DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification

Abstract In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation s...
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Gespeichert in:

Autor*in:	Ullah, Sami [verfasserIn] Garg, Rakesh K. Noor, Farida

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Forensic DNA analysis Paraffin-embedded tissues Formalin fixed samples Fixation

Anmerkung:	© The Author(s) 2017

Übergeordnetes Werk:	Enthalten in: Egyptian Journal of Forensic Sciences - Berlin : Springer, 2011, 7(2017), 1 vom: 06. Dez.
Übergeordnetes Werk:	volume:7 ; year:2017 ; number:1 ; day:06 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s41935-017-0027-5

Katalog-ID:	SPR03834310X

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spelling	10.1186/s41935-017-0027-5 doi (DE-627)SPR03834310X (SPR)s41935-017-0027-5-e DE-627 ger DE-627 rakwb eng Ullah, Sami verfasserin aut DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Abstract In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. Forensic (dpeaa)DE-He213 DNA analysis (dpeaa)DE-He213 Paraffin-embedded tissues (dpeaa)DE-He213 Formalin fixed samples (dpeaa)DE-He213 Fixation (dpeaa)DE-He213 Garg, Rakesh K. aut Noor, Farida aut Enthalten in Egyptian Journal of Forensic Sciences Berlin : Springer, 2011 7(2017), 1 vom: 06. Dez. (DE-627)670211184 (DE-600)2631791-6 2090-5939 nnns volume:7 year:2017 number:1 day:06 month:12 https://dx.doi.org/10.1186/s41935-017-0027-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 GBV_ILN_4753 AR 7 2017 1 06 12
allfields_unstemmed	10.1186/s41935-017-0027-5 doi (DE-627)SPR03834310X (SPR)s41935-017-0027-5-e DE-627 ger DE-627 rakwb eng Ullah, Sami verfasserin aut DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Abstract In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. Forensic (dpeaa)DE-He213 DNA analysis (dpeaa)DE-He213 Paraffin-embedded tissues (dpeaa)DE-He213 Formalin fixed samples (dpeaa)DE-He213 Fixation (dpeaa)DE-He213 Garg, Rakesh K. aut Noor, Farida aut Enthalten in Egyptian Journal of Forensic Sciences Berlin : Springer, 2011 7(2017), 1 vom: 06. Dez. (DE-627)670211184 (DE-600)2631791-6 2090-5939 nnns volume:7 year:2017 number:1 day:06 month:12 https://dx.doi.org/10.1186/s41935-017-0027-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 GBV_ILN_4753 AR 7 2017 1 06 12
allfieldsGer	10.1186/s41935-017-0027-5 doi (DE-627)SPR03834310X (SPR)s41935-017-0027-5-e DE-627 ger DE-627 rakwb eng Ullah, Sami verfasserin aut DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Abstract In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. Forensic (dpeaa)DE-He213 DNA analysis (dpeaa)DE-He213 Paraffin-embedded tissues (dpeaa)DE-He213 Formalin fixed samples (dpeaa)DE-He213 Fixation (dpeaa)DE-He213 Garg, Rakesh K. aut Noor, Farida aut Enthalten in Egyptian Journal of Forensic Sciences Berlin : Springer, 2011 7(2017), 1 vom: 06. Dez. (DE-627)670211184 (DE-600)2631791-6 2090-5939 nnns volume:7 year:2017 number:1 day:06 month:12 https://dx.doi.org/10.1186/s41935-017-0027-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 GBV_ILN_4753 AR 7 2017 1 06 12
allfieldsSound	10.1186/s41935-017-0027-5 doi (DE-627)SPR03834310X (SPR)s41935-017-0027-5-e DE-627 ger DE-627 rakwb eng Ullah, Sami verfasserin aut DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Abstract In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. Forensic (dpeaa)DE-He213 DNA analysis (dpeaa)DE-He213 Paraffin-embedded tissues (dpeaa)DE-He213 Formalin fixed samples (dpeaa)DE-He213 Fixation (dpeaa)DE-He213 Garg, Rakesh K. aut Noor, Farida aut Enthalten in Egyptian Journal of Forensic Sciences Berlin : Springer, 2011 7(2017), 1 vom: 06. Dez. (DE-627)670211184 (DE-600)2631791-6 2090-5939 nnns volume:7 year:2017 number:1 day:06 month:12 https://dx.doi.org/10.1186/s41935-017-0027-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 GBV_ILN_4753 AR 7 2017 1 06 12
language	English
source	Enthalten in Egyptian Journal of Forensic Sciences 7(2017), 1 vom: 06. Dez. volume:7 year:2017 number:1 day:06 month:12
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topic_facet	Forensic DNA analysis Paraffin-embedded tissues Formalin fixed samples Fixation
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authorswithroles_txt_mv	Ullah, Sami @@aut@@ Garg, Rakesh K. @@aut@@ Noor, Farida @@aut@@
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author	Ullah, Sami
spellingShingle	Ullah, Sami misc Forensic misc DNA analysis misc Paraffin-embedded tissues misc Formalin fixed samples misc Fixation DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification
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topic_title	DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification Forensic (dpeaa)DE-He213 DNA analysis (dpeaa)DE-He213 Paraffin-embedded tissues (dpeaa)DE-He213 Formalin fixed samples (dpeaa)DE-He213 Fixation (dpeaa)DE-He213
topic	misc Forensic misc DNA analysis misc Paraffin-embedded tissues misc Formalin fixed samples misc Fixation
topic_unstemmed	misc Forensic misc DNA analysis misc Paraffin-embedded tissues misc Formalin fixed samples misc Fixation
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title	DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification
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title_full	DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification
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title_sort	dna perspectives of fixed and paraffin embedded human tissues as resource materials for the identification
title_auth	DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification
abstract	Abstract In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. © The Author(s) 2017
abstractGer	Abstract In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. © The Author(s) 2017
abstract_unstemmed	Abstract In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. © The Author(s) 2017
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title_short	DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification
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DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification

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