Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester
Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present stud...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Desai, Purvi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Anmerkung: |
© Society of Fetal Medicine 2019 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of fetal medicine - New Delhi : Springer India, 2014, 6(2019), 1 vom: 28. Feb., Seite 31-34 |
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| Übergeordnetes Werk: |
volume:6 ; year:2019 ; number:1 ; day:28 ; month:02 ; pages:31-34 |
| Links: |
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| DOI / URN: |
10.1007/s40556-019-00196-9 |
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| Katalog-ID: |
SPR036653160 |
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| 520 | |a Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present study aimed at confirming the sensitivity of isolated absent NB in the second trimester USG, by reviewing the karyotypes and/or postnatal outcomes of such pregnancies up till at least 6 months of postnatal life. Facial profile was seen in 2D and 3D reconstructed view in all the cases to avoid missing the unilateral absence of nasal bone. Complete detailed scan and FISH on amniotic fluid cells was advised for all the cases with absent nasal bone. The present study concluded that isolated absence of NB in the second trimester may not be an effective marker for diagnosis of Down’s syndrome. Amniocentesis should be advised only if absent nasal bone is associated with any other structural abnormality or additional soft marker. | ||
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| 700 | 1 | |a Chauhan, Binodini |4 aut | |
| 700 | 1 | |a Jhawar, Manisha |0 (orcid)0000-0003-0592-0407 |4 aut | |
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10.1007/s40556-019-00196-9 doi (DE-627)SPR036653160 (SPR)s40556-019-00196-9-e DE-627 ger DE-627 rakwb eng Desai, Purvi verfasserin aut Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society of Fetal Medicine 2019 Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present study aimed at confirming the sensitivity of isolated absent NB in the second trimester USG, by reviewing the karyotypes and/or postnatal outcomes of such pregnancies up till at least 6 months of postnatal life. Facial profile was seen in 2D and 3D reconstructed view in all the cases to avoid missing the unilateral absence of nasal bone. Complete detailed scan and FISH on amniotic fluid cells was advised for all the cases with absent nasal bone. The present study concluded that isolated absence of NB in the second trimester may not be an effective marker for diagnosis of Down’s syndrome. Amniocentesis should be advised only if absent nasal bone is associated with any other structural abnormality or additional soft marker. Nasal bone (NB) absent nasal bone (dpeaa)DE-He213 Hypoplastic nasal bone (dpeaa)DE-He213 NBL nasal bone length (dpeaa)DE-He213 3D three dimension (dpeaa)DE-He213 2D two dimension (dpeaa)DE-He213 Chauhan, Binodini aut Jhawar, Manisha (orcid)0000-0003-0592-0407 aut Enthalten in Journal of fetal medicine New Delhi : Springer India, 2014 6(2019), 1 vom: 28. Feb., Seite 31-34 (DE-627)815914466 (DE-600)2806650-9 2348-8859 nnns volume:6 year:2019 number:1 day:28 month:02 pages:31-34 https://dx.doi.org/10.1007/s40556-019-00196-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2019 1 28 02 31-34 |
| spelling |
10.1007/s40556-019-00196-9 doi (DE-627)SPR036653160 (SPR)s40556-019-00196-9-e DE-627 ger DE-627 rakwb eng Desai, Purvi verfasserin aut Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society of Fetal Medicine 2019 Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present study aimed at confirming the sensitivity of isolated absent NB in the second trimester USG, by reviewing the karyotypes and/or postnatal outcomes of such pregnancies up till at least 6 months of postnatal life. Facial profile was seen in 2D and 3D reconstructed view in all the cases to avoid missing the unilateral absence of nasal bone. Complete detailed scan and FISH on amniotic fluid cells was advised for all the cases with absent nasal bone. The present study concluded that isolated absence of NB in the second trimester may not be an effective marker for diagnosis of Down’s syndrome. Amniocentesis should be advised only if absent nasal bone is associated with any other structural abnormality or additional soft marker. Nasal bone (NB) absent nasal bone (dpeaa)DE-He213 Hypoplastic nasal bone (dpeaa)DE-He213 NBL nasal bone length (dpeaa)DE-He213 3D three dimension (dpeaa)DE-He213 2D two dimension (dpeaa)DE-He213 Chauhan, Binodini aut Jhawar, Manisha (orcid)0000-0003-0592-0407 aut Enthalten in Journal of fetal medicine New Delhi : Springer India, 2014 6(2019), 1 vom: 28. Feb., Seite 31-34 (DE-627)815914466 (DE-600)2806650-9 2348-8859 nnns volume:6 year:2019 number:1 day:28 month:02 pages:31-34 https://dx.doi.org/10.1007/s40556-019-00196-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2019 1 28 02 31-34 |
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10.1007/s40556-019-00196-9 doi (DE-627)SPR036653160 (SPR)s40556-019-00196-9-e DE-627 ger DE-627 rakwb eng Desai, Purvi verfasserin aut Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society of Fetal Medicine 2019 Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present study aimed at confirming the sensitivity of isolated absent NB in the second trimester USG, by reviewing the karyotypes and/or postnatal outcomes of such pregnancies up till at least 6 months of postnatal life. Facial profile was seen in 2D and 3D reconstructed view in all the cases to avoid missing the unilateral absence of nasal bone. Complete detailed scan and FISH on amniotic fluid cells was advised for all the cases with absent nasal bone. The present study concluded that isolated absence of NB in the second trimester may not be an effective marker for diagnosis of Down’s syndrome. Amniocentesis should be advised only if absent nasal bone is associated with any other structural abnormality or additional soft marker. Nasal bone (NB) absent nasal bone (dpeaa)DE-He213 Hypoplastic nasal bone (dpeaa)DE-He213 NBL nasal bone length (dpeaa)DE-He213 3D three dimension (dpeaa)DE-He213 2D two dimension (dpeaa)DE-He213 Chauhan, Binodini aut Jhawar, Manisha (orcid)0000-0003-0592-0407 aut Enthalten in Journal of fetal medicine New Delhi : Springer India, 2014 6(2019), 1 vom: 28. Feb., Seite 31-34 (DE-627)815914466 (DE-600)2806650-9 2348-8859 nnns volume:6 year:2019 number:1 day:28 month:02 pages:31-34 https://dx.doi.org/10.1007/s40556-019-00196-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2019 1 28 02 31-34 |
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10.1007/s40556-019-00196-9 doi (DE-627)SPR036653160 (SPR)s40556-019-00196-9-e DE-627 ger DE-627 rakwb eng Desai, Purvi verfasserin aut Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society of Fetal Medicine 2019 Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present study aimed at confirming the sensitivity of isolated absent NB in the second trimester USG, by reviewing the karyotypes and/or postnatal outcomes of such pregnancies up till at least 6 months of postnatal life. Facial profile was seen in 2D and 3D reconstructed view in all the cases to avoid missing the unilateral absence of nasal bone. Complete detailed scan and FISH on amniotic fluid cells was advised for all the cases with absent nasal bone. The present study concluded that isolated absence of NB in the second trimester may not be an effective marker for diagnosis of Down’s syndrome. Amniocentesis should be advised only if absent nasal bone is associated with any other structural abnormality or additional soft marker. Nasal bone (NB) absent nasal bone (dpeaa)DE-He213 Hypoplastic nasal bone (dpeaa)DE-He213 NBL nasal bone length (dpeaa)DE-He213 3D three dimension (dpeaa)DE-He213 2D two dimension (dpeaa)DE-He213 Chauhan, Binodini aut Jhawar, Manisha (orcid)0000-0003-0592-0407 aut Enthalten in Journal of fetal medicine New Delhi : Springer India, 2014 6(2019), 1 vom: 28. Feb., Seite 31-34 (DE-627)815914466 (DE-600)2806650-9 2348-8859 nnns volume:6 year:2019 number:1 day:28 month:02 pages:31-34 https://dx.doi.org/10.1007/s40556-019-00196-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2019 1 28 02 31-34 |
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10.1007/s40556-019-00196-9 doi (DE-627)SPR036653160 (SPR)s40556-019-00196-9-e DE-627 ger DE-627 rakwb eng Desai, Purvi verfasserin aut Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society of Fetal Medicine 2019 Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present study aimed at confirming the sensitivity of isolated absent NB in the second trimester USG, by reviewing the karyotypes and/or postnatal outcomes of such pregnancies up till at least 6 months of postnatal life. Facial profile was seen in 2D and 3D reconstructed view in all the cases to avoid missing the unilateral absence of nasal bone. Complete detailed scan and FISH on amniotic fluid cells was advised for all the cases with absent nasal bone. The present study concluded that isolated absence of NB in the second trimester may not be an effective marker for diagnosis of Down’s syndrome. Amniocentesis should be advised only if absent nasal bone is associated with any other structural abnormality or additional soft marker. Nasal bone (NB) absent nasal bone (dpeaa)DE-He213 Hypoplastic nasal bone (dpeaa)DE-He213 NBL nasal bone length (dpeaa)DE-He213 3D three dimension (dpeaa)DE-He213 2D two dimension (dpeaa)DE-He213 Chauhan, Binodini aut Jhawar, Manisha (orcid)0000-0003-0592-0407 aut Enthalten in Journal of fetal medicine New Delhi : Springer India, 2014 6(2019), 1 vom: 28. Feb., Seite 31-34 (DE-627)815914466 (DE-600)2806650-9 2348-8859 nnns volume:6 year:2019 number:1 day:28 month:02 pages:31-34 https://dx.doi.org/10.1007/s40556-019-00196-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2019 1 28 02 31-34 |
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Enthalten in Journal of fetal medicine 6(2019), 1 vom: 28. Feb., Seite 31-34 volume:6 year:2019 number:1 day:28 month:02 pages:31-34 |
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Desai, Purvi @@aut@@ Chauhan, Binodini @@aut@@ Jhawar, Manisha @@aut@@ |
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Desai, Purvi |
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Desai, Purvi misc Nasal bone (NB) absent nasal bone misc Hypoplastic nasal bone misc NBL nasal bone length misc 3D three dimension misc 2D two dimension Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester |
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Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester Nasal bone (NB) absent nasal bone (dpeaa)DE-He213 Hypoplastic nasal bone (dpeaa)DE-He213 NBL nasal bone length (dpeaa)DE-He213 3D three dimension (dpeaa)DE-He213 2D two dimension (dpeaa)DE-He213 |
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misc Nasal bone (NB) absent nasal bone misc Hypoplastic nasal bone misc NBL nasal bone length misc 3D three dimension misc 2D two dimension |
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misc Nasal bone (NB) absent nasal bone misc Hypoplastic nasal bone misc NBL nasal bone length misc 3D three dimension misc 2D two dimension |
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Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester |
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Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester |
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Desai, Purvi Chauhan, Binodini Jhawar, Manisha |
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outcome of pregnancies with isolated absent fetal nasal bone in the second trimester |
| title_auth |
Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester |
| abstract |
Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present study aimed at confirming the sensitivity of isolated absent NB in the second trimester USG, by reviewing the karyotypes and/or postnatal outcomes of such pregnancies up till at least 6 months of postnatal life. Facial profile was seen in 2D and 3D reconstructed view in all the cases to avoid missing the unilateral absence of nasal bone. Complete detailed scan and FISH on amniotic fluid cells was advised for all the cases with absent nasal bone. The present study concluded that isolated absence of NB in the second trimester may not be an effective marker for diagnosis of Down’s syndrome. Amniocentesis should be advised only if absent nasal bone is associated with any other structural abnormality or additional soft marker. © Society of Fetal Medicine 2019 |
| abstractGer |
Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present study aimed at confirming the sensitivity of isolated absent NB in the second trimester USG, by reviewing the karyotypes and/or postnatal outcomes of such pregnancies up till at least 6 months of postnatal life. Facial profile was seen in 2D and 3D reconstructed view in all the cases to avoid missing the unilateral absence of nasal bone. Complete detailed scan and FISH on amniotic fluid cells was advised for all the cases with absent nasal bone. The present study concluded that isolated absence of NB in the second trimester may not be an effective marker for diagnosis of Down’s syndrome. Amniocentesis should be advised only if absent nasal bone is associated with any other structural abnormality or additional soft marker. © Society of Fetal Medicine 2019 |
| abstract_unstemmed |
Abstract Absent nasal bone is associated with 58 genetic syndromes, Trisomy 18 and trisomy 21. It increases the sensitivity of second trimester scan for aneuploidy from 83 to 90%. Since 2003, absent or unossified nasal bone is therefore an integral part of the second trimester scan. The present study aimed at confirming the sensitivity of isolated absent NB in the second trimester USG, by reviewing the karyotypes and/or postnatal outcomes of such pregnancies up till at least 6 months of postnatal life. Facial profile was seen in 2D and 3D reconstructed view in all the cases to avoid missing the unilateral absence of nasal bone. Complete detailed scan and FISH on amniotic fluid cells was advised for all the cases with absent nasal bone. The present study concluded that isolated absence of NB in the second trimester may not be an effective marker for diagnosis of Down’s syndrome. Amniocentesis should be advised only if absent nasal bone is associated with any other structural abnormality or additional soft marker. © Society of Fetal Medicine 2019 |
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Outcome of Pregnancies with Isolated Absent Fetal Nasal Bone in the Second Trimester |
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https://dx.doi.org/10.1007/s40556-019-00196-9 |
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Chauhan, Binodini Jhawar, Manisha |
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10.1007/s40556-019-00196-9 |
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2024-07-03T18:54:23.648Z |
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| score |
7.3993473 |