Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel

Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by...
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Autor*in:	Lorusso, Domenica [verfasserIn] Bologna, Alessandra [verfasserIn] Cecere, Sabrina Chiara [verfasserIn] De Matteis, Elisabetta [verfasserIn] Scandurra, Giusy [verfasserIn] Zamagni, Claudio [verfasserIn] Arcangeli, Valentina [verfasserIn] Artioli, Fabrizio [verfasserIn] Bella, Mariangela [verfasserIn] Blanco, Giusi [verfasserIn] Cardalesi, Cinzia [verfasserIn] Casartelli, Clelia [verfasserIn] De Vivo, Rocco [verfasserIn] Di Napoli, Marilena [verfasserIn] Gisone, Emanuele Baldo [verfasserIn] Lauria, Rossella [verfasserIn] Lissoni, Alberto Andrea [verfasserIn] Loizzi, Vera [verfasserIn] Maccaroni, Elena [verfasserIn] Mangili, Giorgia [verfasserIn] Marchetti, Claudia [verfasserIn] Martella, Francesca [verfasserIn] Naglieri, Emanuele [verfasserIn] Parolin, Veronica [verfasserIn] Ricciardi, Giusy [verfasserIn] Ronzino, Graziana [verfasserIn] Salutari, Vanda [verfasserIn] Scarfone, Giovanna [verfasserIn] Secondino, Simona [verfasserIn] Spagnoletti, Ilaria [verfasserIn] Tasca, Giulia [verfasserIn] Tognon, Germana [verfasserIn] Guarneri, Valentina [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Adherence Clinical practice Olaparib Recurrent ovarian cancer Toxicities Transition

Übergeordnetes Werk:	Enthalten in: Supportive care in cancer - Berlin : Springer, 1993, 28(2020), 5 vom: 11. Feb., Seite 2435-2442
Übergeordnetes Werk:	volume:28 ; year:2020 ; number:5 ; day:11 ; month:02 ; pages:2435-2442

Links:	Volltext

DOI / URN:	10.1007/s00520-020-05320-4

Katalog-ID:	SPR039161633

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520			\|a Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. Moreover, in view of the tablet entry into the Italian market, the full and reduced dosages of capsules and tablets were compared. This practical guidance is intended to be a tool to support especially less-experienced physicians in the management of these complex patients, with the aim to help preventing the worsening of patients’ conditions and the unnecessary interruption/reduction of olaparib dosage, which may jeopardize treatment efficacy.
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allfields	10.1007/s00520-020-05320-4 doi (DE-627)SPR039161633 (SPR)s00520-020-05320-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lorusso, Domenica verfasserin aut Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. Moreover, in view of the tablet entry into the Italian market, the full and reduced dosages of capsules and tablets were compared. This practical guidance is intended to be a tool to support especially less-experienced physicians in the management of these complex patients, with the aim to help preventing the worsening of patients’ conditions and the unnecessary interruption/reduction of olaparib dosage, which may jeopardize treatment efficacy. Adherence (dpeaa)DE-He213 Clinical practice (dpeaa)DE-He213 Olaparib (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Toxicities (dpeaa)DE-He213 Transition (dpeaa)DE-He213 Bologna, Alessandra verfasserin aut Cecere, Sabrina Chiara verfasserin aut De Matteis, Elisabetta verfasserin aut Scandurra, Giusy verfasserin aut Zamagni, Claudio verfasserin aut Arcangeli, Valentina verfasserin aut Artioli, Fabrizio verfasserin aut Bella, Mariangela verfasserin aut Blanco, Giusi verfasserin aut Cardalesi, Cinzia verfasserin aut Casartelli, Clelia verfasserin aut De Vivo, Rocco verfasserin aut Di Napoli, Marilena verfasserin aut Gisone, Emanuele Baldo verfasserin aut Lauria, Rossella verfasserin aut Lissoni, Alberto Andrea verfasserin aut Loizzi, Vera verfasserin aut Maccaroni, Elena verfasserin aut Mangili, Giorgia verfasserin aut Marchetti, Claudia verfasserin aut Martella, Francesca verfasserin aut Naglieri, Emanuele verfasserin aut Parolin, Veronica verfasserin aut Ricciardi, Giusy verfasserin aut Ronzino, Graziana verfasserin aut Salutari, Vanda verfasserin aut Scarfone, Giovanna verfasserin aut Secondino, Simona verfasserin aut Spagnoletti, Ilaria verfasserin aut Tasca, Giulia verfasserin aut Tognon, Germana verfasserin aut Guarneri, Valentina verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 28(2020), 5 vom: 11. Feb., Seite 2435-2442 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:28 year:2020 number:5 day:11 month:02 pages:2435-2442 https://dx.doi.org/10.1007/s00520-020-05320-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 28 2020 5 11 02 2435-2442
spelling	10.1007/s00520-020-05320-4 doi (DE-627)SPR039161633 (SPR)s00520-020-05320-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lorusso, Domenica verfasserin aut Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. Moreover, in view of the tablet entry into the Italian market, the full and reduced dosages of capsules and tablets were compared. This practical guidance is intended to be a tool to support especially less-experienced physicians in the management of these complex patients, with the aim to help preventing the worsening of patients’ conditions and the unnecessary interruption/reduction of olaparib dosage, which may jeopardize treatment efficacy. Adherence (dpeaa)DE-He213 Clinical practice (dpeaa)DE-He213 Olaparib (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Toxicities (dpeaa)DE-He213 Transition (dpeaa)DE-He213 Bologna, Alessandra verfasserin aut Cecere, Sabrina Chiara verfasserin aut De Matteis, Elisabetta verfasserin aut Scandurra, Giusy verfasserin aut Zamagni, Claudio verfasserin aut Arcangeli, Valentina verfasserin aut Artioli, Fabrizio verfasserin aut Bella, Mariangela verfasserin aut Blanco, Giusi verfasserin aut Cardalesi, Cinzia verfasserin aut Casartelli, Clelia verfasserin aut De Vivo, Rocco verfasserin aut Di Napoli, Marilena verfasserin aut Gisone, Emanuele Baldo verfasserin aut Lauria, Rossella verfasserin aut Lissoni, Alberto Andrea verfasserin aut Loizzi, Vera verfasserin aut Maccaroni, Elena verfasserin aut Mangili, Giorgia verfasserin aut Marchetti, Claudia verfasserin aut Martella, Francesca verfasserin aut Naglieri, Emanuele verfasserin aut Parolin, Veronica verfasserin aut Ricciardi, Giusy verfasserin aut Ronzino, Graziana verfasserin aut Salutari, Vanda verfasserin aut Scarfone, Giovanna verfasserin aut Secondino, Simona verfasserin aut Spagnoletti, Ilaria verfasserin aut Tasca, Giulia verfasserin aut Tognon, Germana verfasserin aut Guarneri, Valentina verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 28(2020), 5 vom: 11. Feb., Seite 2435-2442 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:28 year:2020 number:5 day:11 month:02 pages:2435-2442 https://dx.doi.org/10.1007/s00520-020-05320-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 28 2020 5 11 02 2435-2442
allfields_unstemmed	10.1007/s00520-020-05320-4 doi (DE-627)SPR039161633 (SPR)s00520-020-05320-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lorusso, Domenica verfasserin aut Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. Moreover, in view of the tablet entry into the Italian market, the full and reduced dosages of capsules and tablets were compared. This practical guidance is intended to be a tool to support especially less-experienced physicians in the management of these complex patients, with the aim to help preventing the worsening of patients’ conditions and the unnecessary interruption/reduction of olaparib dosage, which may jeopardize treatment efficacy. Adherence (dpeaa)DE-He213 Clinical practice (dpeaa)DE-He213 Olaparib (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Toxicities (dpeaa)DE-He213 Transition (dpeaa)DE-He213 Bologna, Alessandra verfasserin aut Cecere, Sabrina Chiara verfasserin aut De Matteis, Elisabetta verfasserin aut Scandurra, Giusy verfasserin aut Zamagni, Claudio verfasserin aut Arcangeli, Valentina verfasserin aut Artioli, Fabrizio verfasserin aut Bella, Mariangela verfasserin aut Blanco, Giusi verfasserin aut Cardalesi, Cinzia verfasserin aut Casartelli, Clelia verfasserin aut De Vivo, Rocco verfasserin aut Di Napoli, Marilena verfasserin aut Gisone, Emanuele Baldo verfasserin aut Lauria, Rossella verfasserin aut Lissoni, Alberto Andrea verfasserin aut Loizzi, Vera verfasserin aut Maccaroni, Elena verfasserin aut Mangili, Giorgia verfasserin aut Marchetti, Claudia verfasserin aut Martella, Francesca verfasserin aut Naglieri, Emanuele verfasserin aut Parolin, Veronica verfasserin aut Ricciardi, Giusy verfasserin aut Ronzino, Graziana verfasserin aut Salutari, Vanda verfasserin aut Scarfone, Giovanna verfasserin aut Secondino, Simona verfasserin aut Spagnoletti, Ilaria verfasserin aut Tasca, Giulia verfasserin aut Tognon, Germana verfasserin aut Guarneri, Valentina verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 28(2020), 5 vom: 11. Feb., Seite 2435-2442 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:28 year:2020 number:5 day:11 month:02 pages:2435-2442 https://dx.doi.org/10.1007/s00520-020-05320-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 28 2020 5 11 02 2435-2442
allfieldsGer	10.1007/s00520-020-05320-4 doi (DE-627)SPR039161633 (SPR)s00520-020-05320-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lorusso, Domenica verfasserin aut Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. Moreover, in view of the tablet entry into the Italian market, the full and reduced dosages of capsules and tablets were compared. This practical guidance is intended to be a tool to support especially less-experienced physicians in the management of these complex patients, with the aim to help preventing the worsening of patients’ conditions and the unnecessary interruption/reduction of olaparib dosage, which may jeopardize treatment efficacy. Adherence (dpeaa)DE-He213 Clinical practice (dpeaa)DE-He213 Olaparib (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Toxicities (dpeaa)DE-He213 Transition (dpeaa)DE-He213 Bologna, Alessandra verfasserin aut Cecere, Sabrina Chiara verfasserin aut De Matteis, Elisabetta verfasserin aut Scandurra, Giusy verfasserin aut Zamagni, Claudio verfasserin aut Arcangeli, Valentina verfasserin aut Artioli, Fabrizio verfasserin aut Bella, Mariangela verfasserin aut Blanco, Giusi verfasserin aut Cardalesi, Cinzia verfasserin aut Casartelli, Clelia verfasserin aut De Vivo, Rocco verfasserin aut Di Napoli, Marilena verfasserin aut Gisone, Emanuele Baldo verfasserin aut Lauria, Rossella verfasserin aut Lissoni, Alberto Andrea verfasserin aut Loizzi, Vera verfasserin aut Maccaroni, Elena verfasserin aut Mangili, Giorgia verfasserin aut Marchetti, Claudia verfasserin aut Martella, Francesca verfasserin aut Naglieri, Emanuele verfasserin aut Parolin, Veronica verfasserin aut Ricciardi, Giusy verfasserin aut Ronzino, Graziana verfasserin aut Salutari, Vanda verfasserin aut Scarfone, Giovanna verfasserin aut Secondino, Simona verfasserin aut Spagnoletti, Ilaria verfasserin aut Tasca, Giulia verfasserin aut Tognon, Germana verfasserin aut Guarneri, Valentina verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 28(2020), 5 vom: 11. Feb., Seite 2435-2442 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:28 year:2020 number:5 day:11 month:02 pages:2435-2442 https://dx.doi.org/10.1007/s00520-020-05320-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 28 2020 5 11 02 2435-2442
allfieldsSound	10.1007/s00520-020-05320-4 doi (DE-627)SPR039161633 (SPR)s00520-020-05320-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lorusso, Domenica verfasserin aut Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. Moreover, in view of the tablet entry into the Italian market, the full and reduced dosages of capsules and tablets were compared. This practical guidance is intended to be a tool to support especially less-experienced physicians in the management of these complex patients, with the aim to help preventing the worsening of patients’ conditions and the unnecessary interruption/reduction of olaparib dosage, which may jeopardize treatment efficacy. Adherence (dpeaa)DE-He213 Clinical practice (dpeaa)DE-He213 Olaparib (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Toxicities (dpeaa)DE-He213 Transition (dpeaa)DE-He213 Bologna, Alessandra verfasserin aut Cecere, Sabrina Chiara verfasserin aut De Matteis, Elisabetta verfasserin aut Scandurra, Giusy verfasserin aut Zamagni, Claudio verfasserin aut Arcangeli, Valentina verfasserin aut Artioli, Fabrizio verfasserin aut Bella, Mariangela verfasserin aut Blanco, Giusi verfasserin aut Cardalesi, Cinzia verfasserin aut Casartelli, Clelia verfasserin aut De Vivo, Rocco verfasserin aut Di Napoli, Marilena verfasserin aut Gisone, Emanuele Baldo verfasserin aut Lauria, Rossella verfasserin aut Lissoni, Alberto Andrea verfasserin aut Loizzi, Vera verfasserin aut Maccaroni, Elena verfasserin aut Mangili, Giorgia verfasserin aut Marchetti, Claudia verfasserin aut Martella, Francesca verfasserin aut Naglieri, Emanuele verfasserin aut Parolin, Veronica verfasserin aut Ricciardi, Giusy verfasserin aut Ronzino, Graziana verfasserin aut Salutari, Vanda verfasserin aut Scarfone, Giovanna verfasserin aut Secondino, Simona verfasserin aut Spagnoletti, Ilaria verfasserin aut Tasca, Giulia verfasserin aut Tognon, Germana verfasserin aut Guarneri, Valentina verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 28(2020), 5 vom: 11. Feb., Seite 2435-2442 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:28 year:2020 number:5 day:11 month:02 pages:2435-2442 https://dx.doi.org/10.1007/s00520-020-05320-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 28 2020 5 11 02 2435-2442
language	English
source	Enthalten in Supportive care in cancer 28(2020), 5 vom: 11. Feb., Seite 2435-2442 volume:28 year:2020 number:5 day:11 month:02 pages:2435-2442
sourceStr	Enthalten in Supportive care in cancer 28(2020), 5 vom: 11. Feb., Seite 2435-2442 volume:28 year:2020 number:5 day:11 month:02 pages:2435-2442
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Adherence Clinical practice Olaparib Recurrent ovarian cancer Toxicities Transition
dewey-raw	610
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container_title	Supportive care in cancer
authorswithroles_txt_mv	Lorusso, Domenica @@aut@@ Bologna, Alessandra @@aut@@ Cecere, Sabrina Chiara @@aut@@ De Matteis, Elisabetta @@aut@@ Scandurra, Giusy @@aut@@ Zamagni, Claudio @@aut@@ Arcangeli, Valentina @@aut@@ Artioli, Fabrizio @@aut@@ Bella, Mariangela @@aut@@ Blanco, Giusi @@aut@@ Cardalesi, Cinzia @@aut@@ Casartelli, Clelia @@aut@@ De Vivo, Rocco @@aut@@ Di Napoli, Marilena @@aut@@ Gisone, Emanuele Baldo @@aut@@ Lauria, Rossella @@aut@@ Lissoni, Alberto Andrea @@aut@@ Loizzi, Vera @@aut@@ Maccaroni, Elena @@aut@@ Mangili, Giorgia @@aut@@ Marchetti, Claudia @@aut@@ Martella, Francesca @@aut@@ Naglieri, Emanuele @@aut@@ Parolin, Veronica @@aut@@ Ricciardi, Giusy @@aut@@ Ronzino, Graziana @@aut@@ Salutari, Vanda @@aut@@ Scarfone, Giovanna @@aut@@ Secondino, Simona @@aut@@ Spagnoletti, Ilaria @@aut@@ Tasca, Giulia @@aut@@ Tognon, Germana @@aut@@ Guarneri, Valentina @@aut@@
publishDateDaySort_date	2020-02-11T00:00:00Z
hierarchy_top_id	254909574
dewey-sort	3610
id	SPR039161633
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR039161633</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519084904.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00520-020-05320-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR039161633</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00520-020-05320-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.81</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Lorusso, Domenica</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. 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spellingShingle	Lorusso, Domenica ddc 610 bkl 44.81 misc Adherence misc Clinical practice misc Olaparib misc Recurrent ovarian cancer misc Toxicities misc Transition Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel
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topic_title	610 ASE 44.81 bkl Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel Adherence (dpeaa)DE-He213 Clinical practice (dpeaa)DE-He213 Olaparib (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Toxicities (dpeaa)DE-He213 Transition (dpeaa)DE-He213
topic	ddc 610 bkl 44.81 misc Adherence misc Clinical practice misc Olaparib misc Recurrent ovarian cancer misc Toxicities misc Transition
topic_unstemmed	ddc 610 bkl 44.81 misc Adherence misc Clinical practice misc Olaparib misc Recurrent ovarian cancer misc Toxicities misc Transition
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title	Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel
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title_full	Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel
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author_browse	Lorusso, Domenica Bologna, Alessandra Cecere, Sabrina Chiara De Matteis, Elisabetta Scandurra, Giusy Zamagni, Claudio Arcangeli, Valentina Artioli, Fabrizio Bella, Mariangela Blanco, Giusi Cardalesi, Cinzia Casartelli, Clelia De Vivo, Rocco Di Napoli, Marilena Gisone, Emanuele Baldo Lauria, Rossella Lissoni, Alberto Andrea Loizzi, Vera Maccaroni, Elena Mangili, Giorgia Marchetti, Claudia Martella, Francesca Naglieri, Emanuele Parolin, Veronica Ricciardi, Giusy Ronzino, Graziana Salutari, Vanda Scarfone, Giovanna Secondino, Simona Spagnoletti, Ilaria Tasca, Giulia Tognon, Germana Guarneri, Valentina
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title_sort	sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an italian expert panel
title_auth	Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel
abstract	Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. Moreover, in view of the tablet entry into the Italian market, the full and reduced dosages of capsules and tablets were compared. This practical guidance is intended to be a tool to support especially less-experienced physicians in the management of these complex patients, with the aim to help preventing the worsening of patients’ conditions and the unnecessary interruption/reduction of olaparib dosage, which may jeopardize treatment efficacy.
abstractGer	Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. Moreover, in view of the tablet entry into the Italian market, the full and reduced dosages of capsules and tablets were compared. This practical guidance is intended to be a tool to support especially less-experienced physicians in the management of these complex patients, with the aim to help preventing the worsening of patients’ conditions and the unnecessary interruption/reduction of olaparib dosage, which may jeopardize treatment efficacy.
abstract_unstemmed	Abstract Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of recurrent ovarian cancer (OC) patients with a BRCA mutation. To achieve the maximum clinical benefit, adherence to olaparib must be persistent. However, in clinical practice, this is challenged by the frequent suboptimal management of toxicities. In view of the expanding use of olaparib also in Italy, physicians must learn how to adequately and promptly manage drug toxicities not to unnecessarily interrupt or reduce the dose. The experts agreed that nausea,vomiting, anemia, and fatigue are the most frequent events experienced by OC patients on olaparib, and that these toxicities usually develop early during treatment, are mainly of grade 1–2 and transient and can be managed with simple non-pharmacological interventions. By sharing their real-world experiences, the panel prepared, for each toxicity, an algorithm organized by grade and besides the procedures indicated in the local label, included supportive care interventions based also on nutritional and lifestyle modifications and psycho-oncology consultation. Moreover, in view of the tablet entry into the Italian market, the full and reduced dosages of capsules and tablets were compared. This practical guidance is intended to be a tool to support especially less-experienced physicians in the management of these complex patients, with the aim to help preventing the worsening of patients’ conditions and the unnecessary interruption/reduction of olaparib dosage, which may jeopardize treatment efficacy.
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title_short	Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel
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author2	Bologna, Alessandra Cecere, Sabrina Chiara De Matteis, Elisabetta Scandurra, Giusy Zamagni, Claudio Arcangeli, Valentina Artioli, Fabrizio Bella, Mariangela Blanco, Giusi Cardalesi, Cinzia Casartelli, Clelia De Vivo, Rocco Di Napoli, Marilena Gisone, Emanuele Baldo Lauria, Rossella Lissoni, Alberto Andrea Loizzi, Vera Maccaroni, Elena Mangili, Giorgia Marchetti, Claudia Martella, Francesca Naglieri, Emanuele Parolin, Veronica Ricciardi, Giusy Ronzino, Graziana Salutari, Vanda Scarfone, Giovanna Secondino, Simona Spagnoletti, Ilaria Tasca, Giulia Tognon, Germana Guarneri, Valentina
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