Effect of raloxifene and its interaction with human PTH on bone formation
Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h...
Ausführliche Beschreibung
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| Autor*in: |
Lin, Y. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2004 |
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| Anmerkung: |
© Italian Society of Endocrinology (SIE) 2004 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of endocrinological investigation - [S. l.] : Springer, 1978, 27(2004), 5 vom: Mai, Seite 416-423 |
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| Übergeordnetes Werk: |
volume:27 ; year:2004 ; number:5 ; month:05 ; pages:416-423 |
| Links: |
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| DOI / URN: |
10.1007/BF03345284 |
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| Katalog-ID: |
SPR036832278 |
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| 245 | 1 | 0 | |a Effect of raloxifene and its interaction with human PTH on bone formation |
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| 520 | |a Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h treatment with $ 10^{−8} $ M hPTH (1–34) at day 8 reduced the nodule area by 75.6% at day 17, and raloxifene added concomi-tantly with hPTH (1–34) reduced this inhibitory effect in a dose-dependent manner. Raloxifene also reduced the hPTH (1–34)-induced inhibition of alkaline phosphatase (ALP) activity. The 10-fold stimulation of c-fos mRNA expression by hPTH (1–34) was not influenced by raloxifene co-treatment. The protein kinase A (PKA) inhibitor 6–22 amide (1.7 nM) and the protein kinase C (PKC) inhibitor-bisindolylmaleimide 1 (10 nM) did not influence the separate effects of PTH and raloxifene on mineralized bone nodule formation. This is the first report on the interaction of PTH and raloxifene in an osteoblast culture system. | ||
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| 700 | 1 | |a Rao, L. |4 aut | |
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10.1007/BF03345284 doi (DE-627)SPR036832278 (SPR)BF03345284-e DE-627 ger DE-627 rakwb eng Lin, Y. verfasserin aut Effect of raloxifene and its interaction with human PTH on bone formation 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2004 Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h treatment with $ 10^{−8} $ M hPTH (1–34) at day 8 reduced the nodule area by 75.6% at day 17, and raloxifene added concomi-tantly with hPTH (1–34) reduced this inhibitory effect in a dose-dependent manner. Raloxifene also reduced the hPTH (1–34)-induced inhibition of alkaline phosphatase (ALP) activity. The 10-fold stimulation of c-fos mRNA expression by hPTH (1–34) was not influenced by raloxifene co-treatment. The protein kinase A (PKA) inhibitor 6–22 amide (1.7 nM) and the protein kinase C (PKC) inhibitor-bisindolylmaleimide 1 (10 nM) did not influence the separate effects of PTH and raloxifene on mineralized bone nodule formation. This is the first report on the interaction of PTH and raloxifene in an osteoblast culture system. Liu, L. J. F. aut Murray, T. aut Sodek, J. aut Rao, L. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 27(2004), 5 vom: Mai, Seite 416-423 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:27 year:2004 number:5 month:05 pages:416-423 https://dx.doi.org/10.1007/BF03345284 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2004 5 05 416-423 |
| spelling |
10.1007/BF03345284 doi (DE-627)SPR036832278 (SPR)BF03345284-e DE-627 ger DE-627 rakwb eng Lin, Y. verfasserin aut Effect of raloxifene and its interaction with human PTH on bone formation 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2004 Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h treatment with $ 10^{−8} $ M hPTH (1–34) at day 8 reduced the nodule area by 75.6% at day 17, and raloxifene added concomi-tantly with hPTH (1–34) reduced this inhibitory effect in a dose-dependent manner. Raloxifene also reduced the hPTH (1–34)-induced inhibition of alkaline phosphatase (ALP) activity. The 10-fold stimulation of c-fos mRNA expression by hPTH (1–34) was not influenced by raloxifene co-treatment. The protein kinase A (PKA) inhibitor 6–22 amide (1.7 nM) and the protein kinase C (PKC) inhibitor-bisindolylmaleimide 1 (10 nM) did not influence the separate effects of PTH and raloxifene on mineralized bone nodule formation. This is the first report on the interaction of PTH and raloxifene in an osteoblast culture system. Liu, L. J. F. aut Murray, T. aut Sodek, J. aut Rao, L. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 27(2004), 5 vom: Mai, Seite 416-423 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:27 year:2004 number:5 month:05 pages:416-423 https://dx.doi.org/10.1007/BF03345284 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2004 5 05 416-423 |
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10.1007/BF03345284 doi (DE-627)SPR036832278 (SPR)BF03345284-e DE-627 ger DE-627 rakwb eng Lin, Y. verfasserin aut Effect of raloxifene and its interaction with human PTH on bone formation 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2004 Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h treatment with $ 10^{−8} $ M hPTH (1–34) at day 8 reduced the nodule area by 75.6% at day 17, and raloxifene added concomi-tantly with hPTH (1–34) reduced this inhibitory effect in a dose-dependent manner. Raloxifene also reduced the hPTH (1–34)-induced inhibition of alkaline phosphatase (ALP) activity. The 10-fold stimulation of c-fos mRNA expression by hPTH (1–34) was not influenced by raloxifene co-treatment. The protein kinase A (PKA) inhibitor 6–22 amide (1.7 nM) and the protein kinase C (PKC) inhibitor-bisindolylmaleimide 1 (10 nM) did not influence the separate effects of PTH and raloxifene on mineralized bone nodule formation. This is the first report on the interaction of PTH and raloxifene in an osteoblast culture system. Liu, L. J. F. aut Murray, T. aut Sodek, J. aut Rao, L. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 27(2004), 5 vom: Mai, Seite 416-423 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:27 year:2004 number:5 month:05 pages:416-423 https://dx.doi.org/10.1007/BF03345284 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2004 5 05 416-423 |
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10.1007/BF03345284 doi (DE-627)SPR036832278 (SPR)BF03345284-e DE-627 ger DE-627 rakwb eng Lin, Y. verfasserin aut Effect of raloxifene and its interaction with human PTH on bone formation 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2004 Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h treatment with $ 10^{−8} $ M hPTH (1–34) at day 8 reduced the nodule area by 75.6% at day 17, and raloxifene added concomi-tantly with hPTH (1–34) reduced this inhibitory effect in a dose-dependent manner. Raloxifene also reduced the hPTH (1–34)-induced inhibition of alkaline phosphatase (ALP) activity. The 10-fold stimulation of c-fos mRNA expression by hPTH (1–34) was not influenced by raloxifene co-treatment. The protein kinase A (PKA) inhibitor 6–22 amide (1.7 nM) and the protein kinase C (PKC) inhibitor-bisindolylmaleimide 1 (10 nM) did not influence the separate effects of PTH and raloxifene on mineralized bone nodule formation. This is the first report on the interaction of PTH and raloxifene in an osteoblast culture system. Liu, L. J. F. aut Murray, T. aut Sodek, J. aut Rao, L. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 27(2004), 5 vom: Mai, Seite 416-423 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:27 year:2004 number:5 month:05 pages:416-423 https://dx.doi.org/10.1007/BF03345284 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2004 5 05 416-423 |
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10.1007/BF03345284 doi (DE-627)SPR036832278 (SPR)BF03345284-e DE-627 ger DE-627 rakwb eng Lin, Y. verfasserin aut Effect of raloxifene and its interaction with human PTH on bone formation 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2004 Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h treatment with $ 10^{−8} $ M hPTH (1–34) at day 8 reduced the nodule area by 75.6% at day 17, and raloxifene added concomi-tantly with hPTH (1–34) reduced this inhibitory effect in a dose-dependent manner. Raloxifene also reduced the hPTH (1–34)-induced inhibition of alkaline phosphatase (ALP) activity. The 10-fold stimulation of c-fos mRNA expression by hPTH (1–34) was not influenced by raloxifene co-treatment. The protein kinase A (PKA) inhibitor 6–22 amide (1.7 nM) and the protein kinase C (PKC) inhibitor-bisindolylmaleimide 1 (10 nM) did not influence the separate effects of PTH and raloxifene on mineralized bone nodule formation. This is the first report on the interaction of PTH and raloxifene in an osteoblast culture system. Liu, L. J. F. aut Murray, T. aut Sodek, J. aut Rao, L. aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 27(2004), 5 vom: Mai, Seite 416-423 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:27 year:2004 number:5 month:05 pages:416-423 https://dx.doi.org/10.1007/BF03345284 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2004 5 05 416-423 |
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Effect of raloxifene and its interaction with human PTH on bone formation |
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Effect of raloxifene and its interaction with human PTH on bone formation |
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effect of raloxifene and its interaction with human pth on bone formation |
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Effect of raloxifene and its interaction with human PTH on bone formation |
| abstract |
Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h treatment with $ 10^{−8} $ M hPTH (1–34) at day 8 reduced the nodule area by 75.6% at day 17, and raloxifene added concomi-tantly with hPTH (1–34) reduced this inhibitory effect in a dose-dependent manner. Raloxifene also reduced the hPTH (1–34)-induced inhibition of alkaline phosphatase (ALP) activity. The 10-fold stimulation of c-fos mRNA expression by hPTH (1–34) was not influenced by raloxifene co-treatment. The protein kinase A (PKA) inhibitor 6–22 amide (1.7 nM) and the protein kinase C (PKC) inhibitor-bisindolylmaleimide 1 (10 nM) did not influence the separate effects of PTH and raloxifene on mineralized bone nodule formation. This is the first report on the interaction of PTH and raloxifene in an osteoblast culture system. © Italian Society of Endocrinology (SIE) 2004 |
| abstractGer |
Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h treatment with $ 10^{−8} $ M hPTH (1–34) at day 8 reduced the nodule area by 75.6% at day 17, and raloxifene added concomi-tantly with hPTH (1–34) reduced this inhibitory effect in a dose-dependent manner. Raloxifene also reduced the hPTH (1–34)-induced inhibition of alkaline phosphatase (ALP) activity. The 10-fold stimulation of c-fos mRNA expression by hPTH (1–34) was not influenced by raloxifene co-treatment. The protein kinase A (PKA) inhibitor 6–22 amide (1.7 nM) and the protein kinase C (PKC) inhibitor-bisindolylmaleimide 1 (10 nM) did not influence the separate effects of PTH and raloxifene on mineralized bone nodule formation. This is the first report on the interaction of PTH and raloxifene in an osteoblast culture system. © Italian Society of Endocrinology (SIE) 2004 |
| abstract_unstemmed |
Abstract We studied the of effects raloxifene alone or in combination with human PTH (hPTH) 1–34 in mineralizing cultures of SaOS-2 cells. Raloxifene ($ 10^{−8} $–$ 10^{−6} $ M) increased bone nodule formation in cultures of SaOS-2 cells when added intermittently from day 8 to day 17. A single 24-h treatment with $ 10^{−8} $ M hPTH (1–34) at day 8 reduced the nodule area by 75.6% at day 17, and raloxifene added concomi-tantly with hPTH (1–34) reduced this inhibitory effect in a dose-dependent manner. Raloxifene also reduced the hPTH (1–34)-induced inhibition of alkaline phosphatase (ALP) activity. The 10-fold stimulation of c-fos mRNA expression by hPTH (1–34) was not influenced by raloxifene co-treatment. The protein kinase A (PKA) inhibitor 6–22 amide (1.7 nM) and the protein kinase C (PKC) inhibitor-bisindolylmaleimide 1 (10 nM) did not influence the separate effects of PTH and raloxifene on mineralized bone nodule formation. This is the first report on the interaction of PTH and raloxifene in an osteoblast culture system. © Italian Society of Endocrinology (SIE) 2004 |
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Effect of raloxifene and its interaction with human PTH on bone formation |
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Liu, L. J. F. Murray, T. Sodek, J. Rao, L. |
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