Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings

Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and sub...
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Autor*in:	Guo, Suqin [verfasserIn] He, Lishan Tisch, Daniel J. Kazura, James Mharakurwa, Sungano Mahanta, Jagadish Herrera, Sócrates Wang, Baomin Cui, Liwang

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Artemisinin-based combination therapies (ACTs) Dipstick Malaria Antibody

Anmerkung:	© The Author(s) 2016

Übergeordnetes Werk:	Enthalten in: Tropical medicine and health - Nagasaki : Nagasaki Univ., 2004, 44(2016), 1 vom: 16. Mai
Übergeordnetes Werk:	volume:44 ; year:2016 ; number:1 ; day:16 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s41182-016-0015-8

Katalog-ID:	SPR038551217

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520			\|a Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel. Results The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test. Conclusion It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings.
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allfields	10.1186/s41182-016-0015-8 doi (DE-627)SPR038551217 (SPR)s41182-016-0015-8-e DE-627 ger DE-627 rakwb eng Guo, Suqin verfasserin aut Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel. Results The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test. Conclusion It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings. Artemisinin-based combination therapies (ACTs) (dpeaa)DE-He213 Dipstick (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 He, Lishan aut Tisch, Daniel J. aut Kazura, James aut Mharakurwa, Sungano aut Mahanta, Jagadish aut Herrera, Sócrates aut Wang, Baomin aut Cui, Liwang aut Enthalten in Tropical medicine and health Nagasaki : Nagasaki Univ., 2004 44(2016), 1 vom: 16. Mai (DE-627)502926252 (DE-600)2209835-5 1349-4147 nnns volume:44 year:2016 number:1 day:16 month:05 https://dx.doi.org/10.1186/s41182-016-0015-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2016 1 16 05
spelling	10.1186/s41182-016-0015-8 doi (DE-627)SPR038551217 (SPR)s41182-016-0015-8-e DE-627 ger DE-627 rakwb eng Guo, Suqin verfasserin aut Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel. Results The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test. Conclusion It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings. Artemisinin-based combination therapies (ACTs) (dpeaa)DE-He213 Dipstick (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 He, Lishan aut Tisch, Daniel J. aut Kazura, James aut Mharakurwa, Sungano aut Mahanta, Jagadish aut Herrera, Sócrates aut Wang, Baomin aut Cui, Liwang aut Enthalten in Tropical medicine and health Nagasaki : Nagasaki Univ., 2004 44(2016), 1 vom: 16. Mai (DE-627)502926252 (DE-600)2209835-5 1349-4147 nnns volume:44 year:2016 number:1 day:16 month:05 https://dx.doi.org/10.1186/s41182-016-0015-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2016 1 16 05
allfields_unstemmed	10.1186/s41182-016-0015-8 doi (DE-627)SPR038551217 (SPR)s41182-016-0015-8-e DE-627 ger DE-627 rakwb eng Guo, Suqin verfasserin aut Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel. Results The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test. Conclusion It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings. Artemisinin-based combination therapies (ACTs) (dpeaa)DE-He213 Dipstick (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 He, Lishan aut Tisch, Daniel J. aut Kazura, James aut Mharakurwa, Sungano aut Mahanta, Jagadish aut Herrera, Sócrates aut Wang, Baomin aut Cui, Liwang aut Enthalten in Tropical medicine and health Nagasaki : Nagasaki Univ., 2004 44(2016), 1 vom: 16. Mai (DE-627)502926252 (DE-600)2209835-5 1349-4147 nnns volume:44 year:2016 number:1 day:16 month:05 https://dx.doi.org/10.1186/s41182-016-0015-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2016 1 16 05
allfieldsGer	10.1186/s41182-016-0015-8 doi (DE-627)SPR038551217 (SPR)s41182-016-0015-8-e DE-627 ger DE-627 rakwb eng Guo, Suqin verfasserin aut Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel. Results The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test. Conclusion It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings. Artemisinin-based combination therapies (ACTs) (dpeaa)DE-He213 Dipstick (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 He, Lishan aut Tisch, Daniel J. aut Kazura, James aut Mharakurwa, Sungano aut Mahanta, Jagadish aut Herrera, Sócrates aut Wang, Baomin aut Cui, Liwang aut Enthalten in Tropical medicine and health Nagasaki : Nagasaki Univ., 2004 44(2016), 1 vom: 16. Mai (DE-627)502926252 (DE-600)2209835-5 1349-4147 nnns volume:44 year:2016 number:1 day:16 month:05 https://dx.doi.org/10.1186/s41182-016-0015-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2016 1 16 05
allfieldsSound	10.1186/s41182-016-0015-8 doi (DE-627)SPR038551217 (SPR)s41182-016-0015-8-e DE-627 ger DE-627 rakwb eng Guo, Suqin verfasserin aut Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2016 Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel. Results The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test. Conclusion It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings. Artemisinin-based combination therapies (ACTs) (dpeaa)DE-He213 Dipstick (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 He, Lishan aut Tisch, Daniel J. aut Kazura, James aut Mharakurwa, Sungano aut Mahanta, Jagadish aut Herrera, Sócrates aut Wang, Baomin aut Cui, Liwang aut Enthalten in Tropical medicine and health Nagasaki : Nagasaki Univ., 2004 44(2016), 1 vom: 16. Mai (DE-627)502926252 (DE-600)2209835-5 1349-4147 nnns volume:44 year:2016 number:1 day:16 month:05 https://dx.doi.org/10.1186/s41182-016-0015-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2016 1 16 05
language	English
source	Enthalten in Tropical medicine and health 44(2016), 1 vom: 16. Mai volume:44 year:2016 number:1 day:16 month:05
sourceStr	Enthalten in Tropical medicine and health 44(2016), 1 vom: 16. Mai volume:44 year:2016 number:1 day:16 month:05
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topic_facet	Artemisinin-based combination therapies (ACTs) Dipstick Malaria Antibody
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container_title	Tropical medicine and health
authorswithroles_txt_mv	Guo, Suqin @@aut@@ He, Lishan @@aut@@ Tisch, Daniel J. @@aut@@ Kazura, James @@aut@@ Mharakurwa, Sungano @@aut@@ Mahanta, Jagadish @@aut@@ Herrera, Sócrates @@aut@@ Wang, Baomin @@aut@@ Cui, Liwang @@aut@@
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author	Guo, Suqin
spellingShingle	Guo, Suqin misc Artemisinin-based combination therapies (ACTs) misc Dipstick misc Malaria misc Antibody Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings
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topic_title	Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings Artemisinin-based combination therapies (ACTs) (dpeaa)DE-He213 Dipstick (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Antibody (dpeaa)DE-He213
topic	misc Artemisinin-based combination therapies (ACTs) misc Dipstick misc Malaria misc Antibody
topic_unstemmed	misc Artemisinin-based combination therapies (ACTs) misc Dipstick misc Malaria misc Antibody
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title	Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings
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title_full	Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings
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author_browse	Guo, Suqin He, Lishan Tisch, Daniel J. Kazura, James Mharakurwa, Sungano Mahanta, Jagadish Herrera, Sócrates Wang, Baomin Cui, Liwang
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title_sort	pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings
title_auth	Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings
abstract	Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel. Results The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test. Conclusion It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings. © The Author(s) 2016
abstractGer	Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel. Results The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test. Conclusion It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings. © The Author(s) 2016
abstract_unstemmed	Background Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. Methods To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel. Results The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test. Conclusion It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings. © The Author(s) 2016
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title_short	Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings
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Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings

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