The effects of clonidine and yohimbine on novelty-induced hypoalgesia
Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rochford, Joseph [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1992 |
|---|
| Schlagwörter: |
|---|
| Anmerkung: |
© Psychonomic Society, Inc. 1992 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Physiological Psychology - Springer-Verlag, 1973, 20(1992), 2 vom: Juni, Seite 163-165 |
|---|---|
| Übergeordnetes Werk: |
volume:20 ; year:1992 ; number:2 ; month:06 ; pages:163-165 |
| Links: |
|---|
| DOI / URN: |
10.3758/BF03327176 |
|---|
| Katalog-ID: |
SPR037018175 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR037018175 | ||
| 003 | DE-627 | ||
| 005 | 20230328181513.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201007s1992 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3758/BF03327176 |2 doi | |
| 035 | |a (DE-627)SPR037018175 | ||
| 035 | |a (SPR)BF03327176-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Rochford, Joseph |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effects of clonidine and yohimbine on novelty-induced hypoalgesia |
| 264 | 1 | |c 1992 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © Psychonomic Society, Inc. 1992 | ||
| 520 | |a Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia. | ||
| 650 | 4 | |a Clonidine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Naloxone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Yohimbine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Colony Room |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Naloxone Administration |7 (dpeaa)DE-He213 | |
| 773 | 0 | 8 | |i Enthalten in |t Physiological Psychology |d Springer-Verlag, 1973 |g 20(1992), 2 vom: Juni, Seite 163-165 |w (DE-627)SPR037003089 |7 nnns |
| 773 | 1 | 8 | |g volume:20 |g year:1992 |g number:2 |g month:06 |g pages:163-165 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.3758/BF03327176 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 20 |j 1992 |e 2 |c 06 |h 163-165 | ||
| author_variant |
j r jr |
|---|---|
| matchkey_str |
rochfordjoseph:1992----:hefcsflndnadoibnonvlyn |
| hierarchy_sort_str |
1992 |
| publishDate |
1992 |
| allfields |
10.3758/BF03327176 doi (DE-627)SPR037018175 (SPR)BF03327176-e DE-627 ger DE-627 rakwb eng Rochford, Joseph verfasserin aut The effects of clonidine and yohimbine on novelty-induced hypoalgesia 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Psychonomic Society, Inc. 1992 Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia. Clonidine (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Yohimbine (dpeaa)DE-He213 Colony Room (dpeaa)DE-He213 Naloxone Administration (dpeaa)DE-He213 Enthalten in Physiological Psychology Springer-Verlag, 1973 20(1992), 2 vom: Juni, Seite 163-165 (DE-627)SPR037003089 nnns volume:20 year:1992 number:2 month:06 pages:163-165 https://dx.doi.org/10.3758/BF03327176 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 20 1992 2 06 163-165 |
| spelling |
10.3758/BF03327176 doi (DE-627)SPR037018175 (SPR)BF03327176-e DE-627 ger DE-627 rakwb eng Rochford, Joseph verfasserin aut The effects of clonidine and yohimbine on novelty-induced hypoalgesia 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Psychonomic Society, Inc. 1992 Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia. Clonidine (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Yohimbine (dpeaa)DE-He213 Colony Room (dpeaa)DE-He213 Naloxone Administration (dpeaa)DE-He213 Enthalten in Physiological Psychology Springer-Verlag, 1973 20(1992), 2 vom: Juni, Seite 163-165 (DE-627)SPR037003089 nnns volume:20 year:1992 number:2 month:06 pages:163-165 https://dx.doi.org/10.3758/BF03327176 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 20 1992 2 06 163-165 |
| allfields_unstemmed |
10.3758/BF03327176 doi (DE-627)SPR037018175 (SPR)BF03327176-e DE-627 ger DE-627 rakwb eng Rochford, Joseph verfasserin aut The effects of clonidine and yohimbine on novelty-induced hypoalgesia 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Psychonomic Society, Inc. 1992 Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia. Clonidine (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Yohimbine (dpeaa)DE-He213 Colony Room (dpeaa)DE-He213 Naloxone Administration (dpeaa)DE-He213 Enthalten in Physiological Psychology Springer-Verlag, 1973 20(1992), 2 vom: Juni, Seite 163-165 (DE-627)SPR037003089 nnns volume:20 year:1992 number:2 month:06 pages:163-165 https://dx.doi.org/10.3758/BF03327176 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 20 1992 2 06 163-165 |
| allfieldsGer |
10.3758/BF03327176 doi (DE-627)SPR037018175 (SPR)BF03327176-e DE-627 ger DE-627 rakwb eng Rochford, Joseph verfasserin aut The effects of clonidine and yohimbine on novelty-induced hypoalgesia 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Psychonomic Society, Inc. 1992 Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia. Clonidine (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Yohimbine (dpeaa)DE-He213 Colony Room (dpeaa)DE-He213 Naloxone Administration (dpeaa)DE-He213 Enthalten in Physiological Psychology Springer-Verlag, 1973 20(1992), 2 vom: Juni, Seite 163-165 (DE-627)SPR037003089 nnns volume:20 year:1992 number:2 month:06 pages:163-165 https://dx.doi.org/10.3758/BF03327176 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 20 1992 2 06 163-165 |
| allfieldsSound |
10.3758/BF03327176 doi (DE-627)SPR037018175 (SPR)BF03327176-e DE-627 ger DE-627 rakwb eng Rochford, Joseph verfasserin aut The effects of clonidine and yohimbine on novelty-induced hypoalgesia 1992 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Psychonomic Society, Inc. 1992 Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia. Clonidine (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Yohimbine (dpeaa)DE-He213 Colony Room (dpeaa)DE-He213 Naloxone Administration (dpeaa)DE-He213 Enthalten in Physiological Psychology Springer-Verlag, 1973 20(1992), 2 vom: Juni, Seite 163-165 (DE-627)SPR037003089 nnns volume:20 year:1992 number:2 month:06 pages:163-165 https://dx.doi.org/10.3758/BF03327176 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 20 1992 2 06 163-165 |
| language |
English |
| source |
Enthalten in Physiological Psychology 20(1992), 2 vom: Juni, Seite 163-165 volume:20 year:1992 number:2 month:06 pages:163-165 |
| sourceStr |
Enthalten in Physiological Psychology 20(1992), 2 vom: Juni, Seite 163-165 volume:20 year:1992 number:2 month:06 pages:163-165 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Clonidine Naloxone Yohimbine Colony Room Naloxone Administration |
| isfreeaccess_bool |
false |
| container_title |
Physiological Psychology |
| authorswithroles_txt_mv |
Rochford, Joseph @@aut@@ |
| publishDateDaySort_date |
1992-06-01T00:00:00Z |
| hierarchy_top_id |
SPR037003089 |
| id |
SPR037018175 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR037018175</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230328181513.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s1992 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3758/BF03327176</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR037018175</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)BF03327176-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Rochford, Joseph</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The effects of clonidine and yohimbine on novelty-induced hypoalgesia</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1992</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Psychonomic Society, Inc. 1992</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Clonidine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Naloxone</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Yohimbine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Colony Room</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Naloxone Administration</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Physiological Psychology</subfield><subfield code="d">Springer-Verlag, 1973</subfield><subfield code="g">20(1992), 2 vom: Juni, Seite 163-165</subfield><subfield code="w">(DE-627)SPR037003089</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:20</subfield><subfield code="g">year:1992</subfield><subfield code="g">number:2</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:163-165</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.3758/BF03327176</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">20</subfield><subfield code="j">1992</subfield><subfield code="e">2</subfield><subfield code="c">06</subfield><subfield code="h">163-165</subfield></datafield></record></collection>
|
| author |
Rochford, Joseph |
| spellingShingle |
Rochford, Joseph misc Clonidine misc Naloxone misc Yohimbine misc Colony Room misc Naloxone Administration The effects of clonidine and yohimbine on novelty-induced hypoalgesia |
| authorStr |
Rochford, Joseph |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)SPR037003089 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
The effects of clonidine and yohimbine on novelty-induced hypoalgesia Clonidine (dpeaa)DE-He213 Naloxone (dpeaa)DE-He213 Yohimbine (dpeaa)DE-He213 Colony Room (dpeaa)DE-He213 Naloxone Administration (dpeaa)DE-He213 |
| topic |
misc Clonidine misc Naloxone misc Yohimbine misc Colony Room misc Naloxone Administration |
| topic_unstemmed |
misc Clonidine misc Naloxone misc Yohimbine misc Colony Room misc Naloxone Administration |
| topic_browse |
misc Clonidine misc Naloxone misc Yohimbine misc Colony Room misc Naloxone Administration |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Physiological Psychology |
| hierarchy_parent_id |
SPR037003089 |
| hierarchy_top_title |
Physiological Psychology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)SPR037003089 |
| title |
The effects of clonidine and yohimbine on novelty-induced hypoalgesia |
| ctrlnum |
(DE-627)SPR037018175 (SPR)BF03327176-e |
| title_full |
The effects of clonidine and yohimbine on novelty-induced hypoalgesia |
| author_sort |
Rochford, Joseph |
| journal |
Physiological Psychology |
| journalStr |
Physiological Psychology |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1992 |
| contenttype_str_mv |
txt |
| container_start_page |
163 |
| author_browse |
Rochford, Joseph |
| container_volume |
20 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Rochford, Joseph |
| doi_str_mv |
10.3758/BF03327176 |
| title_sort |
effects of clonidine and yohimbine on novelty-induced hypoalgesia |
| title_auth |
The effects of clonidine and yohimbine on novelty-induced hypoalgesia |
| abstract |
Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia. © Psychonomic Society, Inc. 1992 |
| abstractGer |
Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia. © Psychonomic Society, Inc. 1992 |
| abstract_unstemmed |
Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia. © Psychonomic Society, Inc. 1992 |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER |
| container_issue |
2 |
| title_short |
The effects of clonidine and yohimbine on novelty-induced hypoalgesia |
| url |
https://dx.doi.org/10.3758/BF03327176 |
| remote_bool |
true |
| ppnlink |
SPR037003089 |
| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.3758/BF03327176 |
| up_date |
2024-07-03T20:46:49.301Z |
| _version_ |
1803592253364502528 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR037018175</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230328181513.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s1992 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3758/BF03327176</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR037018175</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)BF03327176-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Rochford, Joseph</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The effects of clonidine and yohimbine on novelty-induced hypoalgesia</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1992</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Psychonomic Society, Inc. 1992</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Exposure to novel stimuli has been shown to provoke hypoalgesia. The present experiment was conducted to determine whether this hypoalgesia can be influenced by preadministration of the alpha-2 noradrenergic receptor agonist clonidine and the alpha-2 receptor antagonist yohimbine. One group of male Wistar rats (275–300 g) was exposed to a nonfunctional hot-plate apparatus for 90 sec, once a day for 8 days. A second group was not exposed to the apparatus. Both groups were subsequently assessed for pain sensitivity on the functional (48.5°C) hot plate. Animals not previously exposed to the hot plate displayed significantly longer paw-lick latencies than did exposed animals. Preadministration of clonidine (2 µg/kg i.p.) was found to reverse this hypoalgesia, whereas pretreatment with yohimbine (2 mg/kg i.p.) enhanced the effect. These results suggest the importance of noradrenergic substrates in the mediation of novelty-induced hypoalgesia.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Clonidine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Naloxone</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Yohimbine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Colony Room</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Naloxone Administration</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Physiological Psychology</subfield><subfield code="d">Springer-Verlag, 1973</subfield><subfield code="g">20(1992), 2 vom: Juni, Seite 163-165</subfield><subfield code="w">(DE-627)SPR037003089</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:20</subfield><subfield code="g">year:1992</subfield><subfield code="g">number:2</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:163-165</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.3758/BF03327176</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">20</subfield><subfield code="j">1992</subfield><subfield code="e">2</subfield><subfield code="c">06</subfield><subfield code="h">163-165</subfield></datafield></record></collection>
|
| score |
7.3998823 |