Dual checkpoint inhibitor-associated eosinophilic enteritis

Background Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. Case presentation We report a case of dual checkpoint inhibitor-associated hypereos...
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Autor*in:	Yang, J. [verfasserIn] Lagana, S. M. Saenger, Y. M. Carvajal, R. D.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Melanoma Checkpoint inhibition Eosinophilia Eosinophilic enteritis

Anmerkung:	© The Author(s). 2019

Übergeordnetes Werk:	Enthalten in: Journal for ImmunoTherapy of Cancer - London : BioMed Central, 2013, 7(2019), 1 vom: 15. Nov.
Übergeordnetes Werk:	volume:7 ; year:2019 ; number:1 ; day:15 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s40425-019-0743-5

Katalog-ID:	SPR036441155

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allfields	10.1186/s40425-019-0743-5 doi (DE-627)SPR036441155 (SPR)s40425-019-0743-5-e DE-627 ger DE-627 rakwb eng Yang, J. verfasserin aut Dual checkpoint inhibitor-associated eosinophilic enteritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. Case presentation We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone. Conclusions Immune checkpoint inhibition can trigger inflammation in virtually any organ in the body, leading to diverse clinical manifestations. To our knowledge, this is the first case report of eosinophilic enteritis due to ipilimumab plus nivolumab. Melanoma (dpeaa)DE-He213 Checkpoint inhibition (dpeaa)DE-He213 Eosinophilia (dpeaa)DE-He213 Eosinophilic enteritis (dpeaa)DE-He213 Lagana, S. M. aut Saenger, Y. M. aut Carvajal, R. D. (orcid)0000-0002-3796-1118 aut Enthalten in Journal for ImmunoTherapy of Cancer London : BioMed Central, 2013 7(2019), 1 vom: 15. Nov. (DE-627)750086335 (DE-600)2719863-7 2051-1426 nnns volume:7 year:2019 number:1 day:15 month:11 https://dx.doi.org/10.1186/s40425-019-0743-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 15 11
spelling	10.1186/s40425-019-0743-5 doi (DE-627)SPR036441155 (SPR)s40425-019-0743-5-e DE-627 ger DE-627 rakwb eng Yang, J. verfasserin aut Dual checkpoint inhibitor-associated eosinophilic enteritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. Case presentation We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone. Conclusions Immune checkpoint inhibition can trigger inflammation in virtually any organ in the body, leading to diverse clinical manifestations. To our knowledge, this is the first case report of eosinophilic enteritis due to ipilimumab plus nivolumab. Melanoma (dpeaa)DE-He213 Checkpoint inhibition (dpeaa)DE-He213 Eosinophilia (dpeaa)DE-He213 Eosinophilic enteritis (dpeaa)DE-He213 Lagana, S. M. aut Saenger, Y. M. aut Carvajal, R. D. (orcid)0000-0002-3796-1118 aut Enthalten in Journal for ImmunoTherapy of Cancer London : BioMed Central, 2013 7(2019), 1 vom: 15. Nov. (DE-627)750086335 (DE-600)2719863-7 2051-1426 nnns volume:7 year:2019 number:1 day:15 month:11 https://dx.doi.org/10.1186/s40425-019-0743-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 15 11
allfields_unstemmed	10.1186/s40425-019-0743-5 doi (DE-627)SPR036441155 (SPR)s40425-019-0743-5-e DE-627 ger DE-627 rakwb eng Yang, J. verfasserin aut Dual checkpoint inhibitor-associated eosinophilic enteritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. Case presentation We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone. Conclusions Immune checkpoint inhibition can trigger inflammation in virtually any organ in the body, leading to diverse clinical manifestations. To our knowledge, this is the first case report of eosinophilic enteritis due to ipilimumab plus nivolumab. Melanoma (dpeaa)DE-He213 Checkpoint inhibition (dpeaa)DE-He213 Eosinophilia (dpeaa)DE-He213 Eosinophilic enteritis (dpeaa)DE-He213 Lagana, S. M. aut Saenger, Y. M. aut Carvajal, R. D. (orcid)0000-0002-3796-1118 aut Enthalten in Journal for ImmunoTherapy of Cancer London : BioMed Central, 2013 7(2019), 1 vom: 15. Nov. (DE-627)750086335 (DE-600)2719863-7 2051-1426 nnns volume:7 year:2019 number:1 day:15 month:11 https://dx.doi.org/10.1186/s40425-019-0743-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 15 11
allfieldsGer	10.1186/s40425-019-0743-5 doi (DE-627)SPR036441155 (SPR)s40425-019-0743-5-e DE-627 ger DE-627 rakwb eng Yang, J. verfasserin aut Dual checkpoint inhibitor-associated eosinophilic enteritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. Case presentation We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone. Conclusions Immune checkpoint inhibition can trigger inflammation in virtually any organ in the body, leading to diverse clinical manifestations. To our knowledge, this is the first case report of eosinophilic enteritis due to ipilimumab plus nivolumab. Melanoma (dpeaa)DE-He213 Checkpoint inhibition (dpeaa)DE-He213 Eosinophilia (dpeaa)DE-He213 Eosinophilic enteritis (dpeaa)DE-He213 Lagana, S. M. aut Saenger, Y. M. aut Carvajal, R. D. (orcid)0000-0002-3796-1118 aut Enthalten in Journal for ImmunoTherapy of Cancer London : BioMed Central, 2013 7(2019), 1 vom: 15. Nov. (DE-627)750086335 (DE-600)2719863-7 2051-1426 nnns volume:7 year:2019 number:1 day:15 month:11 https://dx.doi.org/10.1186/s40425-019-0743-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 15 11
allfieldsSound	10.1186/s40425-019-0743-5 doi (DE-627)SPR036441155 (SPR)s40425-019-0743-5-e DE-627 ger DE-627 rakwb eng Yang, J. verfasserin aut Dual checkpoint inhibitor-associated eosinophilic enteritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. Case presentation We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone. Conclusions Immune checkpoint inhibition can trigger inflammation in virtually any organ in the body, leading to diverse clinical manifestations. To our knowledge, this is the first case report of eosinophilic enteritis due to ipilimumab plus nivolumab. Melanoma (dpeaa)DE-He213 Checkpoint inhibition (dpeaa)DE-He213 Eosinophilia (dpeaa)DE-He213 Eosinophilic enteritis (dpeaa)DE-He213 Lagana, S. M. aut Saenger, Y. M. aut Carvajal, R. D. (orcid)0000-0002-3796-1118 aut Enthalten in Journal for ImmunoTherapy of Cancer London : BioMed Central, 2013 7(2019), 1 vom: 15. Nov. (DE-627)750086335 (DE-600)2719863-7 2051-1426 nnns volume:7 year:2019 number:1 day:15 month:11 https://dx.doi.org/10.1186/s40425-019-0743-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 15 11
language	English
source	Enthalten in Journal for ImmunoTherapy of Cancer 7(2019), 1 vom: 15. Nov. volume:7 year:2019 number:1 day:15 month:11
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topic_facet	Melanoma Checkpoint inhibition Eosinophilia Eosinophilic enteritis
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author	Yang, J.
spellingShingle	Yang, J. misc Melanoma misc Checkpoint inhibition misc Eosinophilia misc Eosinophilic enteritis Dual checkpoint inhibitor-associated eosinophilic enteritis
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topic_title	Dual checkpoint inhibitor-associated eosinophilic enteritis Melanoma (dpeaa)DE-He213 Checkpoint inhibition (dpeaa)DE-He213 Eosinophilia (dpeaa)DE-He213 Eosinophilic enteritis (dpeaa)DE-He213
topic	misc Melanoma misc Checkpoint inhibition misc Eosinophilia misc Eosinophilic enteritis
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title	Dual checkpoint inhibitor-associated eosinophilic enteritis
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title_full	Dual checkpoint inhibitor-associated eosinophilic enteritis
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author_browse	Yang, J. Lagana, S. M. Saenger, Y. M. Carvajal, R. D.
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title_sort	dual checkpoint inhibitor-associated eosinophilic enteritis
title_auth	Dual checkpoint inhibitor-associated eosinophilic enteritis
abstract	Background Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. Case presentation We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone. Conclusions Immune checkpoint inhibition can trigger inflammation in virtually any organ in the body, leading to diverse clinical manifestations. To our knowledge, this is the first case report of eosinophilic enteritis due to ipilimumab plus nivolumab. © The Author(s). 2019
abstractGer	Background Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. Case presentation We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone. Conclusions Immune checkpoint inhibition can trigger inflammation in virtually any organ in the body, leading to diverse clinical manifestations. To our knowledge, this is the first case report of eosinophilic enteritis due to ipilimumab plus nivolumab. © The Author(s). 2019
abstract_unstemmed	Background Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. Case presentation We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone. Conclusions Immune checkpoint inhibition can trigger inflammation in virtually any organ in the body, leading to diverse clinical manifestations. To our knowledge, this is the first case report of eosinophilic enteritis due to ipilimumab plus nivolumab. © The Author(s). 2019
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title_short	Dual checkpoint inhibitor-associated eosinophilic enteritis
url	https://dx.doi.org/10.1186/s40425-019-0743-5
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author2	Lagana, S. M. Saenger, Y. M. Carvajal, R. D.
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doi_str	10.1186/s40425-019-0743-5
up_date	2024-07-03T17:38:15.927Z
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