Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue
Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Morosini, P. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1994 |
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| Schlagwörter: |
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| Anmerkung: |
© Italian Society of Endocrinology (SIE) 1994 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of endocrinological investigation - [S. l.] : Springer, 1978, 17(1994), 5 vom: Mai, Seite 335-340 |
|---|---|
| Übergeordnetes Werk: |
volume:17 ; year:1994 ; number:5 ; month:05 ; pages:335-340 |
| Links: |
|---|
| DOI / URN: |
10.1007/BF03348995 |
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SPR036813060 |
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| 520 | |a Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The aim of the study was to evaluate the expression of the TGF-ß1 gene in thyroid follicular adenoma (FA) by Northern analysis, and its protein localization by immunohistochemistry. Surgically removed thyroid tissue from 56 patients with thyroid FA was screened for the study. Normal thyroid tissue from 4 patients with papillary carcinoma was used as a control. Sixteen FA (8 with a “cold” and 8 with a “hot” scintiscan pattern) having homogeneous histological characteristics were subsequently selected. FA showed greater TGF-ß1 gene expression than control tissue. There was not a statistically significant difference between “cold” and “hot” FA. Immunohistochemistry analysis showed that TGF-ß1 was located in various histological structures of the adenomas (thyrocytes, endothelium, perinervium and connective tissue); on the other hand, perinodular and control tissue did not show appreciable TGF-ß1 protein. Our data suggest that TGF-ß1 may be involved in the pathogenesis of FA. The different TGF-ß1 distribution in thyrocytes, endothelium, perinervium and connective tissue in FA suggests that TGF-ß1 may be variably expressed during the natural history of FA. Since no significant difference in TGF-ß1 gene expression between “hot” and “cold” adenomas was found, it appears that other factors are involved in their functional differentiation. | ||
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10.1007/BF03348995 doi (DE-627)SPR036813060 (SPR)BF03348995-e DE-627 ger DE-627 rakwb eng Morosini, P. verfasserin aut Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue 1994 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1994 Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The aim of the study was to evaluate the expression of the TGF-ß1 gene in thyroid follicular adenoma (FA) by Northern analysis, and its protein localization by immunohistochemistry. Surgically removed thyroid tissue from 56 patients with thyroid FA was screened for the study. Normal thyroid tissue from 4 patients with papillary carcinoma was used as a control. Sixteen FA (8 with a “cold” and 8 with a “hot” scintiscan pattern) having homogeneous histological characteristics were subsequently selected. FA showed greater TGF-ß1 gene expression than control tissue. There was not a statistically significant difference between “cold” and “hot” FA. Immunohistochemistry analysis showed that TGF-ß1 was located in various histological structures of the adenomas (thyrocytes, endothelium, perinervium and connective tissue); on the other hand, perinodular and control tissue did not show appreciable TGF-ß1 protein. Our data suggest that TGF-ß1 may be involved in the pathogenesis of FA. The different TGF-ß1 distribution in thyrocytes, endothelium, perinervium and connective tissue in FA suggests that TGF-ß1 may be variably expressed during the natural history of FA. Since no significant difference in TGF-ß1 gene expression between “hot” and “cold” adenomas was found, it appears that other factors are involved in their functional differentiation. TGF-ß1 (dpeaa)DE-He213 thyroid follicular adenoma (dpeaa)DE-He213 growth factors (dpeaa)DE-He213 Northern analysis (dpeaa)DE-He213 immunohistochemistry (dpeaa)DE-He213 Taccaliti, A. aut Di Loreto, C. aut Arnaldi, G. aut Faloia, E. aut Giacchetti, G. aut Mantero, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 17(1994), 5 vom: Mai, Seite 335-340 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:17 year:1994 number:5 month:05 pages:335-340 https://dx.doi.org/10.1007/BF03348995 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 17 1994 5 05 335-340 |
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10.1007/BF03348995 doi (DE-627)SPR036813060 (SPR)BF03348995-e DE-627 ger DE-627 rakwb eng Morosini, P. verfasserin aut Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue 1994 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1994 Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The aim of the study was to evaluate the expression of the TGF-ß1 gene in thyroid follicular adenoma (FA) by Northern analysis, and its protein localization by immunohistochemistry. Surgically removed thyroid tissue from 56 patients with thyroid FA was screened for the study. Normal thyroid tissue from 4 patients with papillary carcinoma was used as a control. Sixteen FA (8 with a “cold” and 8 with a “hot” scintiscan pattern) having homogeneous histological characteristics were subsequently selected. FA showed greater TGF-ß1 gene expression than control tissue. There was not a statistically significant difference between “cold” and “hot” FA. Immunohistochemistry analysis showed that TGF-ß1 was located in various histological structures of the adenomas (thyrocytes, endothelium, perinervium and connective tissue); on the other hand, perinodular and control tissue did not show appreciable TGF-ß1 protein. Our data suggest that TGF-ß1 may be involved in the pathogenesis of FA. The different TGF-ß1 distribution in thyrocytes, endothelium, perinervium and connective tissue in FA suggests that TGF-ß1 may be variably expressed during the natural history of FA. Since no significant difference in TGF-ß1 gene expression between “hot” and “cold” adenomas was found, it appears that other factors are involved in their functional differentiation. TGF-ß1 (dpeaa)DE-He213 thyroid follicular adenoma (dpeaa)DE-He213 growth factors (dpeaa)DE-He213 Northern analysis (dpeaa)DE-He213 immunohistochemistry (dpeaa)DE-He213 Taccaliti, A. aut Di Loreto, C. aut Arnaldi, G. aut Faloia, E. aut Giacchetti, G. aut Mantero, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 17(1994), 5 vom: Mai, Seite 335-340 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:17 year:1994 number:5 month:05 pages:335-340 https://dx.doi.org/10.1007/BF03348995 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 17 1994 5 05 335-340 |
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10.1007/BF03348995 doi (DE-627)SPR036813060 (SPR)BF03348995-e DE-627 ger DE-627 rakwb eng Morosini, P. verfasserin aut Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue 1994 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1994 Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The aim of the study was to evaluate the expression of the TGF-ß1 gene in thyroid follicular adenoma (FA) by Northern analysis, and its protein localization by immunohistochemistry. Surgically removed thyroid tissue from 56 patients with thyroid FA was screened for the study. Normal thyroid tissue from 4 patients with papillary carcinoma was used as a control. Sixteen FA (8 with a “cold” and 8 with a “hot” scintiscan pattern) having homogeneous histological characteristics were subsequently selected. FA showed greater TGF-ß1 gene expression than control tissue. There was not a statistically significant difference between “cold” and “hot” FA. Immunohistochemistry analysis showed that TGF-ß1 was located in various histological structures of the adenomas (thyrocytes, endothelium, perinervium and connective tissue); on the other hand, perinodular and control tissue did not show appreciable TGF-ß1 protein. Our data suggest that TGF-ß1 may be involved in the pathogenesis of FA. The different TGF-ß1 distribution in thyrocytes, endothelium, perinervium and connective tissue in FA suggests that TGF-ß1 may be variably expressed during the natural history of FA. Since no significant difference in TGF-ß1 gene expression between “hot” and “cold” adenomas was found, it appears that other factors are involved in their functional differentiation. TGF-ß1 (dpeaa)DE-He213 thyroid follicular adenoma (dpeaa)DE-He213 growth factors (dpeaa)DE-He213 Northern analysis (dpeaa)DE-He213 immunohistochemistry (dpeaa)DE-He213 Taccaliti, A. aut Di Loreto, C. aut Arnaldi, G. aut Faloia, E. aut Giacchetti, G. aut Mantero, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 17(1994), 5 vom: Mai, Seite 335-340 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:17 year:1994 number:5 month:05 pages:335-340 https://dx.doi.org/10.1007/BF03348995 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 17 1994 5 05 335-340 |
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10.1007/BF03348995 doi (DE-627)SPR036813060 (SPR)BF03348995-e DE-627 ger DE-627 rakwb eng Morosini, P. verfasserin aut Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue 1994 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1994 Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The aim of the study was to evaluate the expression of the TGF-ß1 gene in thyroid follicular adenoma (FA) by Northern analysis, and its protein localization by immunohistochemistry. Surgically removed thyroid tissue from 56 patients with thyroid FA was screened for the study. Normal thyroid tissue from 4 patients with papillary carcinoma was used as a control. Sixteen FA (8 with a “cold” and 8 with a “hot” scintiscan pattern) having homogeneous histological characteristics were subsequently selected. FA showed greater TGF-ß1 gene expression than control tissue. There was not a statistically significant difference between “cold” and “hot” FA. Immunohistochemistry analysis showed that TGF-ß1 was located in various histological structures of the adenomas (thyrocytes, endothelium, perinervium and connective tissue); on the other hand, perinodular and control tissue did not show appreciable TGF-ß1 protein. Our data suggest that TGF-ß1 may be involved in the pathogenesis of FA. The different TGF-ß1 distribution in thyrocytes, endothelium, perinervium and connective tissue in FA suggests that TGF-ß1 may be variably expressed during the natural history of FA. Since no significant difference in TGF-ß1 gene expression between “hot” and “cold” adenomas was found, it appears that other factors are involved in their functional differentiation. TGF-ß1 (dpeaa)DE-He213 thyroid follicular adenoma (dpeaa)DE-He213 growth factors (dpeaa)DE-He213 Northern analysis (dpeaa)DE-He213 immunohistochemistry (dpeaa)DE-He213 Taccaliti, A. aut Di Loreto, C. aut Arnaldi, G. aut Faloia, E. aut Giacchetti, G. aut Mantero, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 17(1994), 5 vom: Mai, Seite 335-340 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:17 year:1994 number:5 month:05 pages:335-340 https://dx.doi.org/10.1007/BF03348995 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 17 1994 5 05 335-340 |
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10.1007/BF03348995 doi (DE-627)SPR036813060 (SPR)BF03348995-e DE-627 ger DE-627 rakwb eng Morosini, P. verfasserin aut Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue 1994 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1994 Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The aim of the study was to evaluate the expression of the TGF-ß1 gene in thyroid follicular adenoma (FA) by Northern analysis, and its protein localization by immunohistochemistry. Surgically removed thyroid tissue from 56 patients with thyroid FA was screened for the study. Normal thyroid tissue from 4 patients with papillary carcinoma was used as a control. Sixteen FA (8 with a “cold” and 8 with a “hot” scintiscan pattern) having homogeneous histological characteristics were subsequently selected. FA showed greater TGF-ß1 gene expression than control tissue. There was not a statistically significant difference between “cold” and “hot” FA. Immunohistochemistry analysis showed that TGF-ß1 was located in various histological structures of the adenomas (thyrocytes, endothelium, perinervium and connective tissue); on the other hand, perinodular and control tissue did not show appreciable TGF-ß1 protein. Our data suggest that TGF-ß1 may be involved in the pathogenesis of FA. The different TGF-ß1 distribution in thyrocytes, endothelium, perinervium and connective tissue in FA suggests that TGF-ß1 may be variably expressed during the natural history of FA. Since no significant difference in TGF-ß1 gene expression between “hot” and “cold” adenomas was found, it appears that other factors are involved in their functional differentiation. TGF-ß1 (dpeaa)DE-He213 thyroid follicular adenoma (dpeaa)DE-He213 growth factors (dpeaa)DE-He213 Northern analysis (dpeaa)DE-He213 immunohistochemistry (dpeaa)DE-He213 Taccaliti, A. aut Di Loreto, C. aut Arnaldi, G. aut Faloia, E. aut Giacchetti, G. aut Mantero, F. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 17(1994), 5 vom: Mai, Seite 335-340 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:17 year:1994 number:5 month:05 pages:335-340 https://dx.doi.org/10.1007/BF03348995 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 17 1994 5 05 335-340 |
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Morosini, P. |
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Morosini, P. misc TGF-ß1 misc thyroid follicular adenoma misc growth factors misc Northern analysis misc immunohistochemistry Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue |
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Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue TGF-ß1 (dpeaa)DE-He213 thyroid follicular adenoma (dpeaa)DE-He213 growth factors (dpeaa)DE-He213 Northern analysis (dpeaa)DE-He213 immunohistochemistry (dpeaa)DE-He213 |
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Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue |
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Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue |
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Morosini, P. |
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Journal of endocrinological investigation |
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1994 |
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Morosini, P. Taccaliti, A. Di Loreto, C. Arnaldi, G. Faloia, E. Giacchetti, G. Mantero, F. |
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Morosini, P. |
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10.1007/BF03348995 |
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transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue |
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Transforming growth factor-ß1 is more expressed in thyroid follicular adenoma than in normal tissue |
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Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The aim of the study was to evaluate the expression of the TGF-ß1 gene in thyroid follicular adenoma (FA) by Northern analysis, and its protein localization by immunohistochemistry. Surgically removed thyroid tissue from 56 patients with thyroid FA was screened for the study. Normal thyroid tissue from 4 patients with papillary carcinoma was used as a control. Sixteen FA (8 with a “cold” and 8 with a “hot” scintiscan pattern) having homogeneous histological characteristics were subsequently selected. FA showed greater TGF-ß1 gene expression than control tissue. There was not a statistically significant difference between “cold” and “hot” FA. Immunohistochemistry analysis showed that TGF-ß1 was located in various histological structures of the adenomas (thyrocytes, endothelium, perinervium and connective tissue); on the other hand, perinodular and control tissue did not show appreciable TGF-ß1 protein. Our data suggest that TGF-ß1 may be involved in the pathogenesis of FA. The different TGF-ß1 distribution in thyrocytes, endothelium, perinervium and connective tissue in FA suggests that TGF-ß1 may be variably expressed during the natural history of FA. Since no significant difference in TGF-ß1 gene expression between “hot” and “cold” adenomas was found, it appears that other factors are involved in their functional differentiation. © Italian Society of Endocrinology (SIE) 1994 |
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Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The aim of the study was to evaluate the expression of the TGF-ß1 gene in thyroid follicular adenoma (FA) by Northern analysis, and its protein localization by immunohistochemistry. Surgically removed thyroid tissue from 56 patients with thyroid FA was screened for the study. Normal thyroid tissue from 4 patients with papillary carcinoma was used as a control. Sixteen FA (8 with a “cold” and 8 with a “hot” scintiscan pattern) having homogeneous histological characteristics were subsequently selected. FA showed greater TGF-ß1 gene expression than control tissue. There was not a statistically significant difference between “cold” and “hot” FA. Immunohistochemistry analysis showed that TGF-ß1 was located in various histological structures of the adenomas (thyrocytes, endothelium, perinervium and connective tissue); on the other hand, perinodular and control tissue did not show appreciable TGF-ß1 protein. Our data suggest that TGF-ß1 may be involved in the pathogenesis of FA. The different TGF-ß1 distribution in thyrocytes, endothelium, perinervium and connective tissue in FA suggests that TGF-ß1 may be variably expressed during the natural history of FA. Since no significant difference in TGF-ß1 gene expression between “hot” and “cold” adenomas was found, it appears that other factors are involved in their functional differentiation. © Italian Society of Endocrinology (SIE) 1994 |
| abstract_unstemmed |
Abstract It is well known that TSH is the main factor responsible for thyrocyte proliferation and growth. Recent studies have shown that other growth factors, including transforming growth factor-ß1 (TGF-ß1), have an important role in the control of thyrocyte proliferation and differentiation. The aim of the study was to evaluate the expression of the TGF-ß1 gene in thyroid follicular adenoma (FA) by Northern analysis, and its protein localization by immunohistochemistry. Surgically removed thyroid tissue from 56 patients with thyroid FA was screened for the study. Normal thyroid tissue from 4 patients with papillary carcinoma was used as a control. Sixteen FA (8 with a “cold” and 8 with a “hot” scintiscan pattern) having homogeneous histological characteristics were subsequently selected. FA showed greater TGF-ß1 gene expression than control tissue. There was not a statistically significant difference between “cold” and “hot” FA. Immunohistochemistry analysis showed that TGF-ß1 was located in various histological structures of the adenomas (thyrocytes, endothelium, perinervium and connective tissue); on the other hand, perinodular and control tissue did not show appreciable TGF-ß1 protein. Our data suggest that TGF-ß1 may be involved in the pathogenesis of FA. The different TGF-ß1 distribution in thyrocytes, endothelium, perinervium and connective tissue in FA suggests that TGF-ß1 may be variably expressed during the natural history of FA. Since no significant difference in TGF-ß1 gene expression between “hot” and “cold” adenomas was found, it appears that other factors are involved in their functional differentiation. © Italian Society of Endocrinology (SIE) 1994 |
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