Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out

Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to anti...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Klimek, Ludger [verfasserIn] Aderhold, Christoph Sperl, Annette Trautmann, Axel

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Clindamycin Fluoroquinolones Penicillins Prick test Challenge testing Sulfonamides

Anmerkung:	© Springer Medizin Verlag GmbH 2017

Übergeordnetes Werk:	Enthalten in: Allergo journal international - München : Urban & Vogel, 2014, 26(2017), 6 vom: 22. Mai, Seite 212-218
Übergeordnetes Werk:	volume:26 ; year:2017 ; number:6 ; day:22 ; month:05 ; pages:212-218

Links:	Volltext

DOI / URN:	10.1007/s40629-017-0025-z

Katalog-ID:	SPR037002171

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520			\|a Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics.
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700	1		\|a Trautmann, Axel \|4 aut
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publishDate	2017
allfields	10.1007/s40629-017-0025-z doi (DE-627)SPR037002171 (SPR)s40629-017-0025-z-e DE-627 ger DE-627 rakwb eng Klimek, Ludger verfasserin aut Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag GmbH 2017 Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics. Clindamycin (dpeaa)DE-He213 Fluoroquinolones (dpeaa)DE-He213 Penicillins (dpeaa)DE-He213 Prick test (dpeaa)DE-He213 Challenge testing (dpeaa)DE-He213 Sulfonamides (dpeaa)DE-He213 Aderhold, Christoph aut Sperl, Annette aut Trautmann, Axel aut Enthalten in Allergo journal international München : Urban & Vogel, 2014 26(2017), 6 vom: 22. Mai, Seite 212-218 (DE-627)779923413 (DE-600)2759765-9 2197-0378 nnns volume:26 year:2017 number:6 day:22 month:05 pages:212-218 https://dx.doi.org/10.1007/s40629-017-0025-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2017 6 22 05 212-218
spelling	10.1007/s40629-017-0025-z doi (DE-627)SPR037002171 (SPR)s40629-017-0025-z-e DE-627 ger DE-627 rakwb eng Klimek, Ludger verfasserin aut Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag GmbH 2017 Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics. Clindamycin (dpeaa)DE-He213 Fluoroquinolones (dpeaa)DE-He213 Penicillins (dpeaa)DE-He213 Prick test (dpeaa)DE-He213 Challenge testing (dpeaa)DE-He213 Sulfonamides (dpeaa)DE-He213 Aderhold, Christoph aut Sperl, Annette aut Trautmann, Axel aut Enthalten in Allergo journal international München : Urban & Vogel, 2014 26(2017), 6 vom: 22. Mai, Seite 212-218 (DE-627)779923413 (DE-600)2759765-9 2197-0378 nnns volume:26 year:2017 number:6 day:22 month:05 pages:212-218 https://dx.doi.org/10.1007/s40629-017-0025-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2017 6 22 05 212-218
allfields_unstemmed	10.1007/s40629-017-0025-z doi (DE-627)SPR037002171 (SPR)s40629-017-0025-z-e DE-627 ger DE-627 rakwb eng Klimek, Ludger verfasserin aut Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag GmbH 2017 Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics. Clindamycin (dpeaa)DE-He213 Fluoroquinolones (dpeaa)DE-He213 Penicillins (dpeaa)DE-He213 Prick test (dpeaa)DE-He213 Challenge testing (dpeaa)DE-He213 Sulfonamides (dpeaa)DE-He213 Aderhold, Christoph aut Sperl, Annette aut Trautmann, Axel aut Enthalten in Allergo journal international München : Urban & Vogel, 2014 26(2017), 6 vom: 22. Mai, Seite 212-218 (DE-627)779923413 (DE-600)2759765-9 2197-0378 nnns volume:26 year:2017 number:6 day:22 month:05 pages:212-218 https://dx.doi.org/10.1007/s40629-017-0025-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2017 6 22 05 212-218
allfieldsGer	10.1007/s40629-017-0025-z doi (DE-627)SPR037002171 (SPR)s40629-017-0025-z-e DE-627 ger DE-627 rakwb eng Klimek, Ludger verfasserin aut Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag GmbH 2017 Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics. Clindamycin (dpeaa)DE-He213 Fluoroquinolones (dpeaa)DE-He213 Penicillins (dpeaa)DE-He213 Prick test (dpeaa)DE-He213 Challenge testing (dpeaa)DE-He213 Sulfonamides (dpeaa)DE-He213 Aderhold, Christoph aut Sperl, Annette aut Trautmann, Axel aut Enthalten in Allergo journal international München : Urban & Vogel, 2014 26(2017), 6 vom: 22. Mai, Seite 212-218 (DE-627)779923413 (DE-600)2759765-9 2197-0378 nnns volume:26 year:2017 number:6 day:22 month:05 pages:212-218 https://dx.doi.org/10.1007/s40629-017-0025-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2017 6 22 05 212-218
allfieldsSound	10.1007/s40629-017-0025-z doi (DE-627)SPR037002171 (SPR)s40629-017-0025-z-e DE-627 ger DE-627 rakwb eng Klimek, Ludger verfasserin aut Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Medizin Verlag GmbH 2017 Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics. Clindamycin (dpeaa)DE-He213 Fluoroquinolones (dpeaa)DE-He213 Penicillins (dpeaa)DE-He213 Prick test (dpeaa)DE-He213 Challenge testing (dpeaa)DE-He213 Sulfonamides (dpeaa)DE-He213 Aderhold, Christoph aut Sperl, Annette aut Trautmann, Axel aut Enthalten in Allergo journal international München : Urban & Vogel, 2014 26(2017), 6 vom: 22. Mai, Seite 212-218 (DE-627)779923413 (DE-600)2759765-9 2197-0378 nnns volume:26 year:2017 number:6 day:22 month:05 pages:212-218 https://dx.doi.org/10.1007/s40629-017-0025-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2017 6 22 05 212-218
language	English
source	Enthalten in Allergo journal international 26(2017), 6 vom: 22. Mai, Seite 212-218 volume:26 year:2017 number:6 day:22 month:05 pages:212-218
sourceStr	Enthalten in Allergo journal international 26(2017), 6 vom: 22. Mai, Seite 212-218 volume:26 year:2017 number:6 day:22 month:05 pages:212-218
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Clindamycin Fluoroquinolones Penicillins Prick test Challenge testing Sulfonamides
isfreeaccess_bool	false
container_title	Allergo journal international
authorswithroles_txt_mv	Klimek, Ludger @@aut@@ Aderhold, Christoph @@aut@@ Sperl, Annette @@aut@@ Trautmann, Axel @@aut@@
publishDateDaySort_date	2017-05-22T00:00:00Z
hierarchy_top_id	779923413
id	SPR037002171
language_de	englisch
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author	Klimek, Ludger
spellingShingle	Klimek, Ludger misc Clindamycin misc Fluoroquinolones misc Penicillins misc Prick test misc Challenge testing misc Sulfonamides Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out
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topic_title	Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out Clindamycin (dpeaa)DE-He213 Fluoroquinolones (dpeaa)DE-He213 Penicillins (dpeaa)DE-He213 Prick test (dpeaa)DE-He213 Challenge testing (dpeaa)DE-He213 Sulfonamides (dpeaa)DE-He213
topic	misc Clindamycin misc Fluoroquinolones misc Penicillins misc Prick test misc Challenge testing misc Sulfonamides
topic_unstemmed	misc Clindamycin misc Fluoroquinolones misc Penicillins misc Prick test misc Challenge testing misc Sulfonamides
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title	Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out
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title_full	Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out
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author_browse	Klimek, Ludger Aderhold, Christoph Sperl, Annette Trautmann, Axel
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title_sort	allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out
title_auth	Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out
abstract	Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics. © Springer Medizin Verlag GmbH 2017
abstractGer	Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics. © Springer Medizin Verlag GmbH 2017
abstract_unstemmed	Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. It also helps to reduce the unnecessary application of reserve antibiotics. © Springer Medizin Verlag GmbH 2017
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title_short	Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out
url	https://dx.doi.org/10.1007/s40629-017-0025-z
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author2	Aderhold, Christoph Sperl, Annette Trautmann, Axel
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up_date	2024-07-03T20:43:11.569Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR037002171</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519132024.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2017 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s40629-017-0025-z</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR037002171</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40629-017-0025-z-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Klimek, Ludger</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer Medizin Verlag GmbH 2017</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Antibiotics cause allergic reactions with a disproportionate frequency compared with other drugs. Skin symptoms such as exanthema usually result but systemic anaphylactic responses may also occur. Materials and methods An up-to-date review of the scientific literature on allergies to antibiotics was conducted, based on searches in MEDLINE and PubMed, as well as national and international guideline registers and Cochrane. Results Allergic reactions are observed primarily in response to antibiotics from the group of β‑lactams, but also to clindamycin, sulfonamide antibiotics, fluorochinolones, macrolides, and tetracyclines. In many cases, detailed diagnostic procedures are not carried out. However, claims made in the medical history alone are often insufficient to diagnose antibiotics allergy and may lead to false-positive assessments. Effective antibiotics are, therefore, frequently withheld from patients – or patients refuse to take them – without justification. For example, up to 10% of the whole population claim to be allergic to penicillin, but in only 2% of cases can this be verified by skin tests and challenge testing. Conclusions Thorough diagnostic investigation of possible allergy to antibiotics both allows antibiotic allergy to be reliably diagnosed (in the event of a positive outcome) and, if the results are negative, enables the further use of major groups of antibiotics. 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