Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan

Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabe...
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Autor*in:	Bienert, Agnieszka [verfasserIn] Kamińska, Agnieszka Olszewski, Jan Gracz, Joanna Grabowski, Tomasz Wolc, Anna Grześkowiak, Edmund

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Anmerkung:	© Maj Institute of Pharmacology, Polish Academy of Sciences 2012

Übergeordnetes Werk:	Enthalten in: Pharmacological reports - Heidelberg : Springer Nature, 1998, 64(2012), 2 vom: März, Seite 421-427
Übergeordnetes Werk:	volume:64 ; year:2012 ; number:2 ; month:03 ; pages:421-427

Links:	Volltext

DOI / URN:	10.1016/S1734-1140(12)70783-1

Katalog-ID:	SPR038885875

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100	1		\|a Bienert, Agnieszka \|e verfasserin \|4 aut
245	1	0	\|a Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan
264		1	\|c 2012
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520			\|a Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes.
700	1		\|a Kamińska, Agnieszka \|4 aut
700	1		\|a Olszewski, Jan \|4 aut
700	1		\|a Gracz, Joanna \|4 aut
700	1		\|a Grabowski, Tomasz \|4 aut
700	1		\|a Wolc, Anna \|4 aut
700	1		\|a Grześkowiak, Edmund \|4 aut
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912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
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912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
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912			\|a GBV_ILN_2010
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912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
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912			\|a GBV_ILN_2336
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912			\|a GBV_ILN_2472
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912			\|a GBV_ILN_4012
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912			\|a GBV_ILN_4037
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912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
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912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
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912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
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matchkey_str	article:22995684:2012----::hraoieisnouadsoiinfaaeaoadaaeaoguuoienabtwt
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publishDate	2012
allfields	10.1016/S1734-1140(12)70783-1 doi (DE-627)SPR038885875 (SPR)S1734-1140(12)70783-1-e DE-627 ger DE-627 rakwb eng Bienert, Agnieszka verfasserin aut Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2012 Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes. Kamińska, Agnieszka aut Olszewski, Jan aut Gracz, Joanna aut Grabowski, Tomasz aut Wolc, Anna aut Grześkowiak, Edmund aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 64(2012), 2 vom: März, Seite 421-427 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:64 year:2012 number:2 month:03 pages:421-427 https://dx.doi.org/10.1016/S1734-1140(12)70783-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 64 2012 2 03 421-427
spelling	10.1016/S1734-1140(12)70783-1 doi (DE-627)SPR038885875 (SPR)S1734-1140(12)70783-1-e DE-627 ger DE-627 rakwb eng Bienert, Agnieszka verfasserin aut Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2012 Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes. Kamińska, Agnieszka aut Olszewski, Jan aut Gracz, Joanna aut Grabowski, Tomasz aut Wolc, Anna aut Grześkowiak, Edmund aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 64(2012), 2 vom: März, Seite 421-427 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:64 year:2012 number:2 month:03 pages:421-427 https://dx.doi.org/10.1016/S1734-1140(12)70783-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 64 2012 2 03 421-427
allfields_unstemmed	10.1016/S1734-1140(12)70783-1 doi (DE-627)SPR038885875 (SPR)S1734-1140(12)70783-1-e DE-627 ger DE-627 rakwb eng Bienert, Agnieszka verfasserin aut Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2012 Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes. Kamińska, Agnieszka aut Olszewski, Jan aut Gracz, Joanna aut Grabowski, Tomasz aut Wolc, Anna aut Grześkowiak, Edmund aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 64(2012), 2 vom: März, Seite 421-427 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:64 year:2012 number:2 month:03 pages:421-427 https://dx.doi.org/10.1016/S1734-1140(12)70783-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 64 2012 2 03 421-427
allfieldsGer	10.1016/S1734-1140(12)70783-1 doi (DE-627)SPR038885875 (SPR)S1734-1140(12)70783-1-e DE-627 ger DE-627 rakwb eng Bienert, Agnieszka verfasserin aut Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2012 Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes. Kamińska, Agnieszka aut Olszewski, Jan aut Gracz, Joanna aut Grabowski, Tomasz aut Wolc, Anna aut Grześkowiak, Edmund aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 64(2012), 2 vom: März, Seite 421-427 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:64 year:2012 number:2 month:03 pages:421-427 https://dx.doi.org/10.1016/S1734-1140(12)70783-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 64 2012 2 03 421-427
allfieldsSound	10.1016/S1734-1140(12)70783-1 doi (DE-627)SPR038885875 (SPR)S1734-1140(12)70783-1-e DE-627 ger DE-627 rakwb eng Bienert, Agnieszka verfasserin aut Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2012 Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes. Kamińska, Agnieszka aut Olszewski, Jan aut Gracz, Joanna aut Grabowski, Tomasz aut Wolc, Anna aut Grześkowiak, Edmund aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 64(2012), 2 vom: März, Seite 421-427 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:64 year:2012 number:2 month:03 pages:421-427 https://dx.doi.org/10.1016/S1734-1140(12)70783-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 64 2012 2 03 421-427
language	English
source	Enthalten in Pharmacological reports 64(2012), 2 vom: März, Seite 421-427 volume:64 year:2012 number:2 month:03 pages:421-427
sourceStr	Enthalten in Pharmacological reports 64(2012), 2 vom: März, Seite 421-427 volume:64 year:2012 number:2 month:03 pages:421-427
format_phy_str_mv	Article
institution	findex.gbv.de
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container_title	Pharmacological reports
authorswithroles_txt_mv	Bienert, Agnieszka @@aut@@ Kamińska, Agnieszka @@aut@@ Olszewski, Jan @@aut@@ Gracz, Joanna @@aut@@ Grabowski, Tomasz @@aut@@ Wolc, Anna @@aut@@ Grześkowiak, Edmund @@aut@@
publishDateDaySort_date	2012-03-01T00:00:00Z
hierarchy_top_id	375964215
id	SPR038885875
language_de	englisch
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Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. 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author	Bienert, Agnieszka
spellingShingle	Bienert, Agnieszka Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan
authorStr	Bienert, Agnieszka
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topic_title	Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan
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title	Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan
ctrlnum	(DE-627)SPR038885875 (SPR)S1734-1140(12)70783-1-e
title_full	Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan
author_sort	Bienert, Agnieszka
journal	Pharmacological reports
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author_browse	Bienert, Agnieszka Kamińska, Agnieszka Olszewski, Jan Gracz, Joanna Grabowski, Tomasz Wolc, Anna Grześkowiak, Edmund
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author-letter	Bienert, Agnieszka
doi_str_mv	10.1016/S1734-1140(12)70783-1
title_sort	pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan
title_auth	Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan
abstract	Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes. © Maj Institute of Pharmacology, Polish Academy of Sciences 2012
abstractGer	Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes. © Maj Institute of Pharmacology, Polish Academy of Sciences 2012
abstract_unstemmed	Background This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes. © Maj Institute of Pharmacology, Polish Academy of Sciences 2012
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title_short	Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan
url	https://dx.doi.org/10.1016/S1734-1140(12)70783-1
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author2	Kamińska, Agnieszka Olszewski, Jan Gracz, Joanna Grabowski, Tomasz Wolc, Anna Grześkowiak, Edmund
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doi_str	10.1016/S1734-1140(12)70783-1
up_date	2024-07-03T20:31:39.451Z
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Methods Thirty two New Zealand rabbits were divided into four groups: control group (I, n = 8), control group with diabetes (II, n = 8), rabbits with diabetes receiving paracetamol (III, n = 8), rabbits without diabetes receiving paracetamol (IV, n = 8). To induce diabetes mellitus, alloxan was administrated intravenously (iv) in the dose of 90 mg/kg body weight (b.w.) to 16 rabbits (groups II and III). Eight weeks post induction of the diabetic state, paracetamol was administrated via the ear vein at a dose of 35 mg/kg b.w. to groups III and IV. Blood and aqueous (ocular fluid) samples were collected after drug administration. PK calculations were made based on non-compartmental analysis. Results Significant differences were observed in PK of paracetamol between the studied groups. Lower value of the area under the concentration–time curve and enhanced clearance of paracetamol were noted in the diabetic group. In the case of paracetamol glucuronide, the area under the concentration–time curve was also little lower; however, no changes in the elimination rate were observed. Simultaneously, diminished ocular disposition of paracetamol was obtained in the diabetic group, whereas no changes were noted according to the penetration of paracetamol glucuronide. Conclusions The PK as well as ocular disposition of paracetamol may be altered in non-treated diabetes mellitus The glucuronidation does not seem to be the process responsible for these changes.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kamińska, Agnieszka</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Olszewski, Jan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gracz, Joanna</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Grabowski, Tomasz</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wolc, Anna</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Grześkowiak, Edmund</subfield><subfield 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Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan

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