Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study

Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acut...
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Autor*in:	Kaneko, Tadashi [verfasserIn] Kawamura, Yoshikatsu Maekawa, Tsuyoshi Tagami, Takashi Nakamura, Toshiaki Saito, Nobuyuki Kitazawa, Yasuhide Ishikura, Hiroyasu Sugita, Manabu Okuchi, Kazuo Rinka, Hiroshi Watanabe, Akihiro Kase, Yoichi Kushimoto, Shigeki Izumino, Hiroo Kanemura, Takashi Yoshikawa, Kazuhide Takahashi, Hiroyuki Irahara, Takayuki Sakamoto, Teruo Kuroki, Yuichi Taira, Yasuhiko Seo, Ryutarou Yamaguchi, Junko Takatori, Makoto

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Pulmonary edema Extravascular lung water Multivariate regression analysis Global end-diastolic volume Acute lung injury Acute respiratory distress syndrome

Anmerkung:	© Kaneko et al.; licensee BioMed Central Ltd. 2014

Übergeordnetes Werk:	Enthalten in: Journal of Intensive Care - London : BioMed Central, 2013, 2(2014), 1 vom: 01. Apr.
Übergeordnetes Werk:	volume:2 ; year:2014 ; number:1 ; day:01 ; month:04

Links:	Volltext

DOI / URN:	10.1186/2052-0492-2-25

Katalog-ID:	SPR036659347

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520			\|a Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. Trial registration University Hospital Medical Information Network (UMIN) Clinical Trials Registry UMIN000003627.
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650		4	\|a Global end-diastolic volume \|7 (dpeaa)DE-He213
650		4	\|a Acute lung injury \|7 (dpeaa)DE-He213
650		4	\|a Acute respiratory distress syndrome \|7 (dpeaa)DE-He213
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allfields	10.1186/2052-0492-2-25 doi (DE-627)SPR036659347 (SPR)2052-0492-2-25-e DE-627 ger DE-627 rakwb eng Kaneko, Tadashi verfasserin aut Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kaneko et al.; licensee BioMed Central Ltd. 2014 Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. Trial registration University Hospital Medical Information Network (UMIN) Clinical Trials Registry UMIN000003627. Pulmonary edema (dpeaa)DE-He213 Extravascular lung water (dpeaa)DE-He213 Multivariate regression analysis (dpeaa)DE-He213 Global end-diastolic volume (dpeaa)DE-He213 Acute lung injury (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Kawamura, Yoshikatsu aut Maekawa, Tsuyoshi aut Tagami, Takashi aut Nakamura, Toshiaki aut Saito, Nobuyuki aut Kitazawa, Yasuhide aut Ishikura, Hiroyasu aut Sugita, Manabu aut Okuchi, Kazuo aut Rinka, Hiroshi aut Watanabe, Akihiro aut Kase, Yoichi aut Kushimoto, Shigeki aut Izumino, Hiroo aut Kanemura, Takashi aut Yoshikawa, Kazuhide aut Takahashi, Hiroyuki aut Irahara, Takayuki aut Sakamoto, Teruo aut Kuroki, Yuichi aut Taira, Yasuhiko aut Seo, Ryutarou aut Yamaguchi, Junko aut Takatori, Makoto aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 01. Apr. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:01 month:04 https://dx.doi.org/10.1186/2052-0492-2-25 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 01 04
spelling	10.1186/2052-0492-2-25 doi (DE-627)SPR036659347 (SPR)2052-0492-2-25-e DE-627 ger DE-627 rakwb eng Kaneko, Tadashi verfasserin aut Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kaneko et al.; licensee BioMed Central Ltd. 2014 Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. Trial registration University Hospital Medical Information Network (UMIN) Clinical Trials Registry UMIN000003627. Pulmonary edema (dpeaa)DE-He213 Extravascular lung water (dpeaa)DE-He213 Multivariate regression analysis (dpeaa)DE-He213 Global end-diastolic volume (dpeaa)DE-He213 Acute lung injury (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Kawamura, Yoshikatsu aut Maekawa, Tsuyoshi aut Tagami, Takashi aut Nakamura, Toshiaki aut Saito, Nobuyuki aut Kitazawa, Yasuhide aut Ishikura, Hiroyasu aut Sugita, Manabu aut Okuchi, Kazuo aut Rinka, Hiroshi aut Watanabe, Akihiro aut Kase, Yoichi aut Kushimoto, Shigeki aut Izumino, Hiroo aut Kanemura, Takashi aut Yoshikawa, Kazuhide aut Takahashi, Hiroyuki aut Irahara, Takayuki aut Sakamoto, Teruo aut Kuroki, Yuichi aut Taira, Yasuhiko aut Seo, Ryutarou aut Yamaguchi, Junko aut Takatori, Makoto aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 01. Apr. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:01 month:04 https://dx.doi.org/10.1186/2052-0492-2-25 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 01 04
allfields_unstemmed	10.1186/2052-0492-2-25 doi (DE-627)SPR036659347 (SPR)2052-0492-2-25-e DE-627 ger DE-627 rakwb eng Kaneko, Tadashi verfasserin aut Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kaneko et al.; licensee BioMed Central Ltd. 2014 Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. Trial registration University Hospital Medical Information Network (UMIN) Clinical Trials Registry UMIN000003627. Pulmonary edema (dpeaa)DE-He213 Extravascular lung water (dpeaa)DE-He213 Multivariate regression analysis (dpeaa)DE-He213 Global end-diastolic volume (dpeaa)DE-He213 Acute lung injury (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Kawamura, Yoshikatsu aut Maekawa, Tsuyoshi aut Tagami, Takashi aut Nakamura, Toshiaki aut Saito, Nobuyuki aut Kitazawa, Yasuhide aut Ishikura, Hiroyasu aut Sugita, Manabu aut Okuchi, Kazuo aut Rinka, Hiroshi aut Watanabe, Akihiro aut Kase, Yoichi aut Kushimoto, Shigeki aut Izumino, Hiroo aut Kanemura, Takashi aut Yoshikawa, Kazuhide aut Takahashi, Hiroyuki aut Irahara, Takayuki aut Sakamoto, Teruo aut Kuroki, Yuichi aut Taira, Yasuhiko aut Seo, Ryutarou aut Yamaguchi, Junko aut Takatori, Makoto aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 01. Apr. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:01 month:04 https://dx.doi.org/10.1186/2052-0492-2-25 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 01 04
allfieldsGer	10.1186/2052-0492-2-25 doi (DE-627)SPR036659347 (SPR)2052-0492-2-25-e DE-627 ger DE-627 rakwb eng Kaneko, Tadashi verfasserin aut Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kaneko et al.; licensee BioMed Central Ltd. 2014 Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. Trial registration University Hospital Medical Information Network (UMIN) Clinical Trials Registry UMIN000003627. Pulmonary edema (dpeaa)DE-He213 Extravascular lung water (dpeaa)DE-He213 Multivariate regression analysis (dpeaa)DE-He213 Global end-diastolic volume (dpeaa)DE-He213 Acute lung injury (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Kawamura, Yoshikatsu aut Maekawa, Tsuyoshi aut Tagami, Takashi aut Nakamura, Toshiaki aut Saito, Nobuyuki aut Kitazawa, Yasuhide aut Ishikura, Hiroyasu aut Sugita, Manabu aut Okuchi, Kazuo aut Rinka, Hiroshi aut Watanabe, Akihiro aut Kase, Yoichi aut Kushimoto, Shigeki aut Izumino, Hiroo aut Kanemura, Takashi aut Yoshikawa, Kazuhide aut Takahashi, Hiroyuki aut Irahara, Takayuki aut Sakamoto, Teruo aut Kuroki, Yuichi aut Taira, Yasuhiko aut Seo, Ryutarou aut Yamaguchi, Junko aut Takatori, Makoto aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 01. Apr. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:01 month:04 https://dx.doi.org/10.1186/2052-0492-2-25 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 01 04
allfieldsSound	10.1186/2052-0492-2-25 doi (DE-627)SPR036659347 (SPR)2052-0492-2-25-e DE-627 ger DE-627 rakwb eng Kaneko, Tadashi verfasserin aut Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kaneko et al.; licensee BioMed Central Ltd. 2014 Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. Trial registration University Hospital Medical Information Network (UMIN) Clinical Trials Registry UMIN000003627. Pulmonary edema (dpeaa)DE-He213 Extravascular lung water (dpeaa)DE-He213 Multivariate regression analysis (dpeaa)DE-He213 Global end-diastolic volume (dpeaa)DE-He213 Acute lung injury (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213 Kawamura, Yoshikatsu aut Maekawa, Tsuyoshi aut Tagami, Takashi aut Nakamura, Toshiaki aut Saito, Nobuyuki aut Kitazawa, Yasuhide aut Ishikura, Hiroyasu aut Sugita, Manabu aut Okuchi, Kazuo aut Rinka, Hiroshi aut Watanabe, Akihiro aut Kase, Yoichi aut Kushimoto, Shigeki aut Izumino, Hiroo aut Kanemura, Takashi aut Yoshikawa, Kazuhide aut Takahashi, Hiroyuki aut Irahara, Takayuki aut Sakamoto, Teruo aut Kuroki, Yuichi aut Taira, Yasuhiko aut Seo, Ryutarou aut Yamaguchi, Junko aut Takatori, Makoto aut Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 01. Apr. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:01 month:04 https://dx.doi.org/10.1186/2052-0492-2-25 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 01 04
language	English
source	Enthalten in Journal of Intensive Care 2(2014), 1 vom: 01. Apr. volume:2 year:2014 number:1 day:01 month:04
sourceStr	Enthalten in Journal of Intensive Care 2(2014), 1 vom: 01. Apr. volume:2 year:2014 number:1 day:01 month:04
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pulmonary edema Extravascular lung water Multivariate regression analysis Global end-diastolic volume Acute lung injury Acute respiratory distress syndrome
isfreeaccess_bool	true
container_title	Journal of Intensive Care
authorswithroles_txt_mv	Kaneko, Tadashi @@aut@@ Kawamura, Yoshikatsu @@aut@@ Maekawa, Tsuyoshi @@aut@@ Tagami, Takashi @@aut@@ Nakamura, Toshiaki @@aut@@ Saito, Nobuyuki @@aut@@ Kitazawa, Yasuhide @@aut@@ Ishikura, Hiroyasu @@aut@@ Sugita, Manabu @@aut@@ Okuchi, Kazuo @@aut@@ Rinka, Hiroshi @@aut@@ Watanabe, Akihiro @@aut@@ Kase, Yoichi @@aut@@ Kushimoto, Shigeki @@aut@@ Izumino, Hiroo @@aut@@ Kanemura, Takashi @@aut@@ Yoshikawa, Kazuhide @@aut@@ Takahashi, Hiroyuki @@aut@@ Irahara, Takayuki @@aut@@ Sakamoto, Teruo @@aut@@ Kuroki, Yuichi @@aut@@ Taira, Yasuhiko @@aut@@ Seo, Ryutarou @@aut@@ Yamaguchi, Junko @@aut@@ Takatori, Makoto @@aut@@
publishDateDaySort_date	2014-04-01T00:00:00Z
hierarchy_top_id	771390440
id	SPR036659347
language_de	englisch
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Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. 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author	Kaneko, Tadashi
spellingShingle	Kaneko, Tadashi misc Pulmonary edema misc Extravascular lung water misc Multivariate regression analysis misc Global end-diastolic volume misc Acute lung injury misc Acute respiratory distress syndrome Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study
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topic_title	Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study Pulmonary edema (dpeaa)DE-He213 Extravascular lung water (dpeaa)DE-He213 Multivariate regression analysis (dpeaa)DE-He213 Global end-diastolic volume (dpeaa)DE-He213 Acute lung injury (dpeaa)DE-He213 Acute respiratory distress syndrome (dpeaa)DE-He213
topic	misc Pulmonary edema misc Extravascular lung water misc Multivariate regression analysis misc Global end-diastolic volume misc Acute lung injury misc Acute respiratory distress syndrome
topic_unstemmed	misc Pulmonary edema misc Extravascular lung water misc Multivariate regression analysis misc Global end-diastolic volume misc Acute lung injury misc Acute respiratory distress syndrome
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title	Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study
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title_full	Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study
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author_browse	Kaneko, Tadashi Kawamura, Yoshikatsu Maekawa, Tsuyoshi Tagami, Takashi Nakamura, Toshiaki Saito, Nobuyuki Kitazawa, Yasuhide Ishikura, Hiroyasu Sugita, Manabu Okuchi, Kazuo Rinka, Hiroshi Watanabe, Akihiro Kase, Yoichi Kushimoto, Shigeki Izumino, Hiroo Kanemura, Takashi Yoshikawa, Kazuhide Takahashi, Hiroyuki Irahara, Takayuki Sakamoto, Teruo Kuroki, Yuichi Taira, Yasuhiko Seo, Ryutarou Yamaguchi, Junko Takatori, Makoto
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title_sort	global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study
title_auth	Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study
abstract	Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. Trial registration University Hospital Medical Information Network (UMIN) Clinical Trials Registry UMIN000003627. © Kaneko et al.; licensee BioMed Central Ltd. 2014
abstractGer	Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. Trial registration University Hospital Medical Information Network (UMIN) Clinical Trials Registry UMIN000003627. © Kaneko et al.; licensee BioMed Central Ltd. 2014
abstract_unstemmed	Background Extravascular lung water (EVLW), as measured by the thermodilution method, reflects the extent of pulmonary edema. Currently, there are no clinically effective treatments for preventing increases in pulmonary vascular permeability, a hallmark of lung pathophysiology, in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this study, we examined the contributions of hemodynamic and osmolarity factors, for which appropriate interventions are expected in critical care, to EVLW in patients with ALI/ARDS. Methods We performed a subgroup analysis of a multicenter observational study of patients with acute pulmonary edema. Overall, 207 patients with ALI/ARDS were enrolled in the study. Multivariate regression analysis was used to evaluate the associations of hemodynamic and serum osmolarity parameters with the EVLW index (EVLWI; calculated as EVLW/Ideal body weight). We analyzed factors measured on the day of enrollment (day 0), and on days 1 and 2 after enrollment. Results Multivariate regression analysis showed that global end-diastolic volume index (GEDVI) was significantly associated with EVLWI measured on days 0, 1, and 2 (P = 0.002, P < 0.001, and P = 0.003, respectively), whereas other factors were not significantly associated with EVLWI measured on all 3 days. Conclusions Among several hemodynamic and serum osmolarity factors that could be targets for appropriate intervention, GEDVI appears to be a key contributor to EVLWI in patients with ALI/ARDS. Trial registration University Hospital Medical Information Network (UMIN) Clinical Trials Registry UMIN000003627. © Kaneko et al.; licensee BioMed Central Ltd. 2014
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title_short	Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study
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author2	Kawamura, Yoshikatsu Maekawa, Tsuyoshi Tagami, Takashi Nakamura, Toshiaki Saito, Nobuyuki Kitazawa, Yasuhide Ishikura, Hiroyasu Sugita, Manabu Okuchi, Kazuo Rinka, Hiroshi Watanabe, Akihiro Kase, Yoichi Kushimoto, Shigeki Izumino, Hiroo Kanemura, Takashi Yoshikawa, Kazuhide Takahashi, Hiroyuki Irahara, Takayuki Sakamoto, Teruo Kuroki, Yuichi Taira, Yasuhiko Seo, Ryutarou Yamaguchi, Junko Takatori, Makoto
author2Str	Kawamura, Yoshikatsu Maekawa, Tsuyoshi Tagami, Takashi Nakamura, Toshiaki Saito, Nobuyuki Kitazawa, Yasuhide Ishikura, Hiroyasu Sugita, Manabu Okuchi, Kazuo Rinka, Hiroshi Watanabe, Akihiro Kase, Yoichi Kushimoto, Shigeki Izumino, Hiroo Kanemura, Takashi Yoshikawa, Kazuhide Takahashi, Hiroyuki Irahara, Takayuki Sakamoto, Teruo Kuroki, Yuichi Taira, Yasuhiko Seo, Ryutarou Yamaguchi, Junko Takatori, Makoto
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Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study

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