet Activating Factor in Diseases of Aging
Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabol...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kroegel, Claus [verfasserIn] Kortsik, Cornelius [verfasserIn] Kroegel, Nasim [verfasserIn] Matthys, Heinrich [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1992 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Drugs & aging - Berlin [u.a.] : Springer, 1991, 2(1992), 4 vom: Juli, Seite 345-355 |
|---|---|
| Übergeordnetes Werk: |
volume:2 ; year:1992 ; number:4 ; month:07 ; pages:345-355 |
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| DOI / URN: |
10.2165/00002512-199202040-00007 |
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| 520 | |a Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging. | ||
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10.2165/00002512-199202040-00007 doi (DE-627)SPR033225672 (SPR)00002512-199202040-00007-e DE-627 ger DE-627 rakwb eng 610 ASE Kroegel, Claus verfasserin aut The Pathophysiological Role and Therapeutic Implications of Platelet Activating Factor in Diseases of Aging 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging. Platelet Activate Factor (dpeaa)DE-He213 Glyceryl Ether (dpeaa)DE-He213 Rabbit Platelet (dpeaa)DE-He213 Brotizolam (dpeaa)DE-He213 Platelet Activate Factor Receptor (dpeaa)DE-He213 Kortsik, Cornelius verfasserin aut Kroegel, Nasim verfasserin aut Matthys, Heinrich verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 2(1992), 4 vom: Juli, Seite 345-355 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:2 year:1992 number:4 month:07 pages:345-355 https://dx.doi.org/10.2165/00002512-199202040-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 AR 2 1992 4 07 345-355 |
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10.2165/00002512-199202040-00007 doi (DE-627)SPR033225672 (SPR)00002512-199202040-00007-e DE-627 ger DE-627 rakwb eng 610 ASE Kroegel, Claus verfasserin aut The Pathophysiological Role and Therapeutic Implications of Platelet Activating Factor in Diseases of Aging 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging. Platelet Activate Factor (dpeaa)DE-He213 Glyceryl Ether (dpeaa)DE-He213 Rabbit Platelet (dpeaa)DE-He213 Brotizolam (dpeaa)DE-He213 Platelet Activate Factor Receptor (dpeaa)DE-He213 Kortsik, Cornelius verfasserin aut Kroegel, Nasim verfasserin aut Matthys, Heinrich verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 2(1992), 4 vom: Juli, Seite 345-355 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:2 year:1992 number:4 month:07 pages:345-355 https://dx.doi.org/10.2165/00002512-199202040-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 AR 2 1992 4 07 345-355 |
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10.2165/00002512-199202040-00007 doi (DE-627)SPR033225672 (SPR)00002512-199202040-00007-e DE-627 ger DE-627 rakwb eng 610 ASE Kroegel, Claus verfasserin aut The Pathophysiological Role and Therapeutic Implications of Platelet Activating Factor in Diseases of Aging 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging. Platelet Activate Factor (dpeaa)DE-He213 Glyceryl Ether (dpeaa)DE-He213 Rabbit Platelet (dpeaa)DE-He213 Brotizolam (dpeaa)DE-He213 Platelet Activate Factor Receptor (dpeaa)DE-He213 Kortsik, Cornelius verfasserin aut Kroegel, Nasim verfasserin aut Matthys, Heinrich verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 2(1992), 4 vom: Juli, Seite 345-355 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:2 year:1992 number:4 month:07 pages:345-355 https://dx.doi.org/10.2165/00002512-199202040-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 AR 2 1992 4 07 345-355 |
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10.2165/00002512-199202040-00007 doi (DE-627)SPR033225672 (SPR)00002512-199202040-00007-e DE-627 ger DE-627 rakwb eng 610 ASE Kroegel, Claus verfasserin aut The Pathophysiological Role and Therapeutic Implications of Platelet Activating Factor in Diseases of Aging 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging. Platelet Activate Factor (dpeaa)DE-He213 Glyceryl Ether (dpeaa)DE-He213 Rabbit Platelet (dpeaa)DE-He213 Brotizolam (dpeaa)DE-He213 Platelet Activate Factor Receptor (dpeaa)DE-He213 Kortsik, Cornelius verfasserin aut Kroegel, Nasim verfasserin aut Matthys, Heinrich verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 2(1992), 4 vom: Juli, Seite 345-355 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:2 year:1992 number:4 month:07 pages:345-355 https://dx.doi.org/10.2165/00002512-199202040-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 AR 2 1992 4 07 345-355 |
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10.2165/00002512-199202040-00007 doi (DE-627)SPR033225672 (SPR)00002512-199202040-00007-e DE-627 ger DE-627 rakwb eng 610 ASE Kroegel, Claus verfasserin aut The Pathophysiological Role and Therapeutic Implications of Platelet Activating Factor in Diseases of Aging 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging. Platelet Activate Factor (dpeaa)DE-He213 Glyceryl Ether (dpeaa)DE-He213 Rabbit Platelet (dpeaa)DE-He213 Brotizolam (dpeaa)DE-He213 Platelet Activate Factor Receptor (dpeaa)DE-He213 Kortsik, Cornelius verfasserin aut Kroegel, Nasim verfasserin aut Matthys, Heinrich verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 2(1992), 4 vom: Juli, Seite 345-355 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:2 year:1992 number:4 month:07 pages:345-355 https://dx.doi.org/10.2165/00002512-199202040-00007 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 AR 2 1992 4 07 345-355 |
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The Pathophysiological Role and Therapeutic Implications of Platelet Activating Factor in Diseases of Aging |
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Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging. |
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Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging. |
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Summary Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging. |
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4 |
| title_short |
The Pathophysiological Role and Therapeutic Implications of Platelet Activating Factor in Diseases of Aging |
| url |
https://dx.doi.org/10.2165/00002512-199202040-00007 |
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true |
| author2 |
Kortsik, Cornelius Kroegel, Nasim Matthys, Heinrich |
| author2Str |
Kortsik, Cornelius Kroegel, Nasim Matthys, Heinrich |
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327644281 |
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| doi_str |
10.2165/00002512-199202040-00007 |
| up_date |
2024-07-03T17:25:00.416Z |
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1803579556277256193 |
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PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Platelet Activate Factor</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Glyceryl Ether</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Rabbit Platelet</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Brotizolam</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Platelet Activate Factor Receptor</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kortsik, Cornelius</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kroegel, Nasim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matthys, Heinrich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Drugs & aging</subfield><subfield code="d">Berlin [u.a.] : Springer, 1991</subfield><subfield code="g">2(1992), 4 vom: Juli, Seite 345-355</subfield><subfield code="w">(DE-627)327644281</subfield><subfield code="w">(DE-600)2043689-0</subfield><subfield code="x">1179-1969</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:2</subfield><subfield code="g">year:1992</subfield><subfield code="g">number:4</subfield><subfield code="g">month:07</subfield><subfield code="g">pages:345-355</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.2165/00002512-199202040-00007</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-ASE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">2</subfield><subfield code="j">1992</subfield><subfield code="e">4</subfield><subfield code="c">07</subfield><subfield code="h">345-355</subfield></datafield></record></collection>
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