Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria?
Opinion Statement Urticaria is primarily a disease driven by the actions of mast cell-derived histamine on the dermal vasculature and sensory nerves. Initial treatment with second generation minimally sedating $ H_{1} $-antihistamines is recommended. Start with the standard dose of one tablet daily....
Ausführliche Beschreibung
Autor*in: |
Church, Martin K. [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2016 |
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Schlagwörter: |
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Anmerkung: |
© Springer International Publishing AG 2016 |
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Übergeordnetes Werk: |
Enthalten in: Current treatment options in allergy - Cham : Springer Internat. Publ., 2014, 3(2016), 4 vom: 10. Sept., Seite 416-422 |
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Übergeordnetes Werk: |
volume:3 ; year:2016 ; number:4 ; day:10 ; month:09 ; pages:416-422 |
Links: |
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DOI / URN: |
10.1007/s40521-016-0098-9 |
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Katalog-ID: |
SPR036619124 |
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520 | |a Opinion Statement Urticaria is primarily a disease driven by the actions of mast cell-derived histamine on the dermal vasculature and sensory nerves. Initial treatment with second generation minimally sedating $ H_{1} $-antihistamines is recommended. Start with the standard dose of one tablet daily. Because of the high local levels of histamine in the skin, standard doses of $ H_{1} $-antihistamines are often not able to control the symptoms. Thus, if symptoms persist after 2 weeks, then double the dosage of $ H_{1} $-antihistamines, usually giving one in the morning and one in the evening. If this is still not effective after 2 weeks, double the dose to fourfold of the original dose, two tablets given approximately 12 h apart. For patients still not responsive, then other medication, such as omalizumab or cyclosporine A should be introduced. Omalizumab treatment is highlighted in this review. | ||
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10.1007/s40521-016-0098-9 doi (DE-627)SPR036619124 (SPR)s40521-016-0098-9-e DE-627 ger DE-627 rakwb eng Church, Martin K. verfasserin aut Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG 2016 Opinion Statement Urticaria is primarily a disease driven by the actions of mast cell-derived histamine on the dermal vasculature and sensory nerves. Initial treatment with second generation minimally sedating $ H_{1} $-antihistamines is recommended. Start with the standard dose of one tablet daily. Because of the high local levels of histamine in the skin, standard doses of $ H_{1} $-antihistamines are often not able to control the symptoms. Thus, if symptoms persist after 2 weeks, then double the dosage of $ H_{1} $-antihistamines, usually giving one in the morning and one in the evening. If this is still not effective after 2 weeks, double the dose to fourfold of the original dose, two tablets given approximately 12 h apart. For patients still not responsive, then other medication, such as omalizumab or cyclosporine A should be introduced. Omalizumab treatment is highlighted in this review. H (dpeaa)DE-He213 -antihistamines (dpeaa)DE-He213 Chronic urticaria (dpeaa)DE-He213 Chronic spontaneous urticaria (dpeaa)DE-He213 CSU (dpeaa)DE-He213 Omalizumab (dpeaa)DE-He213 Anti-IgE (dpeaa)DE-He213 Enthalten in Current treatment options in allergy Cham : Springer Internat. Publ., 2014 3(2016), 4 vom: 10. Sept., Seite 416-422 (DE-627)780378458 (DE-600)2760308-8 2196-3053 nnns volume:3 year:2016 number:4 day:10 month:09 pages:416-422 https://dx.doi.org/10.1007/s40521-016-0098-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2016 4 10 09 416-422 |
spelling |
10.1007/s40521-016-0098-9 doi (DE-627)SPR036619124 (SPR)s40521-016-0098-9-e DE-627 ger DE-627 rakwb eng Church, Martin K. verfasserin aut Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG 2016 Opinion Statement Urticaria is primarily a disease driven by the actions of mast cell-derived histamine on the dermal vasculature and sensory nerves. Initial treatment with second generation minimally sedating $ H_{1} $-antihistamines is recommended. Start with the standard dose of one tablet daily. Because of the high local levels of histamine in the skin, standard doses of $ H_{1} $-antihistamines are often not able to control the symptoms. Thus, if symptoms persist after 2 weeks, then double the dosage of $ H_{1} $-antihistamines, usually giving one in the morning and one in the evening. If this is still not effective after 2 weeks, double the dose to fourfold of the original dose, two tablets given approximately 12 h apart. For patients still not responsive, then other medication, such as omalizumab or cyclosporine A should be introduced. Omalizumab treatment is highlighted in this review. H (dpeaa)DE-He213 -antihistamines (dpeaa)DE-He213 Chronic urticaria (dpeaa)DE-He213 Chronic spontaneous urticaria (dpeaa)DE-He213 CSU (dpeaa)DE-He213 Omalizumab (dpeaa)DE-He213 Anti-IgE (dpeaa)DE-He213 Enthalten in Current treatment options in allergy Cham : Springer Internat. Publ., 2014 3(2016), 4 vom: 10. Sept., Seite 416-422 (DE-627)780378458 (DE-600)2760308-8 2196-3053 nnns volume:3 year:2016 number:4 day:10 month:09 pages:416-422 https://dx.doi.org/10.1007/s40521-016-0098-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2016 4 10 09 416-422 |
allfields_unstemmed |
10.1007/s40521-016-0098-9 doi (DE-627)SPR036619124 (SPR)s40521-016-0098-9-e DE-627 ger DE-627 rakwb eng Church, Martin K. verfasserin aut Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG 2016 Opinion Statement Urticaria is primarily a disease driven by the actions of mast cell-derived histamine on the dermal vasculature and sensory nerves. Initial treatment with second generation minimally sedating $ H_{1} $-antihistamines is recommended. Start with the standard dose of one tablet daily. Because of the high local levels of histamine in the skin, standard doses of $ H_{1} $-antihistamines are often not able to control the symptoms. Thus, if symptoms persist after 2 weeks, then double the dosage of $ H_{1} $-antihistamines, usually giving one in the morning and one in the evening. If this is still not effective after 2 weeks, double the dose to fourfold of the original dose, two tablets given approximately 12 h apart. For patients still not responsive, then other medication, such as omalizumab or cyclosporine A should be introduced. Omalizumab treatment is highlighted in this review. H (dpeaa)DE-He213 -antihistamines (dpeaa)DE-He213 Chronic urticaria (dpeaa)DE-He213 Chronic spontaneous urticaria (dpeaa)DE-He213 CSU (dpeaa)DE-He213 Omalizumab (dpeaa)DE-He213 Anti-IgE (dpeaa)DE-He213 Enthalten in Current treatment options in allergy Cham : Springer Internat. Publ., 2014 3(2016), 4 vom: 10. Sept., Seite 416-422 (DE-627)780378458 (DE-600)2760308-8 2196-3053 nnns volume:3 year:2016 number:4 day:10 month:09 pages:416-422 https://dx.doi.org/10.1007/s40521-016-0098-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2016 4 10 09 416-422 |
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10.1007/s40521-016-0098-9 doi (DE-627)SPR036619124 (SPR)s40521-016-0098-9-e DE-627 ger DE-627 rakwb eng Church, Martin K. verfasserin aut Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer International Publishing AG 2016 Opinion Statement Urticaria is primarily a disease driven by the actions of mast cell-derived histamine on the dermal vasculature and sensory nerves. Initial treatment with second generation minimally sedating $ H_{1} $-antihistamines is recommended. Start with the standard dose of one tablet daily. Because of the high local levels of histamine in the skin, standard doses of $ H_{1} $-antihistamines are often not able to control the symptoms. Thus, if symptoms persist after 2 weeks, then double the dosage of $ H_{1} $-antihistamines, usually giving one in the morning and one in the evening. If this is still not effective after 2 weeks, double the dose to fourfold of the original dose, two tablets given approximately 12 h apart. For patients still not responsive, then other medication, such as omalizumab or cyclosporine A should be introduced. Omalizumab treatment is highlighted in this review. H (dpeaa)DE-He213 -antihistamines (dpeaa)DE-He213 Chronic urticaria (dpeaa)DE-He213 Chronic spontaneous urticaria (dpeaa)DE-He213 CSU (dpeaa)DE-He213 Omalizumab (dpeaa)DE-He213 Anti-IgE (dpeaa)DE-He213 Enthalten in Current treatment options in allergy Cham : Springer Internat. Publ., 2014 3(2016), 4 vom: 10. Sept., Seite 416-422 (DE-627)780378458 (DE-600)2760308-8 2196-3053 nnns volume:3 year:2016 number:4 day:10 month:09 pages:416-422 https://dx.doi.org/10.1007/s40521-016-0098-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2016 4 10 09 416-422 |
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Church, Martin K. |
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Church, Martin K. misc H misc -antihistamines misc Chronic urticaria misc Chronic spontaneous urticaria misc CSU misc Omalizumab misc Anti-IgE Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria? |
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Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria? H (dpeaa)DE-He213 -antihistamines (dpeaa)DE-He213 Chronic urticaria (dpeaa)DE-He213 Chronic spontaneous urticaria (dpeaa)DE-He213 CSU (dpeaa)DE-He213 Omalizumab (dpeaa)DE-He213 Anti-IgE (dpeaa)DE-He213 |
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Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria? |
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does antihistamine up-dosing solve chronic spontaneous urticaria? |
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Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria? |
abstract |
Opinion Statement Urticaria is primarily a disease driven by the actions of mast cell-derived histamine on the dermal vasculature and sensory nerves. Initial treatment with second generation minimally sedating $ H_{1} $-antihistamines is recommended. Start with the standard dose of one tablet daily. Because of the high local levels of histamine in the skin, standard doses of $ H_{1} $-antihistamines are often not able to control the symptoms. Thus, if symptoms persist after 2 weeks, then double the dosage of $ H_{1} $-antihistamines, usually giving one in the morning and one in the evening. If this is still not effective after 2 weeks, double the dose to fourfold of the original dose, two tablets given approximately 12 h apart. For patients still not responsive, then other medication, such as omalizumab or cyclosporine A should be introduced. Omalizumab treatment is highlighted in this review. © Springer International Publishing AG 2016 |
abstractGer |
Opinion Statement Urticaria is primarily a disease driven by the actions of mast cell-derived histamine on the dermal vasculature and sensory nerves. Initial treatment with second generation minimally sedating $ H_{1} $-antihistamines is recommended. Start with the standard dose of one tablet daily. Because of the high local levels of histamine in the skin, standard doses of $ H_{1} $-antihistamines are often not able to control the symptoms. Thus, if symptoms persist after 2 weeks, then double the dosage of $ H_{1} $-antihistamines, usually giving one in the morning and one in the evening. If this is still not effective after 2 weeks, double the dose to fourfold of the original dose, two tablets given approximately 12 h apart. For patients still not responsive, then other medication, such as omalizumab or cyclosporine A should be introduced. Omalizumab treatment is highlighted in this review. © Springer International Publishing AG 2016 |
abstract_unstemmed |
Opinion Statement Urticaria is primarily a disease driven by the actions of mast cell-derived histamine on the dermal vasculature and sensory nerves. Initial treatment with second generation minimally sedating $ H_{1} $-antihistamines is recommended. Start with the standard dose of one tablet daily. Because of the high local levels of histamine in the skin, standard doses of $ H_{1} $-antihistamines are often not able to control the symptoms. Thus, if symptoms persist after 2 weeks, then double the dosage of $ H_{1} $-antihistamines, usually giving one in the morning and one in the evening. If this is still not effective after 2 weeks, double the dose to fourfold of the original dose, two tablets given approximately 12 h apart. For patients still not responsive, then other medication, such as omalizumab or cyclosporine A should be introduced. Omalizumab treatment is highlighted in this review. © Springer International Publishing AG 2016 |
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Does Antihistamine Up-dosing Solve Chronic Spontaneous Urticaria? |
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