Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis
abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Slagboom, P. E. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1991 |
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| Schlagwörter: |
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| Anmerkung: |
© Editrice Kurtis s.r.l. 1991 |
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| Übergeordnetes Werk: |
Enthalten in: Aging clinical and experimental research - Berlin : Heidelberg : Springer, 2002, 3(1991), 2 vom: Juni, Seite 141-146 |
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| Übergeordnetes Werk: |
volume:3 ; year:1991 ; number:2 ; month:06 ; pages:141-146 |
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| DOI / URN: |
10.1007/BF03323991 |
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10.1007/BF03323991 doi (DE-627)SPR036584991 (SPR)BF03323991-e DE-627 ger DE-627 rakwb eng Slagboom, P. E. verfasserin aut Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Editrice Kurtis s.r.l. 1991 abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991) Aging (dpeaa)DE-He213 cKi-ras (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 MHC (dpeaa)DE-He213 pituitary gland tumor (dpeaa)DE-He213 Uitterlinden, A. G. aut Vijg, J. aut Enthalten in Aging clinical and experimental research Berlin : Heidelberg : Springer, 2002 3(1991), 2 vom: Juni, Seite 141-146 (DE-627)369554930 (DE-600)2119282-0 1720-8319 nnns volume:3 year:1991 number:2 month:06 pages:141-146 https://dx.doi.org/10.1007/BF03323991 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 3 1991 2 06 141-146 |
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10.1007/BF03323991 doi (DE-627)SPR036584991 (SPR)BF03323991-e DE-627 ger DE-627 rakwb eng Slagboom, P. E. verfasserin aut Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Editrice Kurtis s.r.l. 1991 abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991) Aging (dpeaa)DE-He213 cKi-ras (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 MHC (dpeaa)DE-He213 pituitary gland tumor (dpeaa)DE-He213 Uitterlinden, A. G. aut Vijg, J. aut Enthalten in Aging clinical and experimental research Berlin : Heidelberg : Springer, 2002 3(1991), 2 vom: Juni, Seite 141-146 (DE-627)369554930 (DE-600)2119282-0 1720-8319 nnns volume:3 year:1991 number:2 month:06 pages:141-146 https://dx.doi.org/10.1007/BF03323991 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 3 1991 2 06 141-146 |
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10.1007/BF03323991 doi (DE-627)SPR036584991 (SPR)BF03323991-e DE-627 ger DE-627 rakwb eng Slagboom, P. E. verfasserin aut Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Editrice Kurtis s.r.l. 1991 abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991) Aging (dpeaa)DE-He213 cKi-ras (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 MHC (dpeaa)DE-He213 pituitary gland tumor (dpeaa)DE-He213 Uitterlinden, A. G. aut Vijg, J. aut Enthalten in Aging clinical and experimental research Berlin : Heidelberg : Springer, 2002 3(1991), 2 vom: Juni, Seite 141-146 (DE-627)369554930 (DE-600)2119282-0 1720-8319 nnns volume:3 year:1991 number:2 month:06 pages:141-146 https://dx.doi.org/10.1007/BF03323991 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 3 1991 2 06 141-146 |
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10.1007/BF03323991 doi (DE-627)SPR036584991 (SPR)BF03323991-e DE-627 ger DE-627 rakwb eng Slagboom, P. E. verfasserin aut Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Editrice Kurtis s.r.l. 1991 abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991) Aging (dpeaa)DE-He213 cKi-ras (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 MHC (dpeaa)DE-He213 pituitary gland tumor (dpeaa)DE-He213 Uitterlinden, A. G. aut Vijg, J. aut Enthalten in Aging clinical and experimental research Berlin : Heidelberg : Springer, 2002 3(1991), 2 vom: Juni, Seite 141-146 (DE-627)369554930 (DE-600)2119282-0 1720-8319 nnns volume:3 year:1991 number:2 month:06 pages:141-146 https://dx.doi.org/10.1007/BF03323991 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 3 1991 2 06 141-146 |
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10.1007/BF03323991 doi (DE-627)SPR036584991 (SPR)BF03323991-e DE-627 ger DE-627 rakwb eng Slagboom, P. E. verfasserin aut Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Editrice Kurtis s.r.l. 1991 abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991) Aging (dpeaa)DE-He213 cKi-ras (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 MHC (dpeaa)DE-He213 pituitary gland tumor (dpeaa)DE-He213 Uitterlinden, A. G. aut Vijg, J. aut Enthalten in Aging clinical and experimental research Berlin : Heidelberg : Springer, 2002 3(1991), 2 vom: Juni, Seite 141-146 (DE-627)369554930 (DE-600)2119282-0 1720-8319 nnns volume:3 year:1991 number:2 month:06 pages:141-146 https://dx.doi.org/10.1007/BF03323991 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 3 1991 2 06 141-146 |
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abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991) © Editrice Kurtis s.r.l. 1991 |
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abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991) © Editrice Kurtis s.r.l. 1991 |
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abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991) © Editrice Kurtis s.r.l. 1991 |
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E.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1991</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Editrice Kurtis s.r.l. 1991</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">abstract Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Aging</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cKi-ras</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA methylation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MHC</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">pituitary gland tumor</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Uitterlinden, A. G.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vijg, J.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Aging clinical and experimental research</subfield><subfield code="d">Berlin : Heidelberg : Springer, 2002</subfield><subfield code="g">3(1991), 2 vom: Juni, Seite 141-146</subfield><subfield code="w">(DE-627)369554930</subfield><subfield code="w">(DE-600)2119282-0</subfield><subfield code="x">1720-8319</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:1991</subfield><subfield code="g">number:2</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:141-146</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/BF03323991</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">1991</subfield><subfield code="e">2</subfield><subfield code="c">06</subfield><subfield code="h">141-146</subfield></datafield></record></collection>
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