Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats

Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intr...
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Autor*in:	Wojciechowski, Piotr [verfasserIn] Szereda-Przestaszewska, Małgorzata Lipkowski, Andrzej W.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Anmerkung:	© Maj Institute of Pharmacology, Polish Academy of Sciences 2011

Übergeordnetes Werk:	Enthalten in: Pharmacological reports - Heidelberg : Springer Nature, 1998, 63(2011), 5 vom: Sept., Seite 1235-1242
Übergeordnetes Werk:	volume:63 ; year:2011 ; number:5 ; month:09 ; pages:1235-1242

Links:	Volltext

DOI / URN:	10.1016/S1734-1140(11)70644-2

Katalog-ID:	SPR038884372

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520			\|a Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 μmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of δ-opioid receptors with naltrindole (4.2 μmol/kg) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of δ-opioid receptors adds to the depressive response produced by biphalin.
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912			\|a GBV_ILN_170
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allfields	10.1016/S1734-1140(11)70644-2 doi (DE-627)SPR038884372 (SPR)S1734-1140(11)70644-2-e DE-627 ger DE-627 rakwb eng Wojciechowski, Piotr verfasserin aut Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2011 Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 μmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of δ-opioid receptors with naltrindole (4.2 μmol/kg) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of δ-opioid receptors adds to the depressive response produced by biphalin. Szereda-Przestaszewska, Małgorzata aut Lipkowski, Andrzej W. aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 63(2011), 5 vom: Sept., Seite 1235-1242 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:63 year:2011 number:5 month:09 pages:1235-1242 https://dx.doi.org/10.1016/S1734-1140(11)70644-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 63 2011 5 09 1235-1242
spelling	10.1016/S1734-1140(11)70644-2 doi (DE-627)SPR038884372 (SPR)S1734-1140(11)70644-2-e DE-627 ger DE-627 rakwb eng Wojciechowski, Piotr verfasserin aut Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2011 Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 μmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of δ-opioid receptors with naltrindole (4.2 μmol/kg) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of δ-opioid receptors adds to the depressive response produced by biphalin. Szereda-Przestaszewska, Małgorzata aut Lipkowski, Andrzej W. aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 63(2011), 5 vom: Sept., Seite 1235-1242 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:63 year:2011 number:5 month:09 pages:1235-1242 https://dx.doi.org/10.1016/S1734-1140(11)70644-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 63 2011 5 09 1235-1242
allfields_unstemmed	10.1016/S1734-1140(11)70644-2 doi (DE-627)SPR038884372 (SPR)S1734-1140(11)70644-2-e DE-627 ger DE-627 rakwb eng Wojciechowski, Piotr verfasserin aut Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2011 Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 μmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of δ-opioid receptors with naltrindole (4.2 μmol/kg) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of δ-opioid receptors adds to the depressive response produced by biphalin. Szereda-Przestaszewska, Małgorzata aut Lipkowski, Andrzej W. aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 63(2011), 5 vom: Sept., Seite 1235-1242 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:63 year:2011 number:5 month:09 pages:1235-1242 https://dx.doi.org/10.1016/S1734-1140(11)70644-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 63 2011 5 09 1235-1242
allfieldsGer	10.1016/S1734-1140(11)70644-2 doi (DE-627)SPR038884372 (SPR)S1734-1140(11)70644-2-e DE-627 ger DE-627 rakwb eng Wojciechowski, Piotr verfasserin aut Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2011 Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 μmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of δ-opioid receptors with naltrindole (4.2 μmol/kg) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of δ-opioid receptors adds to the depressive response produced by biphalin. Szereda-Przestaszewska, Małgorzata aut Lipkowski, Andrzej W. aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 63(2011), 5 vom: Sept., Seite 1235-1242 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:63 year:2011 number:5 month:09 pages:1235-1242 https://dx.doi.org/10.1016/S1734-1140(11)70644-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 63 2011 5 09 1235-1242
allfieldsSound	10.1016/S1734-1140(11)70644-2 doi (DE-627)SPR038884372 (SPR)S1734-1140(11)70644-2-e DE-627 ger DE-627 rakwb eng Wojciechowski, Piotr verfasserin aut Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2011 Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 μmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of δ-opioid receptors with naltrindole (4.2 μmol/kg) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of δ-opioid receptors adds to the depressive response produced by biphalin. Szereda-Przestaszewska, Małgorzata aut Lipkowski, Andrzej W. aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 63(2011), 5 vom: Sept., Seite 1235-1242 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:63 year:2011 number:5 month:09 pages:1235-1242 https://dx.doi.org/10.1016/S1734-1140(11)70644-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 63 2011 5 09 1235-1242
language	English
source	Enthalten in Pharmacological reports 63(2011), 5 vom: Sept., Seite 1235-1242 volume:63 year:2011 number:5 month:09 pages:1235-1242
sourceStr	Enthalten in Pharmacological reports 63(2011), 5 vom: Sept., Seite 1235-1242 volume:63 year:2011 number:5 month:09 pages:1235-1242
format_phy_str_mv	Article
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container_title	Pharmacological reports
authorswithroles_txt_mv	Wojciechowski, Piotr @@aut@@ Szereda-Przestaszewska, Małgorzata @@aut@@ Lipkowski, Andrzej W. @@aut@@
publishDateDaySort_date	2011-09-01T00:00:00Z
hierarchy_top_id	375964215
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author	Wojciechowski, Piotr
spellingShingle	Wojciechowski, Piotr Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats
authorStr	Wojciechowski, Piotr
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topic_title	Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats
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title	Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats
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title_full	Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats
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author_browse	Wojciechowski, Piotr Szereda-Przestaszewska, Małgorzata Lipkowski, Andrzej W.
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title_sort	delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats
title_auth	Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats
abstract	Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 μmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of δ-opioid receptors with naltrindole (4.2 μmol/kg) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of δ-opioid receptors adds to the depressive response produced by biphalin. © Maj Institute of Pharmacology, Polish Academy of Sciences 2011
abstractGer	Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 μmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of δ-opioid receptors with naltrindole (4.2 μmol/kg) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of δ-opioid receptors adds to the depressive response produced by biphalin. © Maj Institute of Pharmacology, Polish Academy of Sciences 2011
abstract_unstemmed	Abstract Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 μmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of δ-opioid receptors with naltrindole (4.2 μmol/kg) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of δ-opioid receptors adds to the depressive response produced by biphalin. © Maj Institute of Pharmacology, Polish Academy of Sciences 2011
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title_short	Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats
url	https://dx.doi.org/10.1016/S1734-1140(11)70644-2
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Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats

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