Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources

Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The...
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Autor*in:	Seo, Min-Soo [verfasserIn] Kim, Young-In Kang, Kyung-Ku Oh, Se-Kyung Sung, Soo-Eun Jung, Young-Suk Cho, Joon Yong Song, HyunKeun Hwang, Dae Youn Park, Sang-Joon Kim, Kil Soo

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Korl:ICR Botulinum toxin Muscle ICR mouse

Anmerkung:	© The Author(s) 2019

Übergeordnetes Werk:	Enthalten in: Laboratory Animal Research - Seoul, 2010, 35(2019), 1 vom: 26. Juli
Übergeordnetes Werk:	volume:35 ; year:2019 ; number:1 ; day:26 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s42826-019-0010-4

Katalog-ID:	SPR038689308

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520			\|a Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The three different mouse sources consist of Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) which were purchased from each different vendors. To compare the responses of ICR mice with BoNT/A muscle injection, we examined the body weight, hematological and serum biochemistry analysis. Also, we evaluated the muscle change by histopathological analysis and gene expression patterns of muscle-related target by qPCR. The body weight gain was decreased in the BoNT/A-treated group compared with the control group. In clinical pathologic analysis and gene expression patterns, the data showed that the responses in the BoNT/A-treated group were similar compared with the control group. Decreased muscle fiber was observed in BoNT/A-treated group compared with control group, while Korl:ICR showed a little low response with the other mouse sources. In conclusion, our results suggest that three different sources ICR mice (Korl:ICR, A:ICR and B:ICR) have a similar biological and pathological responses in BoNT/A muscle injection.
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allfields	10.1186/s42826-019-0010-4 doi (DE-627)SPR038689308 (SPR)s42826-019-0010-4-e DE-627 ger DE-627 rakwb eng Seo, Min-Soo verfasserin aut Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The three different mouse sources consist of Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) which were purchased from each different vendors. To compare the responses of ICR mice with BoNT/A muscle injection, we examined the body weight, hematological and serum biochemistry analysis. Also, we evaluated the muscle change by histopathological analysis and gene expression patterns of muscle-related target by qPCR. The body weight gain was decreased in the BoNT/A-treated group compared with the control group. In clinical pathologic analysis and gene expression patterns, the data showed that the responses in the BoNT/A-treated group were similar compared with the control group. Decreased muscle fiber was observed in BoNT/A-treated group compared with control group, while Korl:ICR showed a little low response with the other mouse sources. In conclusion, our results suggest that three different sources ICR mice (Korl:ICR, A:ICR and B:ICR) have a similar biological and pathological responses in BoNT/A muscle injection. Korl:ICR (dpeaa)DE-He213 Botulinum toxin (dpeaa)DE-He213 Muscle (dpeaa)DE-He213 ICR mouse (dpeaa)DE-He213 Kim, Young-In aut Kang, Kyung-Ku aut Oh, Se-Kyung aut Sung, Soo-Eun aut Jung, Young-Suk aut Cho, Joon Yong aut Song, HyunKeun aut Hwang, Dae Youn aut Park, Sang-Joon aut Kim, Kil Soo aut Enthalten in Laboratory Animal Research Seoul, 2010 35(2019), 1 vom: 26. Juli (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:35 year:2019 number:1 day:26 month:07 https://dx.doi.org/10.1186/s42826-019-0010-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2019 1 26 07
spelling	10.1186/s42826-019-0010-4 doi (DE-627)SPR038689308 (SPR)s42826-019-0010-4-e DE-627 ger DE-627 rakwb eng Seo, Min-Soo verfasserin aut Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The three different mouse sources consist of Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) which were purchased from each different vendors. To compare the responses of ICR mice with BoNT/A muscle injection, we examined the body weight, hematological and serum biochemistry analysis. Also, we evaluated the muscle change by histopathological analysis and gene expression patterns of muscle-related target by qPCR. The body weight gain was decreased in the BoNT/A-treated group compared with the control group. In clinical pathologic analysis and gene expression patterns, the data showed that the responses in the BoNT/A-treated group were similar compared with the control group. Decreased muscle fiber was observed in BoNT/A-treated group compared with control group, while Korl:ICR showed a little low response with the other mouse sources. In conclusion, our results suggest that three different sources ICR mice (Korl:ICR, A:ICR and B:ICR) have a similar biological and pathological responses in BoNT/A muscle injection. Korl:ICR (dpeaa)DE-He213 Botulinum toxin (dpeaa)DE-He213 Muscle (dpeaa)DE-He213 ICR mouse (dpeaa)DE-He213 Kim, Young-In aut Kang, Kyung-Ku aut Oh, Se-Kyung aut Sung, Soo-Eun aut Jung, Young-Suk aut Cho, Joon Yong aut Song, HyunKeun aut Hwang, Dae Youn aut Park, Sang-Joon aut Kim, Kil Soo aut Enthalten in Laboratory Animal Research Seoul, 2010 35(2019), 1 vom: 26. Juli (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:35 year:2019 number:1 day:26 month:07 https://dx.doi.org/10.1186/s42826-019-0010-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2019 1 26 07
allfields_unstemmed	10.1186/s42826-019-0010-4 doi (DE-627)SPR038689308 (SPR)s42826-019-0010-4-e DE-627 ger DE-627 rakwb eng Seo, Min-Soo verfasserin aut Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The three different mouse sources consist of Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) which were purchased from each different vendors. To compare the responses of ICR mice with BoNT/A muscle injection, we examined the body weight, hematological and serum biochemistry analysis. Also, we evaluated the muscle change by histopathological analysis and gene expression patterns of muscle-related target by qPCR. The body weight gain was decreased in the BoNT/A-treated group compared with the control group. In clinical pathologic analysis and gene expression patterns, the data showed that the responses in the BoNT/A-treated group were similar compared with the control group. Decreased muscle fiber was observed in BoNT/A-treated group compared with control group, while Korl:ICR showed a little low response with the other mouse sources. In conclusion, our results suggest that three different sources ICR mice (Korl:ICR, A:ICR and B:ICR) have a similar biological and pathological responses in BoNT/A muscle injection. Korl:ICR (dpeaa)DE-He213 Botulinum toxin (dpeaa)DE-He213 Muscle (dpeaa)DE-He213 ICR mouse (dpeaa)DE-He213 Kim, Young-In aut Kang, Kyung-Ku aut Oh, Se-Kyung aut Sung, Soo-Eun aut Jung, Young-Suk aut Cho, Joon Yong aut Song, HyunKeun aut Hwang, Dae Youn aut Park, Sang-Joon aut Kim, Kil Soo aut Enthalten in Laboratory Animal Research Seoul, 2010 35(2019), 1 vom: 26. Juli (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:35 year:2019 number:1 day:26 month:07 https://dx.doi.org/10.1186/s42826-019-0010-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2019 1 26 07
allfieldsGer	10.1186/s42826-019-0010-4 doi (DE-627)SPR038689308 (SPR)s42826-019-0010-4-e DE-627 ger DE-627 rakwb eng Seo, Min-Soo verfasserin aut Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The three different mouse sources consist of Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) which were purchased from each different vendors. To compare the responses of ICR mice with BoNT/A muscle injection, we examined the body weight, hematological and serum biochemistry analysis. Also, we evaluated the muscle change by histopathological analysis and gene expression patterns of muscle-related target by qPCR. The body weight gain was decreased in the BoNT/A-treated group compared with the control group. In clinical pathologic analysis and gene expression patterns, the data showed that the responses in the BoNT/A-treated group were similar compared with the control group. Decreased muscle fiber was observed in BoNT/A-treated group compared with control group, while Korl:ICR showed a little low response with the other mouse sources. In conclusion, our results suggest that three different sources ICR mice (Korl:ICR, A:ICR and B:ICR) have a similar biological and pathological responses in BoNT/A muscle injection. Korl:ICR (dpeaa)DE-He213 Botulinum toxin (dpeaa)DE-He213 Muscle (dpeaa)DE-He213 ICR mouse (dpeaa)DE-He213 Kim, Young-In aut Kang, Kyung-Ku aut Oh, Se-Kyung aut Sung, Soo-Eun aut Jung, Young-Suk aut Cho, Joon Yong aut Song, HyunKeun aut Hwang, Dae Youn aut Park, Sang-Joon aut Kim, Kil Soo aut Enthalten in Laboratory Animal Research Seoul, 2010 35(2019), 1 vom: 26. Juli (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:35 year:2019 number:1 day:26 month:07 https://dx.doi.org/10.1186/s42826-019-0010-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2019 1 26 07
allfieldsSound	10.1186/s42826-019-0010-4 doi (DE-627)SPR038689308 (SPR)s42826-019-0010-4-e DE-627 ger DE-627 rakwb eng Seo, Min-Soo verfasserin aut Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The three different mouse sources consist of Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) which were purchased from each different vendors. To compare the responses of ICR mice with BoNT/A muscle injection, we examined the body weight, hematological and serum biochemistry analysis. Also, we evaluated the muscle change by histopathological analysis and gene expression patterns of muscle-related target by qPCR. The body weight gain was decreased in the BoNT/A-treated group compared with the control group. In clinical pathologic analysis and gene expression patterns, the data showed that the responses in the BoNT/A-treated group were similar compared with the control group. Decreased muscle fiber was observed in BoNT/A-treated group compared with control group, while Korl:ICR showed a little low response with the other mouse sources. In conclusion, our results suggest that three different sources ICR mice (Korl:ICR, A:ICR and B:ICR) have a similar biological and pathological responses in BoNT/A muscle injection. Korl:ICR (dpeaa)DE-He213 Botulinum toxin (dpeaa)DE-He213 Muscle (dpeaa)DE-He213 ICR mouse (dpeaa)DE-He213 Kim, Young-In aut Kang, Kyung-Ku aut Oh, Se-Kyung aut Sung, Soo-Eun aut Jung, Young-Suk aut Cho, Joon Yong aut Song, HyunKeun aut Hwang, Dae Youn aut Park, Sang-Joon aut Kim, Kil Soo aut Enthalten in Laboratory Animal Research Seoul, 2010 35(2019), 1 vom: 26. Juli (DE-627)666217815 (DE-600)2623220-0 2233-7660 nnns volume:35 year:2019 number:1 day:26 month:07 https://dx.doi.org/10.1186/s42826-019-0010-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2019 1 26 07
language	English
source	Enthalten in Laboratory Animal Research 35(2019), 1 vom: 26. Juli volume:35 year:2019 number:1 day:26 month:07
sourceStr	Enthalten in Laboratory Animal Research 35(2019), 1 vom: 26. Juli volume:35 year:2019 number:1 day:26 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Korl:ICR Botulinum toxin Muscle ICR mouse
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container_title	Laboratory Animal Research
authorswithroles_txt_mv	Seo, Min-Soo @@aut@@ Kim, Young-In @@aut@@ Kang, Kyung-Ku @@aut@@ Oh, Se-Kyung @@aut@@ Sung, Soo-Eun @@aut@@ Jung, Young-Suk @@aut@@ Cho, Joon Yong @@aut@@ Song, HyunKeun @@aut@@ Hwang, Dae Youn @@aut@@ Park, Sang-Joon @@aut@@ Kim, Kil Soo @@aut@@
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author	Seo, Min-Soo
spellingShingle	Seo, Min-Soo misc Korl:ICR misc Botulinum toxin misc Muscle misc ICR mouse Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources
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topic_title	Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources Korl:ICR (dpeaa)DE-He213 Botulinum toxin (dpeaa)DE-He213 Muscle (dpeaa)DE-He213 ICR mouse (dpeaa)DE-He213
topic	misc Korl:ICR misc Botulinum toxin misc Muscle misc ICR mouse
topic_unstemmed	misc Korl:ICR misc Botulinum toxin misc Muscle misc ICR mouse
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title	Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources
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title_full	Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources
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author_browse	Seo, Min-Soo Kim, Young-In Kang, Kyung-Ku Oh, Se-Kyung Sung, Soo-Eun Jung, Young-Suk Cho, Joon Yong Song, HyunKeun Hwang, Dae Youn Park, Sang-Joon Kim, Kil Soo
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author-letter	Seo, Min-Soo
doi_str_mv	10.1186/s42826-019-0010-4
title_sort	comparison study of the response with botulinum toxin muscle injection in the icr mice from three different sources
title_auth	Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources
abstract	Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The three different mouse sources consist of Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) which were purchased from each different vendors. To compare the responses of ICR mice with BoNT/A muscle injection, we examined the body weight, hematological and serum biochemistry analysis. Also, we evaluated the muscle change by histopathological analysis and gene expression patterns of muscle-related target by qPCR. The body weight gain was decreased in the BoNT/A-treated group compared with the control group. In clinical pathologic analysis and gene expression patterns, the data showed that the responses in the BoNT/A-treated group were similar compared with the control group. Decreased muscle fiber was observed in BoNT/A-treated group compared with control group, while Korl:ICR showed a little low response with the other mouse sources. In conclusion, our results suggest that three different sources ICR mice (Korl:ICR, A:ICR and B:ICR) have a similar biological and pathological responses in BoNT/A muscle injection. © The Author(s) 2019
abstractGer	Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The three different mouse sources consist of Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) which were purchased from each different vendors. To compare the responses of ICR mice with BoNT/A muscle injection, we examined the body weight, hematological and serum biochemistry analysis. Also, we evaluated the muscle change by histopathological analysis and gene expression patterns of muscle-related target by qPCR. The body weight gain was decreased in the BoNT/A-treated group compared with the control group. In clinical pathologic analysis and gene expression patterns, the data showed that the responses in the BoNT/A-treated group were similar compared with the control group. Decreased muscle fiber was observed in BoNT/A-treated group compared with control group, while Korl:ICR showed a little low response with the other mouse sources. In conclusion, our results suggest that three different sources ICR mice (Korl:ICR, A:ICR and B:ICR) have a similar biological and pathological responses in BoNT/A muscle injection. © The Author(s) 2019
abstract_unstemmed	Abstract Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three different sources to compare and evaluate the biological and pathological response. The three different mouse sources consist of Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) which were purchased from each different vendors. To compare the responses of ICR mice with BoNT/A muscle injection, we examined the body weight, hematological and serum biochemistry analysis. Also, we evaluated the muscle change by histopathological analysis and gene expression patterns of muscle-related target by qPCR. The body weight gain was decreased in the BoNT/A-treated group compared with the control group. In clinical pathologic analysis and gene expression patterns, the data showed that the responses in the BoNT/A-treated group were similar compared with the control group. Decreased muscle fiber was observed in BoNT/A-treated group compared with control group, while Korl:ICR showed a little low response with the other mouse sources. In conclusion, our results suggest that three different sources ICR mice (Korl:ICR, A:ICR and B:ICR) have a similar biological and pathological responses in BoNT/A muscle injection. © The Author(s) 2019
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources
url	https://dx.doi.org/10.1186/s42826-019-0010-4
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author2	Kim, Young-In Kang, Kyung-Ku Oh, Se-Kyung Sung, Soo-Eun Jung, Young-Suk Cho, Joon Yong Song, HyunKeun Hwang, Dae Youn Park, Sang-Joon Kim, Kil Soo
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Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources

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