Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats
Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or e...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Genazzani, Andrea R. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1990 |
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| Anmerkung: |
© Italian Society of Endocrinology (SIE) 1990 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of endocrinological investigation - [S. l.] : Springer, 1978, 13(1990), 2 vom: Feb., Seite 91-96 |
|---|---|
| Übergeordnetes Werk: |
volume:13 ; year:1990 ; number:2 ; month:02 ; pages:91-96 |
| Links: |
|---|
| DOI / URN: |
10.1007/BF03349515 |
|---|
| Katalog-ID: |
SPR036801992 |
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| 520 | |a Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrote-stosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The β-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic β-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic β-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of β-EP was not changed by the concomitant administration of an-tiestrogens. The administration of dihydrotes-tosterone significantly decreased β-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased β-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher β-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic β-EP concentrations in female rats, supporting the view that central β-EP might be a target of gonadal steroid feedback signals. | ||
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10.1007/BF03349515 doi (DE-627)SPR036801992 (SPR)BF03349515-e DE-627 ger DE-627 rakwb eng Genazzani, Andrea R. verfasserin aut Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrote-stosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The β-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic β-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic β-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of β-EP was not changed by the concomitant administration of an-tiestrogens. The administration of dihydrotes-tosterone significantly decreased β-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased β-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher β-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic β-EP concentrations in female rats, supporting the view that central β-EP might be a target of gonadal steroid feedback signals. Petraglia, F. aut Mercuri, N. aut Brilli, G. aut Genazzani, A. D. aut Bergamaschi, M. aut DeRamundo, B. M. aut Volpe, A. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 2 vom: Feb., Seite 91-96 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:2 month:02 pages:91-96 https://dx.doi.org/10.1007/BF03349515 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 2 02 91-96 |
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10.1007/BF03349515 doi (DE-627)SPR036801992 (SPR)BF03349515-e DE-627 ger DE-627 rakwb eng Genazzani, Andrea R. verfasserin aut Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrote-stosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The β-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic β-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic β-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of β-EP was not changed by the concomitant administration of an-tiestrogens. The administration of dihydrotes-tosterone significantly decreased β-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased β-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher β-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic β-EP concentrations in female rats, supporting the view that central β-EP might be a target of gonadal steroid feedback signals. Petraglia, F. aut Mercuri, N. aut Brilli, G. aut Genazzani, A. D. aut Bergamaschi, M. aut DeRamundo, B. M. aut Volpe, A. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 2 vom: Feb., Seite 91-96 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:2 month:02 pages:91-96 https://dx.doi.org/10.1007/BF03349515 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 2 02 91-96 |
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10.1007/BF03349515 doi (DE-627)SPR036801992 (SPR)BF03349515-e DE-627 ger DE-627 rakwb eng Genazzani, Andrea R. verfasserin aut Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrote-stosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The β-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic β-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic β-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of β-EP was not changed by the concomitant administration of an-tiestrogens. The administration of dihydrotes-tosterone significantly decreased β-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased β-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher β-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic β-EP concentrations in female rats, supporting the view that central β-EP might be a target of gonadal steroid feedback signals. Petraglia, F. aut Mercuri, N. aut Brilli, G. aut Genazzani, A. D. aut Bergamaschi, M. aut DeRamundo, B. M. aut Volpe, A. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 2 vom: Feb., Seite 91-96 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:2 month:02 pages:91-96 https://dx.doi.org/10.1007/BF03349515 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 2 02 91-96 |
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10.1007/BF03349515 doi (DE-627)SPR036801992 (SPR)BF03349515-e DE-627 ger DE-627 rakwb eng Genazzani, Andrea R. verfasserin aut Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrote-stosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The β-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic β-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic β-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of β-EP was not changed by the concomitant administration of an-tiestrogens. The administration of dihydrotes-tosterone significantly decreased β-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased β-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher β-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic β-EP concentrations in female rats, supporting the view that central β-EP might be a target of gonadal steroid feedback signals. Petraglia, F. aut Mercuri, N. aut Brilli, G. aut Genazzani, A. D. aut Bergamaschi, M. aut DeRamundo, B. M. aut Volpe, A. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 2 vom: Feb., Seite 91-96 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:2 month:02 pages:91-96 https://dx.doi.org/10.1007/BF03349515 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 2 02 91-96 |
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10.1007/BF03349515 doi (DE-627)SPR036801992 (SPR)BF03349515-e DE-627 ger DE-627 rakwb eng Genazzani, Andrea R. verfasserin aut Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats 1990 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1990 Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrote-stosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The β-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic β-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic β-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of β-EP was not changed by the concomitant administration of an-tiestrogens. The administration of dihydrotes-tosterone significantly decreased β-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased β-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher β-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic β-EP concentrations in female rats, supporting the view that central β-EP might be a target of gonadal steroid feedback signals. Petraglia, F. aut Mercuri, N. aut Brilli, G. aut Genazzani, A. D. aut Bergamaschi, M. aut DeRamundo, B. M. aut Volpe, A. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 13(1990), 2 vom: Feb., Seite 91-96 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:13 year:1990 number:2 month:02 pages:91-96 https://dx.doi.org/10.1007/BF03349515 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 13 1990 2 02 91-96 |
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1990 |
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91 |
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Genazzani, Andrea R. Petraglia, F. Mercuri, N. Brilli, G. Genazzani, A. D. Bergamaschi, M. DeRamundo, B. M. Volpe, A. |
| container_volume |
13 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Genazzani, Andrea R. |
| doi_str_mv |
10.1007/BF03349515 |
| title_sort |
effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats |
| title_auth |
Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats |
| abstract |
Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrote-stosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The β-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic β-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic β-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of β-EP was not changed by the concomitant administration of an-tiestrogens. The administration of dihydrotes-tosterone significantly decreased β-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased β-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher β-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic β-EP concentrations in female rats, supporting the view that central β-EP might be a target of gonadal steroid feedback signals. © Italian Society of Endocrinology (SIE) 1990 |
| abstractGer |
Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrote-stosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The β-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic β-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic β-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of β-EP was not changed by the concomitant administration of an-tiestrogens. The administration of dihydrotes-tosterone significantly decreased β-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased β-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher β-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic β-EP concentrations in female rats, supporting the view that central β-EP might be a target of gonadal steroid feedback signals. © Italian Society of Endocrinology (SIE) 1990 |
| abstract_unstemmed |
Abstract The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (β-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or an-tiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrote-stosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The β-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic β-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic β-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of β-EP was not changed by the concomitant administration of an-tiestrogens. The administration of dihydrotes-tosterone significantly decreased β-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased β-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher β-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic β-EP concentrations in female rats, supporting the view that central β-EP might be a target of gonadal steroid feedback signals. © Italian Society of Endocrinology (SIE) 1990 |
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Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats |
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