Carbidopa/levodopa enteral suspension in advanced Parkinson’s disease: a guide to its use
Abstract Carbidopa/levodopa enteral suspension [carbidopa/levodopa ES; Duopa™ (USA); $ Duodopa^{®} $ (EU, where it is referred to as intestinal gel)] is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease (PD). Its delivery by continuous infusion into the...
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Gespeichert in:
| Autor*in: |
Greig, Sarah L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Drugs & therapy perspectives - [S.l.] : Springer International, 1993, 32(2016), 5 vom: 22. März, Seite 177-185 |
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| Übergeordnetes Werk: |
volume:32 ; year:2016 ; number:5 ; day:22 ; month:03 ; pages:177-185 |
| Links: |
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| DOI / URN: |
10.1007/s40267-016-0297-2 |
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| Katalog-ID: |
SPR033281599 |
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| 520 | |a Abstract Carbidopa/levodopa enteral suspension [carbidopa/levodopa ES; Duopa™ (USA); $ Duodopa^{®} $ (EU, where it is referred to as intestinal gel)] is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease (PD). Its delivery by continuous infusion into the proximal small intestine allows for rapid absorption of levodopa and helps to avoid the fluctuations in levodopa plasma concentrations that occur with oral levodopa therapy. In clinical trials in adults with advanced PD, carbidopa/levodopa ES provided significantly greater improvements in motor fluctuations and troublesome dyskinesia than oral immediate-release carbidopa/levodopa over 12 weeks, and had sustained efficacy in longer-term, open-label studies. Carbidopa/levodopa ES was generally well tolerated in these trials, although complications related to the delivery system were common. | ||
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| 650 | 4 | |a Motor Complication |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Duodopa |7 (dpeaa)DE-He213 | |
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10.1007/s40267-016-0297-2 doi (DE-627)SPR033281599 (SPR)s40267-016-0297-2-e DE-627 ger DE-627 rakwb eng 610 ASE Greig, Sarah L. verfasserin aut Carbidopa/levodopa enteral suspension in advanced Parkinson’s disease: a guide to its use 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Carbidopa/levodopa enteral suspension [carbidopa/levodopa ES; Duopa™ (USA); $ Duodopa^{®} $ (EU, where it is referred to as intestinal gel)] is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease (PD). Its delivery by continuous infusion into the proximal small intestine allows for rapid absorption of levodopa and helps to avoid the fluctuations in levodopa plasma concentrations that occur with oral levodopa therapy. In clinical trials in adults with advanced PD, carbidopa/levodopa ES provided significantly greater improvements in motor fluctuations and troublesome dyskinesia than oral immediate-release carbidopa/levodopa over 12 weeks, and had sustained efficacy in longer-term, open-label studies. Carbidopa/levodopa ES was generally well tolerated in these trials, although complications related to the delivery system were common. Levodopa (dpeaa)DE-He213 Deep Brain Stimulation (dpeaa)DE-He213 Motor Fluctuation (dpeaa)DE-He213 Motor Complication (dpeaa)DE-He213 Duodopa (dpeaa)DE-He213 Enthalten in Drugs & therapy perspectives [S.l.] : Springer International, 1993 32(2016), 5 vom: 22. März, Seite 177-185 (DE-627)343513803 (DE-600)2073078-0 1179-1977 nnns volume:32 year:2016 number:5 day:22 month:03 pages:177-185 https://dx.doi.org/10.1007/s40267-016-0297-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2016 5 22 03 177-185 |
| spelling |
10.1007/s40267-016-0297-2 doi (DE-627)SPR033281599 (SPR)s40267-016-0297-2-e DE-627 ger DE-627 rakwb eng 610 ASE Greig, Sarah L. verfasserin aut Carbidopa/levodopa enteral suspension in advanced Parkinson’s disease: a guide to its use 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Carbidopa/levodopa enteral suspension [carbidopa/levodopa ES; Duopa™ (USA); $ Duodopa^{®} $ (EU, where it is referred to as intestinal gel)] is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease (PD). Its delivery by continuous infusion into the proximal small intestine allows for rapid absorption of levodopa and helps to avoid the fluctuations in levodopa plasma concentrations that occur with oral levodopa therapy. In clinical trials in adults with advanced PD, carbidopa/levodopa ES provided significantly greater improvements in motor fluctuations and troublesome dyskinesia than oral immediate-release carbidopa/levodopa over 12 weeks, and had sustained efficacy in longer-term, open-label studies. Carbidopa/levodopa ES was generally well tolerated in these trials, although complications related to the delivery system were common. Levodopa (dpeaa)DE-He213 Deep Brain Stimulation (dpeaa)DE-He213 Motor Fluctuation (dpeaa)DE-He213 Motor Complication (dpeaa)DE-He213 Duodopa (dpeaa)DE-He213 Enthalten in Drugs & therapy perspectives [S.l.] : Springer International, 1993 32(2016), 5 vom: 22. März, Seite 177-185 (DE-627)343513803 (DE-600)2073078-0 1179-1977 nnns volume:32 year:2016 number:5 day:22 month:03 pages:177-185 https://dx.doi.org/10.1007/s40267-016-0297-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2016 5 22 03 177-185 |
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10.1007/s40267-016-0297-2 doi (DE-627)SPR033281599 (SPR)s40267-016-0297-2-e DE-627 ger DE-627 rakwb eng 610 ASE Greig, Sarah L. verfasserin aut Carbidopa/levodopa enteral suspension in advanced Parkinson’s disease: a guide to its use 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Carbidopa/levodopa enteral suspension [carbidopa/levodopa ES; Duopa™ (USA); $ Duodopa^{®} $ (EU, where it is referred to as intestinal gel)] is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease (PD). Its delivery by continuous infusion into the proximal small intestine allows for rapid absorption of levodopa and helps to avoid the fluctuations in levodopa plasma concentrations that occur with oral levodopa therapy. In clinical trials in adults with advanced PD, carbidopa/levodopa ES provided significantly greater improvements in motor fluctuations and troublesome dyskinesia than oral immediate-release carbidopa/levodopa over 12 weeks, and had sustained efficacy in longer-term, open-label studies. Carbidopa/levodopa ES was generally well tolerated in these trials, although complications related to the delivery system were common. Levodopa (dpeaa)DE-He213 Deep Brain Stimulation (dpeaa)DE-He213 Motor Fluctuation (dpeaa)DE-He213 Motor Complication (dpeaa)DE-He213 Duodopa (dpeaa)DE-He213 Enthalten in Drugs & therapy perspectives [S.l.] : Springer International, 1993 32(2016), 5 vom: 22. März, Seite 177-185 (DE-627)343513803 (DE-600)2073078-0 1179-1977 nnns volume:32 year:2016 number:5 day:22 month:03 pages:177-185 https://dx.doi.org/10.1007/s40267-016-0297-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2016 5 22 03 177-185 |
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10.1007/s40267-016-0297-2 doi (DE-627)SPR033281599 (SPR)s40267-016-0297-2-e DE-627 ger DE-627 rakwb eng 610 ASE Greig, Sarah L. verfasserin aut Carbidopa/levodopa enteral suspension in advanced Parkinson’s disease: a guide to its use 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Carbidopa/levodopa enteral suspension [carbidopa/levodopa ES; Duopa™ (USA); $ Duodopa^{®} $ (EU, where it is referred to as intestinal gel)] is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease (PD). Its delivery by continuous infusion into the proximal small intestine allows for rapid absorption of levodopa and helps to avoid the fluctuations in levodopa plasma concentrations that occur with oral levodopa therapy. In clinical trials in adults with advanced PD, carbidopa/levodopa ES provided significantly greater improvements in motor fluctuations and troublesome dyskinesia than oral immediate-release carbidopa/levodopa over 12 weeks, and had sustained efficacy in longer-term, open-label studies. Carbidopa/levodopa ES was generally well tolerated in these trials, although complications related to the delivery system were common. Levodopa (dpeaa)DE-He213 Deep Brain Stimulation (dpeaa)DE-He213 Motor Fluctuation (dpeaa)DE-He213 Motor Complication (dpeaa)DE-He213 Duodopa (dpeaa)DE-He213 Enthalten in Drugs & therapy perspectives [S.l.] : Springer International, 1993 32(2016), 5 vom: 22. März, Seite 177-185 (DE-627)343513803 (DE-600)2073078-0 1179-1977 nnns volume:32 year:2016 number:5 day:22 month:03 pages:177-185 https://dx.doi.org/10.1007/s40267-016-0297-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2016 5 22 03 177-185 |
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Enthalten in Drugs & therapy perspectives 32(2016), 5 vom: 22. März, Seite 177-185 volume:32 year:2016 number:5 day:22 month:03 pages:177-185 |
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Levodopa Deep Brain Stimulation Motor Fluctuation Motor Complication Duodopa |
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Greig, Sarah L. @@aut@@ |
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Greig, Sarah L. |
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Greig, Sarah L. ddc 610 misc Levodopa misc Deep Brain Stimulation misc Motor Fluctuation misc Motor Complication misc Duodopa Carbidopa/levodopa enteral suspension in advanced Parkinson’s disease: a guide to its use |
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carbidopa/levodopa enteral suspension in advanced parkinson’s disease: a guide to its use |
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Carbidopa/levodopa enteral suspension in advanced Parkinson’s disease: a guide to its use |
| abstract |
Abstract Carbidopa/levodopa enteral suspension [carbidopa/levodopa ES; Duopa™ (USA); $ Duodopa^{®} $ (EU, where it is referred to as intestinal gel)] is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease (PD). Its delivery by continuous infusion into the proximal small intestine allows for rapid absorption of levodopa and helps to avoid the fluctuations in levodopa plasma concentrations that occur with oral levodopa therapy. In clinical trials in adults with advanced PD, carbidopa/levodopa ES provided significantly greater improvements in motor fluctuations and troublesome dyskinesia than oral immediate-release carbidopa/levodopa over 12 weeks, and had sustained efficacy in longer-term, open-label studies. Carbidopa/levodopa ES was generally well tolerated in these trials, although complications related to the delivery system were common. |
| abstractGer |
Abstract Carbidopa/levodopa enteral suspension [carbidopa/levodopa ES; Duopa™ (USA); $ Duodopa^{®} $ (EU, where it is referred to as intestinal gel)] is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease (PD). Its delivery by continuous infusion into the proximal small intestine allows for rapid absorption of levodopa and helps to avoid the fluctuations in levodopa plasma concentrations that occur with oral levodopa therapy. In clinical trials in adults with advanced PD, carbidopa/levodopa ES provided significantly greater improvements in motor fluctuations and troublesome dyskinesia than oral immediate-release carbidopa/levodopa over 12 weeks, and had sustained efficacy in longer-term, open-label studies. Carbidopa/levodopa ES was generally well tolerated in these trials, although complications related to the delivery system were common. |
| abstract_unstemmed |
Abstract Carbidopa/levodopa enteral suspension [carbidopa/levodopa ES; Duopa™ (USA); $ Duodopa^{®} $ (EU, where it is referred to as intestinal gel)] is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease (PD). Its delivery by continuous infusion into the proximal small intestine allows for rapid absorption of levodopa and helps to avoid the fluctuations in levodopa plasma concentrations that occur with oral levodopa therapy. In clinical trials in adults with advanced PD, carbidopa/levodopa ES provided significantly greater improvements in motor fluctuations and troublesome dyskinesia than oral immediate-release carbidopa/levodopa over 12 weeks, and had sustained efficacy in longer-term, open-label studies. Carbidopa/levodopa ES was generally well tolerated in these trials, although complications related to the delivery system were common. |
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Carbidopa/levodopa enteral suspension in advanced Parkinson’s disease: a guide to its use |
| url |
https://dx.doi.org/10.1007/s40267-016-0297-2 |
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| doi_str |
10.1007/s40267-016-0297-2 |
| up_date |
2024-07-03T17:42:56.864Z |
| _version_ |
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