Stability-Indicating Densitometric HPTLC Method for Qualitative and Quantitative Analysis of Arbutin in Commercial Whitening Creams

Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/...
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Autor*in:	Alqasoumi, Saleh I. [verfasserIn] Alam, Prawez [verfasserIn] Abdel-Kader, Maged S. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Übergeordnetes Werk:	Enthalten in: Journal of planar chromatography, modern TLC - Budapest : Akadémiai Kiadó, 2001, 25(2012), 2 vom: 01. Apr., Seite 168-173
Übergeordnetes Werk:	volume:25 ; year:2012 ; number:2 ; day:01 ; month:04 ; pages:168-173

Links:	Volltext

DOI / URN:	10.1556/JPC.25.2012.2.14

Katalog-ID:	SPR039175022

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520			\|a Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/v) mixture was used as mobile phase. Under these chromatographic conditions, arbutin was well separated from other ingredients. This system was found to give a well defined, sharp, and compact spot of arbutin at retention factor (RF) value of 0.40 ± 0.02. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 42.25 and 112.45 ng per spot respectively. The proposed method with high degree of precision and accuracy was employed for the analysis of arbutin both qualitatively and quantitatively in commercial whitening creams. Due to the efficiency of the method in separating arbutin from other ingredients including its degradation products, it can be applied as a stability-indicating method.
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allfields	10.1556/JPC.25.2012.2.14 doi (DE-627)SPR039175022 (SPR)JPC.25.2012.2.14-e DE-627 ger DE-627 rakwb eng 540 530 ASE Alqasoumi, Saleh I. verfasserin aut Stability-Indicating Densitometric HPTLC Method for Qualitative and Quantitative Analysis of Arbutin in Commercial Whitening Creams 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/v) mixture was used as mobile phase. Under these chromatographic conditions, arbutin was well separated from other ingredients. This system was found to give a well defined, sharp, and compact spot of arbutin at retention factor (RF) value of 0.40 ± 0.02. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 42.25 and 112.45 ng per spot respectively. The proposed method with high degree of precision and accuracy was employed for the analysis of arbutin both qualitatively and quantitatively in commercial whitening creams. Due to the efficiency of the method in separating arbutin from other ingredients including its degradation products, it can be applied as a stability-indicating method. Alam, Prawez verfasserin aut Abdel-Kader, Maged S. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 25(2012), 2 vom: 01. Apr., Seite 168-173 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:25 year:2012 number:2 day:01 month:04 pages:168-173 https://dx.doi.org/10.1556/JPC.25.2012.2.14 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_31 GBV_ILN_702 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 AR 25 2012 2 01 04 168-173
spelling	10.1556/JPC.25.2012.2.14 doi (DE-627)SPR039175022 (SPR)JPC.25.2012.2.14-e DE-627 ger DE-627 rakwb eng 540 530 ASE Alqasoumi, Saleh I. verfasserin aut Stability-Indicating Densitometric HPTLC Method for Qualitative and Quantitative Analysis of Arbutin in Commercial Whitening Creams 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/v) mixture was used as mobile phase. Under these chromatographic conditions, arbutin was well separated from other ingredients. This system was found to give a well defined, sharp, and compact spot of arbutin at retention factor (RF) value of 0.40 ± 0.02. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 42.25 and 112.45 ng per spot respectively. The proposed method with high degree of precision and accuracy was employed for the analysis of arbutin both qualitatively and quantitatively in commercial whitening creams. Due to the efficiency of the method in separating arbutin from other ingredients including its degradation products, it can be applied as a stability-indicating method. Alam, Prawez verfasserin aut Abdel-Kader, Maged S. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 25(2012), 2 vom: 01. Apr., Seite 168-173 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:25 year:2012 number:2 day:01 month:04 pages:168-173 https://dx.doi.org/10.1556/JPC.25.2012.2.14 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_31 GBV_ILN_702 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 AR 25 2012 2 01 04 168-173
allfields_unstemmed	10.1556/JPC.25.2012.2.14 doi (DE-627)SPR039175022 (SPR)JPC.25.2012.2.14-e DE-627 ger DE-627 rakwb eng 540 530 ASE Alqasoumi, Saleh I. verfasserin aut Stability-Indicating Densitometric HPTLC Method for Qualitative and Quantitative Analysis of Arbutin in Commercial Whitening Creams 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/v) mixture was used as mobile phase. Under these chromatographic conditions, arbutin was well separated from other ingredients. This system was found to give a well defined, sharp, and compact spot of arbutin at retention factor (RF) value of 0.40 ± 0.02. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 42.25 and 112.45 ng per spot respectively. The proposed method with high degree of precision and accuracy was employed for the analysis of arbutin both qualitatively and quantitatively in commercial whitening creams. Due to the efficiency of the method in separating arbutin from other ingredients including its degradation products, it can be applied as a stability-indicating method. Alam, Prawez verfasserin aut Abdel-Kader, Maged S. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 25(2012), 2 vom: 01. Apr., Seite 168-173 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:25 year:2012 number:2 day:01 month:04 pages:168-173 https://dx.doi.org/10.1556/JPC.25.2012.2.14 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_31 GBV_ILN_702 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 AR 25 2012 2 01 04 168-173
allfieldsGer	10.1556/JPC.25.2012.2.14 doi (DE-627)SPR039175022 (SPR)JPC.25.2012.2.14-e DE-627 ger DE-627 rakwb eng 540 530 ASE Alqasoumi, Saleh I. verfasserin aut Stability-Indicating Densitometric HPTLC Method for Qualitative and Quantitative Analysis of Arbutin in Commercial Whitening Creams 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/v) mixture was used as mobile phase. Under these chromatographic conditions, arbutin was well separated from other ingredients. This system was found to give a well defined, sharp, and compact spot of arbutin at retention factor (RF) value of 0.40 ± 0.02. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 42.25 and 112.45 ng per spot respectively. The proposed method with high degree of precision and accuracy was employed for the analysis of arbutin both qualitatively and quantitatively in commercial whitening creams. Due to the efficiency of the method in separating arbutin from other ingredients including its degradation products, it can be applied as a stability-indicating method. Alam, Prawez verfasserin aut Abdel-Kader, Maged S. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 25(2012), 2 vom: 01. Apr., Seite 168-173 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:25 year:2012 number:2 day:01 month:04 pages:168-173 https://dx.doi.org/10.1556/JPC.25.2012.2.14 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_31 GBV_ILN_702 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 AR 25 2012 2 01 04 168-173
allfieldsSound	10.1556/JPC.25.2012.2.14 doi (DE-627)SPR039175022 (SPR)JPC.25.2012.2.14-e DE-627 ger DE-627 rakwb eng 540 530 ASE Alqasoumi, Saleh I. verfasserin aut Stability-Indicating Densitometric HPTLC Method for Qualitative and Quantitative Analysis of Arbutin in Commercial Whitening Creams 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/v) mixture was used as mobile phase. Under these chromatographic conditions, arbutin was well separated from other ingredients. This system was found to give a well defined, sharp, and compact spot of arbutin at retention factor (RF) value of 0.40 ± 0.02. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 42.25 and 112.45 ng per spot respectively. The proposed method with high degree of precision and accuracy was employed for the analysis of arbutin both qualitatively and quantitatively in commercial whitening creams. Due to the efficiency of the method in separating arbutin from other ingredients including its degradation products, it can be applied as a stability-indicating method. Alam, Prawez verfasserin aut Abdel-Kader, Maged S. verfasserin aut Enthalten in Journal of planar chromatography, modern TLC Budapest : Akadémiai Kiadó, 2001 25(2012), 2 vom: 01. Apr., Seite 168-173 (DE-627)529764563 (DE-600)2304198-5 1789-0993 nnns volume:25 year:2012 number:2 day:01 month:04 pages:168-173 https://dx.doi.org/10.1556/JPC.25.2012.2.14 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_31 GBV_ILN_702 GBV_ILN_2129 GBV_ILN_2190 GBV_ILN_4012 AR 25 2012 2 01 04 168-173
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title_sort	stability-indicating densitometric hptlc method for qualitative and quantitative analysis of arbutin in commercial whitening creams
title_auth	Stability-Indicating Densitometric HPTLC Method for Qualitative and Quantitative Analysis of Arbutin in Commercial Whitening Creams
abstract	Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/v) mixture was used as mobile phase. Under these chromatographic conditions, arbutin was well separated from other ingredients. This system was found to give a well defined, sharp, and compact spot of arbutin at retention factor (RF) value of 0.40 ± 0.02. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 42.25 and 112.45 ng per spot respectively. The proposed method with high degree of precision and accuracy was employed for the analysis of arbutin both qualitatively and quantitatively in commercial whitening creams. Due to the efficiency of the method in separating arbutin from other ingredients including its degradation products, it can be applied as a stability-indicating method.
abstractGer	Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/v) mixture was used as mobile phase. Under these chromatographic conditions, arbutin was well separated from other ingredients. This system was found to give a well defined, sharp, and compact spot of arbutin at retention factor (RF) value of 0.40 ± 0.02. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 42.25 and 112.45 ng per spot respectively. The proposed method with high degree of precision and accuracy was employed for the analysis of arbutin both qualitatively and quantitatively in commercial whitening creams. Due to the efficiency of the method in separating arbutin from other ingredients including its degradation products, it can be applied as a stability-indicating method.
abstract_unstemmed	Summary High-performance thin-layer chromatographic (HPTLC) densitometric method for analysis of arbutin in commercial whitening creams was developed and validated. Aluminum-backed silica gel 60 $ F_{254} $ plates were used as stationary phase while methanol-chloroform-acetic acid 3.5:6:0.5 (%, v/v/v) mixture was used as mobile phase. Under these chromatographic conditions, arbutin was well separated from other ingredients. This system was found to give a well defined, sharp, and compact spot of arbutin at retention factor (RF) value of 0.40 ± 0.02. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 42.25 and 112.45 ng per spot respectively. The proposed method with high degree of precision and accuracy was employed for the analysis of arbutin both qualitatively and quantitatively in commercial whitening creams. Due to the efficiency of the method in separating arbutin from other ingredients including its degradation products, it can be applied as a stability-indicating method.
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title_short	Stability-Indicating Densitometric HPTLC Method for Qualitative and Quantitative Analysis of Arbutin in Commercial Whitening Creams
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doi_str	10.1556/JPC.25.2012.2.14
up_date	2024-07-03T22:28:55.573Z
_version_	1803598677226291200
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Stability-Indicating Densitometric HPTLC Method for Qualitative and Quantitative Analysis of Arbutin in Commercial Whitening Creams

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