The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy
Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters f...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Duque, Anna Sophie [verfasserIn] Corradini, Stefanie [verfasserIn] Kamp, Florian [verfasserIn] Seidensticker, Max [verfasserIn] Streitparth, Florian [verfasserIn] Kurz, Christopher [verfasserIn] Walter, Franziska [verfasserIn] Parodi, Katia [verfasserIn] Verhaegen, Frank [verfasserIn] Ricke, Jens [verfasserIn] Belka, Claus [verfasserIn] Fonseca, Gabriel Paiva [verfasserIn] Landry, Guillaume [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
Interstitial liver brachytherapy |
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| Übergeordnetes Werk: |
Enthalten in: Radiation oncology - London : BioMed Central, 2006, 15(2020), 1 vom: 09. März |
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| Übergeordnetes Werk: |
volume:15 ; year:2020 ; number:1 ; day:09 ; month:03 |
| Links: |
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| DOI / URN: |
10.1186/s13014-020-01492-9 |
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| Katalog-ID: |
SPR039037576 |
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| 245 | 1 | 4 | |a The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy |
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| 520 | |a Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. Results TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for liver parameters was -6.2% of the total liver volume. For OARs, the deviations were all smaller than or equal to -0.5 Gy. Target coverage deviations were as high as -1.5% of the total CTV volume and -3.5% of the prescribed dose. Conclusions In this study we found that TG-43U1 overestimates dose to liver tissue compared to TG-186. This finding may be of clinical importance for cases where dose to the whole liver is the limiting factor. | ||
| 650 | 4 | |a Radiotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Interstitial liver brachytherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a HDR Ir-192 brachytherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Model-based dose calculation algorithm |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Monte Carlo simulation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TG43 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TG186 |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Corradini, Stefanie |e verfasserin |4 aut | |
| 700 | 1 | |a Kamp, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Seidensticker, Max |e verfasserin |4 aut | |
| 700 | 1 | |a Streitparth, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Kurz, Christopher |e verfasserin |4 aut | |
| 700 | 1 | |a Walter, Franziska |e verfasserin |4 aut | |
| 700 | 1 | |a Parodi, Katia |e verfasserin |4 aut | |
| 700 | 1 | |a Verhaegen, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Ricke, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Belka, Claus |e verfasserin |4 aut | |
| 700 | 1 | |a Fonseca, Gabriel Paiva |e verfasserin |4 aut | |
| 700 | 1 | |a Landry, Guillaume |e verfasserin |4 aut | |
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10.1186/s13014-020-01492-9 doi (DE-627)SPR039037576 (SPR)s13014-020-01492-9-e DE-627 ger DE-627 rakwb eng 610 ASE Duque, Anna Sophie verfasserin aut The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. Results TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for liver parameters was -6.2% of the total liver volume. For OARs, the deviations were all smaller than or equal to -0.5 Gy. Target coverage deviations were as high as -1.5% of the total CTV volume and -3.5% of the prescribed dose. Conclusions In this study we found that TG-43U1 overestimates dose to liver tissue compared to TG-186. This finding may be of clinical importance for cases where dose to the whole liver is the limiting factor. Radiotherapy (dpeaa)DE-He213 Interstitial liver brachytherapy (dpeaa)DE-He213 HDR Ir-192 brachytherapy (dpeaa)DE-He213 Model-based dose calculation algorithm (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 TG43 (dpeaa)DE-He213 TG186 (dpeaa)DE-He213 Corradini, Stefanie verfasserin aut Kamp, Florian verfasserin aut Seidensticker, Max verfasserin aut Streitparth, Florian verfasserin aut Kurz, Christopher verfasserin aut Walter, Franziska verfasserin aut Parodi, Katia verfasserin aut Verhaegen, Frank verfasserin aut Ricke, Jens verfasserin aut Belka, Claus verfasserin aut Fonseca, Gabriel Paiva verfasserin aut Landry, Guillaume verfasserin aut Enthalten in Radiation oncology London : BioMed Central, 2006 15(2020), 1 vom: 09. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:15 year:2020 number:1 day:09 month:03 https://dx.doi.org/10.1186/s13014-020-01492-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 09 03 |
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10.1186/s13014-020-01492-9 doi (DE-627)SPR039037576 (SPR)s13014-020-01492-9-e DE-627 ger DE-627 rakwb eng 610 ASE Duque, Anna Sophie verfasserin aut The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. Results TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for liver parameters was -6.2% of the total liver volume. For OARs, the deviations were all smaller than or equal to -0.5 Gy. Target coverage deviations were as high as -1.5% of the total CTV volume and -3.5% of the prescribed dose. Conclusions In this study we found that TG-43U1 overestimates dose to liver tissue compared to TG-186. This finding may be of clinical importance for cases where dose to the whole liver is the limiting factor. Radiotherapy (dpeaa)DE-He213 Interstitial liver brachytherapy (dpeaa)DE-He213 HDR Ir-192 brachytherapy (dpeaa)DE-He213 Model-based dose calculation algorithm (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 TG43 (dpeaa)DE-He213 TG186 (dpeaa)DE-He213 Corradini, Stefanie verfasserin aut Kamp, Florian verfasserin aut Seidensticker, Max verfasserin aut Streitparth, Florian verfasserin aut Kurz, Christopher verfasserin aut Walter, Franziska verfasserin aut Parodi, Katia verfasserin aut Verhaegen, Frank verfasserin aut Ricke, Jens verfasserin aut Belka, Claus verfasserin aut Fonseca, Gabriel Paiva verfasserin aut Landry, Guillaume verfasserin aut Enthalten in Radiation oncology London : BioMed Central, 2006 15(2020), 1 vom: 09. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:15 year:2020 number:1 day:09 month:03 https://dx.doi.org/10.1186/s13014-020-01492-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 09 03 |
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10.1186/s13014-020-01492-9 doi (DE-627)SPR039037576 (SPR)s13014-020-01492-9-e DE-627 ger DE-627 rakwb eng 610 ASE Duque, Anna Sophie verfasserin aut The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. Results TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for liver parameters was -6.2% of the total liver volume. For OARs, the deviations were all smaller than or equal to -0.5 Gy. Target coverage deviations were as high as -1.5% of the total CTV volume and -3.5% of the prescribed dose. Conclusions In this study we found that TG-43U1 overestimates dose to liver tissue compared to TG-186. This finding may be of clinical importance for cases where dose to the whole liver is the limiting factor. Radiotherapy (dpeaa)DE-He213 Interstitial liver brachytherapy (dpeaa)DE-He213 HDR Ir-192 brachytherapy (dpeaa)DE-He213 Model-based dose calculation algorithm (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 TG43 (dpeaa)DE-He213 TG186 (dpeaa)DE-He213 Corradini, Stefanie verfasserin aut Kamp, Florian verfasserin aut Seidensticker, Max verfasserin aut Streitparth, Florian verfasserin aut Kurz, Christopher verfasserin aut Walter, Franziska verfasserin aut Parodi, Katia verfasserin aut Verhaegen, Frank verfasserin aut Ricke, Jens verfasserin aut Belka, Claus verfasserin aut Fonseca, Gabriel Paiva verfasserin aut Landry, Guillaume verfasserin aut Enthalten in Radiation oncology London : BioMed Central, 2006 15(2020), 1 vom: 09. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:15 year:2020 number:1 day:09 month:03 https://dx.doi.org/10.1186/s13014-020-01492-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 09 03 |
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10.1186/s13014-020-01492-9 doi (DE-627)SPR039037576 (SPR)s13014-020-01492-9-e DE-627 ger DE-627 rakwb eng 610 ASE Duque, Anna Sophie verfasserin aut The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. Results TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for liver parameters was -6.2% of the total liver volume. For OARs, the deviations were all smaller than or equal to -0.5 Gy. Target coverage deviations were as high as -1.5% of the total CTV volume and -3.5% of the prescribed dose. Conclusions In this study we found that TG-43U1 overestimates dose to liver tissue compared to TG-186. This finding may be of clinical importance for cases where dose to the whole liver is the limiting factor. Radiotherapy (dpeaa)DE-He213 Interstitial liver brachytherapy (dpeaa)DE-He213 HDR Ir-192 brachytherapy (dpeaa)DE-He213 Model-based dose calculation algorithm (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 TG43 (dpeaa)DE-He213 TG186 (dpeaa)DE-He213 Corradini, Stefanie verfasserin aut Kamp, Florian verfasserin aut Seidensticker, Max verfasserin aut Streitparth, Florian verfasserin aut Kurz, Christopher verfasserin aut Walter, Franziska verfasserin aut Parodi, Katia verfasserin aut Verhaegen, Frank verfasserin aut Ricke, Jens verfasserin aut Belka, Claus verfasserin aut Fonseca, Gabriel Paiva verfasserin aut Landry, Guillaume verfasserin aut Enthalten in Radiation oncology London : BioMed Central, 2006 15(2020), 1 vom: 09. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:15 year:2020 number:1 day:09 month:03 https://dx.doi.org/10.1186/s13014-020-01492-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 09 03 |
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10.1186/s13014-020-01492-9 doi (DE-627)SPR039037576 (SPR)s13014-020-01492-9-e DE-627 ger DE-627 rakwb eng 610 ASE Duque, Anna Sophie verfasserin aut The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. Results TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for liver parameters was -6.2% of the total liver volume. For OARs, the deviations were all smaller than or equal to -0.5 Gy. Target coverage deviations were as high as -1.5% of the total CTV volume and -3.5% of the prescribed dose. Conclusions In this study we found that TG-43U1 overestimates dose to liver tissue compared to TG-186. This finding may be of clinical importance for cases where dose to the whole liver is the limiting factor. Radiotherapy (dpeaa)DE-He213 Interstitial liver brachytherapy (dpeaa)DE-He213 HDR Ir-192 brachytherapy (dpeaa)DE-He213 Model-based dose calculation algorithm (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 TG43 (dpeaa)DE-He213 TG186 (dpeaa)DE-He213 Corradini, Stefanie verfasserin aut Kamp, Florian verfasserin aut Seidensticker, Max verfasserin aut Streitparth, Florian verfasserin aut Kurz, Christopher verfasserin aut Walter, Franziska verfasserin aut Parodi, Katia verfasserin aut Verhaegen, Frank verfasserin aut Ricke, Jens verfasserin aut Belka, Claus verfasserin aut Fonseca, Gabriel Paiva verfasserin aut Landry, Guillaume verfasserin aut Enthalten in Radiation oncology London : BioMed Central, 2006 15(2020), 1 vom: 09. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:15 year:2020 number:1 day:09 month:03 https://dx.doi.org/10.1186/s13014-020-01492-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1 09 03 |
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Duque, Anna Sophie @@aut@@ Corradini, Stefanie @@aut@@ Kamp, Florian @@aut@@ Seidensticker, Max @@aut@@ Streitparth, Florian @@aut@@ Kurz, Christopher @@aut@@ Walter, Franziska @@aut@@ Parodi, Katia @@aut@@ Verhaegen, Frank @@aut@@ Ricke, Jens @@aut@@ Belka, Claus @@aut@@ Fonseca, Gabriel Paiva @@aut@@ Landry, Guillaume @@aut@@ |
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The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy |
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The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy |
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Duque, Anna Sophie |
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Radiation oncology |
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Duque, Anna Sophie Corradini, Stefanie Kamp, Florian Seidensticker, Max Streitparth, Florian Kurz, Christopher Walter, Franziska Parodi, Katia Verhaegen, Frank Ricke, Jens Belka, Claus Fonseca, Gabriel Paiva Landry, Guillaume |
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dosimetric impact of replacing the tg-43 algorithm by model based dose calculation for liver brachytherapy |
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The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy |
| abstract |
Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. Results TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for liver parameters was -6.2% of the total liver volume. For OARs, the deviations were all smaller than or equal to -0.5 Gy. Target coverage deviations were as high as -1.5% of the total CTV volume and -3.5% of the prescribed dose. Conclusions In this study we found that TG-43U1 overestimates dose to liver tissue compared to TG-186. This finding may be of clinical importance for cases where dose to the whole liver is the limiting factor. |
| abstractGer |
Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. Results TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for liver parameters was -6.2% of the total liver volume. For OARs, the deviations were all smaller than or equal to -0.5 Gy. Target coverage deviations were as high as -1.5% of the total CTV volume and -3.5% of the prescribed dose. Conclusions In this study we found that TG-43U1 overestimates dose to liver tissue compared to TG-186. This finding may be of clinical importance for cases where dose to the whole liver is the limiting factor. |
| abstract_unstemmed |
Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. Methods We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. Results TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for liver parameters was -6.2% of the total liver volume. For OARs, the deviations were all smaller than or equal to -0.5 Gy. Target coverage deviations were as high as -1.5% of the total CTV volume and -3.5% of the prescribed dose. Conclusions In this study we found that TG-43U1 overestimates dose to liver tissue compared to TG-186. This finding may be of clinical importance for cases where dose to the whole liver is the limiting factor. |
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The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy |
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Corradini, Stefanie Kamp, Florian Seidensticker, Max Streitparth, Florian Kurz, Christopher Walter, Franziska Parodi, Katia Verhaegen, Frank Ricke, Jens Belka, Claus Fonseca, Gabriel Paiva Landry, Guillaume |
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