Extracting the Benefit of Nexrutine® for Cancer Prevention

Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical pros...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hussain, Suleman S. [verfasserIn] Patel, Darpan Ghosh, Rita Kumar, Addanki P.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Botanicals Chemoprevention Herbal extracts Natural products Nexrutine® Prostate cancer

Anmerkung:	© Springer International Publishing AG 2015

Übergeordnetes Werk:	Enthalten in: Current pharmacology reports - Berlin [u.a.] : Springer, 2015, 1(2015), 6 vom: 21. März, Seite 365-372
Übergeordnetes Werk:	volume:1 ; year:2015 ; number:6 ; day:21 ; month:03 ; pages:365-372

Links:	Volltext

DOI / URN:	10.1007/s40495-015-0029-7

Katalog-ID:	SPR036533580

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520			\|a Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines, we have found that Nexrutine®, a dietary supplement derived from Phellodendron amurense bark extract, has prostate cancer prevention activity. The “extract” nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine® as a chemopreventive agent for prostate cancer management. The potential of Nexrutine® was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore, the focus of this review is on the use of Nexrutine® in prostate cancer. In addition, we have summarized the emerging evidence regarding the use of Nexrutine® in other tumor models to demonstrate the potential benefits of Nexrutine®.
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allfields	10.1007/s40495-015-0029-7 doi (DE-627)SPR036533580 (SPR)s40495-015-0029-7-e DE-627 ger DE-627 rakwb eng Hussain, Suleman S. verfasserin aut Extracting the Benefit of Nexrutine® for Cancer Prevention 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG 2015 Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines, we have found that Nexrutine®, a dietary supplement derived from Phellodendron amurense bark extract, has prostate cancer prevention activity. The “extract” nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine® as a chemopreventive agent for prostate cancer management. The potential of Nexrutine® was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore, the focus of this review is on the use of Nexrutine® in prostate cancer. In addition, we have summarized the emerging evidence regarding the use of Nexrutine® in other tumor models to demonstrate the potential benefits of Nexrutine®. Botanicals (dpeaa)DE-He213 Chemoprevention (dpeaa)DE-He213 Herbal extracts (dpeaa)DE-He213 Natural products (dpeaa)DE-He213 Nexrutine® (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Patel, Darpan aut Ghosh, Rita aut Kumar, Addanki P. aut Enthalten in Current pharmacology reports Berlin [u.a.] : Springer, 2015 1(2015), 6 vom: 21. März, Seite 365-372 (DE-627)81803873X (DE-600)2809351-3 2198-641X nnns volume:1 year:2015 number:6 day:21 month:03 pages:365-372 https://dx.doi.org/10.1007/s40495-015-0029-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 1 2015 6 21 03 365-372
spelling	10.1007/s40495-015-0029-7 doi (DE-627)SPR036533580 (SPR)s40495-015-0029-7-e DE-627 ger DE-627 rakwb eng Hussain, Suleman S. verfasserin aut Extracting the Benefit of Nexrutine® for Cancer Prevention 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG 2015 Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines, we have found that Nexrutine®, a dietary supplement derived from Phellodendron amurense bark extract, has prostate cancer prevention activity. The “extract” nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine® as a chemopreventive agent for prostate cancer management. The potential of Nexrutine® was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore, the focus of this review is on the use of Nexrutine® in prostate cancer. In addition, we have summarized the emerging evidence regarding the use of Nexrutine® in other tumor models to demonstrate the potential benefits of Nexrutine®. Botanicals (dpeaa)DE-He213 Chemoprevention (dpeaa)DE-He213 Herbal extracts (dpeaa)DE-He213 Natural products (dpeaa)DE-He213 Nexrutine® (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Patel, Darpan aut Ghosh, Rita aut Kumar, Addanki P. aut Enthalten in Current pharmacology reports Berlin [u.a.] : Springer, 2015 1(2015), 6 vom: 21. März, Seite 365-372 (DE-627)81803873X (DE-600)2809351-3 2198-641X nnns volume:1 year:2015 number:6 day:21 month:03 pages:365-372 https://dx.doi.org/10.1007/s40495-015-0029-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 1 2015 6 21 03 365-372
allfields_unstemmed	10.1007/s40495-015-0029-7 doi (DE-627)SPR036533580 (SPR)s40495-015-0029-7-e DE-627 ger DE-627 rakwb eng Hussain, Suleman S. verfasserin aut Extracting the Benefit of Nexrutine® for Cancer Prevention 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG 2015 Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines, we have found that Nexrutine®, a dietary supplement derived from Phellodendron amurense bark extract, has prostate cancer prevention activity. The “extract” nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine® as a chemopreventive agent for prostate cancer management. The potential of Nexrutine® was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore, the focus of this review is on the use of Nexrutine® in prostate cancer. In addition, we have summarized the emerging evidence regarding the use of Nexrutine® in other tumor models to demonstrate the potential benefits of Nexrutine®. Botanicals (dpeaa)DE-He213 Chemoprevention (dpeaa)DE-He213 Herbal extracts (dpeaa)DE-He213 Natural products (dpeaa)DE-He213 Nexrutine® (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Patel, Darpan aut Ghosh, Rita aut Kumar, Addanki P. aut Enthalten in Current pharmacology reports Berlin [u.a.] : Springer, 2015 1(2015), 6 vom: 21. März, Seite 365-372 (DE-627)81803873X (DE-600)2809351-3 2198-641X nnns volume:1 year:2015 number:6 day:21 month:03 pages:365-372 https://dx.doi.org/10.1007/s40495-015-0029-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 1 2015 6 21 03 365-372
allfieldsGer	10.1007/s40495-015-0029-7 doi (DE-627)SPR036533580 (SPR)s40495-015-0029-7-e DE-627 ger DE-627 rakwb eng Hussain, Suleman S. verfasserin aut Extracting the Benefit of Nexrutine® for Cancer Prevention 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG 2015 Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines, we have found that Nexrutine®, a dietary supplement derived from Phellodendron amurense bark extract, has prostate cancer prevention activity. The “extract” nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine® as a chemopreventive agent for prostate cancer management. The potential of Nexrutine® was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore, the focus of this review is on the use of Nexrutine® in prostate cancer. In addition, we have summarized the emerging evidence regarding the use of Nexrutine® in other tumor models to demonstrate the potential benefits of Nexrutine®. Botanicals (dpeaa)DE-He213 Chemoprevention (dpeaa)DE-He213 Herbal extracts (dpeaa)DE-He213 Natural products (dpeaa)DE-He213 Nexrutine® (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Patel, Darpan aut Ghosh, Rita aut Kumar, Addanki P. aut Enthalten in Current pharmacology reports Berlin [u.a.] : Springer, 2015 1(2015), 6 vom: 21. März, Seite 365-372 (DE-627)81803873X (DE-600)2809351-3 2198-641X nnns volume:1 year:2015 number:6 day:21 month:03 pages:365-372 https://dx.doi.org/10.1007/s40495-015-0029-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 1 2015 6 21 03 365-372
allfieldsSound	10.1007/s40495-015-0029-7 doi (DE-627)SPR036533580 (SPR)s40495-015-0029-7-e DE-627 ger DE-627 rakwb eng Hussain, Suleman S. verfasserin aut Extracting the Benefit of Nexrutine® for Cancer Prevention 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG 2015 Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines, we have found that Nexrutine®, a dietary supplement derived from Phellodendron amurense bark extract, has prostate cancer prevention activity. The “extract” nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine® as a chemopreventive agent for prostate cancer management. The potential of Nexrutine® was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore, the focus of this review is on the use of Nexrutine® in prostate cancer. In addition, we have summarized the emerging evidence regarding the use of Nexrutine® in other tumor models to demonstrate the potential benefits of Nexrutine®. Botanicals (dpeaa)DE-He213 Chemoprevention (dpeaa)DE-He213 Herbal extracts (dpeaa)DE-He213 Natural products (dpeaa)DE-He213 Nexrutine® (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Patel, Darpan aut Ghosh, Rita aut Kumar, Addanki P. aut Enthalten in Current pharmacology reports Berlin [u.a.] : Springer, 2015 1(2015), 6 vom: 21. März, Seite 365-372 (DE-627)81803873X (DE-600)2809351-3 2198-641X nnns volume:1 year:2015 number:6 day:21 month:03 pages:365-372 https://dx.doi.org/10.1007/s40495-015-0029-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 1 2015 6 21 03 365-372
language	English
source	Enthalten in Current pharmacology reports 1(2015), 6 vom: 21. März, Seite 365-372 volume:1 year:2015 number:6 day:21 month:03 pages:365-372
sourceStr	Enthalten in Current pharmacology reports 1(2015), 6 vom: 21. März, Seite 365-372 volume:1 year:2015 number:6 day:21 month:03 pages:365-372
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Botanicals Chemoprevention Herbal extracts Natural products Nexrutine® Prostate cancer
isfreeaccess_bool	false
container_title	Current pharmacology reports
authorswithroles_txt_mv	Hussain, Suleman S. @@aut@@ Patel, Darpan @@aut@@ Ghosh, Rita @@aut@@ Kumar, Addanki P. @@aut@@
publishDateDaySort_date	2015-03-21T00:00:00Z
hierarchy_top_id	81803873X
id	SPR036533580
language_de	englisch
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author	Hussain, Suleman S.
spellingShingle	Hussain, Suleman S. misc Botanicals misc Chemoprevention misc Herbal extracts misc Natural products misc Nexrutine® misc Prostate cancer Extracting the Benefit of Nexrutine® for Cancer Prevention
authorStr	Hussain, Suleman S.
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topic_title	Extracting the Benefit of Nexrutine® for Cancer Prevention Botanicals (dpeaa)DE-He213 Chemoprevention (dpeaa)DE-He213 Herbal extracts (dpeaa)DE-He213 Natural products (dpeaa)DE-He213 Nexrutine® (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213
topic	misc Botanicals misc Chemoprevention misc Herbal extracts misc Natural products misc Nexrutine® misc Prostate cancer
topic_unstemmed	misc Botanicals misc Chemoprevention misc Herbal extracts misc Natural products misc Nexrutine® misc Prostate cancer
topic_browse	misc Botanicals misc Chemoprevention misc Herbal extracts misc Natural products misc Nexrutine® misc Prostate cancer
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title	Extracting the Benefit of Nexrutine® for Cancer Prevention
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title_full	Extracting the Benefit of Nexrutine® for Cancer Prevention
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author_browse	Hussain, Suleman S. Patel, Darpan Ghosh, Rita Kumar, Addanki P.
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doi_str_mv	10.1007/s40495-015-0029-7
title_sort	extracting the benefit of nexrutine® for cancer prevention
title_auth	Extracting the Benefit of Nexrutine® for Cancer Prevention
abstract	Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines, we have found that Nexrutine®, a dietary supplement derived from Phellodendron amurense bark extract, has prostate cancer prevention activity. The “extract” nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine® as a chemopreventive agent for prostate cancer management. The potential of Nexrutine® was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore, the focus of this review is on the use of Nexrutine® in prostate cancer. In addition, we have summarized the emerging evidence regarding the use of Nexrutine® in other tumor models to demonstrate the potential benefits of Nexrutine®. © Springer International Publishing AG 2015
abstractGer	Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines, we have found that Nexrutine®, a dietary supplement derived from Phellodendron amurense bark extract, has prostate cancer prevention activity. The “extract” nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine® as a chemopreventive agent for prostate cancer management. The potential of Nexrutine® was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore, the focus of this review is on the use of Nexrutine® in prostate cancer. In addition, we have summarized the emerging evidence regarding the use of Nexrutine® in other tumor models to demonstrate the potential benefits of Nexrutine®. © Springer International Publishing AG 2015
abstract_unstemmed	Abstract The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable side effects. In this regard, there is an unmet need to develop strategies that can prevent or delay the development of clinical prostate cancer. One potential area involves the use of natural compounds involving botanicals. Along these lines, we have found that Nexrutine®, a dietary supplement derived from Phellodendron amurense bark extract, has prostate cancer prevention activity. The “extract” nature of this botanical, which constitutes a blend of several active protoberberine alkaloids, allows it to target several pathways deregulated in prostate cancer simultaneously. In this review, we will emphasize the prospective translational benefit of Nexrutine® as a chemopreventive agent for prostate cancer management. The potential of Nexrutine® was first identified and has subsequently been most exhaustively studied with reference to prostate cancer. Therefore, the focus of this review is on the use of Nexrutine® in prostate cancer. In addition, we have summarized the emerging evidence regarding the use of Nexrutine® in other tumor models to demonstrate the potential benefits of Nexrutine®. © Springer International Publishing AG 2015
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container_issue	6
title_short	Extracting the Benefit of Nexrutine® for Cancer Prevention
url	https://dx.doi.org/10.1007/s40495-015-0029-7
remote_bool	true
author2	Patel, Darpan Ghosh, Rita Kumar, Addanki P.
author2Str	Patel, Darpan Ghosh, Rita Kumar, Addanki P.
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doi_str	10.1007/s40495-015-0029-7
up_date	2024-07-03T18:12:19.592Z
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