Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study

Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627). Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Morisawa, Kenichiro [verfasserIn] Fujitani, Shigeki Taira, Yasuhiko Kushimoto, Shigeki Kitazawa, Yasuhide Okuchi, Kazuo Ishikura, Hiroyasu Sakamoto, Teruo Tagami, Takashi Yamaguchi, Junko Sugita, Manabu Kase, Yoichi Kanemura, Takashi Takahashi, Hiroyuki Kuroki, Yuuichi Izumino, Hiroo Rinka, Hiroshi Seo, Ryutarou Takatori, Makoto Kaneko, Tadashi Nakamura, Toshiaki Irahara, Takayuki Saitou, Nobuyuki Watanabe, Akihiro

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Acute pulmonary edema Acute respiratory distress syndrome Indirect injury Direct injury Pulmonary vascular permeability Transpulmonary thermodilution technique

Anmerkung:	© Morisawa et al.; licensee BioMed Central Ltd. 2014

Übergeordnetes Werk:	Enthalten in: Journal of Intensive Care - London : BioMed Central, 2013, 2(2014), 1 vom: 25. März
Übergeordnetes Werk:	volume:2 ; year:2014 ; number:1 ; day:25 ; month:03

Links:	Volltext

DOI / URN:	10.1186/2052-0492-2-24

Katalog-ID:	SPR036659339

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100	1		\|a Morisawa, Kenichiro \|e verfasserin \|4 aut
245	1	0	\|a Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study
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520			\|a Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627).
650		4	\|a Acute pulmonary edema \|7 (dpeaa)DE-He213
650		4	\|a Acute respiratory distress syndrome \|7 (dpeaa)DE-He213
650		4	\|a Indirect injury \|7 (dpeaa)DE-He213
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700	1		\|a Fujitani, Shigeki \|4 aut
700	1		\|a Taira, Yasuhiko \|4 aut
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700	1		\|a Watanabe, Akihiro \|4 aut
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allfields	10.1186/2052-0492-2-24 doi (DE-627)SPR036659339 (SPR)2052-0492-2-24-e DE-627 ger DE-627 rakwb eng Morisawa, Kenichiro verfasserin aut Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Morisawa et al.; licensee BioMed Central Ltd. 2014 Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627). Acute pulmonary edema (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Indirect injury (dpeaa)DE-He213 Direct injury (dpeaa)DE-He213 Pulmonary vascular permeability (dpeaa)DE-He213 Transpulmonary thermodilution technique (dpeaa)DE-He213 Fujitani, Shigeki aut Taira, Yasuhiko aut Kushimoto, Shigeki aut Kitazawa, Yasuhide aut Okuchi, Kazuo aut Ishikura, Hiroyasu aut Sakamoto, Teruo aut Tagami, Takashi aut Yamaguchi, Junko aut Sugita, Manabu aut Kase, Yoichi aut Kanemura, Takashi aut Takahashi, Hiroyuki aut Kuroki, Yuuichi aut Izumino, Hiroo aut Rinka, Hiroshi aut Seo, Ryutarou aut Takatori, Makoto aut Kaneko, Tadashi aut Nakamura, Toshiaki aut Irahara, Takayuki aut Saitou, Nobuyuki aut Watanabe, Akihiro aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 25. März (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:25 month:03 https://dx.doi.org/10.1186/2052-0492-2-24 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 25 03
spelling	10.1186/2052-0492-2-24 doi (DE-627)SPR036659339 (SPR)2052-0492-2-24-e DE-627 ger DE-627 rakwb eng Morisawa, Kenichiro verfasserin aut Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Morisawa et al.; licensee BioMed Central Ltd. 2014 Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627). Acute pulmonary edema (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Indirect injury (dpeaa)DE-He213 Direct injury (dpeaa)DE-He213 Pulmonary vascular permeability (dpeaa)DE-He213 Transpulmonary thermodilution technique (dpeaa)DE-He213 Fujitani, Shigeki aut Taira, Yasuhiko aut Kushimoto, Shigeki aut Kitazawa, Yasuhide aut Okuchi, Kazuo aut Ishikura, Hiroyasu aut Sakamoto, Teruo aut Tagami, Takashi aut Yamaguchi, Junko aut Sugita, Manabu aut Kase, Yoichi aut Kanemura, Takashi aut Takahashi, Hiroyuki aut Kuroki, Yuuichi aut Izumino, Hiroo aut Rinka, Hiroshi aut Seo, Ryutarou aut Takatori, Makoto aut Kaneko, Tadashi aut Nakamura, Toshiaki aut Irahara, Takayuki aut Saitou, Nobuyuki aut Watanabe, Akihiro aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 25. März (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:25 month:03 https://dx.doi.org/10.1186/2052-0492-2-24 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 25 03
allfields_unstemmed	10.1186/2052-0492-2-24 doi (DE-627)SPR036659339 (SPR)2052-0492-2-24-e DE-627 ger DE-627 rakwb eng Morisawa, Kenichiro verfasserin aut Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Morisawa et al.; licensee BioMed Central Ltd. 2014 Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627). Acute pulmonary edema (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Indirect injury (dpeaa)DE-He213 Direct injury (dpeaa)DE-He213 Pulmonary vascular permeability (dpeaa)DE-He213 Transpulmonary thermodilution technique (dpeaa)DE-He213 Fujitani, Shigeki aut Taira, Yasuhiko aut Kushimoto, Shigeki aut Kitazawa, Yasuhide aut Okuchi, Kazuo aut Ishikura, Hiroyasu aut Sakamoto, Teruo aut Tagami, Takashi aut Yamaguchi, Junko aut Sugita, Manabu aut Kase, Yoichi aut Kanemura, Takashi aut Takahashi, Hiroyuki aut Kuroki, Yuuichi aut Izumino, Hiroo aut Rinka, Hiroshi aut Seo, Ryutarou aut Takatori, Makoto aut Kaneko, Tadashi aut Nakamura, Toshiaki aut Irahara, Takayuki aut Saitou, Nobuyuki aut Watanabe, Akihiro aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 25. März (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:25 month:03 https://dx.doi.org/10.1186/2052-0492-2-24 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 25 03
allfieldsGer	10.1186/2052-0492-2-24 doi (DE-627)SPR036659339 (SPR)2052-0492-2-24-e DE-627 ger DE-627 rakwb eng Morisawa, Kenichiro verfasserin aut Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Morisawa et al.; licensee BioMed Central Ltd. 2014 Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627). Acute pulmonary edema (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Indirect injury (dpeaa)DE-He213 Direct injury (dpeaa)DE-He213 Pulmonary vascular permeability (dpeaa)DE-He213 Transpulmonary thermodilution technique (dpeaa)DE-He213 Fujitani, Shigeki aut Taira, Yasuhiko aut Kushimoto, Shigeki aut Kitazawa, Yasuhide aut Okuchi, Kazuo aut Ishikura, Hiroyasu aut Sakamoto, Teruo aut Tagami, Takashi aut Yamaguchi, Junko aut Sugita, Manabu aut Kase, Yoichi aut Kanemura, Takashi aut Takahashi, Hiroyuki aut Kuroki, Yuuichi aut Izumino, Hiroo aut Rinka, Hiroshi aut Seo, Ryutarou aut Takatori, Makoto aut Kaneko, Tadashi aut Nakamura, Toshiaki aut Irahara, Takayuki aut Saitou, Nobuyuki aut Watanabe, Akihiro aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 25. März (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:25 month:03 https://dx.doi.org/10.1186/2052-0492-2-24 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 25 03
allfieldsSound	10.1186/2052-0492-2-24 doi (DE-627)SPR036659339 (SPR)2052-0492-2-24-e DE-627 ger DE-627 rakwb eng Morisawa, Kenichiro verfasserin aut Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Morisawa et al.; licensee BioMed Central Ltd. 2014 Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627). Acute pulmonary edema (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Indirect injury (dpeaa)DE-He213 Direct injury (dpeaa)DE-He213 Pulmonary vascular permeability (dpeaa)DE-He213 Transpulmonary thermodilution technique (dpeaa)DE-He213 Fujitani, Shigeki aut Taira, Yasuhiko aut Kushimoto, Shigeki aut Kitazawa, Yasuhide aut Okuchi, Kazuo aut Ishikura, Hiroyasu aut Sakamoto, Teruo aut Tagami, Takashi aut Yamaguchi, Junko aut Sugita, Manabu aut Kase, Yoichi aut Kanemura, Takashi aut Takahashi, Hiroyuki aut Kuroki, Yuuichi aut Izumino, Hiroo aut Rinka, Hiroshi aut Seo, Ryutarou aut Takatori, Makoto aut Kaneko, Tadashi aut Nakamura, Toshiaki aut Irahara, Takayuki aut Saitou, Nobuyuki aut Watanabe, Akihiro aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 25. März (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:25 month:03 https://dx.doi.org/10.1186/2052-0492-2-24 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 25 03
language	English
source	Enthalten in Journal of Intensive Care 2(2014), 1 vom: 25. März volume:2 year:2014 number:1 day:25 month:03
sourceStr	Enthalten in Journal of Intensive Care 2(2014), 1 vom: 25. März volume:2 year:2014 number:1 day:25 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Acute pulmonary edema Acute respiratory distress syndrome Indirect injury Direct injury Pulmonary vascular permeability Transpulmonary thermodilution technique
isfreeaccess_bool	true
container_title	Journal of Intensive Care
authorswithroles_txt_mv	Morisawa, Kenichiro @@aut@@ Fujitani, Shigeki @@aut@@ Taira, Yasuhiko @@aut@@ Kushimoto, Shigeki @@aut@@ Kitazawa, Yasuhide @@aut@@ Okuchi, Kazuo @@aut@@ Ishikura, Hiroyasu @@aut@@ Sakamoto, Teruo @@aut@@ Tagami, Takashi @@aut@@ Yamaguchi, Junko @@aut@@ Sugita, Manabu @@aut@@ Kase, Yoichi @@aut@@ Kanemura, Takashi @@aut@@ Takahashi, Hiroyuki @@aut@@ Kuroki, Yuuichi @@aut@@ Izumino, Hiroo @@aut@@ Rinka, Hiroshi @@aut@@ Seo, Ryutarou @@aut@@ Takatori, Makoto @@aut@@ Kaneko, Tadashi @@aut@@ Nakamura, Toshiaki @@aut@@ Irahara, Takayuki @@aut@@ Saitou, Nobuyuki @@aut@@ Watanabe, Akihiro @@aut@@
publishDateDaySort_date	2014-03-25T00:00:00Z
hierarchy_top_id	771390440
id	SPR036659339
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR036659339</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519161553.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2014 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/2052-0492-2-24</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR036659339</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)2052-0492-2-24-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Morisawa, Kenichiro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Morisawa et al.; licensee BioMed Central Ltd. 2014</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. 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author	Morisawa, Kenichiro
spellingShingle	Morisawa, Kenichiro misc Acute pulmonary edema misc Acute respiratory distress syndrome misc Indirect injury misc Direct injury misc Pulmonary vascular permeability misc Transpulmonary thermodilution technique Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study
authorStr	Morisawa, Kenichiro
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topic_title	Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study Acute pulmonary edema (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Indirect injury (dpeaa)DE-He213 Direct injury (dpeaa)DE-He213 Pulmonary vascular permeability (dpeaa)DE-He213 Transpulmonary thermodilution technique (dpeaa)DE-He213
topic	misc Acute pulmonary edema misc Acute respiratory distress syndrome misc Indirect injury misc Direct injury misc Pulmonary vascular permeability misc Transpulmonary thermodilution technique
topic_unstemmed	misc Acute pulmonary edema misc Acute respiratory distress syndrome misc Indirect injury misc Direct injury misc Pulmonary vascular permeability misc Transpulmonary thermodilution technique
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title	Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study
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title_full	Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study
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author_browse	Morisawa, Kenichiro Fujitani, Shigeki Taira, Yasuhiko Kushimoto, Shigeki Kitazawa, Yasuhide Okuchi, Kazuo Ishikura, Hiroyasu Sakamoto, Teruo Tagami, Takashi Yamaguchi, Junko Sugita, Manabu Kase, Yoichi Kanemura, Takashi Takahashi, Hiroyuki Kuroki, Yuuichi Izumino, Hiroo Rinka, Hiroshi Seo, Ryutarou Takatori, Makoto Kaneko, Tadashi Nakamura, Toshiaki Irahara, Takayuki Saitou, Nobuyuki Watanabe, Akihiro
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title_sort	difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study
title_auth	Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study
abstract	Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627). © Morisawa et al.; licensee BioMed Central Ltd. 2014
abstractGer	Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627). © Morisawa et al.; licensee BioMed Central Ltd. 2014
abstract_unstemmed	Background Acute respiratory distress syndrome (ARDS) is characterized by the increased pulmonary permeability secondary to diffuse alveolar inflammation and injuries of several origins. Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. Trial registration This report is a sub-group analysis of the study registered with UMIN-CTR (IDUMIN000003627). © Morisawa et al.; licensee BioMed Central Ltd. 2014
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title_short	Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study
url	https://dx.doi.org/10.1186/2052-0492-2-24
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author2	Fujitani, Shigeki Taira, Yasuhiko Kushimoto, Shigeki Kitazawa, Yasuhide Okuchi, Kazuo Ishikura, Hiroyasu Sakamoto, Teruo Tagami, Takashi Yamaguchi, Junko Sugita, Manabu Kase, Yoichi Kanemura, Takashi Takahashi, Hiroyuki Kuroki, Yuuichi Izumino, Hiroo Rinka, Hiroshi Seo, Ryutarou Takatori, Makoto Kaneko, Tadashi Nakamura, Toshiaki Irahara, Takayuki Saitou, Nobuyuki Watanabe, Akihiro
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Especially, the distinction between a direct (pulmonary injury) and an indirect (extrapulmonary injury) lung injury etiology is gaining more attention as a means of better comprehending the pathophysiology of ARDS. However, there are few reports regarding the quantitative methods distinguishing the degree of pulmonary permeability between ARDS patients due to pulmonary injury and extrapulmonary injury. Methods A prospective, observational, multi-institutional study was performed in 23 intensive care units of academic tertiary referral hospitals throughout Japan. During a 2-year period, all consecutive ARDS-diagnosed adult patients requiring mechanical ventilation were collected in which three experts retrospectively determined the pathophysiological mechanisms leading to ARDS. Patients were classified into two groups: patients with ARDS triggered by extrapulmonary injury (ARDSexp) and those caused by pulmonary injury (ARDSp). The degree of pulmonary permeability using the transpulmonary thermodilution technique was obtained during the first three intensive care unit (ICU) days. Results In total, 173 patients were assessed including 56 ARDSexp patients and 117 ARDSp patients. Although the Sequential Organ Failure Assessment (SOFA) score was significantly higher in the ARDSexp group than in the ARDSp group, measurements of the pulmonary vascular permeability index (PVPI) were significantly elevated in the ARDSp group on all days: at day 0 (2.9 ± 1.3 of ARDSexp vs. 3.3 ± 1.3 of ARDSp, p = .008), at day 1 (2.8 ± 1.5 of ARDSexp vs. 3.2 ± 1.2 of ARDSp, p = .01), at day 2 (2.4 ± 1.0 of ARDSexp vs. 2.9 ± 1.3 of ARDSp, p = .01). There were no significant differences in mortality at 28 days, mechanical ventilation days, and hospital length of stay between the two groups. Conclusions The results of this study suggest the existence of several differences in the increased degree of pulmonary permeability between patients with ARDSexp and ARDSp. 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Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study

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