Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain

Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5...
Ausführliche Beschreibung

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Autor*in:	Calderón, G. D. [verfasserIn] Esquivel, Gabriela J. García, Ernestina H. Osnaya, Norma B. Juárez Olguín, H.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Brain diazepam glutathione marijuana rat

Anmerkung:	© Akadémiai Kiadó, Budapest 2010

Übergeordnetes Werk:	Enthalten in: Acta biologica Hungarica - Budapest : Akad. Kiadó, 1983, 61(2010), 2 vom: Juni, Seite 135-144
Übergeordnetes Werk:	volume:61 ; year:2010 ; number:2 ; month:06 ; pages:135-144

Links:	Volltext

DOI / URN:	10.1556/ABiol.61.2010.2.2

Katalog-ID:	SPR038792567

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520			\|a Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. $ Na^{+} $, $ K^{+} $ ATPase and total ATPase activities. GSH and TBARS did not show differences respect to controls. $ Na^{+} $, $ K^{+} $ ATPase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p < 0.05). Levels of 5-HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there.
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912			\|a GBV_ILN_2038
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912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
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matchkey_str	article:1588256X:2010----::fetomrjaandaeaolpdeoiainaapsadeesflt
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publishDate	2010
allfields	10.1556/ABiol.61.2010.2.2 doi (DE-627)SPR038792567 (SPR)ABiol.61.2010.2.2-e DE-627 ger DE-627 rakwb eng Calderón, G. D. verfasserin aut Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Akadémiai Kiadó, Budapest 2010 Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. $ Na^{+} $, $ K^{+} $ ATPase and total ATPase activities. GSH and TBARS did not show differences respect to controls. $ Na^{+} $, $ K^{+} $ ATPase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p < 0.05). Levels of 5-HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there. Brain (dpeaa)DE-He213 diazepam (dpeaa)DE-He213 glutathione (dpeaa)DE-He213 marijuana (dpeaa)DE-He213 rat (dpeaa)DE-He213 Esquivel, Gabriela J. aut García, Ernestina H. aut Osnaya, Norma B. aut Juárez Olguín, H. aut Enthalten in Acta biologica Hungarica Budapest : Akad. Kiadó, 1983 61(2010), 2 vom: Juni, Seite 135-144 (DE-627)364470836 (DE-600)2110466-9 1588-256X nnns volume:61 year:2010 number:2 month:06 pages:135-144 https://dx.doi.org/10.1556/ABiol.61.2010.2.2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2010 2 06 135-144
spelling	10.1556/ABiol.61.2010.2.2 doi (DE-627)SPR038792567 (SPR)ABiol.61.2010.2.2-e DE-627 ger DE-627 rakwb eng Calderón, G. D. verfasserin aut Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Akadémiai Kiadó, Budapest 2010 Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. $ Na^{+} $, $ K^{+} $ ATPase and total ATPase activities. GSH and TBARS did not show differences respect to controls. $ Na^{+} $, $ K^{+} $ ATPase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p < 0.05). Levels of 5-HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there. Brain (dpeaa)DE-He213 diazepam (dpeaa)DE-He213 glutathione (dpeaa)DE-He213 marijuana (dpeaa)DE-He213 rat (dpeaa)DE-He213 Esquivel, Gabriela J. aut García, Ernestina H. aut Osnaya, Norma B. aut Juárez Olguín, H. aut Enthalten in Acta biologica Hungarica Budapest : Akad. Kiadó, 1983 61(2010), 2 vom: Juni, Seite 135-144 (DE-627)364470836 (DE-600)2110466-9 1588-256X nnns volume:61 year:2010 number:2 month:06 pages:135-144 https://dx.doi.org/10.1556/ABiol.61.2010.2.2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2010 2 06 135-144
allfields_unstemmed	10.1556/ABiol.61.2010.2.2 doi (DE-627)SPR038792567 (SPR)ABiol.61.2010.2.2-e DE-627 ger DE-627 rakwb eng Calderón, G. D. verfasserin aut Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Akadémiai Kiadó, Budapest 2010 Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. $ Na^{+} $, $ K^{+} $ ATPase and total ATPase activities. GSH and TBARS did not show differences respect to controls. $ Na^{+} $, $ K^{+} $ ATPase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p < 0.05). Levels of 5-HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there. Brain (dpeaa)DE-He213 diazepam (dpeaa)DE-He213 glutathione (dpeaa)DE-He213 marijuana (dpeaa)DE-He213 rat (dpeaa)DE-He213 Esquivel, Gabriela J. aut García, Ernestina H. aut Osnaya, Norma B. aut Juárez Olguín, H. aut Enthalten in Acta biologica Hungarica Budapest : Akad. Kiadó, 1983 61(2010), 2 vom: Juni, Seite 135-144 (DE-627)364470836 (DE-600)2110466-9 1588-256X nnns volume:61 year:2010 number:2 month:06 pages:135-144 https://dx.doi.org/10.1556/ABiol.61.2010.2.2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2010 2 06 135-144
allfieldsGer	10.1556/ABiol.61.2010.2.2 doi (DE-627)SPR038792567 (SPR)ABiol.61.2010.2.2-e DE-627 ger DE-627 rakwb eng Calderón, G. D. verfasserin aut Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Akadémiai Kiadó, Budapest 2010 Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. $ Na^{+} $, $ K^{+} $ ATPase and total ATPase activities. GSH and TBARS did not show differences respect to controls. $ Na^{+} $, $ K^{+} $ ATPase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p < 0.05). Levels of 5-HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there. Brain (dpeaa)DE-He213 diazepam (dpeaa)DE-He213 glutathione (dpeaa)DE-He213 marijuana (dpeaa)DE-He213 rat (dpeaa)DE-He213 Esquivel, Gabriela J. aut García, Ernestina H. aut Osnaya, Norma B. aut Juárez Olguín, H. aut Enthalten in Acta biologica Hungarica Budapest : Akad. Kiadó, 1983 61(2010), 2 vom: Juni, Seite 135-144 (DE-627)364470836 (DE-600)2110466-9 1588-256X nnns volume:61 year:2010 number:2 month:06 pages:135-144 https://dx.doi.org/10.1556/ABiol.61.2010.2.2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2010 2 06 135-144
allfieldsSound	10.1556/ABiol.61.2010.2.2 doi (DE-627)SPR038792567 (SPR)ABiol.61.2010.2.2-e DE-627 ger DE-627 rakwb eng Calderón, G. D. verfasserin aut Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Akadémiai Kiadó, Budapest 2010 Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. $ Na^{+} $, $ K^{+} $ ATPase and total ATPase activities. GSH and TBARS did not show differences respect to controls. $ Na^{+} $, $ K^{+} $ ATPase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p < 0.05). Levels of 5-HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there. Brain (dpeaa)DE-He213 diazepam (dpeaa)DE-He213 glutathione (dpeaa)DE-He213 marijuana (dpeaa)DE-He213 rat (dpeaa)DE-He213 Esquivel, Gabriela J. aut García, Ernestina H. aut Osnaya, Norma B. aut Juárez Olguín, H. aut Enthalten in Acta biologica Hungarica Budapest : Akad. Kiadó, 1983 61(2010), 2 vom: Juni, Seite 135-144 (DE-627)364470836 (DE-600)2110466-9 1588-256X nnns volume:61 year:2010 number:2 month:06 pages:135-144 https://dx.doi.org/10.1556/ABiol.61.2010.2.2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 61 2010 2 06 135-144
language	English
source	Enthalten in Acta biologica Hungarica 61(2010), 2 vom: Juni, Seite 135-144 volume:61 year:2010 number:2 month:06 pages:135-144
sourceStr	Enthalten in Acta biologica Hungarica 61(2010), 2 vom: Juni, Seite 135-144 volume:61 year:2010 number:2 month:06 pages:135-144
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topic_facet	Brain diazepam glutathione marijuana rat
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authorswithroles_txt_mv	Calderón, G. D. @@aut@@ Esquivel, Gabriela J. @@aut@@ García, Ernestina H. @@aut@@ Osnaya, Norma B. @@aut@@ Juárez Olguín, H. @@aut@@
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author	Calderón, G. D.
spellingShingle	Calderón, G. D. misc Brain misc diazepam misc glutathione misc marijuana misc rat Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain
authorStr	Calderón, G. D.
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topic_title	Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain Brain (dpeaa)DE-He213 diazepam (dpeaa)DE-He213 glutathione (dpeaa)DE-He213 marijuana (dpeaa)DE-He213 rat (dpeaa)DE-He213
topic	misc Brain misc diazepam misc glutathione misc marijuana misc rat
topic_unstemmed	misc Brain misc diazepam misc glutathione misc marijuana misc rat
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title	Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain
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title_full	Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain
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title_sort	effects of marijuana and diazepam on lipid peroxidation, $ na^{+} $, $ k^{+} $ atpase, and levels of glutathione and 5-htp in rat brain
title_auth	Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain
abstract	Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. $ Na^{+} $, $ K^{+} $ ATPase and total ATPase activities. GSH and TBARS did not show differences respect to controls. $ Na^{+} $, $ K^{+} $ ATPase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p < 0.05). Levels of 5-HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there. © Akadémiai Kiadó, Budapest 2010
abstractGer	Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. $ Na^{+} $, $ K^{+} $ ATPase and total ATPase activities. GSH and TBARS did not show differences respect to controls. $ Na^{+} $, $ K^{+} $ ATPase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p < 0.05). Levels of 5-HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there. © Akadémiai Kiadó, Budapest 2010
abstract_unstemmed	Abstract Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), $ Na^{+} $, $ K^{+} $ ATPase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 μL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. $ Na^{+} $, $ K^{+} $ ATPase and total ATPase activities. GSH and TBARS did not show differences respect to controls. $ Na^{+} $, $ K^{+} $ ATPase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p < 0.05). Levels of 5-HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there. © Akadémiai Kiadó, Budapest 2010
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container_issue	2
title_short	Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain
url	https://dx.doi.org/10.1556/ABiol.61.2010.2.2
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author2	Esquivel, Gabriela J. García, Ernestina H. Osnaya, Norma B. Juárez Olguín, H.
author2Str	Esquivel, Gabriela J. García, Ernestina H. Osnaya, Norma B. Juárez Olguín, H.
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doi_str	10.1556/ABiol.61.2010.2.2
up_date	2024-07-03T20:01:07.379Z
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Effects of Marijuana and Diazepam on Lipid Peroxidation, $ Na^{+} $, $ K^{+} $ Atpase, and Levels of Glutathione and 5-HTP in rat Brain

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