Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy
Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Genazzani, A. D. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1990 |
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| Schlagwörter: |
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| Anmerkung: |
© Italian Society of Endocrinology (SIE) 1990 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of endocrinological investigation - [S. l.] : Springer, 1978, 13(1990), 10 vom: Nov., Seite 777-786 |
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| Übergeordnetes Werk: |
volume:13 ; year:1990 ; number:10 ; month:11 ; pages:777-786 |
| Links: |
|---|
| DOI / URN: |
10.1007/BF03349621 |
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SPR036801402 |
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| 100 | 1 | |a Genazzani, A. D. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy |
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| 520 | |a Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. ISR computation also showed that the duration of the secretory events of the gonadotropes is significantly shorter (p < 0.01) than the one estimated on plasma concen-tration, both in normal subjects and in agonadal patients before and during testosterone administration. In conclusion: LH pulse frequency observed in basal conditions in agonadal men was much higher than previously reported in primary testicular failure; during conventional testosterone replacement therapy LH pulse frequency of agonadal men was significantly reduced but still higher (p < 0.01) than in normal men. This finding is probably related to the subnormal plasma levels of testosterone found in agonadal men during the replacement therapy; the analysis of data using a sampling interval of 10 min gave results similar to previous reports, confirming that the choice of sampling interval can markedly affect the evaluation of frequent LH pulsatile secretion. | ||
| 650 | 4 | |a Testosterone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Luteinizing Hormone |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Forti, G. |4 aut | |
| 700 | 1 | |a Maggi, M. |4 aut | |
| 700 | 1 | |a Milloni, M. |4 aut | |
| 700 | 1 | |a Cianfanelli, F. |4 aut | |
| 700 | 1 | |a Guardabasso, V. |4 aut | |
| 700 | 1 | |a Toscano, V. |4 aut | |
| 700 | 1 | |a Serio, M. |4 aut | |
| 700 | 1 | |a Rodbard, D. |4 aut | |
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10.1007/BF03349621 doi (DE-627)SPR036801402 (SPR)BF03349621-e DE-627 ger DE-627 rakwb eng Genazzani, A. D. verfasserin aut Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. ISR computation also showed that the duration of the secretory events of the gonadotropes is significantly shorter (p < 0.01) than the one estimated on plasma concen-tration, both in normal subjects and in agonadal patients before and during testosterone administration. In conclusion: LH pulse frequency observed in basal conditions in agonadal men was much higher than previously reported in primary testicular failure; during conventional testosterone replacement therapy LH pulse frequency of agonadal men was significantly reduced but still higher (p < 0.01) than in normal men. This finding is probably related to the subnormal plasma levels of testosterone found in agonadal men during the replacement therapy; the analysis of data using a sampling interval of 10 min gave results similar to previous reports, confirming that the choice of sampling interval can markedly affect the evaluation of frequent LH pulsatile secretion. Testosterone (dpeaa)DE-He213 Luteinizing Hormone (dpeaa)DE-He213 Luteinizing Hormone Level (dpeaa)DE-He213 Testosterone Replacement Therapy (dpeaa)DE-He213 Serum Luteinizing Hormone (dpeaa)DE-He213 Forti, G. aut Maggi, M. aut Milloni, M. aut Cianfanelli, F. aut Guardabasso, V. aut Toscano, V. aut Serio, M. aut Rodbard, D. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 10 vom: Nov., Seite 777-786 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:10 month:11 pages:777-786 https://dx.doi.org/10.1007/BF03349621 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 10 11 777-786 |
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10.1007/BF03349621 doi (DE-627)SPR036801402 (SPR)BF03349621-e DE-627 ger DE-627 rakwb eng Genazzani, A. D. verfasserin aut Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. ISR computation also showed that the duration of the secretory events of the gonadotropes is significantly shorter (p < 0.01) than the one estimated on plasma concen-tration, both in normal subjects and in agonadal patients before and during testosterone administration. In conclusion: LH pulse frequency observed in basal conditions in agonadal men was much higher than previously reported in primary testicular failure; during conventional testosterone replacement therapy LH pulse frequency of agonadal men was significantly reduced but still higher (p < 0.01) than in normal men. This finding is probably related to the subnormal plasma levels of testosterone found in agonadal men during the replacement therapy; the analysis of data using a sampling interval of 10 min gave results similar to previous reports, confirming that the choice of sampling interval can markedly affect the evaluation of frequent LH pulsatile secretion. Testosterone (dpeaa)DE-He213 Luteinizing Hormone (dpeaa)DE-He213 Luteinizing Hormone Level (dpeaa)DE-He213 Testosterone Replacement Therapy (dpeaa)DE-He213 Serum Luteinizing Hormone (dpeaa)DE-He213 Forti, G. aut Maggi, M. aut Milloni, M. aut Cianfanelli, F. aut Guardabasso, V. aut Toscano, V. aut Serio, M. aut Rodbard, D. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 10 vom: Nov., Seite 777-786 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:10 month:11 pages:777-786 https://dx.doi.org/10.1007/BF03349621 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 10 11 777-786 |
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10.1007/BF03349621 doi (DE-627)SPR036801402 (SPR)BF03349621-e DE-627 ger DE-627 rakwb eng Genazzani, A. D. verfasserin aut Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. ISR computation also showed that the duration of the secretory events of the gonadotropes is significantly shorter (p < 0.01) than the one estimated on plasma concen-tration, both in normal subjects and in agonadal patients before and during testosterone administration. In conclusion: LH pulse frequency observed in basal conditions in agonadal men was much higher than previously reported in primary testicular failure; during conventional testosterone replacement therapy LH pulse frequency of agonadal men was significantly reduced but still higher (p < 0.01) than in normal men. This finding is probably related to the subnormal plasma levels of testosterone found in agonadal men during the replacement therapy; the analysis of data using a sampling interval of 10 min gave results similar to previous reports, confirming that the choice of sampling interval can markedly affect the evaluation of frequent LH pulsatile secretion. Testosterone (dpeaa)DE-He213 Luteinizing Hormone (dpeaa)DE-He213 Luteinizing Hormone Level (dpeaa)DE-He213 Testosterone Replacement Therapy (dpeaa)DE-He213 Serum Luteinizing Hormone (dpeaa)DE-He213 Forti, G. aut Maggi, M. aut Milloni, M. aut Cianfanelli, F. aut Guardabasso, V. aut Toscano, V. aut Serio, M. aut Rodbard, D. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 10 vom: Nov., Seite 777-786 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:10 month:11 pages:777-786 https://dx.doi.org/10.1007/BF03349621 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 10 11 777-786 |
| allfieldsGer |
10.1007/BF03349621 doi (DE-627)SPR036801402 (SPR)BF03349621-e DE-627 ger DE-627 rakwb eng Genazzani, A. D. verfasserin aut Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. ISR computation also showed that the duration of the secretory events of the gonadotropes is significantly shorter (p < 0.01) than the one estimated on plasma concen-tration, both in normal subjects and in agonadal patients before and during testosterone administration. In conclusion: LH pulse frequency observed in basal conditions in agonadal men was much higher than previously reported in primary testicular failure; during conventional testosterone replacement therapy LH pulse frequency of agonadal men was significantly reduced but still higher (p < 0.01) than in normal men. This finding is probably related to the subnormal plasma levels of testosterone found in agonadal men during the replacement therapy; the analysis of data using a sampling interval of 10 min gave results similar to previous reports, confirming that the choice of sampling interval can markedly affect the evaluation of frequent LH pulsatile secretion. Testosterone (dpeaa)DE-He213 Luteinizing Hormone (dpeaa)DE-He213 Luteinizing Hormone Level (dpeaa)DE-He213 Testosterone Replacement Therapy (dpeaa)DE-He213 Serum Luteinizing Hormone (dpeaa)DE-He213 Forti, G. aut Maggi, M. aut Milloni, M. aut Cianfanelli, F. aut Guardabasso, V. aut Toscano, V. aut Serio, M. aut Rodbard, D. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 10 vom: Nov., Seite 777-786 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:10 month:11 pages:777-786 https://dx.doi.org/10.1007/BF03349621 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 10 11 777-786 |
| allfieldsSound |
10.1007/BF03349621 doi (DE-627)SPR036801402 (SPR)BF03349621-e DE-627 ger DE-627 rakwb eng Genazzani, A. D. verfasserin aut Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. ISR computation also showed that the duration of the secretory events of the gonadotropes is significantly shorter (p < 0.01) than the one estimated on plasma concen-tration, both in normal subjects and in agonadal patients before and during testosterone administration. In conclusion: LH pulse frequency observed in basal conditions in agonadal men was much higher than previously reported in primary testicular failure; during conventional testosterone replacement therapy LH pulse frequency of agonadal men was significantly reduced but still higher (p < 0.01) than in normal men. This finding is probably related to the subnormal plasma levels of testosterone found in agonadal men during the replacement therapy; the analysis of data using a sampling interval of 10 min gave results similar to previous reports, confirming that the choice of sampling interval can markedly affect the evaluation of frequent LH pulsatile secretion. Testosterone (dpeaa)DE-He213 Luteinizing Hormone (dpeaa)DE-He213 Luteinizing Hormone Level (dpeaa)DE-He213 Testosterone Replacement Therapy (dpeaa)DE-He213 Serum Luteinizing Hormone (dpeaa)DE-He213 Forti, G. aut Maggi, M. aut Milloni, M. aut Cianfanelli, F. aut Guardabasso, V. aut Toscano, V. aut Serio, M. aut Rodbard, D. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 10 vom: Nov., Seite 777-786 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:10 month:11 pages:777-786 https://dx.doi.org/10.1007/BF03349621 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 10 11 777-786 |
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D.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1990</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Italian Society of Endocrinology (SIE) 1990</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. 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Genazzani, A. D. misc Testosterone misc Luteinizing Hormone misc Luteinizing Hormone Level misc Testosterone Replacement Therapy misc Serum Luteinizing Hormone Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy |
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Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy Testosterone (dpeaa)DE-He213 Luteinizing Hormone (dpeaa)DE-He213 Luteinizing Hormone Level (dpeaa)DE-He213 Testosterone Replacement Therapy (dpeaa)DE-He213 Serum Luteinizing Hormone (dpeaa)DE-He213 |
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pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy |
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Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy |
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Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. ISR computation also showed that the duration of the secretory events of the gonadotropes is significantly shorter (p < 0.01) than the one estimated on plasma concen-tration, both in normal subjects and in agonadal patients before and during testosterone administration. In conclusion: LH pulse frequency observed in basal conditions in agonadal men was much higher than previously reported in primary testicular failure; during conventional testosterone replacement therapy LH pulse frequency of agonadal men was significantly reduced but still higher (p < 0.01) than in normal men. This finding is probably related to the subnormal plasma levels of testosterone found in agonadal men during the replacement therapy; the analysis of data using a sampling interval of 10 min gave results similar to previous reports, confirming that the choice of sampling interval can markedly affect the evaluation of frequent LH pulsatile secretion. © Italian Society of Endocrinology (SIE) 1990 |
| abstractGer |
Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. ISR computation also showed that the duration of the secretory events of the gonadotropes is significantly shorter (p < 0.01) than the one estimated on plasma concen-tration, both in normal subjects and in agonadal patients before and during testosterone administration. In conclusion: LH pulse frequency observed in basal conditions in agonadal men was much higher than previously reported in primary testicular failure; during conventional testosterone replacement therapy LH pulse frequency of agonadal men was significantly reduced but still higher (p < 0.01) than in normal men. This finding is probably related to the subnormal plasma levels of testosterone found in agonadal men during the replacement therapy; the analysis of data using a sampling interval of 10 min gave results similar to previous reports, confirming that the choice of sampling interval can markedly affect the evaluation of frequent LH pulsatile secretion. © Italian Society of Endocrinology (SIE) 1990 |
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Abstract We have reevaluated the question regarding the pulsatile pattern of LH secretion in agonadal men before and following testosterone replacement therapy. Five normal males were used as a reference group and four agonadal men were studied before and during replacement therapy with testosterone enanthate. All the subjects were sampled every 5 min for 12 h (08:00 to 20:00). Data were analyzed using the statistically based and validated pulse detection program DETECT. The normal subjects showed an LH pulse frequency of 10.2 ± 1.7 peaks/12 h (mean ± SEM) and a mean duration of 48.8 ± 14 min, while in agonadal patients without testosterone replacement the frequency of LH peaks (27.5 ± 2 peaks/12 h) was significantly higher than for normal subjects (p < 0.05), and the mean duration of peaks was lower than in controls (17.2 ± 1.2 min; p < 0.01). Following chronic testosterone enanthate replacement therapy (200 mg im every two weeks) these patients showed an increase in the duration and a significant reduction in the frequency of LH peaks (from 27.5 ± 2 to 18.2 ± 2.1 peaks/12 h; p < 0.01) but pulse frequency remained significantly higher than for normal subjects (p < 0.01). This finding is independent of the choice of p values for false positive detection rate (p = 0.01 or p =0.005), but it does depend on sampling frequency and is influenced by large (four-fold) changes in the thresholds for peak detection. Using a “discrete deconvolution” technique we estimated the instantaneous secretory rate (ISR) for the two groups of patients. The results using ISR corroborated the findings obtained using analysis of observed plasma LH measurements. ISR computation also showed that the duration of the secretory events of the gonadotropes is significantly shorter (p < 0.01) than the one estimated on plasma concen-tration, both in normal subjects and in agonadal patients before and during testosterone administration. In conclusion: LH pulse frequency observed in basal conditions in agonadal men was much higher than previously reported in primary testicular failure; during conventional testosterone replacement therapy LH pulse frequency of agonadal men was significantly reduced but still higher (p < 0.01) than in normal men. This finding is probably related to the subnormal plasma levels of testosterone found in agonadal men during the replacement therapy; the analysis of data using a sampling interval of 10 min gave results similar to previous reports, confirming that the choice of sampling interval can markedly affect the evaluation of frequent LH pulsatile secretion. © Italian Society of Endocrinology (SIE) 1990 |
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