The effects of dopamine on digit span in Parkinson’s disease

Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Warden, Clara [verfasserIn] Hwang, Jaclyn Marshall, Anisa Fenesy, Michelle Poston, Kathleen L.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Parkinson’s disease PD Digit span backward Digit span forward Dopamine Working memory Cognitive impairment Dementia

Anmerkung:	© Warden et al. 2016

Übergeordnetes Werk:	Enthalten in: Journal of Clinical Movement Disorders - London : BioMed Central, 2014, 3(2016), 1 vom: 07. März
Übergeordnetes Werk:	volume:3 ; year:2016 ; number:1 ; day:07 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s40734-016-0033-z

Katalog-ID:	SPR037199153

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520			\|a Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients.
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allfields	10.1186/s40734-016-0033-z doi (DE-627)SPR037199153 (SPR)s40734-016-0033-z-e DE-627 ger DE-627 rakwb eng Warden, Clara verfasserin aut The effects of dopamine on digit span in Parkinson’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Warden et al. 2016 Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients. Parkinson’s disease (dpeaa)DE-He213 PD (dpeaa)DE-He213 Digit span backward (dpeaa)DE-He213 Digit span forward (dpeaa)DE-He213 Dopamine (dpeaa)DE-He213 Working memory (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Hwang, Jaclyn aut Marshall, Anisa aut Fenesy, Michelle aut Poston, Kathleen L. aut Enthalten in Journal of Clinical Movement Disorders London : BioMed Central, 2014 3(2016), 1 vom: 07. März (DE-627)81054007X (DE-600)2802032-7 2054-7072 nnns volume:3 year:2016 number:1 day:07 month:03 https://dx.doi.org/10.1186/s40734-016-0033-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2016 1 07 03
spelling	10.1186/s40734-016-0033-z doi (DE-627)SPR037199153 (SPR)s40734-016-0033-z-e DE-627 ger DE-627 rakwb eng Warden, Clara verfasserin aut The effects of dopamine on digit span in Parkinson’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Warden et al. 2016 Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients. Parkinson’s disease (dpeaa)DE-He213 PD (dpeaa)DE-He213 Digit span backward (dpeaa)DE-He213 Digit span forward (dpeaa)DE-He213 Dopamine (dpeaa)DE-He213 Working memory (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Hwang, Jaclyn aut Marshall, Anisa aut Fenesy, Michelle aut Poston, Kathleen L. aut Enthalten in Journal of Clinical Movement Disorders London : BioMed Central, 2014 3(2016), 1 vom: 07. März (DE-627)81054007X (DE-600)2802032-7 2054-7072 nnns volume:3 year:2016 number:1 day:07 month:03 https://dx.doi.org/10.1186/s40734-016-0033-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2016 1 07 03
allfields_unstemmed	10.1186/s40734-016-0033-z doi (DE-627)SPR037199153 (SPR)s40734-016-0033-z-e DE-627 ger DE-627 rakwb eng Warden, Clara verfasserin aut The effects of dopamine on digit span in Parkinson’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Warden et al. 2016 Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients. Parkinson’s disease (dpeaa)DE-He213 PD (dpeaa)DE-He213 Digit span backward (dpeaa)DE-He213 Digit span forward (dpeaa)DE-He213 Dopamine (dpeaa)DE-He213 Working memory (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Hwang, Jaclyn aut Marshall, Anisa aut Fenesy, Michelle aut Poston, Kathleen L. aut Enthalten in Journal of Clinical Movement Disorders London : BioMed Central, 2014 3(2016), 1 vom: 07. März (DE-627)81054007X (DE-600)2802032-7 2054-7072 nnns volume:3 year:2016 number:1 day:07 month:03 https://dx.doi.org/10.1186/s40734-016-0033-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2016 1 07 03
allfieldsGer	10.1186/s40734-016-0033-z doi (DE-627)SPR037199153 (SPR)s40734-016-0033-z-e DE-627 ger DE-627 rakwb eng Warden, Clara verfasserin aut The effects of dopamine on digit span in Parkinson’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Warden et al. 2016 Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients. Parkinson’s disease (dpeaa)DE-He213 PD (dpeaa)DE-He213 Digit span backward (dpeaa)DE-He213 Digit span forward (dpeaa)DE-He213 Dopamine (dpeaa)DE-He213 Working memory (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Hwang, Jaclyn aut Marshall, Anisa aut Fenesy, Michelle aut Poston, Kathleen L. aut Enthalten in Journal of Clinical Movement Disorders London : BioMed Central, 2014 3(2016), 1 vom: 07. März (DE-627)81054007X (DE-600)2802032-7 2054-7072 nnns volume:3 year:2016 number:1 day:07 month:03 https://dx.doi.org/10.1186/s40734-016-0033-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2016 1 07 03
allfieldsSound	10.1186/s40734-016-0033-z doi (DE-627)SPR037199153 (SPR)s40734-016-0033-z-e DE-627 ger DE-627 rakwb eng Warden, Clara verfasserin aut The effects of dopamine on digit span in Parkinson’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Warden et al. 2016 Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients. Parkinson’s disease (dpeaa)DE-He213 PD (dpeaa)DE-He213 Digit span backward (dpeaa)DE-He213 Digit span forward (dpeaa)DE-He213 Dopamine (dpeaa)DE-He213 Working memory (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Hwang, Jaclyn aut Marshall, Anisa aut Fenesy, Michelle aut Poston, Kathleen L. aut Enthalten in Journal of Clinical Movement Disorders London : BioMed Central, 2014 3(2016), 1 vom: 07. März (DE-627)81054007X (DE-600)2802032-7 2054-7072 nnns volume:3 year:2016 number:1 day:07 month:03 https://dx.doi.org/10.1186/s40734-016-0033-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2016 1 07 03
language	English
source	Enthalten in Journal of Clinical Movement Disorders 3(2016), 1 vom: 07. März volume:3 year:2016 number:1 day:07 month:03
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spellingShingle	Warden, Clara misc Parkinson’s disease misc PD misc Digit span backward misc Digit span forward misc Dopamine misc Working memory misc Cognitive impairment misc Dementia The effects of dopamine on digit span in Parkinson’s disease
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topic_title	The effects of dopamine on digit span in Parkinson’s disease Parkinson’s disease (dpeaa)DE-He213 PD (dpeaa)DE-He213 Digit span backward (dpeaa)DE-He213 Digit span forward (dpeaa)DE-He213 Dopamine (dpeaa)DE-He213 Working memory (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Dementia (dpeaa)DE-He213
topic	misc Parkinson’s disease misc PD misc Digit span backward misc Digit span forward misc Dopamine misc Working memory misc Cognitive impairment misc Dementia
topic_unstemmed	misc Parkinson’s disease misc PD misc Digit span backward misc Digit span forward misc Dopamine misc Working memory misc Cognitive impairment misc Dementia
topic_browse	misc Parkinson’s disease misc PD misc Digit span backward misc Digit span forward misc Dopamine misc Working memory misc Cognitive impairment misc Dementia
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title	The effects of dopamine on digit span in Parkinson’s disease
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title_sort	effects of dopamine on digit span in parkinson’s disease
title_auth	The effects of dopamine on digit span in Parkinson’s disease
abstract	Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients. © Warden et al. 2016
abstractGer	Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients. © Warden et al. 2016
abstract_unstemmed	Background Parkinson’s disease patients are at an elevated risk of developing cognitive impairment. Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. Moreover, it reveals a partial beneficial effect of dopamine on Digit Span in Parkinson’s disease patients. © Warden et al. 2016
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Although cognitive impairment is one of the strongest predictors of quality of life, dopaminergic anti-parkinsonian medications are designed to target motor symptoms. However, there is substantial evidence that dopamine also impacts cognition, in particular working memory. It is therefore critical for movement disorders physicians to understand the potential dopaminergic effects on working memory when prescribing these medications. Verbal digit span tasks offer a potentially straightforward and quick assessment of baseline working memory. Moreover, Digit Span Backward was recently validated as a screening tool for mild cognitive impairment in Parkinson’s disease when participants were medicated. Research indicates that the interaction between dopamine and working memory follows an Inverted-U shaped curve, but the effect of dopamine on Digit Span has not been well studied. Our study seeks to: (1) determine the validity of verbal Digit Spans for detecting cognitive impairment in Parkinson’s disease patients both ON and OFF medications; and (2) ascertain the effects of dopaminergic medications on verbal Digit Span. Methods We recruited 64 Parkinson’s disease patients and 22 age-and education-matched controls. Parkinson’s patients completed Digit Span Backward and Digit Span Forward ON and OFF medications, while healthy controls completed them once. All participants were categorized by cognitive diagnosis using level-II consensus criteria. Results Digit Span Backward successfully identified mild cognitive impairment in Parkinson’s disease, both ON and OFF medications. Combining patients with and without cognitive impairment, we found that dopamine significantly improved performance on Digit Span Backward, but not Forward. In a secondary analysis, we found this dopaminergic improvement was restricted to the Low baseline working memory group; the High baseline working memory group was unaffected. Conclusions This study provides evidence for Digit Span Backward as a screening tool for working memory impairment in Parkinson’s disease and for its utility in measuring baseline working memory. 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The effects of dopamine on digit span in Parkinson’s disease

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