Cytomegalovirus Keratouveitis: Charted and Uncharted Territory

Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstr...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Joye, Ashlin [verfasserIn] Gonzales, John [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Cytomegalovirus uveitis Cytomegalovirus anterior uveitis Cytomegalovirus endotheliitis Cytomegalovirus keratouveitis Viral uveitis

Übergeordnetes Werk:	Enthalten in: Current ophthalmology reports - New York, NY : Springer, 2013, 6(2018), 2 vom: 17. Apr., Seite 98-104
Übergeordnetes Werk:	volume:6 ; year:2018 ; number:2 ; day:17 ; month:04 ; pages:98-104

Links:	Volltext

DOI / URN:	10.1007/s40135-018-0170-7

Katalog-ID:	SPR033849897

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520			\|a Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstrated that CMV is an important cause of keratouveitis. PCR has more recently been used to offer a microbiologic indicator (viral load), which has the potential to be correlated to clinical severity and corneal endothelial cell density. This knowledge may be used to help guide management of this chronic disease. Summary Overlapping clinical features of viral keratouveitis, such as ocular hypertension and keratic precipitates, present a challenge in distinguishing CMV from other viral etiologies. Important findings suggestive of CMV include “coin-shaped” precipitates and diffuse iris atrophy. Definitive diagnosis requires identifying CMV using molecular testing. While multiple treatment options appear effective in controlling flares, one challenge is preventing long-term morbidity associated with recurrent inflammation. Thus, further studies on CMV keratouveitis are warranted to understand the relationship between viral burden, clinical features, and the most appropriate antiviral therapy.
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allfields	10.1007/s40135-018-0170-7 doi (DE-627)SPR033849897 (SPR)s40135-018-0170-7-e DE-627 ger DE-627 rakwb eng 610 ASE Joye, Ashlin verfasserin aut Cytomegalovirus Keratouveitis: Charted and Uncharted Territory 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstrated that CMV is an important cause of keratouveitis. PCR has more recently been used to offer a microbiologic indicator (viral load), which has the potential to be correlated to clinical severity and corneal endothelial cell density. This knowledge may be used to help guide management of this chronic disease. Summary Overlapping clinical features of viral keratouveitis, such as ocular hypertension and keratic precipitates, present a challenge in distinguishing CMV from other viral etiologies. Important findings suggestive of CMV include “coin-shaped” precipitates and diffuse iris atrophy. Definitive diagnosis requires identifying CMV using molecular testing. While multiple treatment options appear effective in controlling flares, one challenge is preventing long-term morbidity associated with recurrent inflammation. Thus, further studies on CMV keratouveitis are warranted to understand the relationship between viral burden, clinical features, and the most appropriate antiviral therapy. Cytomegalovirus uveitis (dpeaa)DE-He213 Cytomegalovirus anterior uveitis (dpeaa)DE-He213 Cytomegalovirus endotheliitis (dpeaa)DE-He213 Cytomegalovirus keratouveitis (dpeaa)DE-He213 Viral uveitis (dpeaa)DE-He213 Gonzales, John verfasserin aut Enthalten in Current ophthalmology reports New York, NY : Springer, 2013 6(2018), 2 vom: 17. Apr., Seite 98-104 (DE-627)770398898 (DE-600)2737923-1 2167-4868 nnns volume:6 year:2018 number:2 day:17 month:04 pages:98-104 https://dx.doi.org/10.1007/s40135-018-0170-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2018 2 17 04 98-104
spelling	10.1007/s40135-018-0170-7 doi (DE-627)SPR033849897 (SPR)s40135-018-0170-7-e DE-627 ger DE-627 rakwb eng 610 ASE Joye, Ashlin verfasserin aut Cytomegalovirus Keratouveitis: Charted and Uncharted Territory 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstrated that CMV is an important cause of keratouveitis. PCR has more recently been used to offer a microbiologic indicator (viral load), which has the potential to be correlated to clinical severity and corneal endothelial cell density. This knowledge may be used to help guide management of this chronic disease. Summary Overlapping clinical features of viral keratouveitis, such as ocular hypertension and keratic precipitates, present a challenge in distinguishing CMV from other viral etiologies. Important findings suggestive of CMV include “coin-shaped” precipitates and diffuse iris atrophy. Definitive diagnosis requires identifying CMV using molecular testing. While multiple treatment options appear effective in controlling flares, one challenge is preventing long-term morbidity associated with recurrent inflammation. Thus, further studies on CMV keratouveitis are warranted to understand the relationship between viral burden, clinical features, and the most appropriate antiviral therapy. Cytomegalovirus uveitis (dpeaa)DE-He213 Cytomegalovirus anterior uveitis (dpeaa)DE-He213 Cytomegalovirus endotheliitis (dpeaa)DE-He213 Cytomegalovirus keratouveitis (dpeaa)DE-He213 Viral uveitis (dpeaa)DE-He213 Gonzales, John verfasserin aut Enthalten in Current ophthalmology reports New York, NY : Springer, 2013 6(2018), 2 vom: 17. Apr., Seite 98-104 (DE-627)770398898 (DE-600)2737923-1 2167-4868 nnns volume:6 year:2018 number:2 day:17 month:04 pages:98-104 https://dx.doi.org/10.1007/s40135-018-0170-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2018 2 17 04 98-104
allfields_unstemmed	10.1007/s40135-018-0170-7 doi (DE-627)SPR033849897 (SPR)s40135-018-0170-7-e DE-627 ger DE-627 rakwb eng 610 ASE Joye, Ashlin verfasserin aut Cytomegalovirus Keratouveitis: Charted and Uncharted Territory 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstrated that CMV is an important cause of keratouveitis. PCR has more recently been used to offer a microbiologic indicator (viral load), which has the potential to be correlated to clinical severity and corneal endothelial cell density. This knowledge may be used to help guide management of this chronic disease. Summary Overlapping clinical features of viral keratouveitis, such as ocular hypertension and keratic precipitates, present a challenge in distinguishing CMV from other viral etiologies. Important findings suggestive of CMV include “coin-shaped” precipitates and diffuse iris atrophy. Definitive diagnosis requires identifying CMV using molecular testing. While multiple treatment options appear effective in controlling flares, one challenge is preventing long-term morbidity associated with recurrent inflammation. Thus, further studies on CMV keratouveitis are warranted to understand the relationship between viral burden, clinical features, and the most appropriate antiviral therapy. Cytomegalovirus uveitis (dpeaa)DE-He213 Cytomegalovirus anterior uveitis (dpeaa)DE-He213 Cytomegalovirus endotheliitis (dpeaa)DE-He213 Cytomegalovirus keratouveitis (dpeaa)DE-He213 Viral uveitis (dpeaa)DE-He213 Gonzales, John verfasserin aut Enthalten in Current ophthalmology reports New York, NY : Springer, 2013 6(2018), 2 vom: 17. Apr., Seite 98-104 (DE-627)770398898 (DE-600)2737923-1 2167-4868 nnns volume:6 year:2018 number:2 day:17 month:04 pages:98-104 https://dx.doi.org/10.1007/s40135-018-0170-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2018 2 17 04 98-104
allfieldsGer	10.1007/s40135-018-0170-7 doi (DE-627)SPR033849897 (SPR)s40135-018-0170-7-e DE-627 ger DE-627 rakwb eng 610 ASE Joye, Ashlin verfasserin aut Cytomegalovirus Keratouveitis: Charted and Uncharted Territory 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstrated that CMV is an important cause of keratouveitis. PCR has more recently been used to offer a microbiologic indicator (viral load), which has the potential to be correlated to clinical severity and corneal endothelial cell density. This knowledge may be used to help guide management of this chronic disease. Summary Overlapping clinical features of viral keratouveitis, such as ocular hypertension and keratic precipitates, present a challenge in distinguishing CMV from other viral etiologies. Important findings suggestive of CMV include “coin-shaped” precipitates and diffuse iris atrophy. Definitive diagnosis requires identifying CMV using molecular testing. While multiple treatment options appear effective in controlling flares, one challenge is preventing long-term morbidity associated with recurrent inflammation. Thus, further studies on CMV keratouveitis are warranted to understand the relationship between viral burden, clinical features, and the most appropriate antiviral therapy. Cytomegalovirus uveitis (dpeaa)DE-He213 Cytomegalovirus anterior uveitis (dpeaa)DE-He213 Cytomegalovirus endotheliitis (dpeaa)DE-He213 Cytomegalovirus keratouveitis (dpeaa)DE-He213 Viral uveitis (dpeaa)DE-He213 Gonzales, John verfasserin aut Enthalten in Current ophthalmology reports New York, NY : Springer, 2013 6(2018), 2 vom: 17. Apr., Seite 98-104 (DE-627)770398898 (DE-600)2737923-1 2167-4868 nnns volume:6 year:2018 number:2 day:17 month:04 pages:98-104 https://dx.doi.org/10.1007/s40135-018-0170-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2018 2 17 04 98-104
allfieldsSound	10.1007/s40135-018-0170-7 doi (DE-627)SPR033849897 (SPR)s40135-018-0170-7-e DE-627 ger DE-627 rakwb eng 610 ASE Joye, Ashlin verfasserin aut Cytomegalovirus Keratouveitis: Charted and Uncharted Territory 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstrated that CMV is an important cause of keratouveitis. PCR has more recently been used to offer a microbiologic indicator (viral load), which has the potential to be correlated to clinical severity and corneal endothelial cell density. This knowledge may be used to help guide management of this chronic disease. Summary Overlapping clinical features of viral keratouveitis, such as ocular hypertension and keratic precipitates, present a challenge in distinguishing CMV from other viral etiologies. Important findings suggestive of CMV include “coin-shaped” precipitates and diffuse iris atrophy. Definitive diagnosis requires identifying CMV using molecular testing. While multiple treatment options appear effective in controlling flares, one challenge is preventing long-term morbidity associated with recurrent inflammation. Thus, further studies on CMV keratouveitis are warranted to understand the relationship between viral burden, clinical features, and the most appropriate antiviral therapy. Cytomegalovirus uveitis (dpeaa)DE-He213 Cytomegalovirus anterior uveitis (dpeaa)DE-He213 Cytomegalovirus endotheliitis (dpeaa)DE-He213 Cytomegalovirus keratouveitis (dpeaa)DE-He213 Viral uveitis (dpeaa)DE-He213 Gonzales, John verfasserin aut Enthalten in Current ophthalmology reports New York, NY : Springer, 2013 6(2018), 2 vom: 17. Apr., Seite 98-104 (DE-627)770398898 (DE-600)2737923-1 2167-4868 nnns volume:6 year:2018 number:2 day:17 month:04 pages:98-104 https://dx.doi.org/10.1007/s40135-018-0170-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2018 2 17 04 98-104
language	English
source	Enthalten in Current ophthalmology reports 6(2018), 2 vom: 17. Apr., Seite 98-104 volume:6 year:2018 number:2 day:17 month:04 pages:98-104
sourceStr	Enthalten in Current ophthalmology reports 6(2018), 2 vom: 17. Apr., Seite 98-104 volume:6 year:2018 number:2 day:17 month:04 pages:98-104
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cytomegalovirus uveitis Cytomegalovirus anterior uveitis Cytomegalovirus endotheliitis Cytomegalovirus keratouveitis Viral uveitis
dewey-raw	610
isfreeaccess_bool	false
container_title	Current ophthalmology reports
authorswithroles_txt_mv	Joye, Ashlin @@aut@@ Gonzales, John @@aut@@
publishDateDaySort_date	2018-04-17T00:00:00Z
hierarchy_top_id	770398898
dewey-sort	3610
id	SPR033849897
language_de	englisch
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author	Joye, Ashlin
spellingShingle	Joye, Ashlin ddc 610 misc Cytomegalovirus uveitis misc Cytomegalovirus anterior uveitis misc Cytomegalovirus endotheliitis misc Cytomegalovirus keratouveitis misc Viral uveitis Cytomegalovirus Keratouveitis: Charted and Uncharted Territory
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topic_title	610 ASE Cytomegalovirus Keratouveitis: Charted and Uncharted Territory Cytomegalovirus uveitis (dpeaa)DE-He213 Cytomegalovirus anterior uveitis (dpeaa)DE-He213 Cytomegalovirus endotheliitis (dpeaa)DE-He213 Cytomegalovirus keratouveitis (dpeaa)DE-He213 Viral uveitis (dpeaa)DE-He213
topic	ddc 610 misc Cytomegalovirus uveitis misc Cytomegalovirus anterior uveitis misc Cytomegalovirus endotheliitis misc Cytomegalovirus keratouveitis misc Viral uveitis
topic_unstemmed	ddc 610 misc Cytomegalovirus uveitis misc Cytomegalovirus anterior uveitis misc Cytomegalovirus endotheliitis misc Cytomegalovirus keratouveitis misc Viral uveitis
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title	Cytomegalovirus Keratouveitis: Charted and Uncharted Territory
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title_full	Cytomegalovirus Keratouveitis: Charted and Uncharted Territory
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title_sort	cytomegalovirus keratouveitis: charted and uncharted territory
title_auth	Cytomegalovirus Keratouveitis: Charted and Uncharted Territory
abstract	Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstrated that CMV is an important cause of keratouveitis. PCR has more recently been used to offer a microbiologic indicator (viral load), which has the potential to be correlated to clinical severity and corneal endothelial cell density. This knowledge may be used to help guide management of this chronic disease. Summary Overlapping clinical features of viral keratouveitis, such as ocular hypertension and keratic precipitates, present a challenge in distinguishing CMV from other viral etiologies. Important findings suggestive of CMV include “coin-shaped” precipitates and diffuse iris atrophy. Definitive diagnosis requires identifying CMV using molecular testing. While multiple treatment options appear effective in controlling flares, one challenge is preventing long-term morbidity associated with recurrent inflammation. Thus, further studies on CMV keratouveitis are warranted to understand the relationship between viral burden, clinical features, and the most appropriate antiviral therapy.
abstractGer	Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstrated that CMV is an important cause of keratouveitis. PCR has more recently been used to offer a microbiologic indicator (viral load), which has the potential to be correlated to clinical severity and corneal endothelial cell density. This knowledge may be used to help guide management of this chronic disease. Summary Overlapping clinical features of viral keratouveitis, such as ocular hypertension and keratic precipitates, present a challenge in distinguishing CMV from other viral etiologies. Important findings suggestive of CMV include “coin-shaped” precipitates and diffuse iris atrophy. Definitive diagnosis requires identifying CMV using molecular testing. While multiple treatment options appear effective in controlling flares, one challenge is preventing long-term morbidity associated with recurrent inflammation. Thus, further studies on CMV keratouveitis are warranted to understand the relationship between viral burden, clinical features, and the most appropriate antiviral therapy.
abstract_unstemmed	Purpose of Review This report provides an overview of the current understanding of cytomegalovirus (CMV) keratouveitis: pathophysiology, clinical features, management, and gaps in knowledge. Recent Findings The wide availability of polymerase chain reaction (PCR) testing of ocular fluid has demonstrated that CMV is an important cause of keratouveitis. PCR has more recently been used to offer a microbiologic indicator (viral load), which has the potential to be correlated to clinical severity and corneal endothelial cell density. This knowledge may be used to help guide management of this chronic disease. Summary Overlapping clinical features of viral keratouveitis, such as ocular hypertension and keratic precipitates, present a challenge in distinguishing CMV from other viral etiologies. Important findings suggestive of CMV include “coin-shaped” precipitates and diffuse iris atrophy. Definitive diagnosis requires identifying CMV using molecular testing. While multiple treatment options appear effective in controlling flares, one challenge is preventing long-term morbidity associated with recurrent inflammation. Thus, further studies on CMV keratouveitis are warranted to understand the relationship between viral burden, clinical features, and the most appropriate antiviral therapy.
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container_issue	2
title_short	Cytomegalovirus Keratouveitis: Charted and Uncharted Territory
url	https://dx.doi.org/10.1007/s40135-018-0170-7
remote_bool	true
author2	Gonzales, John
author2Str	Gonzales, John
ppnlink	770398898
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s40135-018-0170-7
up_date	2024-07-03T19:54:47.944Z
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