Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children
Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ghigo, E. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1989 |
|---|
| Anmerkung: |
© Italian Society of Endocrinology (SIE) 1989 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Journal of endocrinological investigation - [S. l.] : Springer, 1978, 12(1989), 2 vom: Feb., Seite 99-101 |
|---|---|
| Übergeordnetes Werk: |
volume:12 ; year:1989 ; number:2 ; month:02 ; pages:99-101 |
| Links: |
|---|
| DOI / URN: |
10.1007/BF03349930 |
|---|
| Katalog-ID: |
SPR036799246 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR036799246 | ||
| 003 | DE-627 | ||
| 005 | 20230519192435.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201007s1989 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/BF03349930 |2 doi | |
| 035 | |a (DE-627)SPR036799246 | ||
| 035 | |a (SPR)BF03349930-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ghigo, E. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children |
| 264 | 1 | |c 1989 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © Italian Society of Endocrinology (SIE) 1989 | ||
| 520 | |a Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature. | ||
| 700 | 1 | |a Goffi, S. |4 aut | |
| 700 | 1 | |a Mazza, E. |4 aut | |
| 700 | 1 | |a Imperiale, E. |4 aut | |
| 700 | 1 | |a Arvat, E. |4 aut | |
| 700 | 1 | |a Bellone, J. |4 aut | |
| 700 | 1 | |a Procopio, M. |4 aut | |
| 700 | 1 | |a Müller, E. E. |4 aut | |
| 700 | 1 | |a Camanni, F. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of endocrinological investigation |d [S. l.] : Springer, 1978 |g 12(1989), 2 vom: Feb., Seite 99-101 |w (DE-627)369556267 |w (DE-600)2119482-8 |x 1720-8386 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:1989 |g number:2 |g month:02 |g pages:99-101 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/BF03349930 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a GBV_ILN_702 | ||
| 912 | |a GBV_ILN_2190 | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 1989 |e 2 |c 02 |h 99-101 | ||
| author_variant |
e g eg s g sg e m em e i ei e a ea j b jb m p mp e e m ee eem f c fc |
|---|---|
| matchkey_str |
article:17208386:1989----::ctamnsrtooprdsimnadlndnhsndiietmltrefco |
| hierarchy_sort_str |
1989 |
| publishDate |
1989 |
| allfields |
10.1007/BF03349930 doi (DE-627)SPR036799246 (SPR)BF03349930-e DE-627 ger DE-627 rakwb eng Ghigo, E. verfasserin aut Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children 1989 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1989 Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature. Goffi, S. aut Mazza, E. aut Imperiale, E. aut Arvat, E. aut Bellone, J. aut Procopio, M. aut Müller, E. E. aut Camanni, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 12(1989), 2 vom: Feb., Seite 99-101 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:12 year:1989 number:2 month:02 pages:99-101 https://dx.doi.org/10.1007/BF03349930 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 12 1989 2 02 99-101 |
| spelling |
10.1007/BF03349930 doi (DE-627)SPR036799246 (SPR)BF03349930-e DE-627 ger DE-627 rakwb eng Ghigo, E. verfasserin aut Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children 1989 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1989 Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature. Goffi, S. aut Mazza, E. aut Imperiale, E. aut Arvat, E. aut Bellone, J. aut Procopio, M. aut Müller, E. E. aut Camanni, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 12(1989), 2 vom: Feb., Seite 99-101 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:12 year:1989 number:2 month:02 pages:99-101 https://dx.doi.org/10.1007/BF03349930 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 12 1989 2 02 99-101 |
| allfields_unstemmed |
10.1007/BF03349930 doi (DE-627)SPR036799246 (SPR)BF03349930-e DE-627 ger DE-627 rakwb eng Ghigo, E. verfasserin aut Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children 1989 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1989 Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature. Goffi, S. aut Mazza, E. aut Imperiale, E. aut Arvat, E. aut Bellone, J. aut Procopio, M. aut Müller, E. E. aut Camanni, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 12(1989), 2 vom: Feb., Seite 99-101 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:12 year:1989 number:2 month:02 pages:99-101 https://dx.doi.org/10.1007/BF03349930 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 12 1989 2 02 99-101 |
| allfieldsGer |
10.1007/BF03349930 doi (DE-627)SPR036799246 (SPR)BF03349930-e DE-627 ger DE-627 rakwb eng Ghigo, E. verfasserin aut Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children 1989 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1989 Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature. Goffi, S. aut Mazza, E. aut Imperiale, E. aut Arvat, E. aut Bellone, J. aut Procopio, M. aut Müller, E. E. aut Camanni, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 12(1989), 2 vom: Feb., Seite 99-101 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:12 year:1989 number:2 month:02 pages:99-101 https://dx.doi.org/10.1007/BF03349930 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 12 1989 2 02 99-101 |
| allfieldsSound |
10.1007/BF03349930 doi (DE-627)SPR036799246 (SPR)BF03349930-e DE-627 ger DE-627 rakwb eng Ghigo, E. verfasserin aut Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children 1989 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1989 Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature. Goffi, S. aut Mazza, E. aut Imperiale, E. aut Arvat, E. aut Bellone, J. aut Procopio, M. aut Müller, E. E. aut Camanni, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 12(1989), 2 vom: Feb., Seite 99-101 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:12 year:1989 number:2 month:02 pages:99-101 https://dx.doi.org/10.1007/BF03349930 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 12 1989 2 02 99-101 |
| language |
English |
| source |
Enthalten in Journal of endocrinological investigation 12(1989), 2 vom: Feb., Seite 99-101 volume:12 year:1989 number:2 month:02 pages:99-101 |
| sourceStr |
Enthalten in Journal of endocrinological investigation 12(1989), 2 vom: Feb., Seite 99-101 volume:12 year:1989 number:2 month:02 pages:99-101 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Journal of endocrinological investigation |
| authorswithroles_txt_mv |
Ghigo, E. @@aut@@ Goffi, S. @@aut@@ Mazza, E. @@aut@@ Imperiale, E. @@aut@@ Arvat, E. @@aut@@ Bellone, J. @@aut@@ Procopio, M. @@aut@@ Müller, E. E. @@aut@@ Camanni, F. @@aut@@ |
| publishDateDaySort_date |
1989-02-01T00:00:00Z |
| hierarchy_top_id |
369556267 |
| id |
SPR036799246 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR036799246</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519192435.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s1989 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/BF03349930</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR036799246</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)BF03349930-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ghigo, E.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1989</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Italian Society of Endocrinology (SIE) 1989</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goffi, S.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mazza, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Imperiale, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Arvat, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bellone, J.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Procopio, M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Müller, E. E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Camanni, F.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of endocrinological investigation</subfield><subfield code="d">[S. l.] : Springer, 1978</subfield><subfield code="g">12(1989), 2 vom: Feb., Seite 99-101</subfield><subfield code="w">(DE-627)369556267</subfield><subfield code="w">(DE-600)2119482-8</subfield><subfield code="x">1720-8386</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:1989</subfield><subfield code="g">number:2</subfield><subfield code="g">month:02</subfield><subfield code="g">pages:99-101</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/BF03349930</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">1989</subfield><subfield code="e">2</subfield><subfield code="c">02</subfield><subfield code="h">99-101</subfield></datafield></record></collection>
|
| author |
Ghigo, E. |
| spellingShingle |
Ghigo, E. Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children |
| authorStr |
Ghigo, E. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)369556267 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1720-8386 |
| topic_title |
Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Journal of endocrinological investigation |
| hierarchy_parent_id |
369556267 |
| hierarchy_top_title |
Journal of endocrinological investigation |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)369556267 (DE-600)2119482-8 |
| title |
Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children |
| ctrlnum |
(DE-627)SPR036799246 (SPR)BF03349930-e |
| title_full |
Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children |
| author_sort |
Ghigo, E. |
| journal |
Journal of endocrinological investigation |
| journalStr |
Journal of endocrinological investigation |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1989 |
| contenttype_str_mv |
txt |
| container_start_page |
99 |
| author_browse |
Ghigo, E. Goffi, S. Mazza, E. Imperiale, E. Arvat, E. Bellone, J. Procopio, M. Müller, E. E. Camanni, F. |
| container_volume |
12 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Ghigo, E. |
| doi_str_mv |
10.1007/BF03349930 |
| title_sort |
acute administration of pyridostigmine and clonidine has an additive stimulatory effect on gh release in normal children |
| title_auth |
Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children |
| abstract |
Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature. © Italian Society of Endocrinology (SIE) 1989 |
| abstractGer |
Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature. © Italian Society of Endocrinology (SIE) 1989 |
| abstract_unstemmed |
Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature. © Italian Society of Endocrinology (SIE) 1989 |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 |
| container_issue |
2 |
| title_short |
Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children |
| url |
https://dx.doi.org/10.1007/BF03349930 |
| remote_bool |
true |
| author2 |
Goffi, S. Mazza, E. Imperiale, E. Arvat, E. Bellone, J. Procopio, M. Müller, E. E. Camanni, F. |
| author2Str |
Goffi, S. Mazza, E. Imperiale, E. Arvat, E. Bellone, J. Procopio, M. Müller, E. E. Camanni, F. |
| ppnlink |
369556267 |
| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/BF03349930 |
| up_date |
2024-07-03T19:40:15.371Z |
| _version_ |
1803588065429553152 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR036799246</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519192435.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s1989 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/BF03349930</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR036799246</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)BF03349930-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ghigo, E.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Acute administration of pyridostigmine and clonidine has an additive stimulatory effect on GH release in normal children</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1989</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Italian Society of Endocrinology (SIE) 1989</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract It has been shown in humans that both alpha2-adrenoceptor activation by clonidine (CLON) and cholinergic enhancement by pyridostigmine (PD) have a clear-cut stimulatory effect on GH release. As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 μg/$ m^{2} $) and PD (60 mg). When administered alone, CLON and PD induced a similar GH increase (peak, mean ±SE: 14.6 ± 2.4 vs 14.2 ± 3.1 ng/ml; area under curve, AUC: 376.9 ± 57.6 vs 390.0 ± 74.3 ng/ml/h). Combined administration of CLON and PD had an additive effect on GH release (peak: 27.5 ± 4.5 ng/ml; AUC: 920.8 ± 153.3 ng/ml/h; p < 0.005 vs CLON and PD alone). In conclusion, presented data show that: i) CLON and PD have similar GH-releasing effect in normal children; ii) The additive stimulatory effect on GH release exerted by acute combined administration of CLON and PD agrees with the hypothesized different mechanism of action of these two drugs; iii) A therapeutic association of CLON and PD may be envisaged in the treatment of some children of short stature.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goffi, S.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mazza, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Imperiale, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Arvat, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bellone, J.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Procopio, M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Müller, E. E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Camanni, F.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of endocrinological investigation</subfield><subfield code="d">[S. l.] : Springer, 1978</subfield><subfield code="g">12(1989), 2 vom: Feb., Seite 99-101</subfield><subfield code="w">(DE-627)369556267</subfield><subfield code="w">(DE-600)2119482-8</subfield><subfield code="x">1720-8386</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:1989</subfield><subfield code="g">number:2</subfield><subfield code="g">month:02</subfield><subfield code="g">pages:99-101</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/BF03349930</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">1989</subfield><subfield code="e">2</subfield><subfield code="c">02</subfield><subfield code="h">99-101</subfield></datafield></record></collection>
|
| score |
7.3993607 |