Oxytocin reduces the activity of N-methyl — D — aspartate receptors in cultured neurons
Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Caruso, S. [verfasserIn] |
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| Sprache: |
Englisch |
| Erschienen: |
1993 |
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| Anmerkung: |
© Italian Society of Endocrinology (SIE) 1993 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of endocrinological investigation - [S. l.] : Springer, 1978, 16(1993), 11 vom: Dez., Seite 921-924 |
|---|---|
| Übergeordnetes Werk: |
volume:16 ; year:1993 ; number:11 ; month:12 ; pages:921-924 |
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| DOI / URN: |
10.1007/BF03348959 |
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| 520 | |a Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (>1 μM) attenuate the stimulation of 45$ Ca^{2+} $ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-β-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory. | ||
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10.1007/BF03348959 doi (DE-627)SPR036810142 (SPR)BF03348959-e DE-627 ger DE-627 rakwb eng Caruso, S. verfasserin aut Oxytocin reduces the activity of N-methyl — D — aspartate receptors in cultured neurons 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1993 Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (>1 μM) attenuate the stimulation of 45$ Ca^{2+} $ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-β-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory. Agnello, C. aut Campo, M. G. aut Nicoletti, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 16(1993), 11 vom: Dez., Seite 921-924 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:16 year:1993 number:11 month:12 pages:921-924 https://dx.doi.org/10.1007/BF03348959 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 16 1993 11 12 921-924 |
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10.1007/BF03348959 doi (DE-627)SPR036810142 (SPR)BF03348959-e DE-627 ger DE-627 rakwb eng Caruso, S. verfasserin aut Oxytocin reduces the activity of N-methyl — D — aspartate receptors in cultured neurons 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1993 Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (>1 μM) attenuate the stimulation of 45$ Ca^{2+} $ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-β-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory. Agnello, C. aut Campo, M. G. aut Nicoletti, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 16(1993), 11 vom: Dez., Seite 921-924 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:16 year:1993 number:11 month:12 pages:921-924 https://dx.doi.org/10.1007/BF03348959 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 16 1993 11 12 921-924 |
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10.1007/BF03348959 doi (DE-627)SPR036810142 (SPR)BF03348959-e DE-627 ger DE-627 rakwb eng Caruso, S. verfasserin aut Oxytocin reduces the activity of N-methyl — D — aspartate receptors in cultured neurons 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1993 Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (>1 μM) attenuate the stimulation of 45$ Ca^{2+} $ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-β-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory. Agnello, C. aut Campo, M. G. aut Nicoletti, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 16(1993), 11 vom: Dez., Seite 921-924 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:16 year:1993 number:11 month:12 pages:921-924 https://dx.doi.org/10.1007/BF03348959 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 16 1993 11 12 921-924 |
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10.1007/BF03348959 doi (DE-627)SPR036810142 (SPR)BF03348959-e DE-627 ger DE-627 rakwb eng Caruso, S. verfasserin aut Oxytocin reduces the activity of N-methyl — D — aspartate receptors in cultured neurons 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1993 Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (>1 μM) attenuate the stimulation of 45$ Ca^{2+} $ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-β-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory. Agnello, C. aut Campo, M. G. aut Nicoletti, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 16(1993), 11 vom: Dez., Seite 921-924 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:16 year:1993 number:11 month:12 pages:921-924 https://dx.doi.org/10.1007/BF03348959 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 16 1993 11 12 921-924 |
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10.1007/BF03348959 doi (DE-627)SPR036810142 (SPR)BF03348959-e DE-627 ger DE-627 rakwb eng Caruso, S. verfasserin aut Oxytocin reduces the activity of N-methyl — D — aspartate receptors in cultured neurons 1993 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1993 Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (>1 μM) attenuate the stimulation of 45$ Ca^{2+} $ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-β-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory. Agnello, C. aut Campo, M. G. aut Nicoletti, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 16(1993), 11 vom: Dez., Seite 921-924 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:16 year:1993 number:11 month:12 pages:921-924 https://dx.doi.org/10.1007/BF03348959 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 16 1993 11 12 921-924 |
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Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (>1 μM) attenuate the stimulation of 45$ Ca^{2+} $ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-β-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory. © Italian Society of Endocrinology (SIE) 1993 |
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Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (>1 μM) attenuate the stimulation of 45$ Ca^{2+} $ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-β-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory. © Italian Society of Endocrinology (SIE) 1993 |
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Abstract N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular $ Ca^{2+} $, with ensuing activation of a variety of $ Ca^{2+} $-dependent enzymes, including protein kinase C. This triggers a cascade of intracellular reactions which is essential for memory formation. In culture neurons, high concentrations of oxytocin (>1 μM) attenuate the stimulation of 45$ Ca^{2+} $ influx promoted by glutamate through the activation NMDA receptors. In addition, the hormone reduces glutamate-stimulated [3H]4-β-phorbol 12,13-dibutyrate (PdBu) binding in intact cells, a parameter that reflects the translocation of protein kinase C from the cytosol to the cell membrane. Taken collectively, these results indicate that oxytocin reduces the activity of NMDA receptors, thus impairing one of the major substrates for the induction of learning and memory. © Italian Society of Endocrinology (SIE) 1993 |
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