Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia
Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women w...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Luppi, Patrizia [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Anmerkung: |
© Society for Reproductive Investigation 2010 |
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| Übergeordnetes Werk: |
Enthalten in: Reproductive sciences - Cham : Springer Nature Switzerland AG, 2007, 17(2010), 7 vom: Juli, Seite 643-652 |
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| Übergeordnetes Werk: |
volume:17 ; year:2010 ; number:7 ; month:07 ; pages:643-652 |
| Links: |
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| DOI / URN: |
10.1177/1933719110366164 |
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| Katalog-ID: |
SPR038835991 |
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| 100 | 1 | |a Luppi, Patrizia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a © Society for Reproductive Investigation 2010 | ||
| 520 | |a Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia. | ||
| 650 | 4 | |a Endothelial progenitor cells |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a pregnancy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a preeclampsia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a angiogenic factors |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Powers, Robert W. |4 aut | |
| 700 | 1 | |a Verma, Vivek |4 aut | |
| 700 | 1 | |a Edmunds, Lia |4 aut | |
| 700 | 1 | |a Plymire, Daniel |4 aut | |
| 700 | 1 | |a Hubel, Carl A. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Reproductive sciences |d Cham : Springer Nature Switzerland AG, 2007 |g 17(2010), 7 vom: Juli, Seite 643-652 |w (DE-627)523194854 |w (DE-600)2266096-3 |x 1933-7205 |7 nnns |
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10.1177/1933719110366164 doi (DE-627)SPR038835991 (SPR)1933719110366164-e DE-627 ger DE-627 rakwb eng Luppi, Patrizia verfasserin aut Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society for Reproductive Investigation 2010 Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia. Endothelial progenitor cells (dpeaa)DE-He213 pregnancy (dpeaa)DE-He213 preeclampsia (dpeaa)DE-He213 angiogenic factors (dpeaa)DE-He213 Powers, Robert W. aut Verma, Vivek aut Edmunds, Lia aut Plymire, Daniel aut Hubel, Carl A. aut Enthalten in Reproductive sciences Cham : Springer Nature Switzerland AG, 2007 17(2010), 7 vom: Juli, Seite 643-652 (DE-627)523194854 (DE-600)2266096-3 1933-7205 nnns volume:17 year:2010 number:7 month:07 pages:643-652 https://dx.doi.org/10.1177/1933719110366164 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2036 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2043 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2125 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2145 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2158 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2193 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 17 2010 7 07 643-652 |
| spelling |
10.1177/1933719110366164 doi (DE-627)SPR038835991 (SPR)1933719110366164-e DE-627 ger DE-627 rakwb eng Luppi, Patrizia verfasserin aut Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society for Reproductive Investigation 2010 Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia. Endothelial progenitor cells (dpeaa)DE-He213 pregnancy (dpeaa)DE-He213 preeclampsia (dpeaa)DE-He213 angiogenic factors (dpeaa)DE-He213 Powers, Robert W. aut Verma, Vivek aut Edmunds, Lia aut Plymire, Daniel aut Hubel, Carl A. aut Enthalten in Reproductive sciences Cham : Springer Nature Switzerland AG, 2007 17(2010), 7 vom: Juli, Seite 643-652 (DE-627)523194854 (DE-600)2266096-3 1933-7205 nnns volume:17 year:2010 number:7 month:07 pages:643-652 https://dx.doi.org/10.1177/1933719110366164 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2036 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2043 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2125 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2145 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2158 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2193 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 17 2010 7 07 643-652 |
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10.1177/1933719110366164 doi (DE-627)SPR038835991 (SPR)1933719110366164-e DE-627 ger DE-627 rakwb eng Luppi, Patrizia verfasserin aut Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society for Reproductive Investigation 2010 Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia. Endothelial progenitor cells (dpeaa)DE-He213 pregnancy (dpeaa)DE-He213 preeclampsia (dpeaa)DE-He213 angiogenic factors (dpeaa)DE-He213 Powers, Robert W. aut Verma, Vivek aut Edmunds, Lia aut Plymire, Daniel aut Hubel, Carl A. aut Enthalten in Reproductive sciences Cham : Springer Nature Switzerland AG, 2007 17(2010), 7 vom: Juli, Seite 643-652 (DE-627)523194854 (DE-600)2266096-3 1933-7205 nnns volume:17 year:2010 number:7 month:07 pages:643-652 https://dx.doi.org/10.1177/1933719110366164 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2036 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2043 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2125 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2145 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2158 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2193 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 17 2010 7 07 643-652 |
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10.1177/1933719110366164 doi (DE-627)SPR038835991 (SPR)1933719110366164-e DE-627 ger DE-627 rakwb eng Luppi, Patrizia verfasserin aut Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society for Reproductive Investigation 2010 Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia. Endothelial progenitor cells (dpeaa)DE-He213 pregnancy (dpeaa)DE-He213 preeclampsia (dpeaa)DE-He213 angiogenic factors (dpeaa)DE-He213 Powers, Robert W. aut Verma, Vivek aut Edmunds, Lia aut Plymire, Daniel aut Hubel, Carl A. aut Enthalten in Reproductive sciences Cham : Springer Nature Switzerland AG, 2007 17(2010), 7 vom: Juli, Seite 643-652 (DE-627)523194854 (DE-600)2266096-3 1933-7205 nnns volume:17 year:2010 number:7 month:07 pages:643-652 https://dx.doi.org/10.1177/1933719110366164 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2036 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2043 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2125 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2145 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2158 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2193 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 17 2010 7 07 643-652 |
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10.1177/1933719110366164 doi (DE-627)SPR038835991 (SPR)1933719110366164-e DE-627 ger DE-627 rakwb eng Luppi, Patrizia verfasserin aut Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Society for Reproductive Investigation 2010 Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia. Endothelial progenitor cells (dpeaa)DE-He213 pregnancy (dpeaa)DE-He213 preeclampsia (dpeaa)DE-He213 angiogenic factors (dpeaa)DE-He213 Powers, Robert W. aut Verma, Vivek aut Edmunds, Lia aut Plymire, Daniel aut Hubel, Carl A. aut Enthalten in Reproductive sciences Cham : Springer Nature Switzerland AG, 2007 17(2010), 7 vom: Juli, Seite 643-652 (DE-627)523194854 (DE-600)2266096-3 1933-7205 nnns volume:17 year:2010 number:7 month:07 pages:643-652 https://dx.doi.org/10.1177/1933719110366164 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2036 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2043 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2125 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2145 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2158 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2193 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 17 2010 7 07 643-652 |
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Enthalten in Reproductive sciences 17(2010), 7 vom: Juli, Seite 643-652 volume:17 year:2010 number:7 month:07 pages:643-652 |
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Enthalten in Reproductive sciences 17(2010), 7 vom: Juli, Seite 643-652 volume:17 year:2010 number:7 month:07 pages:643-652 |
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Endothelial progenitor cells pregnancy preeclampsia angiogenic factors |
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Luppi, Patrizia @@aut@@ Powers, Robert W. @@aut@@ Verma, Vivek @@aut@@ Edmunds, Lia @@aut@@ Plymire, Daniel @@aut@@ Hubel, Carl A. @@aut@@ |
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We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. 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Luppi, Patrizia |
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Luppi, Patrizia misc Endothelial progenitor cells misc pregnancy misc preeclampsia misc angiogenic factors Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia |
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Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia Endothelial progenitor cells (dpeaa)DE-He213 pregnancy (dpeaa)DE-He213 preeclampsia (dpeaa)DE-He213 angiogenic factors (dpeaa)DE-He213 |
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Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia |
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Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia |
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maternal circulating $ cd34^{+} $vegfr-$ 2^{+} $ and $ cd133^{+} $vegfr-$ 2^{+} $ progenitor cells increase during normal pregnancy but are reduced in women with preeclampsia |
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Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia |
| abstract |
Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia. © Society for Reproductive Investigation 2010 |
| abstractGer |
Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia. © Society for Reproductive Investigation 2010 |
| abstract_unstemmed |
Abstract Circulating endothelial progenitor cells (EPCs) may contribute to vascular endothelial cell homeostasis, and low levels of these cells are predictive of cardiovascular disease. We hypothesized that circulating EPCs increase in number during uncomplicated pregnancy but are reduced in women with preeclampsia. Peripheral blood was obtained from pregnant women and from nulligravidas in cross-sectional design. Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry. Both $ CD34^{+} $ VEGFR-$ 2^{+} $ (doubly positive) and $ CD133^{+} $ VEGFR-$ 2^{+} $ cells were significantly increased during the second and third trimesters of uncomplicated pregnancy compared to the first trimester. First trimester and nulligravida groups did not differ. Endothelial progenitor cells, quantified by flow cytometry or by circulating angiogenic cell (CAC) culture assay, were significantly reduced in women with preeclampsia compared to third trimester controls. Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia. © Society for Reproductive Investigation 2010 |
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Maternal Circulating $ CD34^{+} $VEGFR-$ 2^{+} $ and $ CD133^{+} $VEGFR-$ 2^{+} $ Progenitor Cells Increase During Normal Pregnancy but Are Reduced in Women With Preeclampsia |
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| score |
7.3993816 |