Pisa Syndrome Associated With Clozapine: A Rare Case Report and Literature Review
Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral ro...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Faridhosseini, Farhad [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Anmerkung: |
© Scoliosis Research Society 2015 |
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| Übergeordnetes Werk: |
Enthalten in: Spine deformity - Amsterdam [u.a.] : Elsevier, 2013, 3(2015), 4 vom: Juli, Seite 386-389 |
|---|---|
| Übergeordnetes Werk: |
volume:3 ; year:2015 ; number:4 ; month:07 ; pages:386-389 |
| Links: |
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| DOI / URN: |
10.1016/j.jspd.2015.02.003 |
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SPR038868733 |
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| 520 | |a Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral rotation resembled the leaning tower of Pisa. Unfamiliarity of many neuro- and orthopedic surgeons with this syndrome can lead to unnecessary diagnostic and therapeutic interventions. Case Report A 33-year-old woman, who has been treated as a schizophrenic patient for 16 years, was referred to our spine clinic with signs of trunk shift. She was consuming valproic acid 500 mg twice a day and clozapine 100 mg three times daily, as an unchanged regimen for the past 2 years. Few months after treatment with clozapine, her parents noticed that the patient progressively leaned to one side. Physical and imaging examinations revealed a severe left truncal shift associated with right cervical tilt. Drug regimen was changed and clozapine dosage reduced to 200 mg daily, and bipyridine 2 mg daily was added to the therapeutic regimen. By 1 month, the deformity gradually disappeared and normal body posture was restored. At the last follow-up visit, 28 months later, normal body posture was observed to be maintained, and no evidence of spinal deformity was noted. Conclusions Spine deformity surgeons visiting patients with abnormal postures of the trunk need to ask the patient about medications they are receiving and should be aware of their neuropsychiatric complications. Even drugs with the minimum risk of dystonia, such as clozapine, may cause dystonic disorders like Pisa syndrome. | ||
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10.1016/j.jspd.2015.02.003 doi (DE-627)SPR038868733 (SPR)j.jspd.2015.02.003-e DE-627 ger DE-627 rakwb eng Faridhosseini, Farhad verfasserin aut Pisa Syndrome Associated With Clozapine: A Rare Case Report and Literature Review 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Scoliosis Research Society 2015 Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral rotation resembled the leaning tower of Pisa. Unfamiliarity of many neuro- and orthopedic surgeons with this syndrome can lead to unnecessary diagnostic and therapeutic interventions. Case Report A 33-year-old woman, who has been treated as a schizophrenic patient for 16 years, was referred to our spine clinic with signs of trunk shift. She was consuming valproic acid 500 mg twice a day and clozapine 100 mg three times daily, as an unchanged regimen for the past 2 years. Few months after treatment with clozapine, her parents noticed that the patient progressively leaned to one side. Physical and imaging examinations revealed a severe left truncal shift associated with right cervical tilt. Drug regimen was changed and clozapine dosage reduced to 200 mg daily, and bipyridine 2 mg daily was added to the therapeutic regimen. By 1 month, the deformity gradually disappeared and normal body posture was restored. At the last follow-up visit, 28 months later, normal body posture was observed to be maintained, and no evidence of spinal deformity was noted. Conclusions Spine deformity surgeons visiting patients with abnormal postures of the trunk need to ask the patient about medications they are receiving and should be aware of their neuropsychiatric complications. Even drugs with the minimum risk of dystonia, such as clozapine, may cause dystonic disorders like Pisa syndrome. Dystonia (dpeaa)DE-He213 Pisa syndrome (dpeaa)DE-He213 Extrapyramidal side effect (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Omidi-Kashani, Farzad aut Baradaran, Aslan aut Enthalten in Spine deformity Amsterdam [u.a.] : Elsevier, 2013 3(2015), 4 vom: Juli, Seite 386-389 (DE-627)747142815 (DE-600)2717704-X 2212-1358 nnns volume:3 year:2015 number:4 month:07 pages:386-389 https://dx.doi.org/10.1016/j.jspd.2015.02.003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_647 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2190 GBV_ILN_2336 AR 3 2015 4 07 386-389 |
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10.1016/j.jspd.2015.02.003 doi (DE-627)SPR038868733 (SPR)j.jspd.2015.02.003-e DE-627 ger DE-627 rakwb eng Faridhosseini, Farhad verfasserin aut Pisa Syndrome Associated With Clozapine: A Rare Case Report and Literature Review 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Scoliosis Research Society 2015 Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral rotation resembled the leaning tower of Pisa. Unfamiliarity of many neuro- and orthopedic surgeons with this syndrome can lead to unnecessary diagnostic and therapeutic interventions. Case Report A 33-year-old woman, who has been treated as a schizophrenic patient for 16 years, was referred to our spine clinic with signs of trunk shift. She was consuming valproic acid 500 mg twice a day and clozapine 100 mg three times daily, as an unchanged regimen for the past 2 years. Few months after treatment with clozapine, her parents noticed that the patient progressively leaned to one side. Physical and imaging examinations revealed a severe left truncal shift associated with right cervical tilt. Drug regimen was changed and clozapine dosage reduced to 200 mg daily, and bipyridine 2 mg daily was added to the therapeutic regimen. By 1 month, the deformity gradually disappeared and normal body posture was restored. At the last follow-up visit, 28 months later, normal body posture was observed to be maintained, and no evidence of spinal deformity was noted. Conclusions Spine deformity surgeons visiting patients with abnormal postures of the trunk need to ask the patient about medications they are receiving and should be aware of their neuropsychiatric complications. Even drugs with the minimum risk of dystonia, such as clozapine, may cause dystonic disorders like Pisa syndrome. Dystonia (dpeaa)DE-He213 Pisa syndrome (dpeaa)DE-He213 Extrapyramidal side effect (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Omidi-Kashani, Farzad aut Baradaran, Aslan aut Enthalten in Spine deformity Amsterdam [u.a.] : Elsevier, 2013 3(2015), 4 vom: Juli, Seite 386-389 (DE-627)747142815 (DE-600)2717704-X 2212-1358 nnns volume:3 year:2015 number:4 month:07 pages:386-389 https://dx.doi.org/10.1016/j.jspd.2015.02.003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_647 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2190 GBV_ILN_2336 AR 3 2015 4 07 386-389 |
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10.1016/j.jspd.2015.02.003 doi (DE-627)SPR038868733 (SPR)j.jspd.2015.02.003-e DE-627 ger DE-627 rakwb eng Faridhosseini, Farhad verfasserin aut Pisa Syndrome Associated With Clozapine: A Rare Case Report and Literature Review 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Scoliosis Research Society 2015 Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral rotation resembled the leaning tower of Pisa. Unfamiliarity of many neuro- and orthopedic surgeons with this syndrome can lead to unnecessary diagnostic and therapeutic interventions. Case Report A 33-year-old woman, who has been treated as a schizophrenic patient for 16 years, was referred to our spine clinic with signs of trunk shift. She was consuming valproic acid 500 mg twice a day and clozapine 100 mg three times daily, as an unchanged regimen for the past 2 years. Few months after treatment with clozapine, her parents noticed that the patient progressively leaned to one side. Physical and imaging examinations revealed a severe left truncal shift associated with right cervical tilt. Drug regimen was changed and clozapine dosage reduced to 200 mg daily, and bipyridine 2 mg daily was added to the therapeutic regimen. By 1 month, the deformity gradually disappeared and normal body posture was restored. At the last follow-up visit, 28 months later, normal body posture was observed to be maintained, and no evidence of spinal deformity was noted. Conclusions Spine deformity surgeons visiting patients with abnormal postures of the trunk need to ask the patient about medications they are receiving and should be aware of their neuropsychiatric complications. Even drugs with the minimum risk of dystonia, such as clozapine, may cause dystonic disorders like Pisa syndrome. Dystonia (dpeaa)DE-He213 Pisa syndrome (dpeaa)DE-He213 Extrapyramidal side effect (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Omidi-Kashani, Farzad aut Baradaran, Aslan aut Enthalten in Spine deformity Amsterdam [u.a.] : Elsevier, 2013 3(2015), 4 vom: Juli, Seite 386-389 (DE-627)747142815 (DE-600)2717704-X 2212-1358 nnns volume:3 year:2015 number:4 month:07 pages:386-389 https://dx.doi.org/10.1016/j.jspd.2015.02.003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_647 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2190 GBV_ILN_2336 AR 3 2015 4 07 386-389 |
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10.1016/j.jspd.2015.02.003 doi (DE-627)SPR038868733 (SPR)j.jspd.2015.02.003-e DE-627 ger DE-627 rakwb eng Faridhosseini, Farhad verfasserin aut Pisa Syndrome Associated With Clozapine: A Rare Case Report and Literature Review 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Scoliosis Research Society 2015 Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral rotation resembled the leaning tower of Pisa. Unfamiliarity of many neuro- and orthopedic surgeons with this syndrome can lead to unnecessary diagnostic and therapeutic interventions. Case Report A 33-year-old woman, who has been treated as a schizophrenic patient for 16 years, was referred to our spine clinic with signs of trunk shift. She was consuming valproic acid 500 mg twice a day and clozapine 100 mg three times daily, as an unchanged regimen for the past 2 years. Few months after treatment with clozapine, her parents noticed that the patient progressively leaned to one side. Physical and imaging examinations revealed a severe left truncal shift associated with right cervical tilt. Drug regimen was changed and clozapine dosage reduced to 200 mg daily, and bipyridine 2 mg daily was added to the therapeutic regimen. By 1 month, the deformity gradually disappeared and normal body posture was restored. At the last follow-up visit, 28 months later, normal body posture was observed to be maintained, and no evidence of spinal deformity was noted. Conclusions Spine deformity surgeons visiting patients with abnormal postures of the trunk need to ask the patient about medications they are receiving and should be aware of their neuropsychiatric complications. Even drugs with the minimum risk of dystonia, such as clozapine, may cause dystonic disorders like Pisa syndrome. Dystonia (dpeaa)DE-He213 Pisa syndrome (dpeaa)DE-He213 Extrapyramidal side effect (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Omidi-Kashani, Farzad aut Baradaran, Aslan aut Enthalten in Spine deformity Amsterdam [u.a.] : Elsevier, 2013 3(2015), 4 vom: Juli, Seite 386-389 (DE-627)747142815 (DE-600)2717704-X 2212-1358 nnns volume:3 year:2015 number:4 month:07 pages:386-389 https://dx.doi.org/10.1016/j.jspd.2015.02.003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_647 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2190 GBV_ILN_2336 AR 3 2015 4 07 386-389 |
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10.1016/j.jspd.2015.02.003 doi (DE-627)SPR038868733 (SPR)j.jspd.2015.02.003-e DE-627 ger DE-627 rakwb eng Faridhosseini, Farhad verfasserin aut Pisa Syndrome Associated With Clozapine: A Rare Case Report and Literature Review 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Scoliosis Research Society 2015 Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral rotation resembled the leaning tower of Pisa. Unfamiliarity of many neuro- and orthopedic surgeons with this syndrome can lead to unnecessary diagnostic and therapeutic interventions. Case Report A 33-year-old woman, who has been treated as a schizophrenic patient for 16 years, was referred to our spine clinic with signs of trunk shift. She was consuming valproic acid 500 mg twice a day and clozapine 100 mg three times daily, as an unchanged regimen for the past 2 years. Few months after treatment with clozapine, her parents noticed that the patient progressively leaned to one side. Physical and imaging examinations revealed a severe left truncal shift associated with right cervical tilt. Drug regimen was changed and clozapine dosage reduced to 200 mg daily, and bipyridine 2 mg daily was added to the therapeutic regimen. By 1 month, the deformity gradually disappeared and normal body posture was restored. At the last follow-up visit, 28 months later, normal body posture was observed to be maintained, and no evidence of spinal deformity was noted. Conclusions Spine deformity surgeons visiting patients with abnormal postures of the trunk need to ask the patient about medications they are receiving and should be aware of their neuropsychiatric complications. Even drugs with the minimum risk of dystonia, such as clozapine, may cause dystonic disorders like Pisa syndrome. Dystonia (dpeaa)DE-He213 Pisa syndrome (dpeaa)DE-He213 Extrapyramidal side effect (dpeaa)DE-He213 Clozapine (dpeaa)DE-He213 Omidi-Kashani, Farzad aut Baradaran, Aslan aut Enthalten in Spine deformity Amsterdam [u.a.] : Elsevier, 2013 3(2015), 4 vom: Juli, Seite 386-389 (DE-627)747142815 (DE-600)2717704-X 2212-1358 nnns volume:3 year:2015 number:4 month:07 pages:386-389 https://dx.doi.org/10.1016/j.jspd.2015.02.003 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_647 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2190 GBV_ILN_2336 AR 3 2015 4 07 386-389 |
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Pisa Syndrome Associated With Clozapine: A Rare Case Report and Literature Review |
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Pisa Syndrome Associated With Clozapine: A Rare Case Report and Literature Review |
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Faridhosseini, Farhad |
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Faridhosseini, Farhad Omidi-Kashani, Farzad Baradaran, Aslan |
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pisa syndrome associated with clozapine: a rare case report and literature review |
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Pisa Syndrome Associated With Clozapine: A Rare Case Report and Literature Review |
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Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral rotation resembled the leaning tower of Pisa. Unfamiliarity of many neuro- and orthopedic surgeons with this syndrome can lead to unnecessary diagnostic and therapeutic interventions. Case Report A 33-year-old woman, who has been treated as a schizophrenic patient for 16 years, was referred to our spine clinic with signs of trunk shift. She was consuming valproic acid 500 mg twice a day and clozapine 100 mg three times daily, as an unchanged regimen for the past 2 years. Few months after treatment with clozapine, her parents noticed that the patient progressively leaned to one side. Physical and imaging examinations revealed a severe left truncal shift associated with right cervical tilt. Drug regimen was changed and clozapine dosage reduced to 200 mg daily, and bipyridine 2 mg daily was added to the therapeutic regimen. By 1 month, the deformity gradually disappeared and normal body posture was restored. At the last follow-up visit, 28 months later, normal body posture was observed to be maintained, and no evidence of spinal deformity was noted. Conclusions Spine deformity surgeons visiting patients with abnormal postures of the trunk need to ask the patient about medications they are receiving and should be aware of their neuropsychiatric complications. Even drugs with the minimum risk of dystonia, such as clozapine, may cause dystonic disorders like Pisa syndrome. © Scoliosis Research Society 2015 |
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Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral rotation resembled the leaning tower of Pisa. Unfamiliarity of many neuro- and orthopedic surgeons with this syndrome can lead to unnecessary diagnostic and therapeutic interventions. Case Report A 33-year-old woman, who has been treated as a schizophrenic patient for 16 years, was referred to our spine clinic with signs of trunk shift. She was consuming valproic acid 500 mg twice a day and clozapine 100 mg three times daily, as an unchanged regimen for the past 2 years. Few months after treatment with clozapine, her parents noticed that the patient progressively leaned to one side. Physical and imaging examinations revealed a severe left truncal shift associated with right cervical tilt. Drug regimen was changed and clozapine dosage reduced to 200 mg daily, and bipyridine 2 mg daily was added to the therapeutic regimen. By 1 month, the deformity gradually disappeared and normal body posture was restored. At the last follow-up visit, 28 months later, normal body posture was observed to be maintained, and no evidence of spinal deformity was noted. Conclusions Spine deformity surgeons visiting patients with abnormal postures of the trunk need to ask the patient about medications they are receiving and should be aware of their neuropsychiatric complications. Even drugs with the minimum risk of dystonia, such as clozapine, may cause dystonic disorders like Pisa syndrome. © Scoliosis Research Society 2015 |
| abstract_unstemmed |
Study Design Case report. Introduction Pisa syndrome (pleurothotonus) is a rare neurologic syndrome, often considered as a consequence of long-term treatment with neuroleptic drugs, defined as more than 10 degrees tonic lateral flexion in upright spine without any significant associated vertebral rotation resembled the leaning tower of Pisa. Unfamiliarity of many neuro- and orthopedic surgeons with this syndrome can lead to unnecessary diagnostic and therapeutic interventions. Case Report A 33-year-old woman, who has been treated as a schizophrenic patient for 16 years, was referred to our spine clinic with signs of trunk shift. She was consuming valproic acid 500 mg twice a day and clozapine 100 mg three times daily, as an unchanged regimen for the past 2 years. Few months after treatment with clozapine, her parents noticed that the patient progressively leaned to one side. Physical and imaging examinations revealed a severe left truncal shift associated with right cervical tilt. Drug regimen was changed and clozapine dosage reduced to 200 mg daily, and bipyridine 2 mg daily was added to the therapeutic regimen. By 1 month, the deformity gradually disappeared and normal body posture was restored. At the last follow-up visit, 28 months later, normal body posture was observed to be maintained, and no evidence of spinal deformity was noted. Conclusions Spine deformity surgeons visiting patients with abnormal postures of the trunk need to ask the patient about medications they are receiving and should be aware of their neuropsychiatric complications. Even drugs with the minimum risk of dystonia, such as clozapine, may cause dystonic disorders like Pisa syndrome. © Scoliosis Research Society 2015 |
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