Current understanding of substrate specificity and regioselectivity of LPMOs

Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the...
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Gespeichert in:

Autor*in:	Zhou, Xiaoli [verfasserIn] Zhu, Honghui [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Lytic polysaccharide monooxygenase LPMO Substrate specificity Regioselectivity

Übergeordnetes Werk:	Enthalten in: Bioresources and Bioprocessing - Berlin : SpringerOpen, 2014, 7(2020), 1 vom: 02. März
Übergeordnetes Werk:	volume:7 ; year:2020 ; number:1 ; day:02 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s40643-020-0300-6

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520			\|a Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below.
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allfields	10.1186/s40643-020-0300-6 doi (DE-627)SPR038971631 (SPR)s40643-020-0300-6-e DE-627 ger DE-627 rakwb eng 570 ASE Zhou, Xiaoli verfasserin aut Current understanding of substrate specificity and regioselectivity of LPMOs 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below. Lytic polysaccharide monooxygenase (dpeaa)DE-He213 LPMO (dpeaa)DE-He213 Substrate specificity (dpeaa)DE-He213 Regioselectivity (dpeaa)DE-He213 Zhu, Honghui verfasserin aut Enthalten in Bioresources and Bioprocessing Berlin : SpringerOpen, 2014 7(2020), 1 vom: 02. März (DE-627)79738166X (DE-600)2785482-6 2197-4365 nnns volume:7 year:2020 number:1 day:02 month:03 https://dx.doi.org/10.1186/s40643-020-0300-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 02 03
spelling	10.1186/s40643-020-0300-6 doi (DE-627)SPR038971631 (SPR)s40643-020-0300-6-e DE-627 ger DE-627 rakwb eng 570 ASE Zhou, Xiaoli verfasserin aut Current understanding of substrate specificity and regioselectivity of LPMOs 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below. Lytic polysaccharide monooxygenase (dpeaa)DE-He213 LPMO (dpeaa)DE-He213 Substrate specificity (dpeaa)DE-He213 Regioselectivity (dpeaa)DE-He213 Zhu, Honghui verfasserin aut Enthalten in Bioresources and Bioprocessing Berlin : SpringerOpen, 2014 7(2020), 1 vom: 02. März (DE-627)79738166X (DE-600)2785482-6 2197-4365 nnns volume:7 year:2020 number:1 day:02 month:03 https://dx.doi.org/10.1186/s40643-020-0300-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 02 03
allfields_unstemmed	10.1186/s40643-020-0300-6 doi (DE-627)SPR038971631 (SPR)s40643-020-0300-6-e DE-627 ger DE-627 rakwb eng 570 ASE Zhou, Xiaoli verfasserin aut Current understanding of substrate specificity and regioselectivity of LPMOs 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below. Lytic polysaccharide monooxygenase (dpeaa)DE-He213 LPMO (dpeaa)DE-He213 Substrate specificity (dpeaa)DE-He213 Regioselectivity (dpeaa)DE-He213 Zhu, Honghui verfasserin aut Enthalten in Bioresources and Bioprocessing Berlin : SpringerOpen, 2014 7(2020), 1 vom: 02. März (DE-627)79738166X (DE-600)2785482-6 2197-4365 nnns volume:7 year:2020 number:1 day:02 month:03 https://dx.doi.org/10.1186/s40643-020-0300-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 02 03
allfieldsGer	10.1186/s40643-020-0300-6 doi (DE-627)SPR038971631 (SPR)s40643-020-0300-6-e DE-627 ger DE-627 rakwb eng 570 ASE Zhou, Xiaoli verfasserin aut Current understanding of substrate specificity and regioselectivity of LPMOs 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below. Lytic polysaccharide monooxygenase (dpeaa)DE-He213 LPMO (dpeaa)DE-He213 Substrate specificity (dpeaa)DE-He213 Regioselectivity (dpeaa)DE-He213 Zhu, Honghui verfasserin aut Enthalten in Bioresources and Bioprocessing Berlin : SpringerOpen, 2014 7(2020), 1 vom: 02. März (DE-627)79738166X (DE-600)2785482-6 2197-4365 nnns volume:7 year:2020 number:1 day:02 month:03 https://dx.doi.org/10.1186/s40643-020-0300-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 02 03
allfieldsSound	10.1186/s40643-020-0300-6 doi (DE-627)SPR038971631 (SPR)s40643-020-0300-6-e DE-627 ger DE-627 rakwb eng 570 ASE Zhou, Xiaoli verfasserin aut Current understanding of substrate specificity and regioselectivity of LPMOs 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below. Lytic polysaccharide monooxygenase (dpeaa)DE-He213 LPMO (dpeaa)DE-He213 Substrate specificity (dpeaa)DE-He213 Regioselectivity (dpeaa)DE-He213 Zhu, Honghui verfasserin aut Enthalten in Bioresources and Bioprocessing Berlin : SpringerOpen, 2014 7(2020), 1 vom: 02. März (DE-627)79738166X (DE-600)2785482-6 2197-4365 nnns volume:7 year:2020 number:1 day:02 month:03 https://dx.doi.org/10.1186/s40643-020-0300-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 02 03
language	English
source	Enthalten in Bioresources and Bioprocessing 7(2020), 1 vom: 02. März volume:7 year:2020 number:1 day:02 month:03
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topic_facet	Lytic polysaccharide monooxygenase LPMO Substrate specificity Regioselectivity
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container_title	Bioresources and Bioprocessing
authorswithroles_txt_mv	Zhou, Xiaoli @@aut@@ Zhu, Honghui @@aut@@
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author	Zhou, Xiaoli
spellingShingle	Zhou, Xiaoli ddc 570 misc Lytic polysaccharide monooxygenase misc LPMO misc Substrate specificity misc Regioselectivity Current understanding of substrate specificity and regioselectivity of LPMOs
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topic_title	570 ASE Current understanding of substrate specificity and regioselectivity of LPMOs Lytic polysaccharide monooxygenase (dpeaa)DE-He213 LPMO (dpeaa)DE-He213 Substrate specificity (dpeaa)DE-He213 Regioselectivity (dpeaa)DE-He213
topic	ddc 570 misc Lytic polysaccharide monooxygenase misc LPMO misc Substrate specificity misc Regioselectivity
topic_unstemmed	ddc 570 misc Lytic polysaccharide monooxygenase misc LPMO misc Substrate specificity misc Regioselectivity
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title	Current understanding of substrate specificity and regioselectivity of LPMOs
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title_full	Current understanding of substrate specificity and regioselectivity of LPMOs
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title_sort	current understanding of substrate specificity and regioselectivity of lpmos
title_auth	Current understanding of substrate specificity and regioselectivity of LPMOs
abstract	Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below.
abstractGer	Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below.
abstract_unstemmed	Abstract Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below.
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title_short	Current understanding of substrate specificity and regioselectivity of LPMOs
url	https://dx.doi.org/10.1186/s40643-020-0300-6
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up_date	2024-07-03T21:04:14.810Z
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