PAMPs and DAMPs as triggers for DIC

Abstract Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thromb...
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Gespeichert in:

Autor*in:	Ito, Takashi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Immunothrombosis Pathogen-associated molecular patterns (PAMPs) Damage-associated molecular patterns (DAMPs) Tissue factor Neutrophil extracellular traps (NETs) Disseminated intravascular coagulation (DIC)

Anmerkung:	© Ito; licensee BioMed Central. 2014

Übergeordnetes Werk:	Enthalten in: Journal of Intensive Care - London : BioMed Central, 2013, 2(2014), 1 vom: 31. Dez.
Übergeordnetes Werk:	volume:2 ; year:2014 ; number:1 ; day:31 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s40560-014-0065-0

Katalog-ID:	SPR03665969X

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allfields	10.1186/s40560-014-0065-0 doi (DE-627)SPR03665969X (SPR)s40560-014-0065-0-e DE-627 ger DE-627 rakwb eng Ito, Takashi verfasserin aut PAMPs and DAMPs as triggers for DIC 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ito; licensee BioMed Central. 2014 Abstract Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis. Activated monocytes and neutrophils are two major inducers of immunothrombosis. Monocytes and neutrophils are activated when they detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Detection of PAMPs and DAMPs triggers tissue factor expression on monocytes and neutrophil extracellular trap (NET) release by neutrophils, promoting immunothrombosis. Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. Immunothrombosis (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Damage-associated molecular patterns (DAMPs) (dpeaa)DE-He213 Tissue factor (dpeaa)DE-He213 Neutrophil extracellular traps (NETs) (dpeaa)DE-He213 Disseminated intravascular coagulation (DIC) (dpeaa)DE-He213 Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 31. Dez. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:31 month:12 https://dx.doi.org/10.1186/s40560-014-0065-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 31 12
spelling	10.1186/s40560-014-0065-0 doi (DE-627)SPR03665969X (SPR)s40560-014-0065-0-e DE-627 ger DE-627 rakwb eng Ito, Takashi verfasserin aut PAMPs and DAMPs as triggers for DIC 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ito; licensee BioMed Central. 2014 Abstract Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis. Activated monocytes and neutrophils are two major inducers of immunothrombosis. Monocytes and neutrophils are activated when they detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Detection of PAMPs and DAMPs triggers tissue factor expression on monocytes and neutrophil extracellular trap (NET) release by neutrophils, promoting immunothrombosis. Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. Immunothrombosis (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Damage-associated molecular patterns (DAMPs) (dpeaa)DE-He213 Tissue factor (dpeaa)DE-He213 Neutrophil extracellular traps (NETs) (dpeaa)DE-He213 Disseminated intravascular coagulation (DIC) (dpeaa)DE-He213 Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 31. Dez. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:31 month:12 https://dx.doi.org/10.1186/s40560-014-0065-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 31 12
allfields_unstemmed	10.1186/s40560-014-0065-0 doi (DE-627)SPR03665969X (SPR)s40560-014-0065-0-e DE-627 ger DE-627 rakwb eng Ito, Takashi verfasserin aut PAMPs and DAMPs as triggers for DIC 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ito; licensee BioMed Central. 2014 Abstract Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis. Activated monocytes and neutrophils are two major inducers of immunothrombosis. Monocytes and neutrophils are activated when they detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Detection of PAMPs and DAMPs triggers tissue factor expression on monocytes and neutrophil extracellular trap (NET) release by neutrophils, promoting immunothrombosis. Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. Immunothrombosis (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Damage-associated molecular patterns (DAMPs) (dpeaa)DE-He213 Tissue factor (dpeaa)DE-He213 Neutrophil extracellular traps (NETs) (dpeaa)DE-He213 Disseminated intravascular coagulation (DIC) (dpeaa)DE-He213 Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 31. Dez. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:31 month:12 https://dx.doi.org/10.1186/s40560-014-0065-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 31 12
allfieldsGer	10.1186/s40560-014-0065-0 doi (DE-627)SPR03665969X (SPR)s40560-014-0065-0-e DE-627 ger DE-627 rakwb eng Ito, Takashi verfasserin aut PAMPs and DAMPs as triggers for DIC 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ito; licensee BioMed Central. 2014 Abstract Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis. Activated monocytes and neutrophils are two major inducers of immunothrombosis. Monocytes and neutrophils are activated when they detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Detection of PAMPs and DAMPs triggers tissue factor expression on monocytes and neutrophil extracellular trap (NET) release by neutrophils, promoting immunothrombosis. Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. Immunothrombosis (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Damage-associated molecular patterns (DAMPs) (dpeaa)DE-He213 Tissue factor (dpeaa)DE-He213 Neutrophil extracellular traps (NETs) (dpeaa)DE-He213 Disseminated intravascular coagulation (DIC) (dpeaa)DE-He213 Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 31. Dez. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:31 month:12 https://dx.doi.org/10.1186/s40560-014-0065-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 31 12
allfieldsSound	10.1186/s40560-014-0065-0 doi (DE-627)SPR03665969X (SPR)s40560-014-0065-0-e DE-627 ger DE-627 rakwb eng Ito, Takashi verfasserin aut PAMPs and DAMPs as triggers for DIC 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ito; licensee BioMed Central. 2014 Abstract Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis. Activated monocytes and neutrophils are two major inducers of immunothrombosis. Monocytes and neutrophils are activated when they detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Detection of PAMPs and DAMPs triggers tissue factor expression on monocytes and neutrophil extracellular trap (NET) release by neutrophils, promoting immunothrombosis. Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. Immunothrombosis (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Damage-associated molecular patterns (DAMPs) (dpeaa)DE-He213 Tissue factor (dpeaa)DE-He213 Neutrophil extracellular traps (NETs) (dpeaa)DE-He213 Disseminated intravascular coagulation (DIC) (dpeaa)DE-He213 Enthalten in Journal of Intensive Care London : BioMed Central, 2013 2(2014), 1 vom: 31. Dez. (DE-627)771390440 (DE-600)2739853-5 2052-0492 nnns volume:2 year:2014 number:1 day:31 month:12 https://dx.doi.org/10.1186/s40560-014-0065-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2014 1 31 12
language	English
source	Enthalten in Journal of Intensive Care 2(2014), 1 vom: 31. Dez. volume:2 year:2014 number:1 day:31 month:12
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topic_facet	Immunothrombosis Pathogen-associated molecular patterns (PAMPs) Damage-associated molecular patterns (DAMPs) Tissue factor Neutrophil extracellular traps (NETs) Disseminated intravascular coagulation (DIC)
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author	Ito, Takashi
spellingShingle	Ito, Takashi misc Immunothrombosis misc Pathogen-associated molecular patterns (PAMPs) misc Damage-associated molecular patterns (DAMPs) misc Tissue factor misc Neutrophil extracellular traps (NETs) misc Disseminated intravascular coagulation (DIC) PAMPs and DAMPs as triggers for DIC
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topic_title	PAMPs and DAMPs as triggers for DIC Immunothrombosis (dpeaa)DE-He213 Pathogen-associated molecular patterns (PAMPs) (dpeaa)DE-He213 Damage-associated molecular patterns (DAMPs) (dpeaa)DE-He213 Tissue factor (dpeaa)DE-He213 Neutrophil extracellular traps (NETs) (dpeaa)DE-He213 Disseminated intravascular coagulation (DIC) (dpeaa)DE-He213
topic	misc Immunothrombosis misc Pathogen-associated molecular patterns (PAMPs) misc Damage-associated molecular patterns (DAMPs) misc Tissue factor misc Neutrophil extracellular traps (NETs) misc Disseminated intravascular coagulation (DIC)
topic_unstemmed	misc Immunothrombosis misc Pathogen-associated molecular patterns (PAMPs) misc Damage-associated molecular patterns (DAMPs) misc Tissue factor misc Neutrophil extracellular traps (NETs) misc Disseminated intravascular coagulation (DIC)
topic_browse	misc Immunothrombosis misc Pathogen-associated molecular patterns (PAMPs) misc Damage-associated molecular patterns (DAMPs) misc Tissue factor misc Neutrophil extracellular traps (NETs) misc Disseminated intravascular coagulation (DIC)
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title	PAMPs and DAMPs as triggers for DIC
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title_full	PAMPs and DAMPs as triggers for DIC
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title_sort	pamps and damps as triggers for dic
title_auth	PAMPs and DAMPs as triggers for DIC
abstract	Abstract Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis. Activated monocytes and neutrophils are two major inducers of immunothrombosis. Monocytes and neutrophils are activated when they detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Detection of PAMPs and DAMPs triggers tissue factor expression on monocytes and neutrophil extracellular trap (NET) release by neutrophils, promoting immunothrombosis. Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. © Ito; licensee BioMed Central. 2014
abstractGer	Abstract Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis. Activated monocytes and neutrophils are two major inducers of immunothrombosis. Monocytes and neutrophils are activated when they detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Detection of PAMPs and DAMPs triggers tissue factor expression on monocytes and neutrophil extracellular trap (NET) release by neutrophils, promoting immunothrombosis. Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. © Ito; licensee BioMed Central. 2014
abstract_unstemmed	Abstract Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis. Activated monocytes and neutrophils are two major inducers of immunothrombosis. Monocytes and neutrophils are activated when they detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Detection of PAMPs and DAMPs triggers tissue factor expression on monocytes and neutrophil extracellular trap (NET) release by neutrophils, promoting immunothrombosis. Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. © Ito; licensee BioMed Central. 2014
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title_short	PAMPs and DAMPs as triggers for DIC
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up_date	2024-07-03T18:56:42.590Z
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