Anticarcinogenicity and Toxicity of Organotin(IV) Complexes: A Review
Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyri...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ali, Saqib [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Anmerkung: |
© Shiraz University 2016 |
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| Übergeordnetes Werk: |
Enthalten in: Iranian journal of science and technology - Cham, Switzerland : Springer International Pubishing, 2004, 42(2016), 2 vom: 13. Juli, Seite 505-524 |
|---|---|
| Übergeordnetes Werk: |
volume:42 ; year:2016 ; number:2 ; day:13 ; month:07 ; pages:505-524 |
| Links: |
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| DOI / URN: |
10.1007/s40995-016-0048-1 |
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SPR038037726 |
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| 520 | |a Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyrimidine, and aminoalcohols have been reviewed here. The high cytotoxic activity of complexes is affected by (1) the availability of coordination positions at Sn and (2) the occurrence of relatively stable ligand–Sn bonds, e.g., Sn–N and Sn–S, and which result in less hydrolytic decomposition. Furthermore, the lipophilicity due to the presence of the number of carbon atoms in the organotin moiety of organotin(IV) complexes warranted its impressive antitumor activity and cytotoxicity. The cytotoxic activity exhibited by [$ Ph_{3} $Sn(Meclo)] against L-929, A-549, and T24 cell lines shows that the coupling of meclofenamic acid to $ SnPh_{3} $(IV) metal center results in a metallic complex with important biological properties and remarkable cytotoxic activity, since it exhibits $ IC_{50} $ values in a micromolar range better to that of the antitumor drug cisplatin. However, it is observed during biological testing that the major role is attributed to the alkyl/aryl groups attached to tin atom, while ligands play secondary role. | ||
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10.1007/s40995-016-0048-1 doi (DE-627)SPR038037726 (SPR)s40995-016-0048-1-e DE-627 ger DE-627 rakwb eng Ali, Saqib verfasserin aut Anticarcinogenicity and Toxicity of Organotin(IV) Complexes: A Review 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Shiraz University 2016 Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyrimidine, and aminoalcohols have been reviewed here. The high cytotoxic activity of complexes is affected by (1) the availability of coordination positions at Sn and (2) the occurrence of relatively stable ligand–Sn bonds, e.g., Sn–N and Sn–S, and which result in less hydrolytic decomposition. Furthermore, the lipophilicity due to the presence of the number of carbon atoms in the organotin moiety of organotin(IV) complexes warranted its impressive antitumor activity and cytotoxicity. The cytotoxic activity exhibited by [$ Ph_{3} $Sn(Meclo)] against L-929, A-549, and T24 cell lines shows that the coupling of meclofenamic acid to $ SnPh_{3} $(IV) metal center results in a metallic complex with important biological properties and remarkable cytotoxic activity, since it exhibits $ IC_{50} $ values in a micromolar range better to that of the antitumor drug cisplatin. However, it is observed during biological testing that the major role is attributed to the alkyl/aryl groups attached to tin atom, while ligands play secondary role. Organotin(IV) complexes (dpeaa)DE-He213 Anticarcinogenicity (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Structural diversity (dpeaa)DE-He213 Shahzadi, Saira aut Enthalten in Iranian journal of science and technology Cham, Switzerland : Springer International Pubishing, 2004 42(2016), 2 vom: 13. Juli, Seite 505-524 (DE-627)SPR038034816 (DE-600)2843077-3 2364-1819 nnns volume:42 year:2016 number:2 day:13 month:07 pages:505-524 https://dx.doi.org/10.1007/s40995-016-0048-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2016 2 13 07 505-524 |
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10.1007/s40995-016-0048-1 doi (DE-627)SPR038037726 (SPR)s40995-016-0048-1-e DE-627 ger DE-627 rakwb eng Ali, Saqib verfasserin aut Anticarcinogenicity and Toxicity of Organotin(IV) Complexes: A Review 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Shiraz University 2016 Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyrimidine, and aminoalcohols have been reviewed here. The high cytotoxic activity of complexes is affected by (1) the availability of coordination positions at Sn and (2) the occurrence of relatively stable ligand–Sn bonds, e.g., Sn–N and Sn–S, and which result in less hydrolytic decomposition. Furthermore, the lipophilicity due to the presence of the number of carbon atoms in the organotin moiety of organotin(IV) complexes warranted its impressive antitumor activity and cytotoxicity. The cytotoxic activity exhibited by [$ Ph_{3} $Sn(Meclo)] against L-929, A-549, and T24 cell lines shows that the coupling of meclofenamic acid to $ SnPh_{3} $(IV) metal center results in a metallic complex with important biological properties and remarkable cytotoxic activity, since it exhibits $ IC_{50} $ values in a micromolar range better to that of the antitumor drug cisplatin. However, it is observed during biological testing that the major role is attributed to the alkyl/aryl groups attached to tin atom, while ligands play secondary role. Organotin(IV) complexes (dpeaa)DE-He213 Anticarcinogenicity (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Structural diversity (dpeaa)DE-He213 Shahzadi, Saira aut Enthalten in Iranian journal of science and technology Cham, Switzerland : Springer International Pubishing, 2004 42(2016), 2 vom: 13. Juli, Seite 505-524 (DE-627)SPR038034816 (DE-600)2843077-3 2364-1819 nnns volume:42 year:2016 number:2 day:13 month:07 pages:505-524 https://dx.doi.org/10.1007/s40995-016-0048-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2016 2 13 07 505-524 |
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10.1007/s40995-016-0048-1 doi (DE-627)SPR038037726 (SPR)s40995-016-0048-1-e DE-627 ger DE-627 rakwb eng Ali, Saqib verfasserin aut Anticarcinogenicity and Toxicity of Organotin(IV) Complexes: A Review 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Shiraz University 2016 Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyrimidine, and aminoalcohols have been reviewed here. The high cytotoxic activity of complexes is affected by (1) the availability of coordination positions at Sn and (2) the occurrence of relatively stable ligand–Sn bonds, e.g., Sn–N and Sn–S, and which result in less hydrolytic decomposition. Furthermore, the lipophilicity due to the presence of the number of carbon atoms in the organotin moiety of organotin(IV) complexes warranted its impressive antitumor activity and cytotoxicity. The cytotoxic activity exhibited by [$ Ph_{3} $Sn(Meclo)] against L-929, A-549, and T24 cell lines shows that the coupling of meclofenamic acid to $ SnPh_{3} $(IV) metal center results in a metallic complex with important biological properties and remarkable cytotoxic activity, since it exhibits $ IC_{50} $ values in a micromolar range better to that of the antitumor drug cisplatin. However, it is observed during biological testing that the major role is attributed to the alkyl/aryl groups attached to tin atom, while ligands play secondary role. Organotin(IV) complexes (dpeaa)DE-He213 Anticarcinogenicity (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Structural diversity (dpeaa)DE-He213 Shahzadi, Saira aut Enthalten in Iranian journal of science and technology Cham, Switzerland : Springer International Pubishing, 2004 42(2016), 2 vom: 13. Juli, Seite 505-524 (DE-627)SPR038034816 (DE-600)2843077-3 2364-1819 nnns volume:42 year:2016 number:2 day:13 month:07 pages:505-524 https://dx.doi.org/10.1007/s40995-016-0048-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2016 2 13 07 505-524 |
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10.1007/s40995-016-0048-1 doi (DE-627)SPR038037726 (SPR)s40995-016-0048-1-e DE-627 ger DE-627 rakwb eng Ali, Saqib verfasserin aut Anticarcinogenicity and Toxicity of Organotin(IV) Complexes: A Review 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Shiraz University 2016 Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyrimidine, and aminoalcohols have been reviewed here. The high cytotoxic activity of complexes is affected by (1) the availability of coordination positions at Sn and (2) the occurrence of relatively stable ligand–Sn bonds, e.g., Sn–N and Sn–S, and which result in less hydrolytic decomposition. Furthermore, the lipophilicity due to the presence of the number of carbon atoms in the organotin moiety of organotin(IV) complexes warranted its impressive antitumor activity and cytotoxicity. The cytotoxic activity exhibited by [$ Ph_{3} $Sn(Meclo)] against L-929, A-549, and T24 cell lines shows that the coupling of meclofenamic acid to $ SnPh_{3} $(IV) metal center results in a metallic complex with important biological properties and remarkable cytotoxic activity, since it exhibits $ IC_{50} $ values in a micromolar range better to that of the antitumor drug cisplatin. However, it is observed during biological testing that the major role is attributed to the alkyl/aryl groups attached to tin atom, while ligands play secondary role. Organotin(IV) complexes (dpeaa)DE-He213 Anticarcinogenicity (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Structural diversity (dpeaa)DE-He213 Shahzadi, Saira aut Enthalten in Iranian journal of science and technology Cham, Switzerland : Springer International Pubishing, 2004 42(2016), 2 vom: 13. Juli, Seite 505-524 (DE-627)SPR038034816 (DE-600)2843077-3 2364-1819 nnns volume:42 year:2016 number:2 day:13 month:07 pages:505-524 https://dx.doi.org/10.1007/s40995-016-0048-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2016 2 13 07 505-524 |
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10.1007/s40995-016-0048-1 doi (DE-627)SPR038037726 (SPR)s40995-016-0048-1-e DE-627 ger DE-627 rakwb eng Ali, Saqib verfasserin aut Anticarcinogenicity and Toxicity of Organotin(IV) Complexes: A Review 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Shiraz University 2016 Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyrimidine, and aminoalcohols have been reviewed here. The high cytotoxic activity of complexes is affected by (1) the availability of coordination positions at Sn and (2) the occurrence of relatively stable ligand–Sn bonds, e.g., Sn–N and Sn–S, and which result in less hydrolytic decomposition. Furthermore, the lipophilicity due to the presence of the number of carbon atoms in the organotin moiety of organotin(IV) complexes warranted its impressive antitumor activity and cytotoxicity. The cytotoxic activity exhibited by [$ Ph_{3} $Sn(Meclo)] against L-929, A-549, and T24 cell lines shows that the coupling of meclofenamic acid to $ SnPh_{3} $(IV) metal center results in a metallic complex with important biological properties and remarkable cytotoxic activity, since it exhibits $ IC_{50} $ values in a micromolar range better to that of the antitumor drug cisplatin. However, it is observed during biological testing that the major role is attributed to the alkyl/aryl groups attached to tin atom, while ligands play secondary role. Organotin(IV) complexes (dpeaa)DE-He213 Anticarcinogenicity (dpeaa)DE-He213 Toxicity (dpeaa)DE-He213 Structural diversity (dpeaa)DE-He213 Shahzadi, Saira aut Enthalten in Iranian journal of science and technology Cham, Switzerland : Springer International Pubishing, 2004 42(2016), 2 vom: 13. Juli, Seite 505-524 (DE-627)SPR038034816 (DE-600)2843077-3 2364-1819 nnns volume:42 year:2016 number:2 day:13 month:07 pages:505-524 https://dx.doi.org/10.1007/s40995-016-0048-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 42 2016 2 13 07 505-524 |
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Anticarcinogenicity and Toxicity of Organotin(IV) Complexes: A Review |
| abstract |
Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyrimidine, and aminoalcohols have been reviewed here. The high cytotoxic activity of complexes is affected by (1) the availability of coordination positions at Sn and (2) the occurrence of relatively stable ligand–Sn bonds, e.g., Sn–N and Sn–S, and which result in less hydrolytic decomposition. Furthermore, the lipophilicity due to the presence of the number of carbon atoms in the organotin moiety of organotin(IV) complexes warranted its impressive antitumor activity and cytotoxicity. The cytotoxic activity exhibited by [$ Ph_{3} $Sn(Meclo)] against L-929, A-549, and T24 cell lines shows that the coupling of meclofenamic acid to $ SnPh_{3} $(IV) metal center results in a metallic complex with important biological properties and remarkable cytotoxic activity, since it exhibits $ IC_{50} $ values in a micromolar range better to that of the antitumor drug cisplatin. However, it is observed during biological testing that the major role is attributed to the alkyl/aryl groups attached to tin atom, while ligands play secondary role. © Shiraz University 2016 |
| abstractGer |
Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyrimidine, and aminoalcohols have been reviewed here. The high cytotoxic activity of complexes is affected by (1) the availability of coordination positions at Sn and (2) the occurrence of relatively stable ligand–Sn bonds, e.g., Sn–N and Sn–S, and which result in less hydrolytic decomposition. Furthermore, the lipophilicity due to the presence of the number of carbon atoms in the organotin moiety of organotin(IV) complexes warranted its impressive antitumor activity and cytotoxicity. The cytotoxic activity exhibited by [$ Ph_{3} $Sn(Meclo)] against L-929, A-549, and T24 cell lines shows that the coupling of meclofenamic acid to $ SnPh_{3} $(IV) metal center results in a metallic complex with important biological properties and remarkable cytotoxic activity, since it exhibits $ IC_{50} $ values in a micromolar range better to that of the antitumor drug cisplatin. However, it is observed during biological testing that the major role is attributed to the alkyl/aryl groups attached to tin atom, while ligands play secondary role. © Shiraz University 2016 |
| abstract_unstemmed |
Abstract The excellent anticarcinogenicity and toxicity of organotin(IV) complexes of certain acrylates, methylenedioxyphenylpropenoic acid, piperonylic acid, phenylethanoates, carboxylic acid, acetic acid, benzohydroxamato, peptides, dipeptides, benzoates, schiff bases, xylene, nicotinic acid, pyrimidine, and aminoalcohols have been reviewed here. The high cytotoxic activity of complexes is affected by (1) the availability of coordination positions at Sn and (2) the occurrence of relatively stable ligand–Sn bonds, e.g., Sn–N and Sn–S, and which result in less hydrolytic decomposition. Furthermore, the lipophilicity due to the presence of the number of carbon atoms in the organotin moiety of organotin(IV) complexes warranted its impressive antitumor activity and cytotoxicity. The cytotoxic activity exhibited by [$ Ph_{3} $Sn(Meclo)] against L-929, A-549, and T24 cell lines shows that the coupling of meclofenamic acid to $ SnPh_{3} $(IV) metal center results in a metallic complex with important biological properties and remarkable cytotoxic activity, since it exhibits $ IC_{50} $ values in a micromolar range better to that of the antitumor drug cisplatin. However, it is observed during biological testing that the major role is attributed to the alkyl/aryl groups attached to tin atom, while ligands play secondary role. © Shiraz University 2016 |
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| title_short |
Anticarcinogenicity and Toxicity of Organotin(IV) Complexes: A Review |
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https://dx.doi.org/10.1007/s40995-016-0048-1 |
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Shahzadi, Saira |
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10.1007/s40995-016-0048-1 |
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2024-07-03T15:51:51.042Z |
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