Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate
Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Steinborn, Barbara [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© Maj Institute of Pharmacology, Polish Academy of Sciences 2013 |
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| Übergeordnetes Werk: |
Enthalten in: Pharmacological reports - Heidelberg : Springer Nature, 1998, 66(2014), 6 vom: 21. Juni, Seite 972-975 |
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| Übergeordnetes Werk: |
volume:66 ; year:2014 ; number:6 ; day:21 ; month:06 ; pages:972-975 |
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| DOI / URN: |
10.1016/j.pharep.2014.06.005 |
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| Katalog-ID: |
SPR038893746 |
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| 100 | 1 | |a Steinborn, Barbara |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate |
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| 520 | |a Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences from January 2006 to May 2007. Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. | ||
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| 700 | 1 | |a Żarowski, Marcin |4 aut | |
| 700 | 1 | |a Winczewska-Wiktor, Anna |4 aut | |
| 700 | 1 | |a Wójcicka, Marlena |4 aut | |
| 700 | 1 | |a Młodzikowska-Albrecht, Justyna |4 aut | |
| 700 | 1 | |a Losy, Jacek |4 aut | |
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10.1016/j.pharep.2014.06.005 doi (DE-627)SPR038893746 (SPR)j.pharep.2014.06.005-e DE-627 ger DE-627 rakwb eng Steinborn, Barbara verfasserin aut Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2013 Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences from January 2006 to May 2007. Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. VPA (dpeaa)DE-He213 Generalized epilepsy (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Children (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Żarowski, Marcin aut Winczewska-Wiktor, Anna aut Wójcicka, Marlena aut Młodzikowska-Albrecht, Justyna aut Losy, Jacek aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 66(2014), 6 vom: 21. Juni, Seite 972-975 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:66 year:2014 number:6 day:21 month:06 pages:972-975 https://dx.doi.org/10.1016/j.pharep.2014.06.005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2014 6 21 06 972-975 |
| spelling |
10.1016/j.pharep.2014.06.005 doi (DE-627)SPR038893746 (SPR)j.pharep.2014.06.005-e DE-627 ger DE-627 rakwb eng Steinborn, Barbara verfasserin aut Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2013 Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences from January 2006 to May 2007. Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. VPA (dpeaa)DE-He213 Generalized epilepsy (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Children (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Żarowski, Marcin aut Winczewska-Wiktor, Anna aut Wójcicka, Marlena aut Młodzikowska-Albrecht, Justyna aut Losy, Jacek aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 66(2014), 6 vom: 21. Juni, Seite 972-975 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:66 year:2014 number:6 day:21 month:06 pages:972-975 https://dx.doi.org/10.1016/j.pharep.2014.06.005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2014 6 21 06 972-975 |
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10.1016/j.pharep.2014.06.005 doi (DE-627)SPR038893746 (SPR)j.pharep.2014.06.005-e DE-627 ger DE-627 rakwb eng Steinborn, Barbara verfasserin aut Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2013 Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences from January 2006 to May 2007. Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. VPA (dpeaa)DE-He213 Generalized epilepsy (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Children (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Żarowski, Marcin aut Winczewska-Wiktor, Anna aut Wójcicka, Marlena aut Młodzikowska-Albrecht, Justyna aut Losy, Jacek aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 66(2014), 6 vom: 21. Juni, Seite 972-975 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:66 year:2014 number:6 day:21 month:06 pages:972-975 https://dx.doi.org/10.1016/j.pharep.2014.06.005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2014 6 21 06 972-975 |
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10.1016/j.pharep.2014.06.005 doi (DE-627)SPR038893746 (SPR)j.pharep.2014.06.005-e DE-627 ger DE-627 rakwb eng Steinborn, Barbara verfasserin aut Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2013 Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences from January 2006 to May 2007. Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. VPA (dpeaa)DE-He213 Generalized epilepsy (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Children (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Żarowski, Marcin aut Winczewska-Wiktor, Anna aut Wójcicka, Marlena aut Młodzikowska-Albrecht, Justyna aut Losy, Jacek aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 66(2014), 6 vom: 21. Juni, Seite 972-975 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:66 year:2014 number:6 day:21 month:06 pages:972-975 https://dx.doi.org/10.1016/j.pharep.2014.06.005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2014 6 21 06 972-975 |
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10.1016/j.pharep.2014.06.005 doi (DE-627)SPR038893746 (SPR)j.pharep.2014.06.005-e DE-627 ger DE-627 rakwb eng Steinborn, Barbara verfasserin aut Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Maj Institute of Pharmacology, Polish Academy of Sciences 2013 Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences from January 2006 to May 2007. Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. VPA (dpeaa)DE-He213 Generalized epilepsy (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Children (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Żarowski, Marcin aut Winczewska-Wiktor, Anna aut Wójcicka, Marlena aut Młodzikowska-Albrecht, Justyna aut Losy, Jacek aut Enthalten in Pharmacological reports Heidelberg : Springer Nature, 1998 66(2014), 6 vom: 21. Juni, Seite 972-975 (DE-627)375964215 (DE-600)2129019-2 2299-5684 nnns volume:66 year:2014 number:6 day:21 month:06 pages:972-975 https://dx.doi.org/10.1016/j.pharep.2014.06.005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 66 2014 6 21 06 972-975 |
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Steinborn, Barbara @@aut@@ Żarowski, Marcin @@aut@@ Winczewska-Wiktor, Anna @@aut@@ Wójcicka, Marlena @@aut@@ Młodzikowska-Albrecht, Justyna @@aut@@ Losy, Jacek @@aut@@ |
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Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. 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Steinborn, Barbara |
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Steinborn, Barbara misc VPA misc Generalized epilepsy misc Cytokine misc Children misc IL-6 Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate |
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Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate VPA (dpeaa)DE-He213 Generalized epilepsy (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Children (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 |
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Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate |
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(DE-627)SPR038893746 (SPR)j.pharep.2014.06.005-e |
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Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate |
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Steinborn, Barbara Żarowski, Marcin Winczewska-Wiktor, Anna Wójcicka, Marlena Młodzikowska-Albrecht, Justyna Losy, Jacek |
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Steinborn, Barbara |
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10.1016/j.pharep.2014.06.005 |
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concentration of il-1β, il-2, il-6, tnfα in the blood serum in children with generalized epilepsy treated by valproate |
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Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate |
| abstract |
Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences from January 2006 to May 2007. Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. © Maj Institute of Pharmacology, Polish Academy of Sciences 2013 |
| abstractGer |
Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences from January 2006 to May 2007. Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. © Maj Institute of Pharmacology, Polish Academy of Sciences 2013 |
| abstract_unstemmed |
Background The aim of the study was the comparison of concentrations of IL-1β, IL-2, IL-6 and TNFα before and after valproate (VPA) treatment in blood serum in patients with generalized seizures diagnosed and treated in the Department of Developmental Neurology, Poznan University of Medical Sciences from January 2006 to May 2007. Methods The analysis was conducted in a group of 21 patients with well controlled, generalized seizures (mean age 7.7 ± 4.7 years) before and after 4–6 months of VPA therapy. Quantitative determination IL-1β, IL-2, IL-6 and TNFα were performed with method of enzyme-linked immunosorbent assay (ELISA). The serum drug concentration was determined with the use of fluorescence-polarization-immunoassay system (FPIA). Results The concentration of IL-6 in blood serum of patients decreased significantly (p < 0.001) after 4–6 months of VPA therapy, but concentration of IL-1β (p = 0.732), IL-2 (p = 0.865), TNFα (p = 0.079) did not change significantly. The serum concentration of VPA in all of patients was in therapeutic range (mean 77.53 ± 19.71 μg/ml). Conclusions The serum level of pro-inflammatory IL-6 in patients with generalized epilepsy decreased in statistically significant way during VPA therapy, so the anti-inflammatory properties of VPA are also important for the effective control of seizure. Due to the incompatibility of reports on the influence of VPA on cytokine system in patients with generalized epilepsy, this problem needs more investigations, especially in the group of children. © Maj Institute of Pharmacology, Polish Academy of Sciences 2013 |
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Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate |
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https://dx.doi.org/10.1016/j.pharep.2014.06.005 |
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Żarowski, Marcin Winczewska-Wiktor, Anna Wójcicka, Marlena Młodzikowska-Albrecht, Justyna Losy, Jacek |
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Żarowski, Marcin Winczewska-Wiktor, Anna Wójcicka, Marlena Młodzikowska-Albrecht, Justyna Losy, Jacek |
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| score |
7.401388 |