Lymph node location is a risk factor for papillary thyroid cancer-related death

Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was...
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Autor*in:	Sapuppo, G. [verfasserIn] Tavarelli, M. Russo, M. Malandrino, P. Belfiore, A. Vigneri, R. Pellegriti, G.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Thyroid cancer Thyroid cancer-related mortality Latero-cervical lymph node metastases Papillary thyroid cancer Thyroid cancer outcome Thyroid cancer metastases

Anmerkung:	© Italian Society of Endocrinology (SIE) 2018

Übergeordnetes Werk:	Enthalten in: Journal of endocrinological investigation - [S. l.] : Springer, 1978, 41(2018), 11 vom: 16. März, Seite 1349-1353
Übergeordnetes Werk:	volume:41 ; year:2018 ; number:11 ; day:16 ; month:03 ; pages:1349-1353

Links:	Volltext

DOI / URN:	10.1007/s40618-018-0865-5

Katalog-ID:	SPR036861863

Internformat


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245	1	0	\|a Lymph node location is a risk factor for papillary thyroid cancer-related death
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520			\|a Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. Methods PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years). Results Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b. Conclusions The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation.
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650		4	\|a Thyroid cancer-related mortality \|7 (dpeaa)DE-He213
650		4	\|a Latero-cervical lymph node metastases \|7 (dpeaa)DE-He213
650		4	\|a Papillary thyroid cancer \|7 (dpeaa)DE-He213
650		4	\|a Thyroid cancer outcome \|7 (dpeaa)DE-He213
650		4	\|a Thyroid cancer metastases \|7 (dpeaa)DE-He213
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700	1		\|a Malandrino, P. \|4 aut
700	1		\|a Belfiore, A. \|4 aut
700	1		\|a Vigneri, R. \|4 aut
700	1		\|a Pellegriti, G. \|0 (orcid)0000-0001-6102-379X \|4 aut
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allfields	10.1007/s40618-018-0865-5 doi (DE-627)SPR036861863 (SPR)s40618-018-0865-5-e DE-627 ger DE-627 rakwb eng Sapuppo, G. verfasserin aut Lymph node location is a risk factor for papillary thyroid cancer-related death 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2018 Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. Methods PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years). Results Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b. Conclusions The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. Thyroid cancer (dpeaa)DE-He213 Thyroid cancer-related mortality (dpeaa)DE-He213 Latero-cervical lymph node metastases (dpeaa)DE-He213 Papillary thyroid cancer (dpeaa)DE-He213 Thyroid cancer outcome (dpeaa)DE-He213 Thyroid cancer metastases (dpeaa)DE-He213 Tavarelli, M. aut Russo, M. aut Malandrino, P. aut Belfiore, A. aut Vigneri, R. aut Pellegriti, G. (orcid)0000-0001-6102-379X aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 41(2018), 11 vom: 16. März, Seite 1349-1353 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:41 year:2018 number:11 day:16 month:03 pages:1349-1353 https://dx.doi.org/10.1007/s40618-018-0865-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2018 11 16 03 1349-1353
spelling	10.1007/s40618-018-0865-5 doi (DE-627)SPR036861863 (SPR)s40618-018-0865-5-e DE-627 ger DE-627 rakwb eng Sapuppo, G. verfasserin aut Lymph node location is a risk factor for papillary thyroid cancer-related death 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2018 Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. Methods PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years). Results Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b. Conclusions The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. Thyroid cancer (dpeaa)DE-He213 Thyroid cancer-related mortality (dpeaa)DE-He213 Latero-cervical lymph node metastases (dpeaa)DE-He213 Papillary thyroid cancer (dpeaa)DE-He213 Thyroid cancer outcome (dpeaa)DE-He213 Thyroid cancer metastases (dpeaa)DE-He213 Tavarelli, M. aut Russo, M. aut Malandrino, P. aut Belfiore, A. aut Vigneri, R. aut Pellegriti, G. (orcid)0000-0001-6102-379X aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 41(2018), 11 vom: 16. März, Seite 1349-1353 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:41 year:2018 number:11 day:16 month:03 pages:1349-1353 https://dx.doi.org/10.1007/s40618-018-0865-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2018 11 16 03 1349-1353
allfields_unstemmed	10.1007/s40618-018-0865-5 doi (DE-627)SPR036861863 (SPR)s40618-018-0865-5-e DE-627 ger DE-627 rakwb eng Sapuppo, G. verfasserin aut Lymph node location is a risk factor for papillary thyroid cancer-related death 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2018 Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. Methods PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years). Results Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b. Conclusions The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. Thyroid cancer (dpeaa)DE-He213 Thyroid cancer-related mortality (dpeaa)DE-He213 Latero-cervical lymph node metastases (dpeaa)DE-He213 Papillary thyroid cancer (dpeaa)DE-He213 Thyroid cancer outcome (dpeaa)DE-He213 Thyroid cancer metastases (dpeaa)DE-He213 Tavarelli, M. aut Russo, M. aut Malandrino, P. aut Belfiore, A. aut Vigneri, R. aut Pellegriti, G. (orcid)0000-0001-6102-379X aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 41(2018), 11 vom: 16. März, Seite 1349-1353 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:41 year:2018 number:11 day:16 month:03 pages:1349-1353 https://dx.doi.org/10.1007/s40618-018-0865-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2018 11 16 03 1349-1353
allfieldsGer	10.1007/s40618-018-0865-5 doi (DE-627)SPR036861863 (SPR)s40618-018-0865-5-e DE-627 ger DE-627 rakwb eng Sapuppo, G. verfasserin aut Lymph node location is a risk factor for papillary thyroid cancer-related death 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2018 Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. Methods PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years). Results Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b. Conclusions The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. Thyroid cancer (dpeaa)DE-He213 Thyroid cancer-related mortality (dpeaa)DE-He213 Latero-cervical lymph node metastases (dpeaa)DE-He213 Papillary thyroid cancer (dpeaa)DE-He213 Thyroid cancer outcome (dpeaa)DE-He213 Thyroid cancer metastases (dpeaa)DE-He213 Tavarelli, M. aut Russo, M. aut Malandrino, P. aut Belfiore, A. aut Vigneri, R. aut Pellegriti, G. (orcid)0000-0001-6102-379X aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 41(2018), 11 vom: 16. März, Seite 1349-1353 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:41 year:2018 number:11 day:16 month:03 pages:1349-1353 https://dx.doi.org/10.1007/s40618-018-0865-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2018 11 16 03 1349-1353
allfieldsSound	10.1007/s40618-018-0865-5 doi (DE-627)SPR036861863 (SPR)s40618-018-0865-5-e DE-627 ger DE-627 rakwb eng Sapuppo, G. verfasserin aut Lymph node location is a risk factor for papillary thyroid cancer-related death 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Endocrinology (SIE) 2018 Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. Methods PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years). Results Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b. Conclusions The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. Thyroid cancer (dpeaa)DE-He213 Thyroid cancer-related mortality (dpeaa)DE-He213 Latero-cervical lymph node metastases (dpeaa)DE-He213 Papillary thyroid cancer (dpeaa)DE-He213 Thyroid cancer outcome (dpeaa)DE-He213 Thyroid cancer metastases (dpeaa)DE-He213 Tavarelli, M. aut Russo, M. aut Malandrino, P. aut Belfiore, A. aut Vigneri, R. aut Pellegriti, G. (orcid)0000-0001-6102-379X aut Enthalten in Journal of endocrinological investigation [S. l.] : Springer, 1978 41(2018), 11 vom: 16. März, Seite 1349-1353 (DE-627)369556267 (DE-600)2119482-8 1720-8386 nnns volume:41 year:2018 number:11 day:16 month:03 pages:1349-1353 https://dx.doi.org/10.1007/s40618-018-0865-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2018 11 16 03 1349-1353
language	English
source	Enthalten in Journal of endocrinological investigation 41(2018), 11 vom: 16. März, Seite 1349-1353 volume:41 year:2018 number:11 day:16 month:03 pages:1349-1353
sourceStr	Enthalten in Journal of endocrinological investigation 41(2018), 11 vom: 16. März, Seite 1349-1353 volume:41 year:2018 number:11 day:16 month:03 pages:1349-1353
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Thyroid cancer Thyroid cancer-related mortality Latero-cervical lymph node metastases Papillary thyroid cancer Thyroid cancer outcome Thyroid cancer metastases
isfreeaccess_bool	false
container_title	Journal of endocrinological investigation
authorswithroles_txt_mv	Sapuppo, G. @@aut@@ Tavarelli, M. @@aut@@ Russo, M. @@aut@@ Malandrino, P. @@aut@@ Belfiore, A. @@aut@@ Vigneri, R. @@aut@@ Pellegriti, G. @@aut@@
publishDateDaySort_date	2018-03-16T00:00:00Z
hierarchy_top_id	369556267
id	SPR036861863
language_de	englisch
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author	Sapuppo, G.
spellingShingle	Sapuppo, G. misc Thyroid cancer misc Thyroid cancer-related mortality misc Latero-cervical lymph node metastases misc Papillary thyroid cancer misc Thyroid cancer outcome misc Thyroid cancer metastases Lymph node location is a risk factor for papillary thyroid cancer-related death
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topic_title	Lymph node location is a risk factor for papillary thyroid cancer-related death Thyroid cancer (dpeaa)DE-He213 Thyroid cancer-related mortality (dpeaa)DE-He213 Latero-cervical lymph node metastases (dpeaa)DE-He213 Papillary thyroid cancer (dpeaa)DE-He213 Thyroid cancer outcome (dpeaa)DE-He213 Thyroid cancer metastases (dpeaa)DE-He213
topic	misc Thyroid cancer misc Thyroid cancer-related mortality misc Latero-cervical lymph node metastases misc Papillary thyroid cancer misc Thyroid cancer outcome misc Thyroid cancer metastases
topic_unstemmed	misc Thyroid cancer misc Thyroid cancer-related mortality misc Latero-cervical lymph node metastases misc Papillary thyroid cancer misc Thyroid cancer outcome misc Thyroid cancer metastases
topic_browse	misc Thyroid cancer misc Thyroid cancer-related mortality misc Latero-cervical lymph node metastases misc Papillary thyroid cancer misc Thyroid cancer outcome misc Thyroid cancer metastases
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title	Lymph node location is a risk factor for papillary thyroid cancer-related death
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title_full	Lymph node location is a risk factor for papillary thyroid cancer-related death
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author_browse	Sapuppo, G. Tavarelli, M. Russo, M. Malandrino, P. Belfiore, A. Vigneri, R. Pellegriti, G.
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title_sort	lymph node location is a risk factor for papillary thyroid cancer-related death
title_auth	Lymph node location is a risk factor for papillary thyroid cancer-related death
abstract	Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. Methods PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years). Results Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b. Conclusions The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. © Italian Society of Endocrinology (SIE) 2018
abstractGer	Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. Methods PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years). Results Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b. Conclusions The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. © Italian Society of Endocrinology (SIE) 2018
abstract_unstemmed	Purpose Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. Methods PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years). Results Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b. Conclusions The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. © Italian Society of Endocrinology (SIE) 2018
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title_short	Lymph node location is a risk factor for papillary thyroid cancer-related death
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Lymph node location is a risk factor for papillary thyroid cancer-related death

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