Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits
Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hwang, Yawon [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Anmerkung: |
© BioMed Central Ltd 2016 |
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| Übergeordnetes Werk: |
Enthalten in: Laboratory Animal Research - Seoul, 2010, 32(2016), 4 vom: Okt., Seite 181-186 |
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| Übergeordnetes Werk: |
volume:32 ; year:2016 ; number:4 ; month:10 ; pages:181-186 |
| Links: |
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| DOI / URN: |
10.5625/lar.2016.32.4.181 |
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| 520 | |a Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty. | ||
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10.5625/lar.2016.32.4.181 doi (DE-627)SPR038688123 (SPR)lar.2016.32.4.181-e DE-627 ger DE-627 rakwb eng Hwang, Yawon verfasserin aut Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2016 Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty. Keratoprosthesis (dpeaa)DE-He213 cornea (dpeaa)DE-He213 PHEMA-PMMA (dpeaa)DE-He213 rabbit (dpeaa)DE-He213 Kim, Gonhyung aut Enthalten in Laboratory Animal Research Seoul, 2010 32(2016), 4 vom: Okt., Seite 181-186 (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:32 year:2016 number:4 month:10 pages:181-186 https://dx.doi.org/10.5625/lar.2016.32.4.181 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2016 4 10 181-186 |
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10.5625/lar.2016.32.4.181 doi (DE-627)SPR038688123 (SPR)lar.2016.32.4.181-e DE-627 ger DE-627 rakwb eng Hwang, Yawon verfasserin aut Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2016 Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty. Keratoprosthesis (dpeaa)DE-He213 cornea (dpeaa)DE-He213 PHEMA-PMMA (dpeaa)DE-He213 rabbit (dpeaa)DE-He213 Kim, Gonhyung aut Enthalten in Laboratory Animal Research Seoul, 2010 32(2016), 4 vom: Okt., Seite 181-186 (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:32 year:2016 number:4 month:10 pages:181-186 https://dx.doi.org/10.5625/lar.2016.32.4.181 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2016 4 10 181-186 |
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10.5625/lar.2016.32.4.181 doi (DE-627)SPR038688123 (SPR)lar.2016.32.4.181-e DE-627 ger DE-627 rakwb eng Hwang, Yawon verfasserin aut Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2016 Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty. Keratoprosthesis (dpeaa)DE-He213 cornea (dpeaa)DE-He213 PHEMA-PMMA (dpeaa)DE-He213 rabbit (dpeaa)DE-He213 Kim, Gonhyung aut Enthalten in Laboratory Animal Research Seoul, 2010 32(2016), 4 vom: Okt., Seite 181-186 (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:32 year:2016 number:4 month:10 pages:181-186 https://dx.doi.org/10.5625/lar.2016.32.4.181 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2016 4 10 181-186 |
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10.5625/lar.2016.32.4.181 doi (DE-627)SPR038688123 (SPR)lar.2016.32.4.181-e DE-627 ger DE-627 rakwb eng Hwang, Yawon verfasserin aut Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2016 Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty. Keratoprosthesis (dpeaa)DE-He213 cornea (dpeaa)DE-He213 PHEMA-PMMA (dpeaa)DE-He213 rabbit (dpeaa)DE-He213 Kim, Gonhyung aut Enthalten in Laboratory Animal Research Seoul, 2010 32(2016), 4 vom: Okt., Seite 181-186 (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:32 year:2016 number:4 month:10 pages:181-186 https://dx.doi.org/10.5625/lar.2016.32.4.181 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2016 4 10 181-186 |
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10.5625/lar.2016.32.4.181 doi (DE-627)SPR038688123 (SPR)lar.2016.32.4.181-e DE-627 ger DE-627 rakwb eng Hwang, Yawon verfasserin aut Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2016 Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty. Keratoprosthesis (dpeaa)DE-He213 cornea (dpeaa)DE-He213 PHEMA-PMMA (dpeaa)DE-He213 rabbit (dpeaa)DE-He213 Kim, Gonhyung aut Enthalten in Laboratory Animal Research Seoul, 2010 32(2016), 4 vom: Okt., Seite 181-186 (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:32 year:2016 number:4 month:10 pages:181-186 https://dx.doi.org/10.5625/lar.2016.32.4.181 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2016 4 10 181-186 |
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Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits Keratoprosthesis (dpeaa)DE-He213 cornea (dpeaa)DE-He213 PHEMA-PMMA (dpeaa)DE-He213 rabbit (dpeaa)DE-He213 |
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evaluation of stability and biocompatibility of phema-pmma keratoprosthesis by penetrating keratoplasty in rabbits |
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Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits |
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Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty. © BioMed Central Ltd 2016 |
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Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty. © BioMed Central Ltd 2016 |
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Abstract Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty. © BioMed Central Ltd 2016 |
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