Pediatric Vascular Composite Allograft Transplantation: Medical Considerations

Purpose of Review This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascular composite allotransplantation to non-immunocompromised pediatric candi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Amaral, Sandra [verfasserIn] Levin, L. Scott

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Pediatric Vascular composite allograft transplantation Hands

Anmerkung:	© Springer International Publishing AG, part of Springer Nature 2018

Übergeordnetes Werk:	Enthalten in: Current transplantation reports - Cham : Springer Internat. Publ., 2014, 5(2018), 2 vom: 20. März, Seite 121-129
Übergeordnetes Werk:	volume:5 ; year:2018 ; number:2 ; day:20 ; month:03 ; pages:121-129

Links:	Volltext

DOI / URN:	10.1007/s40472-018-0189-6

Katalog-ID:	SPR03649528X

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allfields	10.1007/s40472-018-0189-6 doi (DE-627)SPR03649528X (SPR)s40472-018-0189-6-e DE-627 ger DE-627 rakwb eng Amaral, Sandra verfasserin aut Pediatric Vascular Composite Allograft Transplantation: Medical Considerations 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG, part of Springer Nature 2018 Purpose of Review This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascular composite allotransplantation to non-immunocompromised pediatric candidates. Recent Findings A pediatric recipient of bilateral hand-forearm allotransplantation now over 2 years post-transplant has shown functional recovery that surpassed pre-transplant function, with evidence of somatosensory cortical reorganization. However, the child who was previously immunocompromised has required augmented immunosuppression and rehabilitation demands have been substantial. Summary Pediatric vascular composite allotransplantation is surgically feasible, and short-term outcomes in the first case reveal the potential for functional benefits that exceed the pre-transplant state. Robust immunosuppression and its inherent risks must be clearly discussed with potential pediatric candidates and their families. Additionally, advanced planning for psychological and social support throughout the prolonged rehabilitation period is essential to optimize therapeutic engagement and academic learning. Pediatric (dpeaa)DE-He213 Vascular composite allograft transplantation (dpeaa)DE-He213 Hands (dpeaa)DE-He213 Levin, L. Scott aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 5(2018), 2 vom: 20. März, Seite 121-129 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:5 year:2018 number:2 day:20 month:03 pages:121-129 https://dx.doi.org/10.1007/s40472-018-0189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2018 2 20 03 121-129
spelling	10.1007/s40472-018-0189-6 doi (DE-627)SPR03649528X (SPR)s40472-018-0189-6-e DE-627 ger DE-627 rakwb eng Amaral, Sandra verfasserin aut Pediatric Vascular Composite Allograft Transplantation: Medical Considerations 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG, part of Springer Nature 2018 Purpose of Review This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascular composite allotransplantation to non-immunocompromised pediatric candidates. Recent Findings A pediatric recipient of bilateral hand-forearm allotransplantation now over 2 years post-transplant has shown functional recovery that surpassed pre-transplant function, with evidence of somatosensory cortical reorganization. However, the child who was previously immunocompromised has required augmented immunosuppression and rehabilitation demands have been substantial. Summary Pediatric vascular composite allotransplantation is surgically feasible, and short-term outcomes in the first case reveal the potential for functional benefits that exceed the pre-transplant state. Robust immunosuppression and its inherent risks must be clearly discussed with potential pediatric candidates and their families. Additionally, advanced planning for psychological and social support throughout the prolonged rehabilitation period is essential to optimize therapeutic engagement and academic learning. Pediatric (dpeaa)DE-He213 Vascular composite allograft transplantation (dpeaa)DE-He213 Hands (dpeaa)DE-He213 Levin, L. Scott aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 5(2018), 2 vom: 20. März, Seite 121-129 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:5 year:2018 number:2 day:20 month:03 pages:121-129 https://dx.doi.org/10.1007/s40472-018-0189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2018 2 20 03 121-129
allfields_unstemmed	10.1007/s40472-018-0189-6 doi (DE-627)SPR03649528X (SPR)s40472-018-0189-6-e DE-627 ger DE-627 rakwb eng Amaral, Sandra verfasserin aut Pediatric Vascular Composite Allograft Transplantation: Medical Considerations 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG, part of Springer Nature 2018 Purpose of Review This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascular composite allotransplantation to non-immunocompromised pediatric candidates. Recent Findings A pediatric recipient of bilateral hand-forearm allotransplantation now over 2 years post-transplant has shown functional recovery that surpassed pre-transplant function, with evidence of somatosensory cortical reorganization. However, the child who was previously immunocompromised has required augmented immunosuppression and rehabilitation demands have been substantial. Summary Pediatric vascular composite allotransplantation is surgically feasible, and short-term outcomes in the first case reveal the potential for functional benefits that exceed the pre-transplant state. Robust immunosuppression and its inherent risks must be clearly discussed with potential pediatric candidates and their families. Additionally, advanced planning for psychological and social support throughout the prolonged rehabilitation period is essential to optimize therapeutic engagement and academic learning. Pediatric (dpeaa)DE-He213 Vascular composite allograft transplantation (dpeaa)DE-He213 Hands (dpeaa)DE-He213 Levin, L. Scott aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 5(2018), 2 vom: 20. März, Seite 121-129 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:5 year:2018 number:2 day:20 month:03 pages:121-129 https://dx.doi.org/10.1007/s40472-018-0189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2018 2 20 03 121-129
allfieldsGer	10.1007/s40472-018-0189-6 doi (DE-627)SPR03649528X (SPR)s40472-018-0189-6-e DE-627 ger DE-627 rakwb eng Amaral, Sandra verfasserin aut Pediatric Vascular Composite Allograft Transplantation: Medical Considerations 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG, part of Springer Nature 2018 Purpose of Review This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascular composite allotransplantation to non-immunocompromised pediatric candidates. Recent Findings A pediatric recipient of bilateral hand-forearm allotransplantation now over 2 years post-transplant has shown functional recovery that surpassed pre-transplant function, with evidence of somatosensory cortical reorganization. However, the child who was previously immunocompromised has required augmented immunosuppression and rehabilitation demands have been substantial. Summary Pediatric vascular composite allotransplantation is surgically feasible, and short-term outcomes in the first case reveal the potential for functional benefits that exceed the pre-transplant state. Robust immunosuppression and its inherent risks must be clearly discussed with potential pediatric candidates and their families. Additionally, advanced planning for psychological and social support throughout the prolonged rehabilitation period is essential to optimize therapeutic engagement and academic learning. Pediatric (dpeaa)DE-He213 Vascular composite allograft transplantation (dpeaa)DE-He213 Hands (dpeaa)DE-He213 Levin, L. Scott aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 5(2018), 2 vom: 20. März, Seite 121-129 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:5 year:2018 number:2 day:20 month:03 pages:121-129 https://dx.doi.org/10.1007/s40472-018-0189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2018 2 20 03 121-129
allfieldsSound	10.1007/s40472-018-0189-6 doi (DE-627)SPR03649528X (SPR)s40472-018-0189-6-e DE-627 ger DE-627 rakwb eng Amaral, Sandra verfasserin aut Pediatric Vascular Composite Allograft Transplantation: Medical Considerations 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG, part of Springer Nature 2018 Purpose of Review This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascular composite allotransplantation to non-immunocompromised pediatric candidates. Recent Findings A pediatric recipient of bilateral hand-forearm allotransplantation now over 2 years post-transplant has shown functional recovery that surpassed pre-transplant function, with evidence of somatosensory cortical reorganization. However, the child who was previously immunocompromised has required augmented immunosuppression and rehabilitation demands have been substantial. Summary Pediatric vascular composite allotransplantation is surgically feasible, and short-term outcomes in the first case reveal the potential for functional benefits that exceed the pre-transplant state. Robust immunosuppression and its inherent risks must be clearly discussed with potential pediatric candidates and their families. Additionally, advanced planning for psychological and social support throughout the prolonged rehabilitation period is essential to optimize therapeutic engagement and academic learning. Pediatric (dpeaa)DE-He213 Vascular composite allograft transplantation (dpeaa)DE-He213 Hands (dpeaa)DE-He213 Levin, L. Scott aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 5(2018), 2 vom: 20. März, Seite 121-129 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:5 year:2018 number:2 day:20 month:03 pages:121-129 https://dx.doi.org/10.1007/s40472-018-0189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2018 2 20 03 121-129
language	English
source	Enthalten in Current transplantation reports 5(2018), 2 vom: 20. März, Seite 121-129 volume:5 year:2018 number:2 day:20 month:03 pages:121-129
sourceStr	Enthalten in Current transplantation reports 5(2018), 2 vom: 20. März, Seite 121-129 volume:5 year:2018 number:2 day:20 month:03 pages:121-129
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pediatric Vascular composite allograft transplantation Hands
isfreeaccess_bool	false
container_title	Current transplantation reports
authorswithroles_txt_mv	Amaral, Sandra @@aut@@ Levin, L. Scott @@aut@@
publishDateDaySort_date	2018-03-20T00:00:00Z
hierarchy_top_id	78037844X
id	SPR03649528X
language_de	englisch
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author	Amaral, Sandra
spellingShingle	Amaral, Sandra misc Pediatric misc Vascular composite allograft transplantation misc Hands Pediatric Vascular Composite Allograft Transplantation: Medical Considerations
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topic_title	Pediatric Vascular Composite Allograft Transplantation: Medical Considerations Pediatric (dpeaa)DE-He213 Vascular composite allograft transplantation (dpeaa)DE-He213 Hands (dpeaa)DE-He213
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title	Pediatric Vascular Composite Allograft Transplantation: Medical Considerations
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title_full	Pediatric Vascular Composite Allograft Transplantation: Medical Considerations
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title_sort	pediatric vascular composite allograft transplantation: medical considerations
title_auth	Pediatric Vascular Composite Allograft Transplantation: Medical Considerations
abstract	Purpose of Review This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascular composite allotransplantation to non-immunocompromised pediatric candidates. Recent Findings A pediatric recipient of bilateral hand-forearm allotransplantation now over 2 years post-transplant has shown functional recovery that surpassed pre-transplant function, with evidence of somatosensory cortical reorganization. However, the child who was previously immunocompromised has required augmented immunosuppression and rehabilitation demands have been substantial. Summary Pediatric vascular composite allotransplantation is surgically feasible, and short-term outcomes in the first case reveal the potential for functional benefits that exceed the pre-transplant state. Robust immunosuppression and its inherent risks must be clearly discussed with potential pediatric candidates and their families. Additionally, advanced planning for psychological and social support throughout the prolonged rehabilitation period is essential to optimize therapeutic engagement and academic learning. © Springer International Publishing AG, part of Springer Nature 2018
abstractGer	Purpose of Review This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascular composite allotransplantation to non-immunocompromised pediatric candidates. Recent Findings A pediatric recipient of bilateral hand-forearm allotransplantation now over 2 years post-transplant has shown functional recovery that surpassed pre-transplant function, with evidence of somatosensory cortical reorganization. However, the child who was previously immunocompromised has required augmented immunosuppression and rehabilitation demands have been substantial. Summary Pediatric vascular composite allotransplantation is surgically feasible, and short-term outcomes in the first case reveal the potential for functional benefits that exceed the pre-transplant state. Robust immunosuppression and its inherent risks must be clearly discussed with potential pediatric candidates and their families. Additionally, advanced planning for psychological and social support throughout the prolonged rehabilitation period is essential to optimize therapeutic engagement and academic learning. © Springer International Publishing AG, part of Springer Nature 2018
abstract_unstemmed	Purpose of Review This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascular composite allotransplantation to non-immunocompromised pediatric candidates. Recent Findings A pediatric recipient of bilateral hand-forearm allotransplantation now over 2 years post-transplant has shown functional recovery that surpassed pre-transplant function, with evidence of somatosensory cortical reorganization. However, the child who was previously immunocompromised has required augmented immunosuppression and rehabilitation demands have been substantial. Summary Pediatric vascular composite allotransplantation is surgically feasible, and short-term outcomes in the first case reveal the potential for functional benefits that exceed the pre-transplant state. Robust immunosuppression and its inherent risks must be clearly discussed with potential pediatric candidates and their families. Additionally, advanced planning for psychological and social support throughout the prolonged rehabilitation period is essential to optimize therapeutic engagement and academic learning. © Springer International Publishing AG, part of Springer Nature 2018
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title_short	Pediatric Vascular Composite Allograft Transplantation: Medical Considerations
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up_date	2024-07-03T17:57:58.289Z
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Recent Findings A pediatric recipient of bilateral hand-forearm allotransplantation now over 2 years post-transplant has shown functional recovery that surpassed pre-transplant function, with evidence of somatosensory cortical reorganization. However, the child who was previously immunocompromised has required augmented immunosuppression and rehabilitation demands have been substantial. Summary Pediatric vascular composite allotransplantation is surgically feasible, and short-term outcomes in the first case reveal the potential for functional benefits that exceed the pre-transplant state. Robust immunosuppression and its inherent risks must be clearly discussed with potential pediatric candidates and their families. 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Pediatric Vascular Composite Allograft Transplantation: Medical Considerations

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