Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities
Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wilson, Nicholas M. [verfasserIn] Hilmer, Sarah N. [verfasserIn] March, Lyn M. [verfasserIn] Chen, Jian Sheng [verfasserIn] Gnjidic, Danijela [verfasserIn] Mason, Rebecca S. [verfasserIn] Cameron, Ian D. [verfasserIn] Sambrook, Philip N. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Drugs & aging - Berlin [u.a.] : Springer, 1991, 29(2012), 2 vom: Feb., Seite 157-165 |
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| Übergeordnetes Werk: |
volume:29 ; year:2012 ; number:2 ; month:02 ; pages:157-165 |
| Links: |
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| DOI / URN: |
10.2165/11598570-000000000-00000 |
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| Katalog-ID: |
SPR033243859 |
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| 100 | 1 | |a Wilson, Nicholas M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities |
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| 520 | |a Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. Further research into the adverse effects of medication use on the mortality of institutionalized older individuals is needed. | ||
| 650 | 4 | |a Charlson Comorbidity Index |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anticholinergic Medication |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Charlson Comorbidity Index Score |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sedative Medication |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Residential Aged Care Facility |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Hilmer, Sarah N. |e verfasserin |4 aut | |
| 700 | 1 | |a March, Lyn M. |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jian Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Gnjidic, Danijela |e verfasserin |4 aut | |
| 700 | 1 | |a Mason, Rebecca S. |e verfasserin |4 aut | |
| 700 | 1 | |a Cameron, Ian D. |e verfasserin |4 aut | |
| 700 | 1 | |a Sambrook, Philip N. |e verfasserin |4 aut | |
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10.2165/11598570-000000000-00000 doi (DE-627)SPR033243859 (SPR)11598570-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE Wilson, Nicholas M. verfasserin aut Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. Further research into the adverse effects of medication use on the mortality of institutionalized older individuals is needed. Charlson Comorbidity Index (dpeaa)DE-He213 Anticholinergic Medication (dpeaa)DE-He213 Charlson Comorbidity Index Score (dpeaa)DE-He213 Sedative Medication (dpeaa)DE-He213 Residential Aged Care Facility (dpeaa)DE-He213 Hilmer, Sarah N. verfasserin aut March, Lyn M. verfasserin aut Chen, Jian Sheng verfasserin aut Gnjidic, Danijela verfasserin aut Mason, Rebecca S. verfasserin aut Cameron, Ian D. verfasserin aut Sambrook, Philip N. verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 29(2012), 2 vom: Feb., Seite 157-165 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:29 year:2012 number:2 month:02 pages:157-165 https://dx.doi.org/10.2165/11598570-000000000-00000 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2012 2 02 157-165 |
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10.2165/11598570-000000000-00000 doi (DE-627)SPR033243859 (SPR)11598570-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE Wilson, Nicholas M. verfasserin aut Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. Further research into the adverse effects of medication use on the mortality of institutionalized older individuals is needed. Charlson Comorbidity Index (dpeaa)DE-He213 Anticholinergic Medication (dpeaa)DE-He213 Charlson Comorbidity Index Score (dpeaa)DE-He213 Sedative Medication (dpeaa)DE-He213 Residential Aged Care Facility (dpeaa)DE-He213 Hilmer, Sarah N. verfasserin aut March, Lyn M. verfasserin aut Chen, Jian Sheng verfasserin aut Gnjidic, Danijela verfasserin aut Mason, Rebecca S. verfasserin aut Cameron, Ian D. verfasserin aut Sambrook, Philip N. verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 29(2012), 2 vom: Feb., Seite 157-165 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:29 year:2012 number:2 month:02 pages:157-165 https://dx.doi.org/10.2165/11598570-000000000-00000 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2012 2 02 157-165 |
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10.2165/11598570-000000000-00000 doi (DE-627)SPR033243859 (SPR)11598570-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE Wilson, Nicholas M. verfasserin aut Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. Further research into the adverse effects of medication use on the mortality of institutionalized older individuals is needed. Charlson Comorbidity Index (dpeaa)DE-He213 Anticholinergic Medication (dpeaa)DE-He213 Charlson Comorbidity Index Score (dpeaa)DE-He213 Sedative Medication (dpeaa)DE-He213 Residential Aged Care Facility (dpeaa)DE-He213 Hilmer, Sarah N. verfasserin aut March, Lyn M. verfasserin aut Chen, Jian Sheng verfasserin aut Gnjidic, Danijela verfasserin aut Mason, Rebecca S. verfasserin aut Cameron, Ian D. verfasserin aut Sambrook, Philip N. verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 29(2012), 2 vom: Feb., Seite 157-165 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:29 year:2012 number:2 month:02 pages:157-165 https://dx.doi.org/10.2165/11598570-000000000-00000 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2012 2 02 157-165 |
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10.2165/11598570-000000000-00000 doi (DE-627)SPR033243859 (SPR)11598570-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE Wilson, Nicholas M. verfasserin aut Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. Further research into the adverse effects of medication use on the mortality of institutionalized older individuals is needed. Charlson Comorbidity Index (dpeaa)DE-He213 Anticholinergic Medication (dpeaa)DE-He213 Charlson Comorbidity Index Score (dpeaa)DE-He213 Sedative Medication (dpeaa)DE-He213 Residential Aged Care Facility (dpeaa)DE-He213 Hilmer, Sarah N. verfasserin aut March, Lyn M. verfasserin aut Chen, Jian Sheng verfasserin aut Gnjidic, Danijela verfasserin aut Mason, Rebecca S. verfasserin aut Cameron, Ian D. verfasserin aut Sambrook, Philip N. verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 29(2012), 2 vom: Feb., Seite 157-165 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:29 year:2012 number:2 month:02 pages:157-165 https://dx.doi.org/10.2165/11598570-000000000-00000 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2012 2 02 157-165 |
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10.2165/11598570-000000000-00000 doi (DE-627)SPR033243859 (SPR)11598570-000000000-00000-e DE-627 ger DE-627 rakwb eng 610 ASE Wilson, Nicholas M. verfasserin aut Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. Further research into the adverse effects of medication use on the mortality of institutionalized older individuals is needed. Charlson Comorbidity Index (dpeaa)DE-He213 Anticholinergic Medication (dpeaa)DE-He213 Charlson Comorbidity Index Score (dpeaa)DE-He213 Sedative Medication (dpeaa)DE-He213 Residential Aged Care Facility (dpeaa)DE-He213 Hilmer, Sarah N. verfasserin aut March, Lyn M. verfasserin aut Chen, Jian Sheng verfasserin aut Gnjidic, Danijela verfasserin aut Mason, Rebecca S. verfasserin aut Cameron, Ian D. verfasserin aut Sambrook, Philip N. verfasserin aut Enthalten in Drugs & aging Berlin [u.a.] : Springer, 1991 29(2012), 2 vom: Feb., Seite 157-165 (DE-627)327644281 (DE-600)2043689-0 1179-1969 nnns volume:29 year:2012 number:2 month:02 pages:157-165 https://dx.doi.org/10.2165/11598570-000000000-00000 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 29 2012 2 02 157-165 |
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Enthalten in Drugs & aging 29(2012), 2 vom: Feb., Seite 157-165 volume:29 year:2012 number:2 month:02 pages:157-165 |
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Wilson, Nicholas M. @@aut@@ Hilmer, Sarah N. @@aut@@ March, Lyn M. @@aut@@ Chen, Jian Sheng @@aut@@ Gnjidic, Danijela @@aut@@ Mason, Rebecca S. @@aut@@ Cameron, Ian D. @@aut@@ Sambrook, Philip N. @@aut@@ |
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In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. 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Wilson, Nicholas M. |
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associations between drug burden index and mortality in older people in residential aged care facilities |
| title_auth |
Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities |
| abstract |
Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. Further research into the adverse effects of medication use on the mortality of institutionalized older individuals is needed. |
| abstractGer |
Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. Further research into the adverse effects of medication use on the mortality of institutionalized older individuals is needed. |
| abstract_unstemmed |
Abstract Background: The Drug Burden Index (DBI), a measure of an individual’s exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls. Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs. Methods: Study participants (n= 602; 70.9% female), recruited from 51 RACFs in Sydney, Australia, had a mean ± standard deviation (SD) age of 85.7 ±6.4 years and a mean ± SD DBI score of 0.58 ± 0.64. Results: Exposure to anticholinergic medication was 33.6% and sedative medications 41.9%. All-cause mortality after a variable follow-up time (774–1269 days) was 36.2% (n = 218), with the leading causes of death classified as stroke (n = 46; 21.1%), ischaemic heart disease/cardiovascular system (n = 44; 20.2%) and pneumonia (n = 31; 14.2%). One-year mortality multivariate models showed that the DBI categories low (n = 260; hazard ratio [HR] 1.13; 95% CI 0.82, 1.57) and high (n= 153; HR 1.19; 95% CI 0.82, 1.74) were not associated with mortality. This lack of a significant association remained after dichotomization into the anticholinergic and sedative components of the DBI. Conclusions: We found that with high exposure to anticholinergic and sedative medications, there was no significant association between increasing DBI score and all-cause mortality in old individuals living in RACFs. Further research into the adverse effects of medication use on the mortality of institutionalized older individuals is needed. |
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Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities |
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https://dx.doi.org/10.2165/11598570-000000000-00000 |
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Hilmer, Sarah N. March, Lyn M. Chen, Jian Sheng Gnjidic, Danijela Mason, Rebecca S. Cameron, Ian D. Sambrook, Philip N. |
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Hilmer, Sarah N. March, Lyn M. Chen, Jian Sheng Gnjidic, Danijela Mason, Rebecca S. Cameron, Ian D. Sambrook, Philip N. |
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2024-07-03T17:32:09.698Z |
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| score |
7.4019423 |