Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species
Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mott, Tiffany [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Anmerkung: |
© US Government (outside the USA) 2017 |
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| Übergeordnetes Werk: |
Enthalten in: Current tropical medicine reports - Cham : Springer International Publisher, 2014, 4(2017), 4 vom: 15. Sept., Seite 199-207 |
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| Übergeordnetes Werk: |
volume:4 ; year:2017 ; number:4 ; day:15 ; month:09 ; pages:199-207 |
| Links: |
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| DOI / URN: |
10.1007/s40475-017-0127-1 |
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| Katalog-ID: |
SPR036501743 |
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| 245 | 1 | 0 | |a Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species |
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| 520 | |a Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related species B. thailandensis. Recent Findings Quorum-sensing mechanisms have garnered considerable interest due to their ability to regulate bacterial physiology and metabolism. Research into Burkholderia spp. has led to significant findings that delineate the important role of these redundant, yet distinct, QS pathways in bacterial fitness and pathogenesis. Recently developed methods have shown promise for employing high throughput screening to identify quorum-sensing inhibitors for therapeutic development. Summary Targeting the QS systems provides an attractive alternative strategy to reduce the occurrence of acquired resistance through selection pressure. Combination therapies consisting of QS modulators could potentially be effective treatment options for melioidosis and glanders. | ||
| 650 | 4 | |a Quorum sensing |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Acyl-homoserine lactone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Burkholderia pseudomallei |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Burkholderia mallei |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Burkholderia thailandensis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Therapeutic development |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Panchal, Rekha G. |4 aut | |
| 700 | 1 | |a Rajamani, Sathish |4 aut | |
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| 912 | |a GBV_ILN_2061 | ||
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| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
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| 912 | |a GBV_ILN_2106 | ||
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10.1007/s40475-017-0127-1 doi (DE-627)SPR036501743 (SPR)s40475-017-0127-1-e DE-627 ger DE-627 rakwb eng Mott, Tiffany verfasserin aut Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © US Government (outside the USA) 2017 Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related species B. thailandensis. Recent Findings Quorum-sensing mechanisms have garnered considerable interest due to their ability to regulate bacterial physiology and metabolism. Research into Burkholderia spp. has led to significant findings that delineate the important role of these redundant, yet distinct, QS pathways in bacterial fitness and pathogenesis. Recently developed methods have shown promise for employing high throughput screening to identify quorum-sensing inhibitors for therapeutic development. Summary Targeting the QS systems provides an attractive alternative strategy to reduce the occurrence of acquired resistance through selection pressure. Combination therapies consisting of QS modulators could potentially be effective treatment options for melioidosis and glanders. Quorum sensing (dpeaa)DE-He213 Acyl-homoserine lactone (dpeaa)DE-He213 Burkholderia pseudomallei (dpeaa)DE-He213 Burkholderia mallei (dpeaa)DE-He213 Burkholderia thailandensis (dpeaa)DE-He213 Therapeutic development (dpeaa)DE-He213 Panchal, Rekha G. aut Rajamani, Sathish aut Enthalten in Current tropical medicine reports Cham : Springer International Publisher, 2014 4(2017), 4 vom: 15. Sept., Seite 199-207 (DE-627)780379632 (DE-600)2760516-4 2196-3045 nnns volume:4 year:2017 number:4 day:15 month:09 pages:199-207 https://dx.doi.org/10.1007/s40475-017-0127-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 4 15 09 199-207 |
| spelling |
10.1007/s40475-017-0127-1 doi (DE-627)SPR036501743 (SPR)s40475-017-0127-1-e DE-627 ger DE-627 rakwb eng Mott, Tiffany verfasserin aut Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © US Government (outside the USA) 2017 Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related species B. thailandensis. Recent Findings Quorum-sensing mechanisms have garnered considerable interest due to their ability to regulate bacterial physiology and metabolism. Research into Burkholderia spp. has led to significant findings that delineate the important role of these redundant, yet distinct, QS pathways in bacterial fitness and pathogenesis. Recently developed methods have shown promise for employing high throughput screening to identify quorum-sensing inhibitors for therapeutic development. Summary Targeting the QS systems provides an attractive alternative strategy to reduce the occurrence of acquired resistance through selection pressure. Combination therapies consisting of QS modulators could potentially be effective treatment options for melioidosis and glanders. Quorum sensing (dpeaa)DE-He213 Acyl-homoserine lactone (dpeaa)DE-He213 Burkholderia pseudomallei (dpeaa)DE-He213 Burkholderia mallei (dpeaa)DE-He213 Burkholderia thailandensis (dpeaa)DE-He213 Therapeutic development (dpeaa)DE-He213 Panchal, Rekha G. aut Rajamani, Sathish aut Enthalten in Current tropical medicine reports Cham : Springer International Publisher, 2014 4(2017), 4 vom: 15. Sept., Seite 199-207 (DE-627)780379632 (DE-600)2760516-4 2196-3045 nnns volume:4 year:2017 number:4 day:15 month:09 pages:199-207 https://dx.doi.org/10.1007/s40475-017-0127-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 4 15 09 199-207 |
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10.1007/s40475-017-0127-1 doi (DE-627)SPR036501743 (SPR)s40475-017-0127-1-e DE-627 ger DE-627 rakwb eng Mott, Tiffany verfasserin aut Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © US Government (outside the USA) 2017 Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related species B. thailandensis. Recent Findings Quorum-sensing mechanisms have garnered considerable interest due to their ability to regulate bacterial physiology and metabolism. Research into Burkholderia spp. has led to significant findings that delineate the important role of these redundant, yet distinct, QS pathways in bacterial fitness and pathogenesis. Recently developed methods have shown promise for employing high throughput screening to identify quorum-sensing inhibitors for therapeutic development. Summary Targeting the QS systems provides an attractive alternative strategy to reduce the occurrence of acquired resistance through selection pressure. Combination therapies consisting of QS modulators could potentially be effective treatment options for melioidosis and glanders. Quorum sensing (dpeaa)DE-He213 Acyl-homoserine lactone (dpeaa)DE-He213 Burkholderia pseudomallei (dpeaa)DE-He213 Burkholderia mallei (dpeaa)DE-He213 Burkholderia thailandensis (dpeaa)DE-He213 Therapeutic development (dpeaa)DE-He213 Panchal, Rekha G. aut Rajamani, Sathish aut Enthalten in Current tropical medicine reports Cham : Springer International Publisher, 2014 4(2017), 4 vom: 15. Sept., Seite 199-207 (DE-627)780379632 (DE-600)2760516-4 2196-3045 nnns volume:4 year:2017 number:4 day:15 month:09 pages:199-207 https://dx.doi.org/10.1007/s40475-017-0127-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 4 15 09 199-207 |
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10.1007/s40475-017-0127-1 doi (DE-627)SPR036501743 (SPR)s40475-017-0127-1-e DE-627 ger DE-627 rakwb eng Mott, Tiffany verfasserin aut Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © US Government (outside the USA) 2017 Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related species B. thailandensis. Recent Findings Quorum-sensing mechanisms have garnered considerable interest due to their ability to regulate bacterial physiology and metabolism. Research into Burkholderia spp. has led to significant findings that delineate the important role of these redundant, yet distinct, QS pathways in bacterial fitness and pathogenesis. Recently developed methods have shown promise for employing high throughput screening to identify quorum-sensing inhibitors for therapeutic development. Summary Targeting the QS systems provides an attractive alternative strategy to reduce the occurrence of acquired resistance through selection pressure. Combination therapies consisting of QS modulators could potentially be effective treatment options for melioidosis and glanders. Quorum sensing (dpeaa)DE-He213 Acyl-homoserine lactone (dpeaa)DE-He213 Burkholderia pseudomallei (dpeaa)DE-He213 Burkholderia mallei (dpeaa)DE-He213 Burkholderia thailandensis (dpeaa)DE-He213 Therapeutic development (dpeaa)DE-He213 Panchal, Rekha G. aut Rajamani, Sathish aut Enthalten in Current tropical medicine reports Cham : Springer International Publisher, 2014 4(2017), 4 vom: 15. Sept., Seite 199-207 (DE-627)780379632 (DE-600)2760516-4 2196-3045 nnns volume:4 year:2017 number:4 day:15 month:09 pages:199-207 https://dx.doi.org/10.1007/s40475-017-0127-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 4 15 09 199-207 |
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10.1007/s40475-017-0127-1 doi (DE-627)SPR036501743 (SPR)s40475-017-0127-1-e DE-627 ger DE-627 rakwb eng Mott, Tiffany verfasserin aut Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © US Government (outside the USA) 2017 Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related species B. thailandensis. Recent Findings Quorum-sensing mechanisms have garnered considerable interest due to their ability to regulate bacterial physiology and metabolism. Research into Burkholderia spp. has led to significant findings that delineate the important role of these redundant, yet distinct, QS pathways in bacterial fitness and pathogenesis. Recently developed methods have shown promise for employing high throughput screening to identify quorum-sensing inhibitors for therapeutic development. Summary Targeting the QS systems provides an attractive alternative strategy to reduce the occurrence of acquired resistance through selection pressure. Combination therapies consisting of QS modulators could potentially be effective treatment options for melioidosis and glanders. Quorum sensing (dpeaa)DE-He213 Acyl-homoserine lactone (dpeaa)DE-He213 Burkholderia pseudomallei (dpeaa)DE-He213 Burkholderia mallei (dpeaa)DE-He213 Burkholderia thailandensis (dpeaa)DE-He213 Therapeutic development (dpeaa)DE-He213 Panchal, Rekha G. aut Rajamani, Sathish aut Enthalten in Current tropical medicine reports Cham : Springer International Publisher, 2014 4(2017), 4 vom: 15. Sept., Seite 199-207 (DE-627)780379632 (DE-600)2760516-4 2196-3045 nnns volume:4 year:2017 number:4 day:15 month:09 pages:199-207 https://dx.doi.org/10.1007/s40475-017-0127-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 4 15 09 199-207 |
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Quorum sensing Acyl-homoserine lactone Burkholderia pseudomallei Burkholderia mallei Burkholderia thailandensis Therapeutic development |
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Mott, Tiffany @@aut@@ Panchal, Rekha G. @@aut@@ Rajamani, Sathish @@aut@@ |
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| author |
Mott, Tiffany |
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Mott, Tiffany misc Quorum sensing misc Acyl-homoserine lactone misc Burkholderia pseudomallei misc Burkholderia mallei misc Burkholderia thailandensis misc Therapeutic development Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species |
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Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species Quorum sensing (dpeaa)DE-He213 Acyl-homoserine lactone (dpeaa)DE-He213 Burkholderia pseudomallei (dpeaa)DE-He213 Burkholderia mallei (dpeaa)DE-He213 Burkholderia thailandensis (dpeaa)DE-He213 Therapeutic development (dpeaa)DE-He213 |
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misc Quorum sensing misc Acyl-homoserine lactone misc Burkholderia pseudomallei misc Burkholderia mallei misc Burkholderia thailandensis misc Therapeutic development |
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Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species |
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Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species |
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Mott, Tiffany Panchal, Rekha G. Rajamani, Sathish |
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quorum sensing in burkholderia pseudomallei and other burkholderia species |
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Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species |
| abstract |
Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related species B. thailandensis. Recent Findings Quorum-sensing mechanisms have garnered considerable interest due to their ability to regulate bacterial physiology and metabolism. Research into Burkholderia spp. has led to significant findings that delineate the important role of these redundant, yet distinct, QS pathways in bacterial fitness and pathogenesis. Recently developed methods have shown promise for employing high throughput screening to identify quorum-sensing inhibitors for therapeutic development. Summary Targeting the QS systems provides an attractive alternative strategy to reduce the occurrence of acquired resistance through selection pressure. Combination therapies consisting of QS modulators could potentially be effective treatment options for melioidosis and glanders. © US Government (outside the USA) 2017 |
| abstractGer |
Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related species B. thailandensis. Recent Findings Quorum-sensing mechanisms have garnered considerable interest due to their ability to regulate bacterial physiology and metabolism. Research into Burkholderia spp. has led to significant findings that delineate the important role of these redundant, yet distinct, QS pathways in bacterial fitness and pathogenesis. Recently developed methods have shown promise for employing high throughput screening to identify quorum-sensing inhibitors for therapeutic development. Summary Targeting the QS systems provides an attractive alternative strategy to reduce the occurrence of acquired resistance through selection pressure. Combination therapies consisting of QS modulators could potentially be effective treatment options for melioidosis and glanders. © US Government (outside the USA) 2017 |
| abstract_unstemmed |
Purpose of Review Burkholderia pseudomallei and B. mallei are the etiological agents of severe diseases melioidosis and glanders, respectively, and are recalcitrant to many antibiotics. This review highlights recent findings on the quorum sensing (QS) systems of these pathogens and a closely related species B. thailandensis. Recent Findings Quorum-sensing mechanisms have garnered considerable interest due to their ability to regulate bacterial physiology and metabolism. Research into Burkholderia spp. has led to significant findings that delineate the important role of these redundant, yet distinct, QS pathways in bacterial fitness and pathogenesis. Recently developed methods have shown promise for employing high throughput screening to identify quorum-sensing inhibitors for therapeutic development. Summary Targeting the QS systems provides an attractive alternative strategy to reduce the occurrence of acquired resistance through selection pressure. Combination therapies consisting of QS modulators could potentially be effective treatment options for melioidosis and glanders. © US Government (outside the USA) 2017 |
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| title_short |
Quorum Sensing in Burkholderia pseudomallei and Other Burkholderia species |
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https://dx.doi.org/10.1007/s40475-017-0127-1 |
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Panchal, Rekha G. Rajamani, Sathish |
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Panchal, Rekha G. Rajamani, Sathish |
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| doi_str |
10.1007/s40475-017-0127-1 |
| up_date |
2024-07-03T18:00:20.623Z |
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|
| score |
7.398904 |