Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, ther...
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Autor*in:	Qu, Xiaofeng [verfasserIn] Xu, Kun Zhao, Chao Song, Xiuling Li, Jinhua Li, Li Nie, Wei Bao, Hao Wang, Juan Niu, Fenglan Li, Juan

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Polyoxometalate Acute oral toxicity Subchronic oral toxicity Genotoxicity

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: BMC pharmacology & toxicology - London : BioMed Central, 2012, 18(2017), 1 vom: 05. Apr.
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:1 ; day:05 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s40360-017-0133-x

Katalog-ID:	SPR03637766X

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520			\|a Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks.
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700	1		\|a Xu, Kun \|4 aut
700	1		\|a Zhao, Chao \|4 aut
700	1		\|a Song, Xiuling \|4 aut
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700	1		\|a Nie, Wei \|4 aut
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700	1		\|a Wang, Juan \|4 aut
700	1		\|a Niu, Fenglan \|4 aut
700	1		\|a Li, Juan \|4 aut
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author_variant	x q xq k x kx c z cz x s xs j l jl l l ll w n wn h b hb j w jw f n fn j l jl
matchkey_str	article:20506511:2017----::eooiiynauensbhoitxctsuisfbocieo
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allfields	10.1186/s40360-017-0133-x doi (DE-627)SPR03637766X (SPR)s40360-017-0133-x-e DE-627 ger DE-627 rakwb eng Qu, Xiaofeng verfasserin aut Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. Polyoxometalate (dpeaa)DE-He213 Acute oral toxicity (dpeaa)DE-He213 Subchronic oral toxicity (dpeaa)DE-He213 Genotoxicity (dpeaa)DE-He213 Xu, Kun aut Zhao, Chao aut Song, Xiuling aut Li, Jinhua aut Li, Li aut Nie, Wei aut Bao, Hao aut Wang, Juan aut Niu, Fenglan aut Li, Juan aut Enthalten in BMC pharmacology & toxicology London : BioMed Central, 2012 18(2017), 1 vom: 05. Apr. (DE-627)723899754 (DE-600)2680259-4 2050-6511 nnns volume:18 year:2017 number:1 day:05 month:04 https://dx.doi.org/10.1186/s40360-017-0133-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 05 04
spelling	10.1186/s40360-017-0133-x doi (DE-627)SPR03637766X (SPR)s40360-017-0133-x-e DE-627 ger DE-627 rakwb eng Qu, Xiaofeng verfasserin aut Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. Polyoxometalate (dpeaa)DE-He213 Acute oral toxicity (dpeaa)DE-He213 Subchronic oral toxicity (dpeaa)DE-He213 Genotoxicity (dpeaa)DE-He213 Xu, Kun aut Zhao, Chao aut Song, Xiuling aut Li, Jinhua aut Li, Li aut Nie, Wei aut Bao, Hao aut Wang, Juan aut Niu, Fenglan aut Li, Juan aut Enthalten in BMC pharmacology & toxicology London : BioMed Central, 2012 18(2017), 1 vom: 05. Apr. (DE-627)723899754 (DE-600)2680259-4 2050-6511 nnns volume:18 year:2017 number:1 day:05 month:04 https://dx.doi.org/10.1186/s40360-017-0133-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 05 04
allfields_unstemmed	10.1186/s40360-017-0133-x doi (DE-627)SPR03637766X (SPR)s40360-017-0133-x-e DE-627 ger DE-627 rakwb eng Qu, Xiaofeng verfasserin aut Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. Polyoxometalate (dpeaa)DE-He213 Acute oral toxicity (dpeaa)DE-He213 Subchronic oral toxicity (dpeaa)DE-He213 Genotoxicity (dpeaa)DE-He213 Xu, Kun aut Zhao, Chao aut Song, Xiuling aut Li, Jinhua aut Li, Li aut Nie, Wei aut Bao, Hao aut Wang, Juan aut Niu, Fenglan aut Li, Juan aut Enthalten in BMC pharmacology & toxicology London : BioMed Central, 2012 18(2017), 1 vom: 05. Apr. (DE-627)723899754 (DE-600)2680259-4 2050-6511 nnns volume:18 year:2017 number:1 day:05 month:04 https://dx.doi.org/10.1186/s40360-017-0133-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 05 04
allfieldsGer	10.1186/s40360-017-0133-x doi (DE-627)SPR03637766X (SPR)s40360-017-0133-x-e DE-627 ger DE-627 rakwb eng Qu, Xiaofeng verfasserin aut Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. Polyoxometalate (dpeaa)DE-He213 Acute oral toxicity (dpeaa)DE-He213 Subchronic oral toxicity (dpeaa)DE-He213 Genotoxicity (dpeaa)DE-He213 Xu, Kun aut Zhao, Chao aut Song, Xiuling aut Li, Jinhua aut Li, Li aut Nie, Wei aut Bao, Hao aut Wang, Juan aut Niu, Fenglan aut Li, Juan aut Enthalten in BMC pharmacology & toxicology London : BioMed Central, 2012 18(2017), 1 vom: 05. Apr. (DE-627)723899754 (DE-600)2680259-4 2050-6511 nnns volume:18 year:2017 number:1 day:05 month:04 https://dx.doi.org/10.1186/s40360-017-0133-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 05 04
allfieldsSound	10.1186/s40360-017-0133-x doi (DE-627)SPR03637766X (SPR)s40360-017-0133-x-e DE-627 ger DE-627 rakwb eng Qu, Xiaofeng verfasserin aut Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. Polyoxometalate (dpeaa)DE-He213 Acute oral toxicity (dpeaa)DE-He213 Subchronic oral toxicity (dpeaa)DE-He213 Genotoxicity (dpeaa)DE-He213 Xu, Kun aut Zhao, Chao aut Song, Xiuling aut Li, Jinhua aut Li, Li aut Nie, Wei aut Bao, Hao aut Wang, Juan aut Niu, Fenglan aut Li, Juan aut Enthalten in BMC pharmacology & toxicology London : BioMed Central, 2012 18(2017), 1 vom: 05. Apr. (DE-627)723899754 (DE-600)2680259-4 2050-6511 nnns volume:18 year:2017 number:1 day:05 month:04 https://dx.doi.org/10.1186/s40360-017-0133-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 05 04
language	English
source	Enthalten in BMC pharmacology & toxicology 18(2017), 1 vom: 05. Apr. volume:18 year:2017 number:1 day:05 month:04
sourceStr	Enthalten in BMC pharmacology & toxicology 18(2017), 1 vom: 05. Apr. volume:18 year:2017 number:1 day:05 month:04
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Polyoxometalate Acute oral toxicity Subchronic oral toxicity Genotoxicity
isfreeaccess_bool	true
container_title	BMC pharmacology & toxicology
authorswithroles_txt_mv	Qu, Xiaofeng @@aut@@ Xu, Kun @@aut@@ Zhao, Chao @@aut@@ Song, Xiuling @@aut@@ Li, Jinhua @@aut@@ Li, Li @@aut@@ Nie, Wei @@aut@@ Bao, Hao @@aut@@ Wang, Juan @@aut@@ Niu, Fenglan @@aut@@ Li, Juan @@aut@@
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Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polyoxometalate</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Acute oral toxicity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Subchronic oral toxicity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genotoxicity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xu, Kun</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhao, Chao</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Song, Xiuling</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Jinhua</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Li</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nie, Wei</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bao, Hao</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Juan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Niu, Fenglan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Juan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">BMC pharmacology & toxicology</subfield><subfield code="d">London : BioMed Central, 2012</subfield><subfield code="g">18(2017), 1 vom: 05. 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author	Qu, Xiaofeng
spellingShingle	Qu, Xiaofeng misc Polyoxometalate misc Acute oral toxicity misc Subchronic oral toxicity misc Genotoxicity Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
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topic_title	Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats Polyoxometalate (dpeaa)DE-He213 Acute oral toxicity (dpeaa)DE-He213 Subchronic oral toxicity (dpeaa)DE-He213 Genotoxicity (dpeaa)DE-He213
topic	misc Polyoxometalate misc Acute oral toxicity misc Subchronic oral toxicity misc Genotoxicity
topic_unstemmed	misc Polyoxometalate misc Acute oral toxicity misc Subchronic oral toxicity misc Genotoxicity
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title	Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
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title_full	Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
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journal	BMC pharmacology & toxicology
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author_browse	Qu, Xiaofeng Xu, Kun Zhao, Chao Song, Xiuling Li, Jinhua Li, Li Nie, Wei Bao, Hao Wang, Juan Niu, Fenglan Li, Juan
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doi_str_mv	10.1186/s40360-017-0133-x
title_sort	genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in wistar rats
title_auth	Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
abstract	Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. © The Author(s). 2017
abstractGer	Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. © The Author(s). 2017
abstract_unstemmed	Background $ Cs_{2} %$ K_{4} $Na [$ SiW_{9} %$ Nb_{3} %$ O_{40} $] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. © The Author(s). 2017
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title_short	Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
url	https://dx.doi.org/10.1186/s40360-017-0133-x
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author2	Xu, Kun Zhao, Chao Song, Xiuling Li, Jinhua Li, Li Nie, Wei Bao, Hao Wang, Juan Niu, Fenglan Li, Juan
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up_date	2024-07-03T17:15:30.367Z
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Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. 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Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

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