Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory

Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been establishe...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Luo, Wenhao [verfasserIn] Yang, Gang [verfasserIn] Luo, Wentao [verfasserIn] Cao, Zhe [verfasserIn] Liu, Yueze [verfasserIn] Qiu, Jiangdong [verfasserIn] Chen, Guangyu [verfasserIn] You, Lei [verfasserIn] Zhao, Fangyu [verfasserIn] Zheng, Lianfang [verfasserIn] Zhang, Taiping [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Vaccination Pancreatic cancer Metastasis Immune therapy Novel strategies

Übergeordnetes Werk:	Enthalten in: Cancer cell international - London : BioMed Central, 2001, 20(2020), 1 vom: 04. März
Übergeordnetes Werk:	volume:20 ; year:2020 ; number:1 ; day:04 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s12935-020-1147-9

Katalog-ID:	SPR038998572

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allfields	10.1186/s12935-020-1147-9 doi (DE-627)SPR038998572 (SPR)s12935-020-1147-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Luo, Wenhao verfasserin aut Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer. Vaccination (dpeaa)DE-He213 Pancreatic cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 Immune therapy (dpeaa)DE-He213 Novel strategies (dpeaa)DE-He213 Yang, Gang verfasserin aut Luo, Wentao verfasserin aut Cao, Zhe verfasserin aut Liu, Yueze verfasserin aut Qiu, Jiangdong verfasserin aut Chen, Guangyu verfasserin aut You, Lei verfasserin aut Zhao, Fangyu verfasserin aut Zheng, Lianfang verfasserin aut Zhang, Taiping verfasserin aut Enthalten in Cancer cell international London : BioMed Central, 2001 20(2020), 1 vom: 04. März (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:20 year:2020 number:1 day:04 month:03 https://dx.doi.org/10.1186/s12935-020-1147-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 04 03
spelling	10.1186/s12935-020-1147-9 doi (DE-627)SPR038998572 (SPR)s12935-020-1147-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Luo, Wenhao verfasserin aut Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer. Vaccination (dpeaa)DE-He213 Pancreatic cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 Immune therapy (dpeaa)DE-He213 Novel strategies (dpeaa)DE-He213 Yang, Gang verfasserin aut Luo, Wentao verfasserin aut Cao, Zhe verfasserin aut Liu, Yueze verfasserin aut Qiu, Jiangdong verfasserin aut Chen, Guangyu verfasserin aut You, Lei verfasserin aut Zhao, Fangyu verfasserin aut Zheng, Lianfang verfasserin aut Zhang, Taiping verfasserin aut Enthalten in Cancer cell international London : BioMed Central, 2001 20(2020), 1 vom: 04. März (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:20 year:2020 number:1 day:04 month:03 https://dx.doi.org/10.1186/s12935-020-1147-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 04 03
allfields_unstemmed	10.1186/s12935-020-1147-9 doi (DE-627)SPR038998572 (SPR)s12935-020-1147-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Luo, Wenhao verfasserin aut Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer. Vaccination (dpeaa)DE-He213 Pancreatic cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 Immune therapy (dpeaa)DE-He213 Novel strategies (dpeaa)DE-He213 Yang, Gang verfasserin aut Luo, Wentao verfasserin aut Cao, Zhe verfasserin aut Liu, Yueze verfasserin aut Qiu, Jiangdong verfasserin aut Chen, Guangyu verfasserin aut You, Lei verfasserin aut Zhao, Fangyu verfasserin aut Zheng, Lianfang verfasserin aut Zhang, Taiping verfasserin aut Enthalten in Cancer cell international London : BioMed Central, 2001 20(2020), 1 vom: 04. März (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:20 year:2020 number:1 day:04 month:03 https://dx.doi.org/10.1186/s12935-020-1147-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 04 03
allfieldsGer	10.1186/s12935-020-1147-9 doi (DE-627)SPR038998572 (SPR)s12935-020-1147-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Luo, Wenhao verfasserin aut Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer. Vaccination (dpeaa)DE-He213 Pancreatic cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 Immune therapy (dpeaa)DE-He213 Novel strategies (dpeaa)DE-He213 Yang, Gang verfasserin aut Luo, Wentao verfasserin aut Cao, Zhe verfasserin aut Liu, Yueze verfasserin aut Qiu, Jiangdong verfasserin aut Chen, Guangyu verfasserin aut You, Lei verfasserin aut Zhao, Fangyu verfasserin aut Zheng, Lianfang verfasserin aut Zhang, Taiping verfasserin aut Enthalten in Cancer cell international London : BioMed Central, 2001 20(2020), 1 vom: 04. März (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:20 year:2020 number:1 day:04 month:03 https://dx.doi.org/10.1186/s12935-020-1147-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 04 03
allfieldsSound	10.1186/s12935-020-1147-9 doi (DE-627)SPR038998572 (SPR)s12935-020-1147-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.00 bkl Luo, Wenhao verfasserin aut Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer. Vaccination (dpeaa)DE-He213 Pancreatic cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 Immune therapy (dpeaa)DE-He213 Novel strategies (dpeaa)DE-He213 Yang, Gang verfasserin aut Luo, Wentao verfasserin aut Cao, Zhe verfasserin aut Liu, Yueze verfasserin aut Qiu, Jiangdong verfasserin aut Chen, Guangyu verfasserin aut You, Lei verfasserin aut Zhao, Fangyu verfasserin aut Zheng, Lianfang verfasserin aut Zhang, Taiping verfasserin aut Enthalten in Cancer cell international London : BioMed Central, 2001 20(2020), 1 vom: 04. März (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:20 year:2020 number:1 day:04 month:03 https://dx.doi.org/10.1186/s12935-020-1147-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 ASE AR 20 2020 1 04 03
language	English
source	Enthalten in Cancer cell international 20(2020), 1 vom: 04. März volume:20 year:2020 number:1 day:04 month:03
sourceStr	Enthalten in Cancer cell international 20(2020), 1 vom: 04. März volume:20 year:2020 number:1 day:04 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Vaccination Pancreatic cancer Metastasis Immune therapy Novel strategies
dewey-raw	610
isfreeaccess_bool	true
container_title	Cancer cell international
authorswithroles_txt_mv	Luo, Wenhao @@aut@@ Yang, Gang @@aut@@ Luo, Wentao @@aut@@ Cao, Zhe @@aut@@ Liu, Yueze @@aut@@ Qiu, Jiangdong @@aut@@ Chen, Guangyu @@aut@@ You, Lei @@aut@@ Zhao, Fangyu @@aut@@ Zheng, Lianfang @@aut@@ Zhang, Taiping @@aut@@
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author	Luo, Wenhao
spellingShingle	Luo, Wenhao ddc 610 bkl 44.00 misc Vaccination misc Pancreatic cancer misc Metastasis misc Immune therapy misc Novel strategies Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory
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topic_title	610 ASE 44.00 bkl Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory Vaccination (dpeaa)DE-He213 Pancreatic cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 Immune therapy (dpeaa)DE-He213 Novel strategies (dpeaa)DE-He213
topic	ddc 610 bkl 44.00 misc Vaccination misc Pancreatic cancer misc Metastasis misc Immune therapy misc Novel strategies
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title	Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory
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title_full	Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory
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title_sort	novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory
title_auth	Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory
abstract	Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer.
abstractGer	Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer.
abstract_unstemmed	Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer.
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title_short	Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory
url	https://dx.doi.org/10.1186/s12935-020-1147-9
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author2	Yang, Gang Luo, Wentao Cao, Zhe Liu, Yueze Qiu, Jiangdong Chen, Guangyu You, Lei Zhao, Fangyu Zheng, Lianfang Zhang, Taiping
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up_date	2024-07-03T21:15:49.084Z
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The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. 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Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory

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