Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging

Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion infor...
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Autor*in:	Federau, Christian [verfasserIn] Nguyen, Audrey Christensen, Soren Saba, Luca Wintermark, Max

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Perfusion IVIM Brain Cerebral death

Anmerkung:	© Federau et al. 2016

Übergeordnetes Werk:	Enthalten in: Neurovascular Imaging - London : BioMed Central, 2015, 2(2016), 1 vom: 10. Mai
Übergeordnetes Werk:	volume:2 ; year:2016 ; number:1 ; day:10 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s40809-016-0020-7

Katalog-ID:	SPR037844210

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520			\|a Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients.
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allfields	10.1186/s40809-016-0020-7 doi (DE-627)SPR037844210 (SPR)s40809-016-0020-7-e DE-627 ger DE-627 rakwb eng Federau, Christian verfasserin aut Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Federau et al. 2016 Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients. Perfusion (dpeaa)DE-He213 IVIM (dpeaa)DE-He213 Brain (dpeaa)DE-He213 Cerebral death (dpeaa)DE-He213 Nguyen, Audrey aut Christensen, Soren aut Saba, Luca aut Wintermark, Max aut Enthalten in Neurovascular Imaging London : BioMed Central, 2015 2(2016), 1 vom: 10. Mai (DE-627)837629993 (DE-600)2837312-1 2055-5792 nnns volume:2 year:2016 number:1 day:10 month:05 https://dx.doi.org/10.1186/s40809-016-0020-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 1 10 05
spelling	10.1186/s40809-016-0020-7 doi (DE-627)SPR037844210 (SPR)s40809-016-0020-7-e DE-627 ger DE-627 rakwb eng Federau, Christian verfasserin aut Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Federau et al. 2016 Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients. Perfusion (dpeaa)DE-He213 IVIM (dpeaa)DE-He213 Brain (dpeaa)DE-He213 Cerebral death (dpeaa)DE-He213 Nguyen, Audrey aut Christensen, Soren aut Saba, Luca aut Wintermark, Max aut Enthalten in Neurovascular Imaging London : BioMed Central, 2015 2(2016), 1 vom: 10. Mai (DE-627)837629993 (DE-600)2837312-1 2055-5792 nnns volume:2 year:2016 number:1 day:10 month:05 https://dx.doi.org/10.1186/s40809-016-0020-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 1 10 05
allfields_unstemmed	10.1186/s40809-016-0020-7 doi (DE-627)SPR037844210 (SPR)s40809-016-0020-7-e DE-627 ger DE-627 rakwb eng Federau, Christian verfasserin aut Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Federau et al. 2016 Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients. Perfusion (dpeaa)DE-He213 IVIM (dpeaa)DE-He213 Brain (dpeaa)DE-He213 Cerebral death (dpeaa)DE-He213 Nguyen, Audrey aut Christensen, Soren aut Saba, Luca aut Wintermark, Max aut Enthalten in Neurovascular Imaging London : BioMed Central, 2015 2(2016), 1 vom: 10. Mai (DE-627)837629993 (DE-600)2837312-1 2055-5792 nnns volume:2 year:2016 number:1 day:10 month:05 https://dx.doi.org/10.1186/s40809-016-0020-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 1 10 05
allfieldsGer	10.1186/s40809-016-0020-7 doi (DE-627)SPR037844210 (SPR)s40809-016-0020-7-e DE-627 ger DE-627 rakwb eng Federau, Christian verfasserin aut Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Federau et al. 2016 Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients. Perfusion (dpeaa)DE-He213 IVIM (dpeaa)DE-He213 Brain (dpeaa)DE-He213 Cerebral death (dpeaa)DE-He213 Nguyen, Audrey aut Christensen, Soren aut Saba, Luca aut Wintermark, Max aut Enthalten in Neurovascular Imaging London : BioMed Central, 2015 2(2016), 1 vom: 10. Mai (DE-627)837629993 (DE-600)2837312-1 2055-5792 nnns volume:2 year:2016 number:1 day:10 month:05 https://dx.doi.org/10.1186/s40809-016-0020-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 1 10 05
allfieldsSound	10.1186/s40809-016-0020-7 doi (DE-627)SPR037844210 (SPR)s40809-016-0020-7-e DE-627 ger DE-627 rakwb eng Federau, Christian verfasserin aut Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Federau et al. 2016 Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients. Perfusion (dpeaa)DE-He213 IVIM (dpeaa)DE-He213 Brain (dpeaa)DE-He213 Cerebral death (dpeaa)DE-He213 Nguyen, Audrey aut Christensen, Soren aut Saba, Luca aut Wintermark, Max aut Enthalten in Neurovascular Imaging London : BioMed Central, 2015 2(2016), 1 vom: 10. Mai (DE-627)837629993 (DE-600)2837312-1 2055-5792 nnns volume:2 year:2016 number:1 day:10 month:05 https://dx.doi.org/10.1186/s40809-016-0020-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 1 10 05
language	English
source	Enthalten in Neurovascular Imaging 2(2016), 1 vom: 10. Mai volume:2 year:2016 number:1 day:10 month:05
sourceStr	Enthalten in Neurovascular Imaging 2(2016), 1 vom: 10. Mai volume:2 year:2016 number:1 day:10 month:05
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Perfusion IVIM Brain Cerebral death
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container_title	Neurovascular Imaging
authorswithroles_txt_mv	Federau, Christian @@aut@@ Nguyen, Audrey @@aut@@ Christensen, Soren @@aut@@ Saba, Luca @@aut@@ Wintermark, Max @@aut@@
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Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Perfusion</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">IVIM</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Brain</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cerebral death</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nguyen, Audrey</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Christensen, Soren</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Saba, Luca</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wintermark, Max</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Neurovascular Imaging</subfield><subfield code="d">London : BioMed Central, 2015</subfield><subfield code="g">2(2016), 1 vom: 10. 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author	Federau, Christian
spellingShingle	Federau, Christian misc Perfusion misc IVIM misc Brain misc Cerebral death Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging
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topic_title	Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging Perfusion (dpeaa)DE-He213 IVIM (dpeaa)DE-He213 Brain (dpeaa)DE-He213 Cerebral death (dpeaa)DE-He213
topic	misc Perfusion misc IVIM misc Brain misc Cerebral death
topic_unstemmed	misc Perfusion misc IVIM misc Brain misc Cerebral death
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title	Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging
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title_full	Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging
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author_browse	Federau, Christian Nguyen, Audrey Christensen, Soren Saba, Luca Wintermark, Max
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doi_str_mv	10.1186/s40809-016-0020-7
title_sort	cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging
title_auth	Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging
abstract	Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients. © Federau et al. 2016
abstractGer	Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients. © Federau et al. 2016
abstract_unstemmed	Background The assessment of brain death can be challenging in critically ill patients, and cerebral perfusion quantification might give information on the brain tissue viability. Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. Conclusion Intravoxel incoherent motion perfusion imaging is a promising tool to assess local brain tissue viability in critically ill patients. © Federau et al. 2016
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title_short	Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging
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author2	Nguyen, Audrey Christensen, Soren Saba, Luca Wintermark, Max
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Intravoxel incoherent motion perfusion imaging is a magnetic resonance imaging technique, which extracts perfusion information from a diffusion-weighted sequence, and provides local, microvascular perfusion assessment without contrast media injection. Methods Diffusion weighted images were acquired with 16 b-values (0–900 s/$ mm^{2} $) in the brain in two patients with cerebral death, confirmed by clinical assessment and evolution, as well as in two age-matched healthy subjects. The intravoxel incoherent motion perfusion fraction maps were obtained by fitting the bi-exponential signal equation model. 8 regions of interest were drawn blindly in the brain neocortex (in the frontal, temporal, parietal, and occipital lobes on both sides) and perfusion fractions were compared between patients with cerebral death and healthy control. Statistical significance was assessed using two-sided Wilcoxon signed rank test, and set to α < 0.05. Results Intravoxel incoherent motion (IVIM) perfusion fraction was vanishing in the brain of the two patients with cerebral brain death compared to the healthy controls. Mean (± standard deviation) cortex perfusion fraction was 0.016 ± 0.005 respectively 0.005 ± 0.008 in the cerebral death patients, compared to respectively 0.052 ± 0.021 (p = 0.02) and 0.071 ± 0.042 (p = 0.008) in the age-matched controls. 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Cerebral perfusion measurement in brain death with intravoxel incoherent motion imaging

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