Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study
Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also rec...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
van der Meer, M. J. M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1996 |
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| Anmerkung: |
© Italian Society of Endocrinology (SIE) 1996 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of endocrinological investigation - [S. l.] : Springer, 1978, 19(1996), 3 vom: März, Seite 175-182 |
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| Übergeordnetes Werk: |
volume:19 ; year:1996 ; number:3 ; month:03 ; pages:175-182 |
| Links: |
|---|
| DOI / URN: |
10.1007/BF03349862 |
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SPR036816825 |
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| 245 | 1 | 0 | |a Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study |
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| 520 | |a Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an icv implanted cannula. Iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma B levels, whereas icv injection of TNFα in doses up to 1000 ng/rat was not effective. Iv pretreatment of rats with anti-CRH antiserum had no significant overall effect on the plasma B response to iv administered IL-1ß (500 and 3000 ng/rat), whereas the plasma B response to iv TNFα or IL-6 administration (3000 ng/rat) were significantly reduced. Iv pretreatment of the animals with recombinant human IL-1 receptor antagonist (IL-1ra) significantly blocked the plasma B response to iv treatment with IL-1ß, whereas the TNFα- and IL-6-induced increases in plasma B levels were not affected. Our data show that: 1) iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß or IL-6 dose-dependently stimulate the HPA axis; 2) when given iv or icv, IL-1ß is more powerful than TNFα and IL-6 in activating the HPA axis; 3) endogenous CRH is involved in the activation of the HPA axis by acute iv administration of TNFα and IL-6. It is most likely that in case of iv treatment with IL-1ß a CRH-independent mechanism is involved. This study provides no arguments for the involvement of endogenous IL-1 in TNFα- or IL-6-induced activation of the HPA axis. | ||
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10.1007/BF03349862 doi (DE-627)SPR036816825 (SPR)BF03349862-e DE-627 ger DE-627 rakwb eng van der Meer, M. J. M. verfasserin aut Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1996 Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an icv implanted cannula. Iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma B levels, whereas icv injection of TNFα in doses up to 1000 ng/rat was not effective. Iv pretreatment of rats with anti-CRH antiserum had no significant overall effect on the plasma B response to iv administered IL-1ß (500 and 3000 ng/rat), whereas the plasma B response to iv TNFα or IL-6 administration (3000 ng/rat) were significantly reduced. Iv pretreatment of the animals with recombinant human IL-1 receptor antagonist (IL-1ra) significantly blocked the plasma B response to iv treatment with IL-1ß, whereas the TNFα- and IL-6-induced increases in plasma B levels were not affected. Our data show that: 1) iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß or IL-6 dose-dependently stimulate the HPA axis; 2) when given iv or icv, IL-1ß is more powerful than TNFα and IL-6 in activating the HPA axis; 3) endogenous CRH is involved in the activation of the HPA axis by acute iv administration of TNFα and IL-6. It is most likely that in case of iv treatment with IL-1ß a CRH-independent mechanism is involved. This study provides no arguments for the involvement of endogenous IL-1 in TNFα- or IL-6-induced activation of the HPA axis. Sweep, C. G. J. aut Rijnkels, C. E. M. aut Pesman, G. J. aut Tilders, F. J. H. aut Kloppenborg, P. W. C. aut Hermus, A. R. M. M. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 19(1996), 3 vom: März, Seite 175-182 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:19 year:1996 number:3 month:03 pages:175-182 https://dx.doi.org/10.1007/BF03349862 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 19 1996 3 03 175-182 |
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10.1007/BF03349862 doi (DE-627)SPR036816825 (SPR)BF03349862-e DE-627 ger DE-627 rakwb eng van der Meer, M. J. M. verfasserin aut Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1996 Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an icv implanted cannula. Iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma B levels, whereas icv injection of TNFα in doses up to 1000 ng/rat was not effective. Iv pretreatment of rats with anti-CRH antiserum had no significant overall effect on the plasma B response to iv administered IL-1ß (500 and 3000 ng/rat), whereas the plasma B response to iv TNFα or IL-6 administration (3000 ng/rat) were significantly reduced. Iv pretreatment of the animals with recombinant human IL-1 receptor antagonist (IL-1ra) significantly blocked the plasma B response to iv treatment with IL-1ß, whereas the TNFα- and IL-6-induced increases in plasma B levels were not affected. Our data show that: 1) iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß or IL-6 dose-dependently stimulate the HPA axis; 2) when given iv or icv, IL-1ß is more powerful than TNFα and IL-6 in activating the HPA axis; 3) endogenous CRH is involved in the activation of the HPA axis by acute iv administration of TNFα and IL-6. It is most likely that in case of iv treatment with IL-1ß a CRH-independent mechanism is involved. This study provides no arguments for the involvement of endogenous IL-1 in TNFα- or IL-6-induced activation of the HPA axis. Sweep, C. G. J. aut Rijnkels, C. E. M. aut Pesman, G. J. aut Tilders, F. J. H. aut Kloppenborg, P. W. C. aut Hermus, A. R. M. M. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 19(1996), 3 vom: März, Seite 175-182 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:19 year:1996 number:3 month:03 pages:175-182 https://dx.doi.org/10.1007/BF03349862 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 19 1996 3 03 175-182 |
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10.1007/BF03349862 doi (DE-627)SPR036816825 (SPR)BF03349862-e DE-627 ger DE-627 rakwb eng van der Meer, M. J. M. verfasserin aut Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1996 Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an icv implanted cannula. Iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma B levels, whereas icv injection of TNFα in doses up to 1000 ng/rat was not effective. Iv pretreatment of rats with anti-CRH antiserum had no significant overall effect on the plasma B response to iv administered IL-1ß (500 and 3000 ng/rat), whereas the plasma B response to iv TNFα or IL-6 administration (3000 ng/rat) were significantly reduced. Iv pretreatment of the animals with recombinant human IL-1 receptor antagonist (IL-1ra) significantly blocked the plasma B response to iv treatment with IL-1ß, whereas the TNFα- and IL-6-induced increases in plasma B levels were not affected. Our data show that: 1) iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß or IL-6 dose-dependently stimulate the HPA axis; 2) when given iv or icv, IL-1ß is more powerful than TNFα and IL-6 in activating the HPA axis; 3) endogenous CRH is involved in the activation of the HPA axis by acute iv administration of TNFα and IL-6. It is most likely that in case of iv treatment with IL-1ß a CRH-independent mechanism is involved. This study provides no arguments for the involvement of endogenous IL-1 in TNFα- or IL-6-induced activation of the HPA axis. Sweep, C. G. J. aut Rijnkels, C. E. M. aut Pesman, G. J. aut Tilders, F. J. H. aut Kloppenborg, P. W. C. aut Hermus, A. R. M. M. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 19(1996), 3 vom: März, Seite 175-182 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:19 year:1996 number:3 month:03 pages:175-182 https://dx.doi.org/10.1007/BF03349862 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 19 1996 3 03 175-182 |
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10.1007/BF03349862 doi (DE-627)SPR036816825 (SPR)BF03349862-e DE-627 ger DE-627 rakwb eng van der Meer, M. J. M. verfasserin aut Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1996 Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an icv implanted cannula. Iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma B levels, whereas icv injection of TNFα in doses up to 1000 ng/rat was not effective. Iv pretreatment of rats with anti-CRH antiserum had no significant overall effect on the plasma B response to iv administered IL-1ß (500 and 3000 ng/rat), whereas the plasma B response to iv TNFα or IL-6 administration (3000 ng/rat) were significantly reduced. Iv pretreatment of the animals with recombinant human IL-1 receptor antagonist (IL-1ra) significantly blocked the plasma B response to iv treatment with IL-1ß, whereas the TNFα- and IL-6-induced increases in plasma B levels were not affected. Our data show that: 1) iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß or IL-6 dose-dependently stimulate the HPA axis; 2) when given iv or icv, IL-1ß is more powerful than TNFα and IL-6 in activating the HPA axis; 3) endogenous CRH is involved in the activation of the HPA axis by acute iv administration of TNFα and IL-6. It is most likely that in case of iv treatment with IL-1ß a CRH-independent mechanism is involved. This study provides no arguments for the involvement of endogenous IL-1 in TNFα- or IL-6-induced activation of the HPA axis. Sweep, C. G. J. aut Rijnkels, C. E. M. aut Pesman, G. J. aut Tilders, F. J. H. aut Kloppenborg, P. W. C. aut Hermus, A. R. M. M. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 19(1996), 3 vom: März, Seite 175-182 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:19 year:1996 number:3 month:03 pages:175-182 https://dx.doi.org/10.1007/BF03349862 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 19 1996 3 03 175-182 |
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10.1007/BF03349862 doi (DE-627)SPR036816825 (SPR)BF03349862-e DE-627 ger DE-627 rakwb eng van der Meer, M. J. M. verfasserin aut Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 1996 Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an icv implanted cannula. Iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma B levels, whereas icv injection of TNFα in doses up to 1000 ng/rat was not effective. Iv pretreatment of rats with anti-CRH antiserum had no significant overall effect on the plasma B response to iv administered IL-1ß (500 and 3000 ng/rat), whereas the plasma B response to iv TNFα or IL-6 administration (3000 ng/rat) were significantly reduced. Iv pretreatment of the animals with recombinant human IL-1 receptor antagonist (IL-1ra) significantly blocked the plasma B response to iv treatment with IL-1ß, whereas the TNFα- and IL-6-induced increases in plasma B levels were not affected. Our data show that: 1) iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß or IL-6 dose-dependently stimulate the HPA axis; 2) when given iv or icv, IL-1ß is more powerful than TNFα and IL-6 in activating the HPA axis; 3) endogenous CRH is involved in the activation of the HPA axis by acute iv administration of TNFα and IL-6. It is most likely that in case of iv treatment with IL-1ß a CRH-independent mechanism is involved. This study provides no arguments for the involvement of endogenous IL-1 in TNFα- or IL-6-induced activation of the HPA axis. Sweep, C. G. J. aut Rijnkels, C. E. M. aut Pesman, G. J. aut Tilders, F. J. H. aut Kloppenborg, P. W. C. aut Hermus, A. R. M. M. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 19(1996), 3 vom: März, Seite 175-182 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:19 year:1996 number:3 month:03 pages:175-182 https://dx.doi.org/10.1007/BF03349862 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_702 GBV_ILN_2190 AR 19 1996 3 03 175-182 |
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Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study |
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Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study |
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Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study |
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van der Meer, M. J. M. Sweep, C. G. J. Rijnkels, C. E. M. Pesman, G. J. Tilders, F. J. H. Kloppenborg, P. W. C. Hermus, A. R. M. M. |
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acute stimulation of the hypothalamic-pituitary-adrenal axis by il-1ß, tnfα and il-6: a dose response study |
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Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study |
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Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an icv implanted cannula. Iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma B levels, whereas icv injection of TNFα in doses up to 1000 ng/rat was not effective. Iv pretreatment of rats with anti-CRH antiserum had no significant overall effect on the plasma B response to iv administered IL-1ß (500 and 3000 ng/rat), whereas the plasma B response to iv TNFα or IL-6 administration (3000 ng/rat) were significantly reduced. Iv pretreatment of the animals with recombinant human IL-1 receptor antagonist (IL-1ra) significantly blocked the plasma B response to iv treatment with IL-1ß, whereas the TNFα- and IL-6-induced increases in plasma B levels were not affected. Our data show that: 1) iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß or IL-6 dose-dependently stimulate the HPA axis; 2) when given iv or icv, IL-1ß is more powerful than TNFα and IL-6 in activating the HPA axis; 3) endogenous CRH is involved in the activation of the HPA axis by acute iv administration of TNFα and IL-6. It is most likely that in case of iv treatment with IL-1ß a CRH-independent mechanism is involved. This study provides no arguments for the involvement of endogenous IL-1 in TNFα- or IL-6-induced activation of the HPA axis. © Italian Society of Endocrinology (SIE) 1996 |
| abstractGer |
Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an icv implanted cannula. Iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma B levels, whereas icv injection of TNFα in doses up to 1000 ng/rat was not effective. Iv pretreatment of rats with anti-CRH antiserum had no significant overall effect on the plasma B response to iv administered IL-1ß (500 and 3000 ng/rat), whereas the plasma B response to iv TNFα or IL-6 administration (3000 ng/rat) were significantly reduced. Iv pretreatment of the animals with recombinant human IL-1 receptor antagonist (IL-1ra) significantly blocked the plasma B response to iv treatment with IL-1ß, whereas the TNFα- and IL-6-induced increases in plasma B levels were not affected. Our data show that: 1) iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß or IL-6 dose-dependently stimulate the HPA axis; 2) when given iv or icv, IL-1ß is more powerful than TNFα and IL-6 in activating the HPA axis; 3) endogenous CRH is involved in the activation of the HPA axis by acute iv administration of TNFα and IL-6. It is most likely that in case of iv treatment with IL-1ß a CRH-independent mechanism is involved. This study provides no arguments for the involvement of endogenous IL-1 in TNFα- or IL-6-induced activation of the HPA axis. © Italian Society of Endocrinology (SIE) 1996 |
| abstract_unstemmed |
Abstract We investigated the effects of iv and intracerebroventricular (icv) administration of increasing doses of recombinant human IL-1ß, TNFα and IL-6 on plasma corticosterone (B) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an icv implanted cannula. Iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma B levels, whereas icv injection of TNFα in doses up to 1000 ng/rat was not effective. Iv pretreatment of rats with anti-CRH antiserum had no significant overall effect on the plasma B response to iv administered IL-1ß (500 and 3000 ng/rat), whereas the plasma B response to iv TNFα or IL-6 administration (3000 ng/rat) were significantly reduced. Iv pretreatment of the animals with recombinant human IL-1 receptor antagonist (IL-1ra) significantly blocked the plasma B response to iv treatment with IL-1ß, whereas the TNFα- and IL-6-induced increases in plasma B levels were not affected. Our data show that: 1) iv administration of IL-1ß, TNFα or IL-6 and icv administration of IL-1ß or IL-6 dose-dependently stimulate the HPA axis; 2) when given iv or icv, IL-1ß is more powerful than TNFα and IL-6 in activating the HPA axis; 3) endogenous CRH is involved in the activation of the HPA axis by acute iv administration of TNFα and IL-6. It is most likely that in case of iv treatment with IL-1ß a CRH-independent mechanism is involved. This study provides no arguments for the involvement of endogenous IL-1 in TNFα- or IL-6-induced activation of the HPA axis. © Italian Society of Endocrinology (SIE) 1996 |
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Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1ß, TNFα and IL-6: A dose response study |
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